Objectives : We investigated the actual status of antifungal agents for onychomycosis, including percentages of drugs prescribed and drug selection by onychomycosis subtype after 18months of topical onychomycosis agent launch. Survey method : We received responses from 137 hospital dermatologists (HP) and 203 general practice dermatologists (GP) nationwide pharmacologically treating 10 or more onychomycosis patients in the prior month. This internet survey was conducted between March 2 and 8, 2016. Results and discussion : The mean number of patients receiving pharmacological therapy per month was 42.1. Distal and lateral subungual onychomycosis (DLSO) was the most common subtype (46.3% of total), followed by total dystrophic onychomycosis (TDO) at 18.9%, spike-shaped at 17.5%, superficial white onychomycosis (SWO) at 10.9%, and proximal subungual onychomycosis (PSO) at 6.4%. Oral agents (including topical agent combinations) were used by 13.5 patients (32.0%), topical agent for onychomycosis by 18.4 (43.7%), and existing topical agents without indication by 9.5 (22.5%), showing topical agent for onychomycosis to be most commonly used by both HP and GP. Oral agents were highly evaluated for "high clinical effect," topical agent for "high safety," and existing topical agents without indication for "high safety" and "drug price." The first-line therapies by subtype excluding severe DLSO and TDO were topical agent for onychomycosis. Although treatment selection should be based on subtype and severity, topical agent is presumably selected frequently for their high safety. The percentage of patients cured was highest among those receiving oral agents, then topical agent and, finally, existing topical agents without indication. Although oral agents exert superior treatment effects, safety often takes precedence over efficacy. However, the treatment objective is cure; therefore, highly effective drugs must be selected by subtype and severity.
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