日本医科大学雑誌
Online ISSN : 1884-0108
Print ISSN : 0048-0444
ISSN-L : 0048-0444
58 巻, 6 号
選択された号の論文の23件中1~23を表示しています
  • 高野 照夫
    1991 年 58 巻 6 号 p. 609-614
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
  • 清水 一雄, 庄司 佑
    1991 年 58 巻 6 号 p. 615-620
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 特にpulsatility indexの意義について
    石郷岡 聡
    1991 年 58 巻 6 号 p. 621-629
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    Transcranial Doppler Ultrasonography (TCD) is now commonly used to evaluate the cerebral hemodynamics. However, the blood velocity measured with TCD isnot always accurate, because as a rule the direction of the blood flow does not completely coincide with that of the ultrasonic beam. The error in the measurement could be as large as 15%. This could be eliminated by calculating pulsatility index (PI) from the Doppler ultrasonography.
    This study evaluates the reliability of the PI as an index of cerebral hemodynamics. In total, 164 measurements were made in patients with various cerebrovascular diseases (CVD), including 14 of brain death patients (group B) and 14 of inpending herniation patients (group I). Of CVD, 46 were persistent vegetative state patients (group V), and 43 were in relatively good conditions (group A). Other including 15 of hydrocephalus patients (group H) and 19 of cerebral vasospasm after subarachnoid hemorrhages (group S) were also investigated. Nineteen normal young volunteers (group N) were used as controls. The mean level of PI in group N shows 0.82. PI in group A was increased to 1.04, and in group V, 1.27. Furthermore in the brain death group, the mean level of PI was increased to 3.86, which was statistically significant. It was concluded that measurement of PI was very useful to evaluate the changes of cerebral hemodynamics, and the levels of PI was affected more with the changes in diastolic than in systolic flow velocity.
  • エソドトキシン刺激による多核白血球の活性酸素産生を中心として
    斎藤 忠生
    1991 年 58 巻 6 号 p. 630-639
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    It is well known that endotoxin (Et) plays an important role in severe surgical infectious diseases such as peritonitis. Recently, it has been reported that increased superoxide (0-2) formation and accelerated lipidperoxidation cause the progress of Et shock. The present study was designed to estimate the changes in the amount of lipid-peroxides in the liver and the relationship between Et and lipid-peroxidation in bacterial peritonitis. Plasma Et levels, lipid-peroxides in the liver, the number of leukocytes in the blood and the number of bacteria in the blood and peritoneal cavity were determined using an experimental peritonitis model that was induced by intraperitoneal (i. p.) injection of E. coli, E. faecalis and B. fragilis, as well as experimental endotoxemia model induced i. p. injection of Et. The influence of Et on the function of polymorphonuclear leukocytes (PMN), that was considered to be one of the origins of O-2 production, was studied using PMN from the peritoneal cavity of rats. The plasma Et level was increased in an E. coli group and mixed injection group, and the lipid-peroxide levels in the liver were increased in these two groups as well as in a B. fragilis group. Plasma Et and lipid-peroxide levels in the liver were also increased in Et injected mice. In the study of the influence of Et on PMN function, O-2 formation of PMN was increased when PMN was stimulated by Et with a high concentration and hexose monophosphate shunt activity was increased in all PMN stimulated by Et.
    These results suggest that O-2 from PMN stimulated by Et is related to lipid-peroxidation in the liver, which is considered an index of injury in bacterial peritonitis.
  • 胃潰瘍, 胃癌症例について
    花牟礼 康生
    1991 年 58 巻 6 号 p. 640-652
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    This study investigated the relationship between the gastric mucosa, gastric emptying and the peroral iron loading test in gastric ulcer and gastric cancer cases. The gastric mucosa in gastric ulcer cases was similar to that in gastric cancer cases. Gastric emptying in the M portion was delayed more than in the C and A portions as well as in the control group. In both early and advanced gastric cancer cases, gastric emptying was delayed slightly more than in the control group. The results of the peroral iron loading test showed that the serum iron level in the gastric ulcer cases in the active stage increased more remarkably than in the healing stage. In early gastric cancer cases the results of the peroral iron loading test were similar to those of the gastric ulcer cases. In advanced gastric cancer cases, the quantity of the serum iron did not increase significantly. In both gastric ulcer and gastric cancer cases, the quantity of serum iron in the cases with anemia was significantly increased. In both gastric ulcer and gastric cancer cases, negative correlation was recognized between serum ferritin and an increased quantity of serum iron. In gastric ulcer cases on the M portion, positive correlation was recognized between the increased quantity of serum iron and gastric emptying. In both gastric ulcer and gastric cancer cases, the in creased quantity of serum iron in cases with severe atrophic gastric mucosa was more significant than in those with mild atrophic gastric mucosa.
  • 井口 俊
    1991 年 58 巻 6 号 p. 653-662
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    Morphological measurements of the kidney were made using X-CT images. Anteroposterior width of the kidney as well as the renal sinus on both right and left sides and the transverse width of the first lumbar vertebral body were measured from CT images. Changes according to age in anteroposterior width of the kidney and the transverse width of the lumbar vertebral body were investigated. As to the ratio of the anteroposterior width of the kidney (both right and left) to the transverse width of the lumbar vertebral body, and the ratio of the anteroposterior width of the kidney to the anteroposterior width of the renal sinus, the changes due to aging and the differences between male and female were studied.
    1) In actual CT measurements, the average anteroposterior width of the right kidney was 47 mm, while that of the left kidney was 49 mm. The left kidney was slightly larger than the right kidney with statistical significance. In subjects up to 19 years of age, both the anteroposterior width of the kidney and the transverse width of the lumbar vertebral body showed correlation with age, while after the age of 20, there was no age-related correlation.
    2) The average ratio of the anteroposterior width of the kidney to the transverse width of the lumbar vertebral body was 1.13 for the right kidney and 1.19 for the left kidney. The difference between those two items was statistically significant and the changes due to aging were slight. During the age between 4 and 64 years, they were constant and no significant change was noticed. No difference between male and female was found. From the age of 65 years, a decreasing tendency was noticed.
    3) The ratios of anteroposterior width of the kidney to the anteroposterior width of renal sinus for both right and left kidneys in males and females were found to be inversely correlated with age. They were similar to the changes due to aging in renal functions of the cortex system. As seen on CT image, the ratio of the anteroposterior width of the kidney to the transverse width of the lumbar vertebral body, and the ratio of the anteroposterior width of the kidney to the anteroposterior width of the renal sinus could be the index of both the size of the kidney and the thickness of the renal parenchyma respectively.
  • 吾妻安 良太
    1991 年 58 巻 6 号 p. 663-672
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    In this study, we show that bispecific hetero-F (ab′)2 enhances cytolytic activity in human lymphokine activated killer (LAK) cells derived from peripheral bloodmononuclear cells against human small cell lung cancer (SCLC) cell lines.
    We used two types of bispecific F (ab′)2 (anti-CD3-LU246mAb, anti-CD16-LU246mAb) which play different roles in the enhancement of cytolytic activity in LAK cells against the human SCLC cell lines N231, H69 and Lu135. Anti-CD3 Fab′ or anti-CD16 Fab′ were coupled with LU246 Fab′ that recognized the antigen on human SCLC cells for reproducing bispecific F (ab′)2. Anti-CD16 (3G8) Fab′ conjugated with LU246 Fab′ targeted NK-LAK cells to SCLC cells to mediate cytolysis, but NK-LAK cells induced by LGL-enriched fraction did not display enhanced cytotoxicity even when bispecificantibody was used in 51Cr release assay. Anti-CD3 (OKT3) Fab′ conjugated with LU246 Fab′ cross-linked T-LAK cells to SCLC cells activated T-LAK cells through the CD3 complex, and enhanced the cytolytic activity of T-LAK cells against SCLC lines. Although OKT3-LU246 F (ab′)2 was not so potent in enhancing cytolytic activity in 51Cr release assay, it played a greater role in enhancing the inhibitory effect on tumor growth than 3G8-LU246 F (ab′)2 in human tumor clonogenic assay and in vivo tumor neutralization assay. In addition, the enhancement of target cell lysis by bispecific antibodies was generally more potent than antibodydependent cellular cytotoxicity (ADCC) using LU246 monoclonal antibody.
  • 第2報血圧, 心拍数と血中, 尿中カテコラミソkineticsの関連
    玉川 恭士
    1991 年 58 巻 6 号 p. 673-685
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
    Noradrenaline (NA) levels in blood and urine were measured in 7 male adults before, during, and after a mild ergometer exercise. Blood pressure (BP) and heart rate (HR) were continuously recorded during all of their stages. Blood specimens were obtained with a catheter introduced into the antecubital vein and plasma NA (PNA) level was measured with high performance liquid chromatography (HPLC) with electrochemical detection. NA and vanillylmandelic acid (VMA) levels in urine were measured by HPLC.
    The sequential changes of BP, HR, PNA, UNA, and VMA were simulated in a mathematical models of multiexponential functions as expressed by: Σ Aiex p (. Bi (tt) ; time).
    The present study suggests that the sequential changes of HR and systolic blood pressure (SBP) reflected the amount of NA secreted at sympathetic nerve endings on the effectors subserving HR and SBP changes, and therefore they were related to overflow of NA into plasma and urine, and also that of VMA into urine. The net NA levels at the nerve endings, as a result of NA kinetics, could be estimated from SBP and HR and could determine the rate of overflow of NA into plasma and urine. It was also revealed that the levels of SBP, PNA, UNA and urine volume immediately before the exercise were closely related to the rate of the diffusion. The rate of diffusion of NA into urine decreased to some extent as that of NA into plasma increased, but the rate of diffusion turned to an increase, when the latter exceeded a critical level.
  • 高石 康子, 橋本 清, 榎戸 久
    1991 年 58 巻 6 号 p. 686-695
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    Twenty five idiopathic epileptic children with occipital electroencephalographic (EEG) foci have been studied for more than 3 years clinically as well as electroencephalographically. They were categorized into two groups, i.e., those with (A group) and without (B group) visual symptoms. Not only visual symptoms, but also headache, nausea, vomiting or generalized tonic clonic convulsion (GTC) were observed in group A. GTC or tonic deviation of the eyes were observed in group B. Migrainous symptoms were present in 3 cases of group A. Interictal EEGs consisted of spikes or spike and wave complexes in the occiptal area. In some cases epileptic foci existed not only in the occipital area, but also in other regions.
    The mean age of the onset of the clinical symptoms was 8 in group A and 5 in group B. Beyond the age of 15, the abnormal EEGs were observed in 80% of the cases in group A, and in 18% of the cases in group B. The symptoms disappered by 9 years of age in 92% of the cases in group B, and by 15 years of age in 82% of the cases in group A.
    From these results the prognosis of idiopathic epilepsy of childhood with occipital EEG foci was considered as good.
  • Takao Endo, Naoki Sato, Haruo Kaneko, Kaname Kiuchi, Shinsuke Fujita, ...
    1991 年 58 巻 6 号 p. 696-702
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
    In order to evaluate the radioactive microsphere techniqueused in our laboratory for measuring regional myocardial blood flow (RMBF) in dogs with myocardial ischemia, simultaneous blood flow measurements with three different nuclide (141Ce, 51Cr or 113Sn) -labeledm icrospheres were performed after coronary artery occlusion. There were excellent correlations between all paired RMBF values in 80 samples. The linear regression lines were expressed as: 51Cr=1.09x 141Ce-0.02 (r=0.996, SEE=0.06) ; 113sn=0.99x 141Ce+ 0.01 (r=0.997, SEE=0.05); 113Sn=0.90x 51Cr + 0.03 (r=0.991, SEE=0.08). The duplicate variability ranged from 5.5±0.7 to 9.9±1.1%. When RMBF was measured before and after ntravenous administration of nipradilol (0.2 mg/kg), a new beta-blocker, in a dog with myocardial ischemia, RMBF fell in the normal zone (23.6±1.6%), and did not change in the severely ischemiczone. Thus, this study demonstrated that RMBF can be measured accurately and repeatedly with radioactive microspheres in dogs with regional myocardial ischemia.
  • AIDSウイルス (HIV) をモデルとして
    高橋 秀実
    1991 年 58 巻 6 号 p. 703-707
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
  • 猪口 孝一
    1991 年 58 巻 6 号 p. 708-712
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
  • 太田 秀穂
    1991 年 58 巻 6 号 p. 713-716
    発行日: 1991/12/15
    公開日: 2010/10/14
    ジャーナル フリー
  • 1991 年 58 巻 6 号 p. 717
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 新任教授特別講演
    1991 年 58 巻 6 号 p. 720-740
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 奨学賞受賞記念講演
    1991 年 58 巻 6 号 p. 741
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 海外留学者講演
    1991 年 58 巻 6 号 p. 742-755
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 一般講演
    1991 年 58 巻 6 号 p. 756-769
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 展示発表 (その1)
    1991 年 58 巻 6 号 p. 769-776
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 展示発表 (その2)
    1991 年 58 巻 6 号 p. 777-786
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 展示発表 (その3)
    1991 年 58 巻 6 号 p. 787-795
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 展示発表 (その4)
    1991 年 58 巻 6 号 p. 796-804
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
  • 展示発表 (その5)
    1991 年 58 巻 6 号 p. 805-810
    発行日: 1991/12/15
    公開日: 2010/12/22
    ジャーナル フリー
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