巻号一覧
32 巻, 3 号
選択された号の論文の9件中1～9を表示しています
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金沢 正一郎, Victor HERBERT1986 年 32 巻 3 号 p. 251-257
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーTwenty-seven alcoholic patients were studied for folate status. Twenty-two (81%) had neutrophil hypersegmentation and were detected as folate deficient by also having low serum folate, erythrocyte folate, lymphocyte folate and/or an abnormal peripheral blood lym-phocyte deoxyuridine suppression test. Seventeen (63%) had an abnormal lymphocyte deoxyuridine suppression test and all 17 were corrected by the addition of methyltetrahydrofolate or pteroylglutamate.
Comparison of these 63% abnormal (corrected by folate) results using the peripheral blood lymphocyte deoxyuridine suppression test with the lower percent abnormal (corrected by folate) bone marrow deoxyuridine sup-pression tests found in folate-deficient alcoholics by others suggests that the peripheral blood deoxyuridine suppression test may be more useful than the bone marrow deoxyuridine suppression test for laboratory diagnosis of folate deficiency responsive to folate therapy in alcoholism. Hidden iron deficiency is common in alcoholism, and in the concomitant presence of deficiencies of hemoglobin synthesis and of folate, the serum and erythrocyte folate and deoxyuridine suppression test in bone marrow are frequently normal, despite the suppression test being abnormal in lymphocytes and corrected by folate.抄録全体を表示PDF形式でダウンロード (637K) -
大塚 惠, 倉田 忠男, 荒川 信彦1986 年 32 巻 3 号 p. 259-266
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーThe tissue distribution of L-ascorbic acid (AsA) and dehydro-L-ascorbic acid (DAsA) in guinea pigs injected with DAsA intravenously was examined using high-performance liquid chromatog-raphy. DAsA injected into guinea pigs fed normal diets containing AsA (control group) was readily taken into erythrocytes, and AsA contents of plasma and other tissues rapidly increased after DAsA injection. In animals fed vitamin C-deficient diets, DAsA was also detected in eryth-rocytes; however, the increase of AsA in their tissues was considerably less than that of control group. From these results; it was suggested that utilization of DAsA as AsA in vitamin C-deficient guinea pigs was less than that of control animals, and the reduction mechanism of DAsA to AsA in vitamin C-deficient guinea pigs may have differed from that of control groups.抄録全体を表示PDF形式でダウンロード (687K) -
田寺 謙次郎, 有馬 みどり, 吉野 慎一郎, 八木 史郎, 小林 昭1986 年 32 巻 3 号 p. 267-277
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーIn experiments designed to examine interactions between pyridoxine (PN) and food components, PN was found to be converted into an unidentified compound in the presence of the homogenates of various plant foods under mild conditions. The formation of the compound tended to be higher when food samples had a higher ascorbic acid (AsA) content. The reaction was neither thermal decomposition nor photodecomposition.
This compound was also formed by incubating PN with AsA in the dark. Conversion of PN into the compound proceeded with oxidation of AsA, and was negligible under anaerobic conditions. The pH optimum for the reaction was between 4 and 7, and the temperature optimum was between 30 and 50°C. The compound was purified by ion-exchange chromatography, isolated as colorless needles, and identified as 6-hydroxypyridoxine from UV, PMR, IR and MS spectral data. 6-Hydroxypyridoxine had neither vitamin B6 nor antivitamin B6 activity for Saccharomyces carlsbergensis 4228 (ATCC 9080).
From these results, we inferred that hydroxylation of PN in the presence of food components, especially AsA, caused loss of vitamin B6 in plant foods during food processing, storage and cooking.抄録全体を表示PDF形式でダウンロード (961K) -
大堺 美弥子, 田村 光司, 和泉 好計, 山田 秀明1986 年 32 巻 3 号 p. 279-286
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーCompound X, reported as an intermediate in the biosyn-thesis of biotin from dethiobiotin (DTB) (Biochem. Biophys. Res. Commun., 88, 312 (1979)), was found to contain N-formyl DTB and biotin. The methyl ester of N-formyl biotin was considered to be a product from the biotin, which was biosynthesized from DTB by resting cells of E. coli C 124, through treatment with diazomethane in the presence of a trace amount of formic acid after Dowex 1X2 column chromatography. NMR analysis revealed that biotin was formylated at 1'-N. N-Formylated DTB and biotin are new biotin derivatives.抄録全体を表示PDF形式でダウンロード (688K) -
山中 優美子, 辻 啓介, 市川 富夫1986 年 32 巻 3 号 p. 287-296
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーThe effects of dietary taurine on fecal steroid excretion and bile acid pool size were investigated in Jcl: ICR strain mice. The mice were fed on semi-purified diets for five weeks: a cholesterol-free diet (Standard), a lithogenic diet containing 0.5% cholesterol and 0.25% sodium cholate (C-CA) and a lithogenic diet supplemented with 5% taurine (C-CA+5% taurine). The changes in fecal steroid excretion were studied as a function of time and the bile acid pool size was estimated. Dietary taurine affected fecal bile acid excretion both quantitatively and qualitatively. No change in bile acid pool size was observed. The fecal excretion of bile acids increased in taurine-supplemented mice. The increase in the fecal neutral steroid excretion was less than that in C-CA fed mice. The proportion of chenodeoxycholic acid (CDCA) and the related bile acids to total bile acids increased both in the fecal bile acids and in the bile acid pool. Therefore, the protective effect of dietary taurine against cholesterol gallstone formation may be related to the stimulation of bile acid synthesis, especially of CDCA and related compounds.抄録全体を表示PDF形式でダウンロード (935K) -
川井 紘一, 奥田 諭吉, 千葉 之宣, 山下 亀次郎1986 年 32 巻 3 号 p. 297-306
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーPalatinose (6-O-α-D-glucopyranosyl-D-fructose) is a na-turally occurring compound which may be valuable as both a sweetener and parenteral nutrient. Its advantage over maltose is that its hydrolysis generates both fructose and glucose. In the present study, conducted with a view to possible clinical use, its metabolic effects and fate after iv injection were investigated. Using dogs as the experimental model, it was found that the behavior of parenterally administered palatinose is in many respects similar to maltose and is likely to be clinically valuable. Importantly, hypertriglyceridemia, a side effect of fructose administration, did not occur, indicating that palatinose may be superior to the use of fructose alone.抄録全体を表示PDF形式でダウンロード (813K) -
津田 淑江, 福場 博保1986 年 32 巻 3 号 p. 307-315
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーWhen the isotachoelectrophoretical method is used with HCI-β-alanine as the leading electrolyte solution (pH 3.6), ascorbic acid forms a mixed zone with glutamic acid, and it is difficult to separate the two. Therefore, the application of a computer simulation system to separate the two acids was investigated.
This system can be used with compounds for which the absolute elec-trophoretical mobility and dissociation constant have already been de-termined. Values for glutamic acid alone were entered in the data bank “SIPS-l, ” and then those for ascorbic acid were estimated from the values of similar compounds. Values for aspartic acid were used, and the electrophoretical behavior of ascorbic and glutamic acids was simulated at pH range from 3 to 9.9. Based on this simulation, separation appeared possible at pH 9.0 to 10.0, and indeed, experimental determination of ascorbic acid was successfully performed with a leading electrolyte solution composed of HCl-ethanolamine (pH 9.4) without any glutamic acid interference.
Even though ascorbic acid is highly susceptible to oxidation in an alkaline medium, because the ascorbic acid solution is injected at the interface of the leading and terminal electrolyte solutions in the electrophoretical procedure, it does not come in contact with air during electrophoresis. This explains why ascorbic acid can be determined in an alkaline medium.抄録全体を表示PDF形式でダウンロード (726K) -
金子 佳代子, 西田 京子, 谷ッ田 淳子, 長 里美, 小池 五郎1986 年 32 巻 3 号 p. 317-325
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーFive female subjects were given four types of test diets containing various levels of protein for four consecutive 5-day periods and their dietary fiber and feces were collected throughout the experimental period. Diet A was a high-fiber, low-protein diet containing brown rice. Diet B was a semi-purified, low-protein diet containing agar agar as the sole source of dietary fiber. Diet C was a low-fiber, normal-protein diet containing polished rice. Diet D was a high-fiber, normal-protein diet containing brown rice. A fecal marker was given at breakfast on the first day of each five-day test period and on the day after the end of the experiment.
Fecal weight increased during the period on high-fiber diets (diets A and D). The apparent digestibilities of protein and fat were significantly depressed by high-fiber diet. Fecal excretion of calcium did not increase on the high-fiber diets. A decrease in the apparent digestibility on a high-fiber, low-protein diet was partly due to the low intake of calcium during this period. Fecal excretion of cholesterol increased markedly during the periods on high-fiber diets. The difference between the intake and fecal excretion of dietary fiber suggested that the fiber was partially digested in the colon.抄録全体を表示PDF形式でダウンロード (835K) -
Anurag CHATURVEDI, P. GEERVANI1986 年 32 巻 3 号 p. 327-334
発行日: 1986年
公開日: 2009/04/28
ジャーナル フリーGroundnuts are fairly rich in niacin. Bioavailability of niacin from roasted and boiled groundnuts was assessed in adult human subjects. A local variety commonly cultivated in Andhra Pradesh, India was used in the study. Six women in the age range of 23-25 years were selected for the study. The linear dose response technique was used to assess the availability. Excretion of N1-methylnicotinamide in urine was used as an index of assessment. The results revealed that 87.0 to 91.7% of niacin was available from roasted and boiled groundnuts, respectively.抄録全体を表示PDF形式でダウンロード (726K)
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