esCCO (estimated Continuous Cardiac Output) is a method that continuously estimates cardiac output using PWTT (pulse wave transit time) derived from electrocardiograms and pulse waves obtained through SpO2 monitoring. These are regularly measured in operating rooms and intensive care units. This method is entirely noninvasive and involves no additional cost.
The use of pulse wave velocity for diagnosing arterial stiffness has a long history and has been implemented in practice, including through sensor development. Based on knowledge gained from this application, esCCO was developed to apply PWTT to primary and critical care monitoring.
The development followed the trajectory described below. It was known that the pulse wave velocity between two arterial points is influenced by the degree of arterial stiffness and blood pressure. Therefore, if arterial stiffening progresses slowly, it was hypothesized that blood pressure could be estimated from PWTT once calibrated. Furthermore, a simple method for continuous measurement was required. Under these circumstances, PWTT-based blood pressure estimation was put into practical use, although it faced the limitation of decreased accuracy during the administration of vasoactive drugs.
On the other hand, this limitation does not apply when focusing on the relationship between PWTT and SV (stroke volume). Furthermore, when the endpoint of PWTT measurement is defined using pulse oximetry waveforms, the time it takes for the waveform to reach peripheral sites varies depending on the diameter of peripheral blood vessels. This variation was found to contribute to improved accuracy in measuring SV.
This review article provides an overview of esCCO and then explains three key ideas that led to its development.
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