In hypertensives, whose microcirculation is generally poor, two methods are generally applied for treatment, namely antihypertensive agents, and other treatments, including exercise, diet and relaxation etc.. To maintain tissue good conditions, materials,O2 and CO2 should be transported. The microcirculation may be the primary site of these functions. The good condition of this system leads not only the tissue but also the entire body to better, and the quality of life will be improved. Evaluation of the microcirculations is considered to contribute to determination of the adequate antihypertensive agents and its optimal dose.
In our comparative study on the living, health and social conditions, eating habits, nutrition and results of medical examinations between the elderly who had experience of emigration to Canada (28 persons) at their young or manhood period and the elderly of non-emigration (39persons), we have got some conclusions as follows; 1) In emigrant group, we found more cases of l iving alone and being old couple than in non-emigrant group and 20% of them received pension (200$/month) from Canada. 2) Daily living: The proportion of persons in emigrant group who engag ed in works at farm or seaside, helped to their familie's business and so on, and did every thing they had a mind to do and enjoyed their favourite garden works is comparatively larger than that of those in non-emigrant group. 3) Eating habites: E migrant group has tendency to eat more bread every day and to take more meats, vegitables, fruit and dairy products than non-emigrant group. Emigrant group has inclination not to refrain from eating the foods boiled down in soy. 4) Health conditions: About 60% of emigrant group have their own s ubjective symtoms of being health and number of those who have some diseases (about 14%) are a half to those of non-emigrant group (28%). 5) Results of the health examin ation: The result of the health examination, such as Dementia Rating Scale (Hasegawa), dental examination, ophthalmological examination, ECG test and blood test was that non-abnormal among all aged are only 3. Emigrant group has more gastrointestinal diseases and anemia and non-emigrant group has comparatively more cardiac diseases, skeletal-joint disorder, rheumatism-neuritis and asthma. Average of numbers of diagnosis per a person is 1.4 and there is no difference in diagnosis numbers between emigrant group and non-emigrant group. 6) Result of the nourishment examination: There is no significant difference between emigrant group and non-emigrant group.
In the present study, the author intended to clarify the action mechanism of inrerferons (α, β, γ) and their antineoplastic effects in vitro using flow cytometry (FCM). The present study also concerns evaluation of the influence on the cellular immunopotentiality of patients with use of interferons and their effects in actual clinical cases. The action mechanism of interferons based on the cell c ycle was elucidated to be the S phase blocking, which fact was enforced by the concomitant measurement of the cell viability. A correlation between the positive cell rate and cell viability was, observed with fluorescein isothiocyanate-labeling of interferons, a method designed and developed by the author. Interferon-αand-βshowed different antineoplastic effect from that of interferon-γ. Such difference might be due to the difference of the affinity between the interferons and tumor cells. Using recently prevailed two-color analysis with FCM, the indirect antineoplastic effect of the interferons on the cellular immunopotentiality in brain tumor patients was evaluated. The increases of Leu 3a+8- (helper T) and Leu 3a/2a ratio were observed, which fact indicated that decreased immunopotentiality of patients was significantly improved. The indirect antineoplastic effect of NK cell was significantly enforced by the concomitant use of interferons (α, β, γ), but there was no difference in the effects between the interferons. Clinically, calcified and decreased mass was revealed on CT in two out of 13 patients, showing remarkable improvement with interferons. The above results suggest th at sensitivity may be evaluated with the present method using FITC-labeled interferons, and excellent clinical results can be expected with use of interferons not only for initiation therapy but for maintenance therapy.
Broadwin first made psychological researches into truancy in the 1930's. Since Johnson (1941) defined the term of "school phobia" discriminated from truancy, non-attendance at school has been known as the childhood neurosis. In our country, this term is used for neurotic disability of attending school. In this communication, we h ave reported our psychotherapeutic procedures used with a 14-year-old girl who had been unable to attend school when transferring to another school. Neither her personality nor home environment were so distorted as expected. Just after admitting new class, she had quarreled with one of the classmates. Because of that, she was left alone from most of them, and she became unable to attend school. Though she had repeatedly tried to go to school over and over again. At every attempt to atttend school, she had been suffered from “IJIME (ill-treatment)”. After a few weeks, she visited our hospital together with her mother for the first time. The authors have described the psychotherapeu tic procedures used in her treatment, and discussed about some aspects of her good school adjustment newly obtained through psychotherapy.