関西医科大学雑誌

Effect of Human Platelets on the Amidolytic Activity of Human Factor XII Activated by Kaolin

Yutaka Komiyama, Hiroshi Egawa, Hideki Kuriki, Kenjiro Murata

1984 年 36 巻 Supplement 号 p. s1-s10
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s1

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We have established an assay system for the amidolytic activity of purified human factor XII which is activated only by the negatively charged substance, kaolin, and examined the effect of washed platelets, ADP and serotonin on the amidolytic activity of kaolin-activated factor XII. Kaolin-treated platelets and serotonin of a physiological content in human platelet were found to promote the amidolytic activity of kaolin-activated factor XII, but ADP of a physiological content in human platelet had no such effect. The promoting effect of kaolintreated platelets and serotonin were inhibited by the addition of methysergide. Furthermore, it seems that serotonin affects the amidolytic activity of already activated factor XII by negatively charged substance.

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A case of psoriasis pustulosa. Treatment with potassium iodide and measurement of oxygen intermediates

Kyoko Nakajima, Jinro Komura, Setsuko Nishijima, Yasuo Asada, Yukie Ni ...

1984 年 36 巻 Supplement 号 p. s11-s16
発行日: 1984年
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s11

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A female patient with psoriasis vulgaris developed pustularform eruptions while being treated with thiamazole for her hyperthyroidism. The exudative pustular eruptions rapidly subsided with the use of oral potassium iodide. The measurement of oxygen intermediates showed that the generation of superoxide anion (0₂) and hydroxyl radical (OH ·) by polymorphonuclear neutrophils in the peripheral blood was high at the peak of the pustular attack.

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Effects of TRH-T and DN-1417 on Photopalpebral Reflex and Microvibration

Motohiro Yasuhara, Hiroe Naito, Kyoko Takemura, Masahisa Sawada, Naoko ...

1984 年 36 巻 Supplement 号 p. s17-s29
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s17

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We studied the effects of TRH and DN-1 417 on the PPR and MV of rabbits and obtained the following results:
1. TRH had a stronger facilitating activity on the central components, such as, PPR₅, PPR₇and PPR₈, among various components of PPR.
2. DN-1417 had a facilitating activity on such components of PPR₅, PPR₆, PPR₇ and PPR₈ but its activity was weaker than that of TRH.
3. TRH and DN-1417 also showed facilitating effects for individual components of MV but the activity was stronger with TRH than with DN-1417.
These results suggest that TRH has a stro nger facilitating activity on the nervous activity involving tissues other than the brainstem reticular formation than DN-1417.

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An Experimental Study on the Relationship between Phagocytized Necrotic Cells and Ceroidogenesis in Macrophages

Motohiro Ogura, Hideko Arichi, Chieh-Wen Liu, Masayuki Shintaku, Ryuei ...

1984 年 36 巻 Supplement 号 p. s30-s42
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s30

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The possible close relationship between phagocytized necrotic cells and ceroidogenesis in macrophages has been shown at varying intervals after interruption of the blood supply of localized hepatic and splenic tissues.

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"Fosterage Experiments" and Other Supplementary Experiments Related to Ferric Nitrilotriacetate (Fe-NTA) -induced "F1 Amyloidosis"

Motohiro Ogura, Junko Toki, Ryuei Maeda

1984 年 36 巻 Supplement 号 p. s43-s63
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s43

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ICR/JCL strain mice used were divided into 3 groups ( I, II and III ) which were treated as described in a chapter of materials and methods.
The results from groups I, II and III suggest that because of immunological memory for the antigen (Fe-NTA conjugate) remaining in the F₁ mouse blood as a result of maternal transmission of the antigen via the placenta, the F₁ mice given Fe-NTA chronically may have responded much more strongly with the same antigen than their maternal mice, eventually leading up to macrophage dysfunction to synthesize amyloid fibrils.

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Electron Microscopic Studies on Iron Micelles and Ferritin Particles Occurring in the Liver after an Intravenous Injection of Iron-Dextran

Junko Toki, Bonpei Matsuo, Hideko Arichi, Ryuei Maeda

1984 年 36 巻 Supplement 号 p. s64-s83
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s64

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Iron deposition, ferritin synthesis and excretion of ferritin or iron micelles in mouse liver were examined by electron microscopy at various time intervals ranging between 15 minutes and 3 weeks after injection of ID.
Conversion of ID to ferri tin molecules within digestive vacuoles or lysosomes occurred in hepatocytes 3 days after injection of ID and in Kupffer cells only 24 hours after the injection. Fusion among lysosomes suggesting an intracellular pathway of acid-phosphatase activity or iron metabolism and crystalline lattice formation within an aggregate of., ferritin were found in hepatocytes 3 weeks after the injection. Evidence was obtained suggesting that excess amounts of iron or ferritin deposited in the liver cell may be excreted via lysosomes into the bile canaliculi.

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Ferric Nitrilotriacetate (Fe-NTA) -Induced Transfer Amyloidosis

Junko Toki, Motohiro Ogura, Ryuei Maeda

1984 年 36 巻 Supplement 号 p. s84-s101
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s84

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The results showed that spleen cell suspensions from mice which had received 72 daily injections of Fe-NTA over 90 days were effective for developing transfer amyloidosis after recipients had receivied 99 injections of Fe-NTA over 120 days. Amyloidosis was proposed to be brought about by macrophage dysfunction induced as a result of a secondary immune response although it remains undetermined whether “amyloid- inducing (or accelerating) factor” may be involved in the genesis of Fe-NTA-induced transfer amyloidosis. Electron microscopic findings of the amyloidotic spleen were discussed with special reference to the significance of proteolytic enzymes released from the cell surface of RE cells assumed to be involved in extracellular amyloid synthesis.

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Elemental Analysis of the Intrapulmonary Deposits in the Reported Autopsy Case of Aluminum Dust Lung Using Electron Probe X-ray Microanalysis

Junko Toki, Jiro Tateiwa, Ryuei Maeda

1984 年 36 巻 Supplement 号 p. s102-s116
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s102

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The Black Thyroid. Histochemical and Electron Mficroscopical Studies on the Brown Pigment Granules

Motohiro Ogura, Hideko Arichi, Bonpei Matsuo, Ryuei Maeda

1984 年 36 巻 Supplement 号 p. s117-s125
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s117

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An Electron Microscopic Study on Ferritn from Erytbrocytes Containing Heinz Bodies Phagocytized by Kupffer Cells in Phenylhydrazine-Treated Mouse Liver

Bonpei Matsuo

1984 年 36 巻 Supplement 号 p. s126-s147
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s126

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The present study using perfusion fixation showed the occurrene of ferritin molecules within the Kupffer cells which phagocytized and digested erythrocytes containing Heinz bodies in the liver of the mice given 3 injections of 1 mg or a single injection of 5 mg phenylhydrazine. Evidence was obtained showing a fusion between a small-sized siderosome and a relatively large phagolysosome containing a few amount of ferritin molecules, suggesting an intracellular pathway of iron metabolism in the Kupffer cells. Supplement to J. Kansai Med. Univ., Vol.36, Dec.1984

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Hyperasialoglycoproteinemia in Acute Liver Diseases

Takaya Sawamura, Shinobu Kawasato, Masanao Tsuda, Yuji Naitoh, Hiroshi ...

1984 年 36 巻 Supplement 号 p. s148-s154
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s148

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Hyperasialoglycoproteinemia in acute liver diseases was studied by the correlation between the amount of serum asialoglycoproteins and results of liver function tests and by measuring the asialoglycoprotein receptor activity in hepatic tissues. Serum asialoglycoproteins accumulated markedly in sera of patients with acute, subacute and fluminant hepatitis. There were significant correlations between asialoglycoproteins level and the values of GOT, GPT and LDH (p < 0.001). The activity of asialoglycoprotein receptor in subacute hepatitis was O.013 U/mg microsomal protein, i. e.,20% of control value (0.064 ± 0.017 U/mg microsomal protein) and the activity in fluminant hepatitis was negligible. These results indicated that a severe liver damage causes the decrease in the receptor activity and an accumulation of serum asialoglycoproteins, and suggested that asialoglycoproteins level could be a good marker of hepatic dysfunction in patients with acute liver diseases.

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Amyloid and. Transfer Amyloid Induction in ICR/JCL Mice by Azocasein Administration in Comparison with Fe-NTA-induced “F₁ Amyloidosis” and Related Transfer Amyloidosis

Ryuei Maeda, Junko Toki, Motohiro Ogura, Hideko Arichi

1984 年 36 巻 Supplement 号 p. s155-s169
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s155

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In comparison with the fact that more th an 49 injections of azocasein antigenicity was sufficient for amyloid and transfer amyloidosis induction in ICR/JCL mice, while Fe-NTA appears to be too weak an antigen as to provoke amyloidosis in the same strain of mice, although it can induce “F₁ amyloidosis” propably as a result of a secondary immune response. The results are discussed in terms of the antigenicity of azo casein as well as Fe-NTA in the experimental induction of transfer amyloidosis.

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Ultracytochemical Studies on Lining Layer of Lung Alveoli

Nobutoshi Kotani

1984 年 36 巻 Supplement 号 p. s170-s186
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s170

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Technical improvement described by the author for the investigation of pulmonary surfactant system in adult rats are as follows; ( 1 ) Vascular perfusion of dilute Karnovsky's fixative was used for the lung tissues after air instillation into their airways. ( 2 ) Minute tissue blocks were prepared by quick freezing and trimming of the prefixed lungs. (3) Phospholipase-digestive method using a purified phospholipase A₂ or C was performed in the floating prefixed minute blocks. (4)After postfixation in 2% osmium buffer, acetone was used for dehydration of the digested minute blocks to preserve phospholipids. In addition, Dermer's technique for saturated phospholipids and the ultracytochemical procedure using ruthenium red for mucopolysaccharides were also performed, in which wire-meshed cagos were utilized as carriers of the minute lung tissues to prevent the floating.
Saturated phospholipids were clearly demonstrated on the surface film of the alveolar lining layers. In addition, positivity for phospholipids could be detected in a few myelin figures in Type 2 alveolar epithelial cells and the alveolar cavities. Mucopolysaccharides were observed in the whole acellular lining layers of the lung alveoli.

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An Analytical Electron Microscopic Study on Two Autopsy Cases of Pulmonary Barium Granuloma

Motohiro Ogura, Junko Toki, Masayuki Shintaku, Bonpei Matsuo, Ryuei Ma ...

1984 年 36 巻 Supplement 号 p. s187-s203
発行日: 1984/12/20
公開日: 2013/02/19

DOIhttps://doi.org/10.5361/jkmu1956.36.Supplement_s187

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Electron probe X-ray microanalysis of the lung specimens were performed in both the two autopsy cases where the patients aspirated mistakenly barium sulfate used as a radiographic contrast medium for the gastrointestinal tract. The results obtained revealed that irregularly shaped, electron-dense granules filling up macrophages in “barium granuloma” corresponded to Ba SO₄.

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