Objectives: Although use of the small-sized catheters is less invasive for cerebral angiography (CA), difficult manipulability for tortuous vessels is a limitation. We report the clinical feasibility of a newly developed 3.3Fr catheter for CA in terms of manipulability. Methods: The data of 80 consecutive patients who underwent CA via the femoral or radial arteries using the newly developed 3.3Fr catheter were analyzed retrospectively. The duration of the CA procedure and fluoroscopy procedure in patients who underwent CA using a 3.3Fr catheter were compared with those in patients who underwent CA using a 4Fr catheter. We also analyzed the data of 14 patients who underwent CA with the new 3.3Fr catheter and had previously undergone CA with a 4Fr catheter using the same procedures including access routes and selected vessels. Results: CA was completed in all patients without any complications using the 3.3Fr catheter. The differences in the durations of CA and fluoroscopy were not statistically significant between the 3.3Fr and 4Fr catheter groups. There was also no significant difference in CA outcome in the 14 patients who underwent the same procedure using different sized catheters. Conclusions: The newly developed 3.3Fr catheter is useful for CA and its manipulability is the same as that of the 4Fr catheter.