関西医科大学雑誌
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
39 巻, Supplement 号
選択された号の論文の7件中1~7を表示しています
  • Tokuji Nogawa, Katsuyuki Kiatayama, Shinya Masuko, Heiji Okuda, Morio ...
    1987 年 39 巻 Supplement 号 p. S1-S12
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    Relationship between the latency of visual evoked potential (VEP) and the depth of anesthesia was investigated in the surgical patients in order to evaluate the applicability of VEP to monitor the depth of anesthesia. The VEP was recorded with a standard EEG electrode from the midline parietal region (V-potential) with reference to both earlobes linked to the ground. The array of light-emitting-diodes (LED) mounted in opaque goggles was used to stimulate both eyes simultaneously and photic stimuli were delivered at random inter-stimulus intervals with uniform distribution ranged from 2 to 5 seconds. Fifty segments of data were averaged to estimate the Pmax latency, i. e., the latent period from the photic stimulus to the maximum positive peak.
    It was observed that the Pmax latency increased following the administration of anesthesia and returned to the preanesthetic value after the recovery of anesthesia. The Pmax latency showed an increase in proportion to the inspiratory concentration of enflurane gas. The latency of Pmax was also prolonged with addition of the neuro-lept-anesthesia (NLA) and with decrease in blood pressure during enflurane anesthesia. In case of patient with hypoglycemia, the Pmax latency increased drastically, which suggests an extreme sensitivity to anesthesia during hypoglycemia. It is concluded that the observation of the latency of VEP is found to be very useful for monitoring the depth of anesthesia and the vital conditions of the patients under anesthesia.
  • Jiro Sugimoto, Hitomi Otani, Seiichi Yuasa, Masayasu Suzuki
    1987 年 39 巻 Supplement 号 p. S13-S17
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    1. The effects of propranolol, verapam il and trimetazidine were compared on calciuminduced and potassium-induced contractions of guinea-pig isolated vas deferens in a sucrose medium. The preparations were pretreated with tetrasodium edetate before eliciting calciuminduced contractions.
    2. Pro pranolol (0.1 mM) and verapamil (5 μM) depressed potassium-induced contractions, but did not depress calcium-induced contractions until the concentration of the antagonist was increased at least ten-fold.
    3. Trimetazidine (3 μM) depressed calcium-induced contractions, but increased potassiuminduced contractions.
  • Jiro Sugimoto, Seiichi Yuasa, Masayasu Suzuki, Mitsuhiro Nagata
    1987 年 39 巻 Supplement 号 p. S18-S25
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    Isolated rat atrial and papillary muscles were kept in a Locke's solution aerated with 100%oxygen at 30°C, of which refractory period was measured by using Govier's double stimulus method. Changes of the refractory period were examined when the temperature of the medium was changed from 30°C to 25 or 40°C and oxygen concentraton in the aeration gas from 100% to 60,40,20 or 10% by replacing the oxygen by nitrogen. In the case in which the medium was aerated with 100% oxygen gas, the refractory period of the atrial and papillary muscles was lengthened when the temperature was lowered from 30 to 25°C, and was shortened when it was raised from 30 to 40°C. Each refractory period generally shortened with reducing the oxygen concentration in aeration gas: it was most marked when the atrial muscle was kept at 25,30 or 40°C and when the papillary muscle was kept at 40°C; and not so marked when the papillary muscle was kept at 25 or 30°C. By the presence of trimetazidine [0.0001 and 0.001% (w/v), i. e., 0.003 and 0.03 mM] in the medium, the shortening of the refractory period induced by the reduction of oxygen concentration was prevented in atrial muscle kept at 25,30 or 40°C and in papillary muscle kept at 40°C; although the shortening of the refractory period was not so marked in papillary muscle kept at 25 or 30°C, the drug caused it longer than value obtained in the muscle aerated by 100%oxygen gas. The results suggest a new possible application of trimetazidine to the clinical field, as no serious side effect of the drug has been reported in spite of its wide clinical use as an anti-anginal drug in this country.
  • Susumu Okubo, Taeko Sudo, Tomoko Ishida, Kojiro Yasunaga
    1987 年 39 巻 Supplement 号 p. S26-S31
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    Self-control of indirect Coombs tests gave positive results at the frequency of 5.5% (585cases) among 10,727 pretransfusion cross-matchings. Drugs (antibiotics, methyldopa) (46.3%), adsorption of complement along with anti- I (17.8%), autoantibodies (3.6%), and anti-A or anti-B (0.7%) were the main causes of these positives. On the other hand, no such causes could be found in the remaining 30.8%.
    In the 460 cases who received blo od transfusion in spite of their positive self-controls, no clinical side effects were obserevd.
  • Takaya Tanaka, Kenji Suzuki, Nobuaki Matsuo, Fumihiro Nozu, Kazunobu Y ...
    1987 年 39 巻 Supplement 号 p. S32-S36
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    This report describes a case of aged patient with severe acute pancreatitis successfully treated with peritoneal dialysis. Since no improvements were observed, showing amylase levels at 4,800 IU/l in the blood,7,700 IU/l in the urine, and 6,468 IU/l in the ascites, respectively, though continuous intravenous administration of proteninase inhibitors was conducted, continuous peritoneal dialysis was performed for 10 days with the peritoneal perfusion fluid mixed with proteinase inhibitors and antibiotics, resulting in the improvements of parameters and disappearance of subjective symptoms. Thus, our present case demonstrates that peritoneal dialysis is very effective for intractable acute pancreatitis.
  • Fumio Hara
    1987 年 39 巻 Supplement 号 p. S37-S43
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    Twenty six,31 and 53 young female Sprague-Dawley rats in Groups A, C and E, respectively, were administered 10 mg/Kg Bromocryptine daily by intubation for 3 weeks from 31 to 51 days of age. Twenty five rats each in Groups B and D served as the controls. Tail blood was collected for radioimmunoassay of prolactin from only meta- and di-estrus rats in Groups A, B and E around 10 am at the age of 51-58 days, and the sampling was not repeated in any animal. A rebound increase of serum prolactin level occurred within 3 days after the termination of Bromocryptine treatment. A single dose of 5mg/rat DMBA in Groups A and B and 2.5mg/rat in Groups C and D was given orally around 11 am at the age of 52days, and the carcinogenesis with DMBA was evaluated 22 weeks after the single administration of carcinogen. Mammary adenocarcinoma developed in some animals, but no other tumors could be found. When a single weaker dose of DMBA was administered orally on the day after the cessation of the 3 week treatment with Bromocryptine, the chemical induction of mammary carcinogenesis was enhanced distinctly.
  • Hiroshi Hosokawa, Sumihito Horio, Yasuko Takiuchi, Naoki Maruyama, Yas ...
    1987 年 39 巻 Supplement 号 p. S44-S50
    発行日: 1987/12/20
    公開日: 2013/02/19
    ジャーナル フリー
    Naturally occurring T lymphocytotoxic antibodies (T-LCA) have been detected in a variety of diseases including autoimmune diseases, viral infections and the acquired immune deficiency syndrome (AIDS). This study was undertaken to determine whether T-LCA in viral and related diseases are directed against a particular subset of T cells. After lysis of normal T cells with T-LCA and complement, the residual T cell population was studied using a series of T cell subset specific monoclonal antibodies. Our results indicate that T-LCA present in viral exanthema, pityriasis rosea and systemic lupus erythematosus (SLE) may be preferentially directed against OKT-8 (suppressor/cytotoxic) positive T cells, whereas those of nasopharyngeal carcinoma may be preferentially directed against OKT-4 (helper/inducer) positive T cells. These findings suggest that different reactivities of T-LCA with T cell subsets are dependent upon a variety of factors. It is also noted that the sera of patients with nasopharyngeal carcinoma showed higher titers of T-LCA than those of patients with viral exanthema and pityriasis rosea.
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