The fatty acid composition of serum phospholipids of 277 persons, aged 63-97y (average 78y), was measured. Subjects had been living independently in a facility with full food service for 1y or more. Eleven saturated and unsaturated fatty acids were detected in all the subjects. Stearic acid (18:0) was positively (
p=0.028) and dihomo-gamma-linolenic acid (20:3
n-6) was negatively (
p=0.012) related to age. Arachidonic acid (20:4
n-6) tended to decline with age (p=0.063). In addition, the oleic acid (18:1
n-9)/18:0 ratio decreased significantly with age (
p=0.024). 18:0 and total saturated fatty acids were lower, and linoleic acid (18:2
n-6) and 20:4
n-6 and
n-6 fatty acids were higher in males than in females. These results suggest deficits in
n-6 essential fatty acids as age advances, particularly in females.
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