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Volume 63 (1996)
- Issue 6 Pages 441-
- Issue 5 Pages 319-
- Issue 4 Pages 255-
- Issue 3 Pages 175-
- Issue 2 Pages 79-
- Issue 1 Pages 2-
Volume 63, Issue 5
Displaying 1-19 of 19 articles from this issue
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Kazuo Dan1996 Volume 63 Issue 5 Pages 319-326
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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A comparison with fetal blood gas analysisTakuji Iwasaki1996 Volume 63 Issue 5 Pages 327-342
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSDepartment of Obstetrics and Gynecology, Nippon Medical School Pulsed Doppler ultrasonography was used to asses the pulsatility index (PI) on flow velocity waveforms in uterine, umbilical and fetal middle cerebral arteries from a total of 659 pregnancies and the standard curves of each PI in relation with the gestational age were obtained from a total of 472 normal pregnancies. Cordocentesis was performed on 20 patients (centesis group) of PIH (pregnancy-induced hypertension) complicated with intrauterine growth retardation (IUGR) and fetal blood from the umbilical vein was sampled for blood gas analysis. Fetuses in the centesis group were acidemic (pH<7.25) in 10 cases (50%), hypercapnemic (pCO2≥50 mmHg) in 8 cases (40%), and hypoxemic (pO2<20 mmHg) in 6 cases (30%). In 13 cases (65%) in the centesis group, PI of the uterine artery (UTPI) was higher than+1.5 SD (standard division) of the standard curve (high UTPI), in 9 cases (45%) PI of the umbilical artery (UAPI) was higher than +1.5 SD of the standard curve (high UAPI), and in 10 cases (50%) PI of the middle cerebral artery (MCAPI) was lower than-1.5 SD of the standard curve (low MCAPI). All acidemic fetuses (100%) had high UTPI, 9 (90%) had high UAPI, and 8 (80%) had low MCAPI. All hypercapnemic fetuses had high UTPI, high UAPI and low MCAPI. All hypoxemic fetuses had high UTPI, high UAPI and low MCAPI. In the centesis group, the sensitivity, specificity, positive predictive value and negative predictive value of high UTPI to fetal acidosis was 100%, 70%, 76.9% and 100%, respectively. The sensitivity and the specificity of high UAPI and low MCAPI to fetal acidosis was 80% and 100%, respectively. The positive predictive value was 100% and negative predictive value was 83.3%. From this study, we conclude that measurement of uterine and fetal blood flow waveforms by pulsed Doppler ultrasonography is useful to assess fetal well-being in IUGR caused by hypertension during pregnancy.View full abstractDownload PDF (3974K) -
Koroku Negishi, Yoichi Yamane, Masami Yoshimoto, Hironobu Ito1996 Volume 63 Issue 5 Pages 343-348
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSBy means of tyrosine hydroxylase immnocytochemical detection, regional densities of dopaminergic (DAergic) neurons were measured in 6 whole-mounted retinas of a marine teleost, Thamnoconus (Navodon) modestus. Isodensity lines of DAergic cells in the right retina were drawn to make a contour map. Depending upon the range of cell densities, the retinal field was divided into 3 regions: zone A, containing more than 300 per mm square; zone B, from 200 to 299; and zone C, below 200. Zone A was located in the small temporal (A 1) and nasal (A 2) areas as well as in the peripheral margin (A 3). Zone B formed a horizontal streak-like band between regions A 1 and A 2. Low density areas (C) were located dorsally or ventrally to zone B. Where the densities were higher, soma sizes appeared to be smaller. DAergic neurons in the peripheral zone A 3 were bipolar and the dendrites ran parallel to the retinal margin, while DAergic neurons in the other zones were multipolar and the dendrites ran in various directions. The presence of the small temporal (A 1) and nasal areas (A 2) with high densities of DAergic neurons, as well as the streak-like area (B) with a relatively high density, may correspond to similar areas in the isodensity contour map of ganglion cells.View full abstractDownload PDF (1202K) -
Masaaki Maruyama1996 Volume 63 Issue 5 Pages 349-355
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSThe important role of Helicobacter pylori (H. pylori) in idiopathic duodenal ulcer disease is widely acknowledged. Treatment with amoxicillin and omeprazole has been highly successful in eradicating H. pylori in some pilot studies. We conducted a study in patients with active duodenal ulcer disease and H. pylori colonization of gastric mucosa using a combination of amoxicillin and lansoprazole. Lansoprazole has been shown to exhibit lower MIC than omeprazole. Sixty three patients who qualified for admission to the study were randomly assigned to receive either oral lansoprazole (30 mg, p. o., qam, daily for 6 weeks) (n=30) or lansoprazole (6 weeks) plus amoxicillin (1500 mg, p. o, t. i. d., daily for 2 weeks) (n=33). Six weeks after the initiation of treatment with lansoprazole, healing of the ulcers was assessed using electronic endoscope according to the classification of Sakita & Miwa. When lansoprazole alone was administered to the patients, H. pylori dormancy was attained in none of the patients, whereas dormancy was ascertained in 17 out of 33 patients when lansoprazole and amoxicillin were administered in combination. H. pyloridomancy was assessed by 13C urea breath test, histological examination of gastric mucosa and rapid urease test. Endoscopic evaluations revealed that S 2/S 1 ratio was significantly higher in patients with H. pylori dormancy than in those without. The results of our study confirmed that treatment to eradicate H. pylori with drugs such as lansoprazole and amoxicillin is effective in the healing of idiopathic duodenal ulcer disease.View full abstractDownload PDF (1465K) -
The sensitizing ability of active ingredients and cross-sensitivityEiko Yoneyama1996 Volume 63 Issue 5 Pages 356-364
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSSince the introduction of clotrimazole cream to the Japanese market in 1979, topical imidazole antimycotics have been used with increasing frequency in the treatment of superficial fungal infections. Topical imidazole antimycotics are in common use today and new imidazole derivatives continue to be developed.
In this study, the author discussed allergic contact dermatitis due to topical imidazole antimycotics and cross-reactions among them. Of the 3, 049 outpatients who were patch-tested for contact dermatitis at the Department of Dermatology, Nippon Medical School Hospital from January, 1984 to August, 1994, 218 were patch-tested with topical antimycotic agents. Of these 218 cases, 18 were tested with imidazole derivatives and 66 showed positive. Thirty-five were allergic to the active ingredients; 16 were allergic to sulconazole, 11 to croconazole, 3 to tioconazole, 3 to miconazole, one to bifonazole, and one to clotrimazole.
The reason why sulconazole induced the most frequent positive reactions is probably that sulconazole was prescribed most frequently at our department during the period. The duration and the total amount of topical imidazole needed until contact dermatitis occurred, were statistically analyzed by t-test. Croconazole needed a significantly shorter duration and smaller quantity than sulconazole. This means that the sensitizing ability of croconazole is stronger than that of sulconazole. Since 21 of the 35 imidazole-allergic cases cross-reacted to other imidazole (s), the imidazole derivatives are considered to cross-react frequently.View full abstractDownload PDF (1696K) -
Ryu Tsunoda1996 Volume 63 Issue 5 Pages 365-377
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSForty cases of malignant fibrous histiocytomas (MFHs) consisting of 33 cases of storiformpleomorphic subtype MFH and 7 cases of myxoid subtype MFH, were studied immunohistochemically. Immunohistchemical stains were performed by the labelled streptavidin biotin method. The primary antibodies used in this study were classified into 4 groups according to their main specificities: 1) epithelial and non-epithelial (mesenchymal) markers, 2) histiocytic markers, 3) myogenic markers, 4) and that considered as possible lipogenic marker. In addition to these markers, alcian-blue stain, periodic acid-Schiff stain, Masson-trichrome stain, silver impregnation stain, oil red O stain, and Sudan III stain were performed in some cases at the same time. Over 85% of the cases were positive for mesenchymal and histiocytic markers, and no cases were positive for epithelial markers. About 40% of MFH were positive for some myogenic markers, but none of these cases were positive for any skeletal muscle markers. S-100 protein, considered as a possible lipogenic marker through the results of other special stains, was positive in about 10% of the MFHs. The immunohistochemical results of myogenic and lipogenic markers were parallel to the histological subtype; the positive percentages for myogenic markers were abour 50% in the cases of storiform-pleomorphic subtype, but were 17% in the cases of myxoid subtype. On the other hand, the positive percentage for lipogenic marker was only 4% in the cases of storiform-pleomorphic subtype, but was 50% in the cases of myxoid subtype. These were supposed to be additional and occult characteristics of MFH. Therefore, the interrelation between the immunohistochemical results and histological subtype of MFH interestingly suggested a new entity of MFH concerning the histogenesis of MFH: MFH was suspected to contain some groups of very poorly differentiated and/or dedifferentiated sarcomas and to be the precondition of some sarcomas.View full abstractDownload PDF (3833K) -
Shoji Kudo, Yuh Fukuda1996 Volume 63 Issue 5 Pages 378
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Yuh Fukuda1996 Volume 63 Issue 5 Pages 379-383
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Moritaka Suga1996 Volume 63 Issue 5 Pages 384-390
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Fumitaka Ogushi1996 Volume 63 Issue 5 Pages 391-394
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Oichi Kawanami1996 Volume 63 Issue 5 Pages 395-399
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Masashi Sato1996 Volume 63 Issue 5 Pages 400-403
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Akira Murata1996 Volume 63 Issue 5 Pages 404-408
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Kiyoshi Koizumi, Shigeo Tanaka, Shuji Haraguchi, Hirohiko Akiyama, Iwa ...1996 Volume 63 Issue 5 Pages 409-413
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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Yuichi Komaba, Shin Kitamura, Akiro Terashi, Michiko Tamotsu, Yuusuke ...1996 Volume 63 Issue 5 Pages 414-418
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSA 48-year-old Japanese woman from Kyushu was admitted to the Nippon Medical School First Hospital with complaints of numbness in both legs, gait disturbance, and urinary problems. On examination, her lower extremities were spastic with increased reflexes and positive Babinski sign. Sensation was absent below the T4 spinal level. The cerebrospinal fluid contained HTLV-I antibodies and she was diagnosed with HTLV-I associated myelopathy. Her symptoms were resolved with prednisolone, but six months later a visual disturbance of the left eye edema developed. Orbital CT scans showed that left optic nerve was edematous. T2 enhanced MRI revealed a high intensity lesion of the left optic nerve. ERG was normal and no VEP was detected in response to flashing stimulation to the left eye. The HTLV-I antigen titer of CBF was very high. Her optic neuritis improved following oral administration of prednisolone and retrobulbar injections of dexamethasone. This is the first case report of HTLV-I associated myelopathy complicated by optic neuritis.View full abstractDownload PDF (1151K) -
Michinobu Koda, Shinichi Yoshino, Hiroshi Nakamura, Goro Asano1996 Volume 63 Issue 5 Pages 419-423
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSTo investigate the effects of disease modifying antirheumatic drugs (DMARDs) and DEX on production of IL-1 β, IL-6 and TNF-α, synovial cells were observed after IL-1 β administration in vitro.
Materials and Methods: Synovial tissue was obtained aseptically from 8 rheumatoid arthritis patients during joint surgery. The dissected tissue was treated with collagenase and adherent cells were passaged before using as samples. They were stimulated with IL-1 β (1ng/ml) and cultured with DMARDs and DEX in serum-free media.
After 24 hours' incubation, the production of IL-1 β, IL-6 and TNF-α in the supernatants was measured.
Results: DEX inhibited the production of IL-6. GST inhibited the production of IL-1 β and IL-6.
Conclusion: DEX and GST may modulate the disease activity by inhibiting the cytokine production from synovial cells.View full abstractDownload PDF (824K) -
Yoshihiro Fukuo, Toshiaki Kitami, Tatsuya Nomoto, Akiro Terashi1996 Volume 63 Issue 5 Pages 424-430
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
JOURNAL FREE ACCESSWe administered 400 mg of bezafibrate daily to 27 patients with hyperlipidemia for seven moths. Most biochemical parameters remained unchanged, whereas levels of alkaline phosphatase (Al-P) and gamma-glutamyl transpeptidase (y-GTP), which are the hepatobiliary enzymes, were significantly decreased. Blood lipid levels were improved. Al-P levels de-creased significantly from the baseline level of 174.5 IU/l to 116.7 IU/l (-26.5%) and γ-GTP levels also decreased from 64.4 IU/l to 34.4 IU/l (-29.5%) (p<0.001). When we compared the changes in serum lipid levels with those in Al-P and γ-GTP levels following bezafibrate therapy, we found a slight degree of correlation between changes in y-GTP and triglyceride (T-G) levels, but no correlation at all between the changes of Al-P and total-cholesterol (T-cho), T-G or high density lipoprotein cholesterol (HDL-C). A close correlation was observed between both Al-P and y-GTP (r=0.81, p<0.001). From these results it was suggested that bezafibrate has not only a lipid lowering effect but has a favorable efficacy on the hepatobiliary enzymes.View full abstractDownload PDF (1001K) -
Hiroshi Nakano, Shuzou Satoh1996 Volume 63 Issue 5 Pages 431-435
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1996 Volume 63 Issue 5 Pages 436-437
Published: October 15, 1996
Released on J-STAGE: March 01, 2010
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