Journal of Occupational Health
Online ISSN : 1348-9585
Print ISSN : 1341-9145
ISSN-L : 1341-9145
Volume 49, Issue 4
Displaying 1-10 of 10 articles from this issue
Original
  • Kasuke Nagano, Yumi Umeda, Misae Saito, Tomoshi Nishizawa, Naoki Ikawa ...
    2007 Volume 49 Issue 4 Pages 249-259
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    Subchronic toxicity of carbon tetrachloride (CCl4) was examined by inhalation exposure of F344 rats and BDF1 mice of both sexes to 0, 10, 30, 90, 270 or 810 ppm (v/v) CCl4 vapor for 13 wk (6 h/d and 5 d/wk). In the high exposure levels at 270 and 810 ppm, altered cell foci in the livers of both rats and mice, and fibrosis and cirrhosis in the rat liver were observed. Hematoxylin and eosin-stained altered cell foci of rats were recognized as glutathione-S-transferase placental form (GST-P) positive foci, which are preneoplastic lesions of hepatocarcinogenesis. The most sensitive endpoint of CCl4-induced toxicity was fatty change with large droplets in rats of both sexes and male mice, and cytoplasmic globules in male mice, as well as increased relative liver weight in male rats. Those endpoints were manifested at 10 ppm and the LOAEL was determined as 10 ppm for the hepatic endpoints in rats and mice. Enhanced cytolytic release of liver transaminases into plasma in rats and mice and its close association with hepatic collapse in mice were observed at medium and high levels of inhalation exposure. Both CCl4-induced hematotoxicity and nephrotoxicity were observed in both rats and mice, but those toxicities were manifested at higher exposure concentrations than hepatotoxicity. The LOAEL for the hepatic endpoint and the GST-P-stained altered cell foci provide relevant animal data for reconsidering the occupational exposure limit value of 5 ppm for CCl4 and strengthen the evidence of CCl4-induced hepatocarcinogenicity which is used in its carcinogenicity classification.
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  • Kunio Hara, Mihoko Mori, Tatsuya Ishitake, Hiroki Kitajima, Kazuhiro S ...
    2007 Volume 49 Issue 4 Pages 260-267
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    The UN-GHS, a globally harmonized system of classifying and labeling chemicals that was recommended by the United Nations in 2003, will be implemented globally in 2008. This system is expected to encourage people to behave in a way that reduces the risk of accidents or diseases caused by chemicals. However, the UN-GHS differs significantly from the present Japanese system of classifying and labeling chemicals. In particular, since the Japanese system does not require pictographic labels, ordinary Japanese people are not familiar with the new pictographic labels defined in the UN-GHS. Hence, before introducing the UN-GHS at the Japanese workplace, it is critical to clarify the actual usage conditions and the problems that this labeling system of hazardous chemicals poses, and to manage the related problems. We conducted recognition tests on Japanese subjects of the labels presently used in Japan and the UN-GHS labels. The results revealed that the subjects faced some difficulty in recognizing the meanings of some UN-GHS labels. The percentage of questions that were answered correctly with regard to the labels depicting `cylinder,' `corrosion,' `health hazard,' and `aqueous hazard,' with no accompanying explanatory statements, was less than 60. The results of the answers regarding the labels depicting `flame' and `flame over circle' revealed that many subjects were unable to distinguish one from the other. Further, many subjects were unable to clearly distinguish `skull and crossbones' from `health hazard.' These results indicate that it is very important to impart correct education regarding these labels.
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  • Sung-Jo Bang, Seong Hoon Choi, Neung Hwa Park, Jung Woo Shin, Nari Cho ...
    2007 Volume 49 Issue 4 Pages 268-272
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    Although high signal intensities in the globus pallidus are frequently observed in T1-weighted magnetic resonance images (MRI) of patients with liver cirrhosis, it is unclear whether these increases are due to portal-systemic shunt or obstruction of biliary excretion. We therefore studied pallidal signals in 18 cancer patients with bile duct obstruction and marked jaundice (>10 mg/dl). Patients who had fever, leukocytosis or liver cirrhosis were excluded to ensure that jaundice was due to bile duct obstruction. All patients showed a dilated intrahepatic duct on computed tomography (CT) scan. A high pallidal signal was observed in one of 18 biliary obstructive patients whereas high signals were highly prevalent in liver cirrhosis. A portal-systemic shunt rather than an obstruction of biliary excretion may be responsible for the increased blood manganese concentrations and pallidal T1 signals in chronic liver diseases.
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  • Masoud Neghab, Alireza Choobineh
    2007 Volume 49 Issue 4 Pages 273-278
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, therefore, undertaken to more thoroughly examine the effects of occupational exposure to cement dust on the respiratory system. The study population consisted of a group of 88, randomly selected, male workers with current exposure to cement dust and 80 healthy male office workers without present or past history of exposure to dust that served as the referent group. Subjects were interviewed and were given respiratory symptom questionnaires to answer. They also underwent chest X-ray and lung function tests. Additionally, personal dust monitoring for airborne inhalable and respirable dust was carried out at nine different worksites. Moreover, X-ray diffraction (XRD) and X-ray fluorescence (XRF) techniques were performed to determine the silica phases and the SiO2 contents of the dust samples. Levels of exposures to inhalable and respirable cement dust were estimated to be 53.4 ± 42.6 and 26 ± 14.2 mg/m3, respectively (Mean ± SD). Statistical analysis of the data revealed that symptoms like regular cough, phlegm, wheezing and shortness of breath were significantly (p<0.05) more prevalent among exposed workers. Similarly, chest radiographs of exposed workers showed various degrees of abnormalities including emphysematous changes, old calcified granulomas, emphysematous changes associated with inflammatory processes, evidence of chronic inflammatory processes, focusal calcification of the lungs and infiltrative changes. However, no significant changes were noted in the radiographs of the referent group. Furthermore, exposed workers compared to their referent counterparts showed significant reductions in the parameters of lung function. In conclusions, our data provide corroborative evidence further substantiating the contention that exposure to cement dust is associated with respiratory symptoms and functional impairments.
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  • Cui-Qin Xiang, Chun-Lin Shen, Zi-Rong Wu, Yi-Qiu Qin, Yun-Ying Zhang, ...
    2007 Volume 49 Issue 4 Pages 279-284
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    To investigate the expression of mutant p53 protein in workers occupationally exposed to benzidine, we detected mutant p53 protein by immuno-PCR assay in the serum of 331 benzidine-exposed healthy workers, while we classified exfoliated urothelial cells in urine samples with Papanicoloau's grading (PG). The Papanicoloau's grading classified exfoliated urothelial cells of the subjects from grade I (normal cells) to grade III (suspicious malignant cells). The subjects were also divided into high, medium and low exposure groups according to the exposure intensity index. The results revealed that mutant p53 protein in the medium and high exposure groups were significantly higher than the in low exposure group (p<0.05), and in PG II and III were significantly higher than in the PG I (p<0.05). There was no significant differences among Papanicoloau's gradings strata in the low exposure group on the incidence and quantity of mutant p53 protein. In the medium and high exposure groups, the incidence and/or quantity of mutant p53 protein in the stratum of PG II and/or III were significantly higher than that of PG I (p<0.05). Detection of mutant p53 protein in conjunction with benzidine exposure level and Papanicoloau's gradings of exfoliated urothelial cells could provide more information to help us elevate surveillance efficiency and diagnose bladder cancer in the early period.
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  • Hong-I Chen, Saou-Hsing Liou, Ming-Hong Hsieh, Tung-Sheng Shih, Chien- ...
    2007 Volume 49 Issue 4 Pages 285-293
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    The objective of this study was to evaluate an intervention program, implemented in year 1999, of wearing rubber gloves in addition to engineering control, and to follow-up the hematological effects of 2-ethoxyethanol acetate (2-EEA) exposure among workers in a silk-screening factory. All workers from the printing department with direct exposure to 2-EEA were recruited as the exposed group. Workers from the other departments were recruited as the comparison group. Hematological parameters were measured during health surveys conducted 3 times every two years. Information on personal characteristics and working habits was obtained through a structured questionnaire. More female workers were involved in manual printing resulting in higher exposure to 2-EEA. Hemoglobin and haematocrit levels in female exposed workers were significantly lower than those of female comparison workers in the 1st (1998) health survey, but not in the 2nd (2000) and 3rd (2002) health surveys. No difference was found between male exposed and comparison workers for all three surveys. Longitudinal analysis after adjusting for confounders using the general estimating equation model showed the hemoglobin, haematocrit, and RBC count were significantly higher for 2-EEA exposed workers than comparison workers across the 3 surveys (n=42). The results show that wearing rubber gloves in addition to local ventilation was effective at preventing direct dermal exposure to 2-EEA and ameliorated the hematological effects of 2-EEA exposure.
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  • Inga-Lill Engkvist
    2007 Volume 49 Issue 4 Pages 294-304
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    The aim of the study was to evaluate expectations and attitudes towards a No Lifting Policy programme, the "No Lift system", among nurses at hospitals where an introduction of the intervention was planned (PreNLS hospitals), and to make a comparison with nurses' experiences and attitudes at one hospital where the intervention had already been implemented (NLS hospital). A cross-sectional study of nurses at two PreNLS hospitals and one NLS hospital was performed. Most nurses at both the PreNLS hospitals and the NLS hospital were positive or very positive to the intervention. The expected and experienced obstacles differed between nurses at the PreNLS hospitals and the NLS hospital; however, there was more agreement concerning benefits. The most frequently expected obstacles at the PreNLS hospitals were organisational issues and obstacles related to the facilities, while most obstacles identified at the NLS hospital concerned specific transfers or were patient-related. A decrease in the number of injuries was the most often considered benefit among most nurses. Nurses at the NLS hospital rated their physical exertion as lower in seven out of nine specific patient transfers compared with nurses at the PreNLS hospitals. They also reported increased well-being at work and an improved ability to manage their daily work. The comprehensive approach and participatory design, including all levels of staff and extensive support from the nurses' own union and management, is probably one important explanation for the positive attitudes and successful introduction of the intervention.
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Case Study
Field Study
  • Wen-Ching Chen, Jung-Der Wang, Chih-Yin Lew-Ting, Hsien-Jane Chiu, Yi- ...
    2007 Volume 49 Issue 4 Pages 311-316
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    It has been noted that workplace violence most frequently occurrs in psychiatric settings. The purpose of this study was to explore the workplace violence, including violence situation, victims' feeling, and the prevention strategies, on workers caring for long-term institutionalized schizophrenic patients in Taiwan. We conducted a face-to-face, in-depth, and semi-structured interview with 13 health care workers suffering from physical violence and/or sexual harassment by patients in 2002. First, the interviews were taped and/or paper-notes recorded, then transcribed, organized, and analyzed. Results found that all of the victims alleged they did not receive enough post-incident support, and more than a half of the victims could not call others for help during the violence. To avoid further attack, most victims offered prevention strategies which were considered valuable for establishing guidelines. However, some victims regarded workplace violence as inevitable and part of the job. The most common situations of workplace violence were during routine ward inspections, especially when the victims were alone. The most serious psychological harm was post-traumatic stress disorder (PTSD). In conclusion, we recommended a re-engineering of the organization to a supportive and safe working environment for prevention of workplace violence in the study hospital.
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  • Batoul Shariati, Ali Shahidzadeh-Mahani, Turadj Oveysi, Hengameh Akhla ...
    2007 Volume 49 Issue 4 Pages 317-321
    Published: 2007
    Released on J-STAGE: August 09, 2007
    JOURNAL FREE ACCESS
    Healthcare workers and medical students are at risk of exposure to blood-borne viruses such as HBV, HCV HIV, etc. Here we report the results of a survey of the frequency and causes of cutaneous blood exposure accidents (CBEA) among medical students. Anonymous questionnaires were randomly distributed to 200 interns in their second year of internship in hospitals affiliated to Tehran University of Medical Sciences. A definite exposure was defined as injury by a sharp object causing obvious bleeding, whereas a possible exposure was defined as subtle or superficial injury due to contact with a contaminated instrument or needle but without bleeding, or contamination of an existing wound with blood or other body fluids. One hundred eigthy-four subjects (92% of the original sample) responded to the questionnaire. We recorded 121 definite exposures and 259 possible exposures over a mean time interval of 14 months. Needles were the most common objects (41% of exposure episodes) causing CBEAs, while phlebotomy and suturing were the hospital procedures that accounted for the highest percentage of exposure episodes (30 and 28 percent, respectively). Only a minority of students regularly observed basic safety measures (wearing gloves, not recapping used needles and proper disposal of sharp objects). Considering the high incidence of blood exposure in medical interns at Tehran University of Medical Sciences and the ensuing risk of blood-borne infections, the subjects are likely to develop such infections during their internship period.
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