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Volume 56 (2004)
- Issue 2-4 Pages 169-
Volume 56, Issue 2-4
Displaying 1-7 of 7 articles from this issue
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T Kajiura, Y Isami, K Katsura, Inami N, S Kanazawa, K Yamada, T Kitano ...2004 Volume 56 Issue 2-4 Pages 169-171
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSConsidering that dialysis patients are often elderly, the onset risk of gastric mucosa disorder is increased in them. Therefore, the use of a selective cyclooxigenase (COX)-2 inhibitor that is expected to reduce the digestive disorders in the dialysis patients is of great significance. We investigated pharmacokinetics of meloxicam which is a selective COX-2 inhibitor approved in over 100 countries including Japan. Nine renal patients (4 males and 5 females) on hemodialysis were investigated. Single oral administration of meloxicam was conducted after supper the day before dialysis and plasma consentration was determined. The blood was taken at 1 hour, before start of dialysis. The meloxicam concentratio n was analysed by ultrafiltration. The mean plasma meloxicam concentration (meant-SD) at 1 hour before start of dialysis and at 1,4 and 48 hours after the start of dialysis were 541±168 ng/ml,532±153,512± 161,42± 72, respectively. The re sults indicated not significant changes in the plasma concentration at 1 and 4 hours after start of dialysis.View full abstractDownload PDF (515K) -
Ortwein H, Muehlinghaus I, Schnabel KP, Terzioglu P, Wilke A, Scheffne ...2004 Volume 56 Issue 2-4 Pages 172-181
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (2018K) -
[in Japanese]2004 Volume 56 Issue 2-4 Pages 182-184
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSDownload PDF (677K) -
Nobuaki SHIKATA, Masayuki SHINTAKU, Naoyuki DANBARA, Naoto SHIMANO, Sh ...2004 Volume 56 Issue 2-4 Pages 185-192
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSAn autopsy case of an 81-year-old man with a 14-year clinical course of sporadic Parkinson's disease is reported. The patient was apparently well until 63 years of age when he noticed weight loss and was diagnosed as having diabetes mellitus. At 67 years of age, he noticed a gait disturbance, and MRI examination showed cerebral arteriosclerosis withmultiple lacunae located at the corona radiata and thalamus. Based on the neurological examination and the MRI, he was diagnosed as having vascular parkinsonism. Despite medication, the patient's parkinsonism gradually progressed. At age 81, fourteen years after he first noticed a gait disturbance, he developed pneumonia and suffered a cardiopulmonary arrest. Post-mortem examination revealed a pulmonary abscess due to methicillin-resistant Staphylococcus aureus infection and adult respiratory distress syndrome. Neuropathological examination revealed characteristic findings, such as marked neuronal loss in the substantia nigra zona compacta and locus coeruleus, and Lewy bodies immunohistochemically positive for ubiquitin and α-synuclein in the remaining neurons. Lewy bodies were also seen in the basal nucleus of Meynert, amygdaloid nucleus, oculomotor nucleus, dorsal raphe nucleus, posterior lobe of the hypophysis, and in the peripheral autonomic nerve system (adrenal medulla, cardiac plexus, and myenteric plexus). Since the patient had no family history of Parkinson's disease, the patient was diagnosed as a sporadic case of idiopathic Parkinson's disease whose death was caused by respiratory distress.View full abstractDownload PDF (4223K) -
Angiogenesis by Implantation of Peripheral Blood Mononuclear Cells and Platelets into Ischemic LimbsOsamu Iba, Hiroaki Matsubara, Yoshihisa Nozawa, Soichiro Fujiyama, Kat ...2004 Volume 56 Issue 2-4 Pages 194-205
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESSBackground: Peripheral blood-mononuclear cells (PBMNCs), platelets or polymorphonuclear leukocytes (PMNs) contain various angiogenic factors. Methods and Results: Unilateral hindlimb ischemia was surgically induced in athymic nude rats, and fluorescence-labeled human blood cells (PBMNCs-107 cells+platelets-109, PBMNCs-107 cells +platelets-109+PMNsplatelets-109 or PMNs-107) were intramuscularly implanted into the ischemic limbs. Laser Do p pler imaging revealed markedly increased blood perfusion in PBMNC +platelet-implanted limbs (44% increase on day 21, P<0.001) compared with control implantation of human umbilical vascular endothelial cells (HUVEC). The addition of PMNs to PBMNCs +platelets attenuated blood perfusion (27% decrease, P <0.01). Neocapillary densities were increased by implantation of PBMNCs + platelets or platelets alone (3.5- and 2.4-fold, respectively; P<0.001), while PMNs inhibited (32%, P<0.05 )PBMNC+platelet-mediated capillary formation. There was no incorporation of implanted-PBMNCs into neocapillaries, whereas PBMNCs and platelets accumulated around arterioles after implantation. Cellular extract from PBMNCs+platelets, in which vascular endothelial growth factor (VEGF), basic fibroblast growth factor, platelet-derived growth factor-AB, and transforming growth factor-beta were detected, markedly stimulated tubule formation of human umbilical vein vascular endothelial cells. Anti-VEGF neutralizing antibody markedly inhibited tubule formation and in vivo vessel formation. Neutrophil elastase inhibitor blocked the antiangiogenic action of PMNs, whereas inhibitors of oxygen metabolites had no effect. Conclusions: This study demonstrated that implanatation of PBMNCs and platelets into ischemic limbs effectively induces collateral vessel formation by supplying angiogenic factors (mainly VEGF) and cytokines, suggesting that this cell therapy is useful as a novel strategy for therapeutic angiogenesis.View full abstractDownload PDF (4932K) -
Junko ASADA2004 Volume 56 Issue 2-4 Pages 206-211
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESS -
Kazutaka UEHIRA2004 Volume 56 Issue 2-4 Pages 212-219
Published: December 30, 2004
Released on J-STAGE: February 19, 2013
JOURNAL FREE ACCESS
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