The Brain & Neural Networks
Online ISSN : 1883-0455
Print ISSN : 1340-766X
ISSN-L : 1340-766X
Search
Advanced search
OR
Browse
Search
Volume 8, Issue 2
Displaying 1-6 of 6 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • Spatial Distributions of Hippocampal LTP/LTD Induced Electrically from Schaffer Collaterals and Stratum Oriens with Relative Timing
    Yuki Kobayashi, Hide-aki Shimazaki, Takeshi Aihara, Minoru Tsukada
    2001 Volume 8 Issue 2 Pages 57-64
    Published: June 05, 2001
    Released on J-STAGE: January 31, 2011
    DOIhttps://doi.org/10.3902/jnns.8.57
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Spatial distributions of LTP/LTD were investigated in the CA1 area of hippocampal slices by optical imaging method. A pair of electrical pulse stimuli was used to stimulate the schaffer collateral (Stim. A) and the stratum oriens (Stim. B) with various sets of the relative timing (τ). LTP was induced with -10ms<τ<10ms, τ=0ms led to the widest and strongest LTP. On the other hand, τ=±20ms induced LTD. In particular, this LTD at τ=20ms was something that had not been observed by others using cultured hippocampal neurons. The LTD at τ=20ms was blocked by bicuculline (GABA (gamma-aminobutyric acid) receptor antagonist). The importance of precise spike timing in hippocampal CA1 network is discussed in the light of computational neuroscience involving the covariance learning rule.
    View full abstract
    Download PDF (2649K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top