D-Pantethine is a compound in which two molecules of
D-pantetheine bind through an S-S linkage.
D-Pantethine is available from commercial sources as well as from
D-pantothenic acid. We investigated if
D-pantethine has the same vitamin activity as
D-pantothenic acid by comparing the recovery from a deficiency of
D-pantothenic acid in rats.
D-Pantothenic acid-deficient rats were developed by weaning rats on a diet lacking
D-pantothenic acid for 47 d. At that time, the urinary excretion of
D-pantothenic acid was almost zero, and the body weight extremely low, compared with the control (
p<0.05); the contents of free
D-pantothenic acid were also significantly reduced in comparison with those of controls (
p<0.05).
D-Pantothenic acid-deficient rats were administered a diet containing
D-pantothenic acid or
D-pantethine for 7 d.
D-Pantethine and
D-pantothenic acid contents of the diets were equimolar in forms of
D-pantothenic acid. We compared various parameters concerning nutritional status between rats fed
D-pantothenic acid- and
D-pantethine-containing diets. The recoveries of body weight, tissue weights, and tissue concentrations of free
D-pantothenic acid, dephospho-CoA, CoA, and acetyl-CoA were identical between rats fed diets containing
D-pantothenic acid and
D-pantethine. Thus, the biological efficiency for recovering from a deficiency of
D-pantothenic acid in rats was equivalent between
D-pantothenic acid and
D-pantethine.
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