産業医学

Dusts containing lead compounds frequently cause poisoning. It is suggested that the poisonous characters are realised differently by the size of the dust. Considering this, we classified the suspending dust arising from the workshop, where lead compounds were being handled, into four size fractions by a cascade centripeter. The content of lead was determined by the atomic absorption method, acetyleneair flame being made use of. The findings were as follos: 1) At the place where the primary dust developed, particles larger than 14 microns in diameter gave relatively higher percentage of lead content. 2) At the place where the secondary dust developed, particles less than 4 microns in diameter and larger than 14 microns in diameter gave higher percentages of lead content. 3) At both places, lead content was low in the case of particles of 4-14 microns, but their amounts were higher.

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This sutdy was carried out to find out some early diagnosis methods on man exposed to methyl iodide or methyl bromide. When methyl iodide was administrated to rabbits, this substance was found in the brain, especially in the cerebral cortex, and in the liver and kidneys. Gait disturbance, the most severe effect of methyl iodide on the nervous system, seemed to be represented as an increase of d-tubocurarine susceptibility of the rabbit. In this state of the rabbit, abnormal metabolic patterns of lipids and of energy rich phosphate compoounds such as decrease of phosphatidylserine, lecithin and ATP were observed in the brain. As reported previously, changes of serum proteins and lipids were clearer than such changes in the brain. The change of serum lipids, especially changes of triglyceride and of the total lipids, was further ascertained in man exposed to methyl iodide or methyl bromide.

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