産業医学
Online ISSN : 1881-1302
Print ISSN : 0047-1879
ISSN-L : 0047-1879
14 巻, 6 号
選択された号の論文の12件中1~12を表示しています
  • 小泉 明
    1972 年 14 巻 6 号 p. 527
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 山田 信也
    1972 年 14 巻 6 号 p. 529-541
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
    (1) Since 1964, I have mainly investigated vibration hazards of operators of gasoline powered chain-saws among forest workers. My study of the vibration hazards are divided into three themes, i.e., (i) dynamics of the peripheral blood circulation, (ii) pathological changes of the nervous function, (iii) pathological changes of the general function through disturbance of the central nervous system. In this paper, I report observations on the dynamics of the peripheral blood cicrulation.
    (2) In Chubu District of Japan, I investigated 124 chain-saw operators who had experienced the appearance of white waxy changes of their fingers. It was found that (i) the primary factor of the occurrence of white waxy changes is the occurrence of the chill feeling and presumably, not any fall in the temperature of the finger skin, (ii) autobicycle riding contributed most frequently to the white waxy changes.
    (3) The course of the occurrence of white waxy changes by autobicycle riding is shown in Fig. 1. I noticed white changes of the nail colour before chill feeling before the occurrence of white waxy changes. And I worked up the “nail press test” as means of a physiological examination of vibration hazards.
    (4) The procedure of the “nail press test” is as follows. (i) Press the nail of the subject by the tester's thumb and 2nd finger for 10 seconds (Fig. 2). (ii) Start a stop watch to run immediately after the begining of the pressing. After 10 seconds, take quickly the tester's finger off from the subject's nail. White changes of the nail colour will gradually appear and red colour tone will recover gradually. And at last, red colour will spread in a moment over the whole area of the nail (Fig. 3). Just at that moment, stop running the watch. I called the time from the release of the press to the disappearance of white changes as the “value of nail press test”. Posture and the strain of the arm and the hand of the subject influence this value. It is important that subject should relax the arm, hand and finger in the posture as shown in Fig. 4. The value of nail press test depends on the vasospastic state of artelioles and the flow speed of the arterial blood into capillaries.
    (5) The tendency is observed, that lowering of the temperatures and of the atmospheric environment as well as finger prolongs the time value of the nail press test. In workers suffering from vibration hazards, this tendency is more remarkable.
    (6) Cooling test of the whole body was performed during the measurement of the temperature of finger skin and the nail press test. Subject were four chain-saw operators (A group) who experienced appearance of white waxy changes of their fingers every day, and four healthy forest workers without such experience (B group) as controls. (Table 1)
    Experiment 1 : Standing outdoor for 40 min. at 5°C atmospheric temperature. Experiment 2 : Autobicycle riding for 20 min. at the speed of 30km/hr and after that standing for 20 min. outdoors.
    Experiment 2 was performed when wearing thin clothes or when wearing thick clothes after warming of the body.
    (7) Results of Experiment 1, 2 show that as chill feeling occured temperature of the finger skin of A group dropped more rapidly and remained at lower levels than in B group (Fig.5, Fig.6 (T) -A, Fig. 7 (T) -a). Raise the values of nail press test took place more rapidly than the fall of the temperature of the finger skin. The value increased to several tens of seconds before the appearance of white waxy changes (Fig. 5, Fig. 6 (N) -a, Fig. 7 (N) -a). White waxy changes appeared in four workers of A group (100%) on autobicycle riding wearing thin clothes.
    (8) When white waxy changes appeared, no remarkable difference observed between the temperature of white waxy fingers and that of other fingers in every subject (Table. 2), (Fig. 7 (T) -a). This result showed that cold vasospastic reaction in the larger vessels, controlling
  • 竹内 康浩, 田中 豊穂, 松本 忠雄, 松下 敏夫
    1972 年 14 巻 6 号 p. 543-553
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
    Diencephalon-hypohysis-adrenal cortex system is one of the most sensitive systems to harmful evironmental factors and this system has an important role for the organism to exist in the harmful environment. Takeuchi, one of the authors, in the previous experiment, obtained the. results that toluene vapor might effect diencephalon-hypohysis-adrenal cortex system and that the function of this system might decrease in the chronic exposure to toluene.
    We think in order to make clear toxicity of organic solvents, it is very important to study the response of this system to organic solvents. And we performed the following animal experiments using male rats. As indices of the responce of diencephalon-hypohysis-adrenal cortex system, adrenal weight, 11-OHCS concentration in the blood, eosinophile count of the blood and thymus weight were determined.
    The results are as follows :
    1) In 8 hr exposure to 2000 ppm toluene vapor, adrenal weight and 11-OHCS concentration in the blood of the exposed animal increased significantly and eosinophile count of the blood decreased significantly in comparison with the control. But, 16 hr after the end of exposure, these significant differences were not found.
    2) In 8 hr exposure to 1000 ppm toluene, adrenal weight and 11-OHCS concentration in the blood of the exposed animals significantly increased and eosinophile count of the blood was significantly smaller in comparison with the control as well. And in 8 hr exposure to 100 ppm toluene, the change of these indices was similar as in the case of 1000 ppm, except adrenal weight which did not significantly increase in comparison with the control. The changes of these indices in 8 hr exposure to 100 ppm toluene were larger than in the case of 100 ppm.
    3) In the exposure of 8 hr a day for 4 weeks to 1000 ppm toluene, adrenal weight of the exposed animals increased significantly in comparison with the control after 2 weeks and became still larger after 4 weeks. Eosinophile count increased and after 4 weeks it was significantly larger than the control. 11-OHCS concentration in the blood of the exposed animals decreased after 1 week but the difference between the exposed and the control was not found after 2 weeks.After 4 weeks, 11-OHCS concentration in the blood of the exposed animals increased but this increase was statistically not significant in comparison with the control. The reactivity of these indices against the exposure to 1000 ppm toluene chan gedbetween the exposed and the control remarkably after 4 weeks.
    From the results of these three animal experiments, it was found that the diencephalon-hypohysis-adrenal cortex system responses remarkably against the exposure to toluene vapor, and even in 8 hr exposure to 100 ppm toluene the changes of these indices are found, and in 4 weeks exposure to 1000 ppm toluene, the changes of these indices are cummulative.
  • 山口 正義, 祐田 泰延, 山本 丈夫
    1972 年 14 巻 6 号 p. 555-561
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
    On the effect of ethanol administration on porphyrin metabolism in rats intoxicated with lead acetate, the urinary excretion of δ-aminolevulinic acid and coproporphyrin was determined, and the activity of δ-aminolevulinic acid produced in rats liver homogenate was measured. The following results were obtained.
    1) The urinary excretion of coproporphyrin and δ-aminolevulinic acid in rats intoxicated with lead acetate was increased by ethanol treatment.
    2) It was demonstrated that the hepatic δ-aminolevulinic acid producing activity in rats intoxicated with lead acetate was additively enhanced by ethanol treatment.
    3) The activation of hepatic δ-aminolevulinic acid producing activity with ethanol was inhibted by pre-treatment of pyrazole.
  • 竹内 康浩, 西崎 恒男, 高城 晋, 馬淵 千之
    1972 年 14 巻 6 号 p. 563-571
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
    Large amount of organic solvents is used in the processing industries and most of these industries are medium or small enterprises. Therefore, health of workers working there is liable to be disturbed by organic solvents. And as the workers exposed to organic solvents usually complain of indefinite oilments, recently health of workers exposed to organic solvents became to be studied endocrinologically and neurologically.
    Two workers exposed to organic solvents in a paints industry consulted us and complained of dizziness, headache, tinnitus, insomnia, slight fever, disturbance of appetite, decrease of body weight, cramp of lower extremities, etc. And in our clinical examination, hypofunction of diencephalon-hypohysis-adrenal cortex system, hypesthesia on one side, continuous slight fever, slight orthostatism, abnormal EEG etc. were found and diagnosed as diencephalon syndrome.
    Working conditions were investigated. This paints industry is medium enterprise but the work room where the two patients were working was small and ventilated not sufficiently. And it was found that the two worker were being exposed to toluene vapor of which concentration ranged from several hundred ppm to one thausand and several hundred ppm and to smaller concentration of other organic solvents. Therefore, it was thought that the disorders of these two patients were caused chiefly by exposure to toluene vapor.
    The two patients were detached from the work place and treated in our hospital, but disorders of them were not rapidly improved.
    In view of these serious health disorders of the two workers, we think it is very important that the toxicity of organic solvents should be still more studied especially concerning the effect to the endocrine and nervous systems, and that the working conditions in work place using organic solvents should be still more improved for prevention of organic solvent poisoning.
  • 池田 正之
    1972 年 14 巻 6 号 p. 572-573
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 飯田 英男, 酒井 哲代, 荒井 保経
    1972 年 14 巻 6 号 p. 574-575
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 奥田 三雄, 渡部 真也
    1972 年 14 巻 6 号 p. 576-577
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 鈴木 継美
    1972 年 14 巻 6 号 p. 578-579
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 守 和子
    1972 年 14 巻 6 号 p. 580-581
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 1972 年 14 巻 6 号 p. 583-589
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
  • 酒井 好道, 池田 正之, 皆川 洋二, 大道 明
    1972 年 14 巻 6 号 p. 595-598
    発行日: 1972年
    公開日: 2011/03/04
    ジャーナル フリー
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