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Volume 46 (1994)
- Issue 1-2 Pages 1-
Volume 46, Issue 1-2
Displaying 1-9 of 9 articles from this issue
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[in Japanese], [in Japanese], [in Japanese]1994 Volume 46 Issue 1-2 Pages 1-3
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
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Hiroya Masaki, Mitsushige Nishikawa, Masaya Urakami, Mitsuo Inada1994 Volume 46 Issue 1-2 Pages 4-9
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSThe effect of 3,3',5'-triiodothyronine (rT3) on angiotensin II (AII)-induced calcium mobilization and formation of inositol 1,4,5-trisphosphate (IP3) in vascular smooth muscle cells (VSMC) was studied in this paper. rT3 at concentrations of 10 and 50,μM inhibited All (1μM)-induced increase in cytosolic calcium concentration ([Ca2+]i) and IP3 formation in VSMC dose-dependently.
These results indicate the possibility that rT3 which is regarded as an inactive metabolite of thyroxine (T4) has inhibitory effects on vascular smooth muscle function.View full abstractDownload PDF (829K) -
Kooichi Mochida, Tominori Kimura1994 Volume 46 Issue 1-2 Pages 10-24
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSAn extensive biological characterization of phototrophic bacterium R. capsulatus was performed to obtain relevant information for a possible medical use. Firstly, a weak anti-microbial activity against B. subtilis was found secreted from the cells. By all means examined, the bacteria was nontoxic: i. e., no biotoxicity was found positive when both cultured media and bacterial cells were tested in either ICR mice or JWR rabbits. Thirdly, to determine subcellular localization of the photosynthetic enzyme, ribulose 1,5-bisphosphate carboxylase/oxygenase, an immunoelectron microscopic examination was performed on ultra thin frozen sections of R. capsulatus. The immunoelectron microscopy revealed that even under aerobic conditions in darkness the enzyme that mediates the conversion of ribulose 1,5-bisphosphate to 3phosphoglycerate in the Calvin cycle was synthesized to localize at the chromatophores in the bacterial cells. Fourthly and lastly, to optimize the production of the biodegradable polymer, poly 3-hydroxybutyric acid (PHB), R. capsulatus was cultured under conditions that lacked nitrogen. The titration of mannitol as a carbon source showed that the production of PHB was maximized to occupy 78% of dried weight of bacteria when the cells were cultured in 1% mannitolcontaining medium. Unexpectedly, PHB was found synthesized even if the bacteria was cultured in the presence of nitrogen. The findings unraveled the previously poorly understood biolodical features of the bacteria and can pave the way for the possible medical use of R. capsulatus in near future.View full abstractDownload PDF (3364K) -
Iwao Hashimoto, Tominori Kimura, Akio Ohyama1994 Volume 46 Issue 1-2 Pages 25-44
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSPrimary cultures of murine cortical neurons and glia cells obtained from mouse embryos at 15 days of gestation were employed to study the polarized sorting of infected Herpes simplex virus type I (HSV-1)envelope glycoproteins. Following trypsinization the cortical neurons were successfully maintained at low density on polylysine-coated coverslips or culture dishes in a glucose-enriched medium. The intracellular distribution of viral glycoproteins was monitored by laser scanning confocal immunofluorescence microscopy. In mature, fully polarized neurons the HSV-1 glycoprotein moved from the perinuclear Golgilike region to the dendritic domains, whereas in underdeveloped immature neurons and glia cells no polarized distribution of the viral glycoproteins was observed. Since the HSV-1 glycoproteins are sorted to the basolateral plasma membrane of MDCK cells in a polarized manner', it is suggested that a common mechanism for polarized protein sorting could be shared between neurons and epithelial cells. Implications of the polarized sorting of the viral glycoproteins are also discussed on the basis for the pathogenesis of HSV-1 encephalitis.View full abstractDownload PDF (7484K) -
Shigeo Kyutoku, Yutaka Ogawa1994 Volume 46 Issue 1-2 Pages 45-50
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSA prominent, gonialangle, so called benign masseteric hypertrophy, is rather common and considered to be unattractive feature in the Orient. A face with this kind of deformity can only be corrected surgically Though most of the procedures are performed intraorally, exposure of the operation site is often not large enough for osteoplasty to proceed safely. Since the definite indication of the site of osteotomy is needed, especially in a narrower operative field, a special instrument was deviced to perform safe and accurate mandibular angle osteotomy.View full abstractDownload PDF (2205K) -
1994 Volume 46 Issue 1-2 Pages 59-61
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
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1994 Volume 46 Issue 1-2 Pages 62-68
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
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1994 Volume 46 Issue 1-2 Pages 69-77
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (5377K) -
1994 Volume 46 Issue 1-2 Pages 78-86
Published: June 20, 1994
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (5264K)
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