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Volume 35 (1989)
- Issue 6 Pages 535-
- Issue 5 Pages 383-
- Issue 4 Pages 211-
- Issue 3 Pages 163-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
Predecessor
Volume 35, Issue 3
Displaying 1-5 of 5 articles from this issue
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Yosuke SHIGEMATSU, Yoshiharu KIKAWA, Masakatsu SUDO, Yoshinori ITOKAWA1989 Volume 35 Issue 3 Pages 163-170
Published: 1989
Released on J-STAGE: April 28, 2009
JOURNAL FREE ACCESSWe showed elevated plasma levels of branched-chain amino acids, a-ketoacids, a-hydroxyacids in thiamin-deprived rats, which had decreased liver thiamin levels (2.4% of control) after 4 weeks of feeding of thiamin-deficient diet. The ratios of mean levels of these acids in thiamin-deficient rats to those in control rats were as follows: total branched-chain amino acids 1.6; total branched-chain α-ketoacids 2.7; total branched-chain a-hydroxyacids 3.6; pyruvic acid 1.6. The plasma level of total branched-chain a-hydroxyacids was correlated to liver thiamin concentration (γ=-0.67, p<0.01), but those of the other two acids were not correlated. Although the increased levels of branched-chain acids in thiamin-deprived rats were less remarkable than those of ill patients with maple syrup urine disease, they reflect the reportedly decreased branched-chain a-ketoacid dehydrogenase activities (about 40% of control), and we discussed whether the toxic effects of individual branched-chain acid could be demonstrated by its administration to the thiamin-deprived rats.View full abstractDownload PDF (760K) -
Toshikatsu TOUKAIRIN-ODA, Eiko SAKAMOTO, Naoyuki HIROSE, Mitsuaki MORI ...1989 Volume 35 Issue 3 Pages 171-180
Published: 1989
Released on J-STAGE: April 28, 2009
JOURNAL FREE ACCESSThrough use of a simplified analyzing system, seven vitamin B6 derivatives were determined with a satisfactory sensitivity and precision. This system consisted of a single reversed-phase ODS column with a fluorescence detector employing an isocratic solvent system. Each vitamin B6 derivative in some foods and biological materials was determined, based on the measurement of the integrated peak area. The data obtained by this method were compared with those obtained from a bioassay by Saccharomyces uvarum ATCC 9080, after acid hydrolysis of these materials.View full abstractDownload PDF (1109K) -
Frank J. MENOLASCINO, John Y. DONALDSON, Thomas F. GALLAGHER, Charles ...1989 Volume 35 Issue 3 Pages 181-192
Published: 1989
Released on J-STAGE: April 28, 2009
JOURNAL FREE ACCESSDr. Ruth Harrell and her colleagues conducted a study in 1981 in which the administration of high dosages of vitamins were determined to dramatically improve the intellectual functioning of mentally retarded children. This paper documents the efforts of its authors to replicate the Harrell et al. research and, although no significant differences were found between active treatment groups and control groups at study's end, a thorough comparison is made between the two research efforts.View full abstractDownload PDF (1309K) -
A. J. OGUNLEYE, A. A. ODUTUGA1989 Volume 35 Issue 3 Pages 193-197
Published: 1989
Released on J-STAGE: April 28, 2009
JOURNAL FREE ACCESSAfter 21-day-old weanling rats were maintained on diets deficient in riboflavin the weights of their brains were 19.8% less than those of rats on control diets. In riboflavin deficiency, the myelin lipids, cerebrosides, and sphingomyelin, as well as phosphatidylethanolamine, a significant component of the myelin membrane, were considerably reduced in proportion. It is considered that riboflavin plays some role in the metabolism of essential fatty acids in brain lipids and the pathological effect of its deficiency is similar to that of essential fatty acid deficiency, causing a fast impairment to brain development and maturation.View full abstractDownload PDF (540K) -
Toru RIKIMARU, Tomoko OOZEKI, Mineko ICHIKAWA, Hidemichi EBISAWA, Yosh ...1989 Volume 35 Issue 3 Pages 199-209
Published: 1989
Released on J-STAGE: April 28, 2009
JOURNAL FREE ACCESSUrinary excretions of creatinine (CR) and 3-methylhistidine (3-MeHis), and skeletal muscle mass (SKM) were measured in rats (male, Wistar, weighing about 290g) fed a 20% casein diet ad libitum, rats restricted to 70% of the food intake of the ad libitum group, and rats deprived of food for 20 days. At the same time, catabolic rates of muscle protein derived from 3-MeHis/CR, 3-MeHis/BW, and 3-MeHis/SKM were compared. The CR/SKM ratio in the energy-restricted group was similar to the ad libitum group, while the ratio was higher in the food-deprived group than in the other two groups. This means that CR excretion was promoted per unit of skeletal muscle mass by food deprivation. These results indicate that CR excretion can be an index for SKM under the condition of energy restriction, but not under the condition of food deprivation. The present data also suggest that it is possible to use the 3-MeHis/CR ratio instead of 3-MeHis/SKM which is the most reliable index of the three indices, under the condition of mild energy restriction. In food deprivation, however, the 3-MeHis/CR data tended to underestimate the catabolic rate of muscle protein compared with the 3-MeHis/SKM data. The 3-MeHis/BW data was similar to the 3-MeHis/SKM with all dietary conditions. The catabolic rate of muscle protein was constant or decreased very slightly under ad libitum feeding, decreased slightly in energy restriction, and increased drastically with food deprivation.View full abstractDownload PDF (1110K)
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