A study was made of the actions of various drugs on average evoked potential from the cerebral cortex, the brain stem reticular formation, CM and the hippocampus following stimulation of the sciatic nerve, intestines and uterus in rabbits.
I. Following stimulation of the sciatic nerve, intestines and the uterus, there appeared spike like negative response (N
1, N
2, N
3) followed by positive response (P) in the cerebral cortex.
2. Follo wing stimulation of the sciatic nerve, intestines and the uterus, there appeared spike like negative response (RN
1, CN
1, HN
1) follwed by slight curved negative response (RN
2, CN
2, HN
2) in the brain stem reticular formation, CM and the hippocampus.
3. Morphine chiefly inhibited N
1, RN
1, CN
1, HN
1, and HN
2; it eith er inhibited or accelerated N
2, N
3, P, RN
2 and CN
2. Thus it was led to assume that the afferent pathway consists of one nervous system which was related with the development of N
1, RN
1, and CN
1 and the other nervous system which was related with N
2, RN
2, and CN
2, the former system being responsible for the development of pain.
4. Barbiturate inhibited N
1, N
2, N
3, RN
2, CN
1, and HN
1, a ccelerated P. either inhibited or accelerated RN
1, CN
2, and HN
2. It characteristically inhibited RN
2 markedly. Therefore it was strongly suggested that the nervous system which was related with the development of RN
2 took part in the forming of consciousness.
5. Experiments with aminopyrine, chlorpromazine and myanesin as to average evoked potential revealed that these agents acted similarly on RN
1 and HN
2. The above data supported to conclude that the nervous system which was related with the development of HN
2 in the hippocampus might be responsible for the development of pain keeping a certain relationship with pain reaction.
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