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Volume 40 (1988)
- Issue 4 Pages 435-
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Volume 40, Issue 4
Displaying 1-9 of 9 articles from this issue
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[in Japanese]1988 Volume 40 Issue 4 Pages 435-441
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (7343K) -
[in Japanese], [in Japanese]1988 Volume 40 Issue 4 Pages 442-448
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (989K) -
(Part 1) The factors affecting left ventricular ejection fraction during exercise -Clinical significance of systolic blood pressure/left ventricular end-systolic volumeYutaka Kimura1988 Volume 40 Issue 4 Pages 449-455
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSTo elucidate the factors affecting left ventricular ejection fraction (LVEF) during exercise (EX), bicycle ergometer EX test was performed in 47 patients with old myocardial in farction (MI) using RI angiocardiography. Multiple regression analysis was performed to determine the important variables related to the change of LVEF during EX based on 12 variables; left ventricular end-diastolic volume (LVEDV), LVEF, heart rate (HR), systolic blood preassure (BPS) and BPS/left ventricular end-systolic volume (BPS/LVESV) at rest, % ΔLVEDV, %ΔHR, and % ΔBPS/LVESV during EX, age, sex and site of MI. The change of LVEF durin g EX was positively related to % ΔBPS/LVESV and % ΔVEDV during EX (P<0.01). ΔLVEF had a good correlation with % ΔBPS/LVESV (r=0.53, P<0.01) which reflects cardiac contractility, while, tiLVEF had no significant relation with % LILVEDV which reflects preload. There was a significant and negative relation between % 4BPS/LVESV and %ziLVEDV (r= 0.64, P<0.01).
Therefore, it is important to assess the change of BPS/LVESV as well as LVEF for evaluating cardiac performance in the patients with old MI.View full abstractDownload PDF (1217K) -
(Part 2) The change of left ventricular ejection fraction from 1 month to 1 year after myocardial infarction-the relation between global and regional ejection fractionYutaka Kimura1988 Volume 40 Issue 4 Pages 456-463
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSWe studied the change of left ventricular ejection fraction (LVEF) and infarcted and noninfarcted regional ejection fraction (REF) during bicycle ergometer exercise as an index of cardiac performance in 30 patients with myocardial infarction (MI) at 1 month after the onset of MI using RI angiocardiography. LVEF, I-REF and N-REF were reestimated at 1 year after MI in 23 patients.
LVEF in cresed significantly from 42±13% to 45±12% during exercise, N-REF also incresed from 47±14 to 52±16% during exercise, but I-REF did not change during exercise at 1 month after MI. However, LVEF, N-REF and I-REF at rest increased significantly from 1 month to 1 year. % change of LVEF during exercise at 1 month after MI correlated well with %change of resting LVEF from 1 month to 1 year (r= 0.65, P<0.05). Moreover, % change of N-REF during exercise at 1 month after MI showed more excellent correlation with %change of N-REF from 1 month to 1 year than % change of LVEF during exercise at 1month (r =0.72, P<0.01).
Thus, N-REF is a majo r determinant of the change of cardiac performance during exercise at 1 month after MI. The change of cardiac performance at 1 year after MI could be predicted by evaluating the change of N-REF during exercise at 1 month after MI.View full abstractDownload PDF (2264K) -
An Electrophysiological Study of Arousal Reaction and Evoked Muscular DischargesHiroe Naito, Hiroshi Sakurai, Masahiro Nagata, Kyoko Takemura, Tomoko ...1988 Volume 40 Issue 4 Pages 464-477
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe effects of YM-14673 on central nervous system activity in rabbits were investigated electrophysiologically.
1. The threshold of arousal reaction of the cerebral cortex and hippocampus and those of evoked muscular discharges in the fore and hind limbs due to stimulation of the brain stem reticular formation decreased after administration of YM-14673.
2. The threshold of the evoked muscular discha rges in the fore and hind limbs due to stimulation of the cerebral cortex decreased after administration of YM-14673.
3. The threshold of the evoked muscular discharges in the fore and hi nd limbs due to stimulation of the hippocampus increased after administration of YM-14673.
4. The threshold of arousal reaction and evoked muscular dis charges in the fore and hind limbs due to stimulation of the cerebral cortex, which had been elevated by destruction of the internal capsule, was lowered after daily administration of YM-14673 0.05mg/kg.
The findings suggest that YM-14673 has a consciousness-arousing effect, a facil itatory effect on the pyramidal system and an inhibitory effect on the extrapyramidal system.View full abstractDownload PDF (3463K) -
I. Effects on Arousal Reaction and Evoked Muscular DischargesHiroe Naito, Hiroshi Sakurai, Masahiro Nagata, Takanori Saito, Hiroshi ...1988 Volume 40 Issue 4 Pages 478-492
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSEffects of TRH on the central nervous system activity were investigated electrophysiologically. TRH (0.05-1.0mg/kg) was injected intravenously in the rabbit and the following were observed.
1. The threshold of arousal reaction of the cerebral cortex EEG and hippocampus EEG and those of evoked muscular discharges in the fore and hind limbs due to 100Hz stimulation of the brain stem reticular formation decreased after administration of TRH.
2. These decreases persisted a considerably long time (at least on e hour).
3. The threshold of the evoked muscular discharges in the fore and hind limbs due to stimulation of the cerebral cortex decreased after administration of TRH.
4. The threshold of the evoked muscular discharges in the for e and hind limbs due to stimulation of the hippocampus increased after administration of TRH. It was suggested that the TRH has consciousness-arousing act ivity, a facilitatory effect on the pyramidal system and an inhibitory effect on the extrapyramidal system.View full abstractDownload PDF (2629K) -
Akira Shouzu1988 Volume 40 Issue 4 Pages 493-500
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSA highly sensitive RIA for albumin was developed and urinary excretion of albumin was determined in 29 diabetics (DM), who had no proteinuria by routine urinalysis, and in 30normal subjects (N). Glycated albumin (GA) in serum and urine as well as urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) were also estimated. The 24 hour urinary albumin excretion in N ranged from 4.0 to 12.9 mg/day (mean +SD,7.3±2.8), and the albumin excretion averaged 16.5±13.7 in DM, which was significantly higher than that in N. A significantly positive correlation existed between albumin excretion rate (μg/min, AER) and the first morning urinary albumin index (mg/g creatinine, AI), suggesting that Al is a good predictor of AER.
The mean values of Al and of NAG index (U/g⋅creatinine) were apparently elevated in DM, however, no significant relation was found between Al and NAG index. The urinary GA/serum GA ratio was decreased in DM prior to the elevation of urinary albumin excretion and these returned to normal by metabolic control. These results suggest that the selectivity of urinary GA excretion is an indicator of the glomerular changes at the early stage of diabetic nephropathy.View full abstractDownload PDF (1533K) -
Hiroyasu Okuno, Koji Tamura, Kazuto Mino, Junko Hirohara, Shigeru Take ...1988 Volume 40 Issue 4 Pages 501-508
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSA 73-year-old female was admitted to the hospital because of the disturbance of consciousness. She had been administered iron intravenously during the last six years for the treatment of anemia.
Laboratory findings on admission revealed leukocytosis and eosinophilia, liver dysfunction, hyponaturemia (117mEq/l) and hyperkalemia (5.5mEq/l). The serum levels of Fe and ferritin were increased to 388μg/d1 and 20004ng/dl, respectively, and the level of UIBC was decreased to 21 μg/dl. Endocrinological examination showed hypothyroidism without the elevation of TSH and reduced levels of LH and FSH. A decreased urinary excretion of 17-OHCS, and a decreased level of aldosterone with elevated plasma renin activity were also observed.
Parenchymal high density on X-CT and low intensity on MRI suggested iron deposition in the liver. Brain MRI revealed pituitary atrophy.
Histological examination of the liver sh owed precirrhosis with excessive hemosiderin deposits in hepatocytes and bile duct epithelium. Hemosiderin deposits were also observed in the epitheliums of fundic glands in the gastric mucosa and Brunner's glands in the duodenal bulb. The urinary excretion of iron increased to 7mg/24hr after the administration of desfferioxamine (500mg).
After the treatment with thyroid hormone and corticosteroid, the status of the patient markedly improved. Subsequently, a series of endocrinological stimulation tests was performed, which confirmed panhypopituitarism (LH FSH, TSH, ACTH, GH, prolactin), adrenal insufficiency (cortisol, aldosterone) and secondary (or secondary + primary) hypothyroidism.
In hemochromatosis, excessive iron deposits involve the endocrine sys tem, such as pituitary, thyroid, parathyroid, adrenal, testis and pancreas. Diabetes mellitus and hypogonadism are commonly complicated with hemochromatosis; in contrast, other endocrine disorders are rarely observed. Our patient is a vary rare case, which was diagnosed as secondary hemochromatosis associated with panhypopituitarism, adrenal insufficiency and hypothyroidism (secondary or secondary + primary).View full abstractDownload PDF (2069K) -
[in Japanese]1988 Volume 40 Issue 4 Pages 543-548
Published: December 20, 1988
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (8504K)
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