An investigation was made on the effects of aspartate and vitamin B
1 upon the fatigue in 75 apple cultivating farmers. These farmers were divided into three groups, to each member of which a tablet including 150 mg of K- and Mg-aspartate, a tablet including 5 mg of VB
1, and a tablet of placebo was respectively given every day. In some of them, the fatigue, subjective and objective, was estimated weekly; namely, the former was estimated by the questionnaire method and the latter by measuring body weight, physiological functions (flicker fusion frequency, threshold of patellar reflex, and blood pressure), Donaggio reaction and uropepsin during the farming season, May, June and July. In the other farmers, the subjective fatigue, body weight and blood pressure were measured once a month in the same season. The results were as follows: (1) The subjective fatigue in the group given aspartate and VB
1 tends to decline in the later period of the season (Figs.1 & 2). (2) The body weight decreases gradually through the farming period. However, the decrease in the aspartate group is lower than in the other groups (Fig.3, Tab.1). This fact suggests an anabolic effect of aspartate through activation of the adrenal gland. (3) The flicker fusion frequency increases and the threshold of patellar reflex decreases in the middle period, and these changes are more remarkable in the group of aspartate and VB
1 than in the placebo group. In the last period the flicker value decreases and the threshold value increases, and these changes are less in the former two groups than in the latter (Fig.5 and Tabs.2, 3). (4) Examinations of Donaggio reaction and uropepsin in the urine after the farming work revealed that the former tended to be lower in the VB
1 group and the latter lower in the aspartate group (Fig.6). (5) The blood pressure tends to decline monthly in the aspartate and the control group, but not in the VB
1 group (Fig.4). This tendency suggests that the seasonal variation of the physiological functions, including the blood pressure, is related not only to the variation of climate but of nutrition and other factors. These results show first that the aspartate and VB
1 lighten the chronic fatigue in the farming seasons. However, it is a question whether the subjects were deficient in VB
1 and the above effect of VB
1 on the VB
1 group was not pharmacological and positive but nutritional just supplying the deficiency. From this point of view, the effect of aspartate also should be further reexamined in the experimental conditions in which the nutritional requirements of VB
1 in the subjects have certainly been fulfiled.
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