Purpose: The author had already pointed out in Report 1 that the borderline group comprised the most important subjects in order to perform an effective medical care for hypertension in the field of occupational health practice. From this point of view, the effect of drug administration to the borderline-hypertensive group was studied. Methods: 173 men from the borderline-hypertensive group were divided into three groups A, U and C. A-group was administered drug A; included recerpin 0.1 mg. U-group was administered drug U, which had no effect to decrease blood pressure. C-group was the control; .no drug was administered. The blood pressure of each group was examined before administration and also once a month after administration for four months. Results: conclusions of the studies were as follows: 1) Comparing the average of the blood pressure among the three groups, the author found the most remarkable change during the four months in the A-group. 2) By administering drugs, the author obtained good results on the rate of acception of mass examination of the blood pressure. 3) No harmfull reaction of drugs was found during the whole process.

View full abstract

It is well known that aromatic nitro- and amino-compounds can produce met-hemoglobin. But, in the case of p-chlor-nitrobenzene (pCNB), no report has been found on the mechanism of met-hemoglobin formation through its metabolic compounds. The author has investigated the formation of met-homeglobin and Heinz-bodies in animals with various intermediary metabolic compounds of pCNB. The metabolic pathways of pCNB is shown in Fig.1. There has been no report on the evidence of the pathway indicated as two broken lines in the figure (2-hydroxy-4-chlor-nitrobenzene or 4, 4'-dichlor-azo-benzene-N-oxide as an intermediate). But, believing in the existence of either or both pathways, the author made an investigation, of which the results are briefly as follows. 1. Synthesis of intermediary metabolites Compounds which were newly composed are shown in below. Details of these syntheses are described in the text of this report. 5-chlor-2-nitro-phenol (nitrophenol) 5-chlor-2-amino-phenol (aminophenol) N-(p-chlorphenyl)-hydroxylamine (hydroxylamine) p-chlor-acetoanilide (acetoanilide) N-(2-quinon-4-chlorphenyl)-imid (quinonimine) 2. Heinz-body formation These seven compounds were tested as to their Heinz-body formation at a dose of 4.4×10^-4 mol/kg in rabbits. As shown in Fig.2, hydroxylamine is most strong in inducing the appearance of this body. As it can be supposed by these results that nitrocompound (pCNB) could produce this body by being changed to hydroxylamine, the author thinks only two kinds of compounds, hydroxylamine and amino compounds, can produce this body at this dose. (Aminophenol can produce it only at threefold dose and over.) 3. Met-hemoglobin formation These seven compounds were also tested on the met-hemoglobin formation at a dose of 6.0×10^-4 mol/kg. Results in rabbits are shown in Fig.3. Hydroxylamine was also most effective in the case of met-hemoglobin formation. This agent is superbly strong as compared to others and produces met-hemoglobin immediately. But, notwithstanding this powerfulness, met-hemoglobin produced by this agent disappears after eight hours. Methemoglobin formed by other agents such as nitro, amino, aminophenol, quinonimine persists longer, so the mechanism of met-hemoglobin formation with hydroxylamine is supposed to be different from others. The difference of mechanisms among intermediary metabolic compounds will be reported in the following papers.

View full abstract

Worker employed in the Japan National Railways (JNR) are uniform as to their social backgrounds, although they are distributed all over Japan. I investigated into the status of sickness absenteeism in Shizuoka Jurisdictional District and in its neighboring districts in order to find out any feature specific to the district covered by Shizuoka Administrative Bureau. Used data are those on non-occupational injuries and diseases lasting over six consecutive days of absence. And other data are those on deaths from non-occupational causes and data on the sickness allowance of the JNR Co-operative Society. The results are as follows. 1. Cases of sickness allowance per person, i.e. the rate of being medically treated (RMT), versus percentage of the cases of absence over six consecutive days due to injuries or diseases or both (SA6) occupying in all the cases of medical treatment. And, RMT versus the ratio of SA6 per 1, 00Q workers in the same period, i.e. rate of incidence. Inverse correlations which are statistically significant were found in both of these sets of cases. 2. Between days of absence per case in SA6 and rate of incidence a statistically significant inverse correlation was found as well. 3. From the above results, I can indicate the following trends: Lower (or higher) RMT⇾higher (or lower) rate of incidence, and higher (or lower) rate of in cidence⇾shorter (or longer) days of absence per case. 4. The facts that markedly low RMT, markedly high rate of incidence, and short days of absence were found in the district of Shizuoka Bureau can be understood as general but conspicuously exaggerated in that district, being noticeable as a steady annual change which may be said as specific to the district. 5. Sick-absenteeism in the district of Shizuoka Bureau is very much similar to that of Tokyo Bureau, but it is different from that of Nagoya Bureau. 6. From these results, presence of big social factors prevailing in the district is inferable apart from laboring conditions including working environments. From the above conclusions I should like to stress the necessity of following-up of health conditions and factors related to them, which are acting especially on the non-occupational ailments apart from specifically acting labor conditions.

View full abstract