岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
100 巻, 11-12 号
選択された号の論文の27件中1~27を表示しています
  • 川崎 幸子, 田邉 正忠, 玉井 豊理, 大川 元臣, 高島 均, 児島 完治, 佐藤 功, 瀬尾 裕之, 細川 敦之, 松野 慎介, 宮本 ...
    1988 年 100 巻 11-12 号 p. 981-988
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    The aim of this study was to compare Tl-201 scintigraphy with I-131 scintigraphy and to assess whether T1-201 scintigraphy has diagnostic advantages in detecting metastasis of patients with thyroid carcinoma. All patients had undergone total thyroidectomy or subthyroidectomy. The study population included 4 men and 11 women, with ages ranging from 11-69 years. Eight had follicular adenocarcinomas, and 7 had papillary adenocarcinomas (including mixed papillary-follicular). The positive detection rate of both Tl-201 and I-131 scintigraphy was 67%, which correlated with the histological type (75% of papillary type and 63% of follicular type). Tl-201 scintigraphy has the advantage of detecting non-functioning metastases. On the other hand, I-131 scintigraphy has the advantage of detecting occult functioning metastases.
    Factors affecting the effect of radioiodine treatment for metastasis of 15 patients with differentiated thyroid cancer were studied. We evaluated the effect of I-131 treatment by the degree of I-131 accumulation shown on the scintigram. The degree of I-131 uptake in metastases was related to age, histology and type of metastatic lesion. Good I-131 uptake in metastases was found in patients less than 40 years old, with papillary adenocarcinoma and without bone metastasis.
  • 瀬尾 裕之, 田邉 正忠
    1988 年 100 巻 11-12 号 p. 989-995
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Kr-81m gas has been used as a ventilation imaging agent. Continuous Kr-81m gas inspiration reflects the distribution of regional ventilation, but quantitative evaluation is difficult because of the short half-life of the gas.
    We obtained lung flow time activity curves during steady-state Kr-81m gas inhalation. Each respiratory cycle was defined between successive maxima of inspiration. Temporal Fourier analysis was applied to Kr-81m gas time activity curves to determine the pulmonary maximum expiratory (PER) and inspiratory rates (PIR) of the first harmonic of a single composite respiratory cycle. After forced inspiration of a bolus of Kr-81m gas, the time constant was calculated from the expiration time activity curve which was corrected for physical decay. These results were compared with a pulmonary function test and Xe-133 washout phase. Correlation between PER, PIR and %VC was noted. The time constant correlated negatively with %FEV1 and positively with mean transit time (MTT) of Xe-133 gas in the washout phase.
    Dynamic ventilation study appears to be a potentially useful noninvasive technique to assess local lung function.
  • 佐藤 功, 影山 淳一, 外山 芳弘, 森 泰胤, 川瀬 良郎, 児島 完治, 水川 帰一郎, 玉井 豊理, 田邉 正忠, 白川 洋一, 上 ...
    1988 年 100 巻 11-12 号 p. 997-1001
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Nine patients with pneumomediastinum ranging in age from 0 to 72 years were reviewed. X-ray CT (“ReView” or high resolution CT) showed interstitial pulmonary emphysema (IPE) in perivascular and peribronchial space in 2 of the patients. IPE has been widely recognized as a cause of pneumomediastinum. Plain chest radiography did not demonstrate IPE because of the superimposition of pneumomediatinum, subctaneous emphysema, and lucency of the lung. Nevertheless, X-ray CT was useful for the diagnosis of patients in the intensive care unit. Recognition of IPE is important because it may directly impair pulmonary ventilation and may be followed by the development of pneumomediastinum or secondary infection.
  • 佐藤 功, 余田 みどり, 津内 保彦, 坂本 和裕, 合田 文則, 川瀬 良郎, 川崎 幸子, 水川 帰一郎, 高島 均, 大川 元臣, ...
    1988 年 100 巻 11-12 号 p. 1003-1006
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    In a recent study, radiologic and pathologic examination of inflated and fixed lung specimens proved useful in the diagnosis of diffuse pulmonary diseases. In general, the margin of the nodular shadow is believed to be ill-defined in cases of sarcoidosis. Our patient was 47-year-old man, who has worked as a stone miner for 16 years. Chest radiography and CT revealed BHL and multiple nodular shadows with well-defined margins throughout the lung field. Those shadows were less than 1cm in diameter. TBLB showed epithelioid granulomas around the double refractile crystals. The finding suggests that the formation of epithelioid cell granuloma is related to silicate particles.
  • 原田 良昭
    1988 年 100 巻 11-12 号 p. 1007-1015
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Twenty-nine herniated lumbar disc fragments from patients over 60 years old were pathohistologically studied. For the comparison, 109 disc fragments from patients under 59 years of age were also observed. They were classified into 7 types according to their composition. In 80% of the patients over 65, fragments were composed of annulus fibrosus (AF) and cartilaginous end plate (EP) (sometimes also with bone). The interconnections between EP and the vertebral body are weak, but collagen fibers of AF anchor it firmly to EP. As degeneration progresses, EP separates from the vertebral body and AF becomes fissured. We suppose that EP avulsed from the vertebral body and herniated with AF (sometimes accompanying a part of the vertebral body). This type can be found more than herniation of the nucleus pulposus (NP) in patients over 30, and probably appears typically in elderly patients because of the advanced degeneration of their discs.
  • 川瀬 良郎, 佐藤 功, 森 泰胤, 外山 芳弘, 津内 保彦, 高島 均, 水川 帰一郎, 玉井 豊理, 田邉 正忠, 中村 憲二, 前田 ...
    1988 年 100 巻 11-12 号 p. 1017-1021
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    An abnormal shadow was noted on a chest radiogram of a 61-year-old woman three years ago. This abnormal shadow has changed little over the three years. Examinations changed this year, including chest tomogram, CT and bronchofiberscopy, showed atelectasis of the right S3 without obstruction of and . Histologically, a well differentiated adenocarcinoma was found in a transverse bronchial lung biopsy specimen. Postoperative staging was confirmed to be pT2NoMo.
  • 坂本 和裕, 佐藤 功, 川瀬 良郎, 余田 みどり, 影山 淳一, 合田 文則, 高島 均, 水川 帰一郎, 玉井 豊理, 田邉 正忠, ...
    1988 年 100 巻 11-12 号 p. 1023-1027
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    A case of benign localized pleural mesothelioma is reported. The patient was a 30-year-old female with no complaint. The mesothelioma was detected by routine chest radiography. The chest radiogram on admission revealed a mass located in the right middle-lower lung field adjacent to the lateral chest wall. Physical and laboratory examinations did not show any abnormality. Ultrasonography demonstarated a homogeneous mass between the chest wall and the lung. CT examination revealed a soft tissue mass adjacent to the chest wall having an extrapulmonary sign. A percutaneous needle biopsy was done. These examinations suggested that the mass was a slow growing pleural tumor. The patient underwent tumorectomy with partial resection of the right lung. The tumor was solid and approximately 4cm in diameter and 1.5cm in thickness. It arose from the visceral pleura and was pendunculated. The histological diagnosis was of a benign localized fibrous mesothelioma of the pleura.
  • 67Gaシンチグラフィーと病理所見の対比
    田邉 正忠, 合田 文則, 余田 みどり, 坂本 和裕, 宮本 勉, 瀬尾 裕之, 川崎 幸子, 大川 元臣, 玉井 豊理, 山本 眞也, ...
    1988 年 100 巻 11-12 号 p. 1029-1034
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    A 27-year-old male was admitted to our hospital with the chief complaint of dyspnea. Radiologically, he was found to have a large tumor shadow in the left hemithorax with pleural effusion. The first thoracotomy was done to resect the tumor on January 14, 1988. The second and third thoracotomies were done because of local recurrence in the left hemithorax. Histological diagnosis was of a hmangio-pericytoma. Before the third operation, Ga-67 scintigraphy was performed. Ga-67 accumulation was noted in parts of the tumor mass. Histological findings of the resected tumor were compared with the degree and location of Ga-67 accumulation. Histologically, Ga-67 accumulation occurred in areas of bleeding and necrosis in the tumor tissue, but not in viable parts of the tumor. Ga-67 accumulation usually occurs in viable tumor cells, but our findings were contrary to this generality.
  • Stainless Steel Coilを用いて
    大川 元臣, 坂本 和裕, 宮本 勉, 松野 慎介, 細川 敦之, 瀬尾 裕之, 児島 完治, 佐藤 功, 川崎 幸子, 高島 均, 玉井 ...
    1988 年 100 巻 11-12 号 p. 1035-1043
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Four patients with hemoptysis were treated by bronchial artery embolization, using only stainless steel coils 5mm or 3mm in diameter as the embolic material. Immediate control of hemoptysis was achieved in 3 of the 4 patients without any significant complication. Two of these patients are alive without recurrent hemoptysis, one of them 3 months and the other two years one month after the embolization. One of these patient died of renal failure 5 days after embolization. Recurrent hemoptysis occurred in 1 of the 4 patients with incomplete embolization. A second attempt at embolization failed because the coil fell down through the aorta into the iliac artery. The coil was surgically removed under fluoroscopy. Since the stainless steel coil is a non-absorbable embolic material, if carefully used, longer therapeutic results can be achieved for patients with hemoptysis.
  • 松野 慎介, 田邉 正忠
    1988 年 100 巻 11-12 号 p. 1045-1053
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Planar scan and single photon emission CT (SPECT) findings using Ga-67 and Tl-201 were compared with Pathological findings after thoracotomy in 23 patients with proven primary lung cancer. The stage was pT1N0 in 9 cases, pT2N0 in 5 cases, pT2N1 in 2 cases, pT2N2 in 1 cases, pT3N0 in 1 cases, pT3N1 in 2 cases, pT3N0 in 3 cases. The patients were injected 6mCi of Tl-201, planar images were taken at 15 minutes, SPECT images were taken at 1 hour. Ga-67 planar scan and SPECT were performed 48-72 hours after intravenous administration of 3mCi of Ga-67. When accumulations of these radiopharmaceuticals was noted in the primary lesion, hilar and mediastinal regions, the results were considered to be positive. The sensitivity of primary lesion detection was 33% with planar Ga-67 scintigraphy, 50% with Ga-67 SPECT, and 68% with planar Tl-201 scintigraphy, 100% with Tl-201 SPECT. For detection of hilar nodal involvement, Ga-67 SPECT had 100% sensitivity and 31% specificity, and Tl-201 SPECT had 86% sensitivity and 100% specificity. In mediastinal staging, Ga-67 SPECT had 100% sensitivity and 31% specificity, and Tl-201 SPECT had 100% sensitivity and 88% specificity. For evaluation of the primary lesion and lymph node metastasis, Tl-201 SPECT proved superior to Tl-201 planar scan, Ga-67 planar scan and Ga-67 SPECT.
  • 第1編 臨床的研究
    三宅 敬二郎
    1988 年 100 巻 11-12 号 p. 1055-1066
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Thoracotomy is generally considered to give rise to very severe pain. Although the efficacy of several new procedures of postoperative pain relief has been emphasized, postoperative pain is still a difficult problem to solve. Since July 1986, cryoanalgesia has been used for the relief of pain after thoracotomy as a routine method of postoperative pain control in our unit. This study showed that the patients who received cryoanalgesia required significantly less narcotics after operation than those who did not receive cryoanalgesia. The effectiveness of cryoanalgesia was verified not only by subjective parameters such as pain, but also by a definite improvement in spirometric parameters and additional benefits attributed to a decrease in the occurrence of postoperative pulmonary complications.
    These findings suggest that cryoanalgesia has a definite advantage over previous forms of control of postthoracotomy pain, and the additional time needed to apply cryoanalgesia is well justified.
  • 第2編 基礎的研究
    三宅 敬二郎
    1988 年 100 巻 11-12 号 p. 1067-1076
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Since July 1986, cryoanalgesia has been used for the relief of pain after thoracotomy as a routine method of postoperative pain control in our unit. A clinical study of cryoanalgesia showed that it was effective in controling postthoracotomy pain. There is little doubt that freezing provides an effective method of producing prolonged interruption of nerve conduction. This study showed the ultrastructual changes induced by freezing the intercostal serve of mongrel dogs. The earliest changes were dissociation of leaflets of the myelin seath and contraction of the axon followed by the degeneration of both elements. The second change was the absorption of degenerated myelin followed by the regeneration of nerves which were observed at a time when some degenerative changes were still progressing. No relationship has been found between nerve fiber size and susceptibility to freezing. There was a relationship between the duration of freezing and the time required for regeneration of the nerve. Although nerve function was not studied in this experiment, the structual changes were in accord with the clinical findiing of reduced sensitivity during and immediately following cryoanalgesia and also with the recovery of function within a few months of freezing.
  • 心筋組織炭酸ガス分圧連続測定による保護能評価
    水野 裕
    1988 年 100 巻 11-12 号 p. 1077-1087
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    To evaluate the effectiveness of myocardial protection during cardiac surgery, continuous measurement was made of the intramyocardial carbon dioxide (PCO2) level and pH during aortic cross clamping for 60 minutes under extracorporeal circulation in adult mongrel dogs. Also, samples of myocardium were resected at intervals, and the mitochondrial function and ATP level of these samples were measured in order to judge myocardial injury. The intramyocardial PCO2 level increased linearly immediately after aortic cross clamping, but after an average of 15.1 minutes, the rate of increase declined. At this point, the ATP levels remained at 70% of the level before aortic cross clamping, and no disturbance of mitochondrial function was found. The intramyocardial pH values revealed slight acidosis. Thus, aortic cross clamping for about 15 minutes did not induce ischemia of the myocardium.
    It was concluded that monitoring intramyocardial PCO2 and observing its rate of increase could be useful for determining the effectiveness of myocardial protection during a surgical procedure.
  • 田邉 正忠, 松野 慎介, 玉井 豊理, 山本 光利
    1988 年 100 巻 11-12 号 p. 1089-1093
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    A 60-year-old man was diagnosed as having progressive supranuclear palsy on the basis of his clinical symptoms of disturbance of balance and gait with unexpected falls, masking of the face, reduction is the volume of the voice and ophthalmoplegia. I-123 IMP, Tc-99m PAO SPECT and CT were performed. The CT examination showed atrophy of the midbrain, inter-brain and pons. SPECT studies revealed severe hypoperfusion bilaterally in the frontal cortex. These SPECT findings correspond to the report of frontal cortex hypometabolism detected by position tomography in patients with progressive supranuclear palsy (Brain 1985, 108, 785-799).
  • 田邉 正忠
    1988 年 100 巻 11-12 号 p. 1095-1099
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    To obtain gated respiratory cycle imaging, we made an experimental device in which siglals of the respiratory cycle are monitored with a thermistor. The signals of the respiratory cycle are utilized to reconstruct pulmonary dynamic images in multiple sequential frames. Application of this device adds the dimension of time to the resolution of regional ventilation. The device has the potential for separating tidal and residual components, and way be useful for studying the pathophysiologic aspects of regional ventilation.
  • 田邉 正忠, 宮本 勉, 大川 元臣, 玉井 豊理, 川崎 幸子, 植田 清隆, 大本 尭史
    1988 年 100 巻 11-12 号 p. 1101-1105
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    I-123 IMP, Tc-99m PAO SPECT and stable Xe-CT were performed in patients with cerebral infarction. I-123 IMP and Tc-99m PAO SPECT seemed to be superior to stable Xe-CT in detectability and delineation of the lesion. We obtained similar information in these cases by I-123 IMP and Tc-99m PAO SPECT.
  • 田邉 正忠, 宮本 勉
    1988 年 100 巻 11-12 号 p. 1107-1112
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    I-123 IMP, Tc-99m PAO SPECT and stable Xe-CT were performed within one week of each other in patients with cerebral infarction. We obtained the hypoperfusion ratio in these studies. The coefficient of correlation of the hypoperfusion ratio was 0.92 (p<0.001) between I-123 IMP and Tc-99m PAO, 0.87 (p<0.001) between Tc-99m PAO and Xe-CT, and 0.88 (p<0.001) between I-123 IMP and Xe-CT.
  • 田邉 正忠, 川瀬 良郎, 瀬尾 裕之, 佐藤 功, 細川 敦之, 宮本 勉, 松野 慎介
    1988 年 100 巻 11-12 号 p. 1113-1116
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Factor analysis of the steady state breathing cycle using Kr-81m gas wa performed in 7 normal volunteers. Two-factor analysis showed diaphragmatic and thoracic components, including the large airway space component. The contribution of the former was 19.2%±2.1% SD, and the contribution of the latter was 80.2%±2.1% SD. Three-factor analysis showed diaphragmatic (14.3%±3.3% SD), thoracic (55.7%±2.1% SD) and large airway space (29.5%±12.1% SD) components. Factor analysis of dynamic structures appears to be a very useful method for the study of lung ventilation.
  • 佐藤 功, 影山 淳一, 川瀬 良郎, 児島 完治, 水川 帰一郎, 田邉 正忠, 小笠原 望, 森田 純二
    1988 年 100 巻 11-12 号 p. 1117-1122
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    We reported one case each of pulmonary tuberculosis, allergic bronchopulmonary aspergillosis and intimal sarcoma of the pulmonary artery. In pulmonary tuberculosis and allergic bronchopulmonary aspergillosis, we recognized gloved finger like shadows. In the former, the shadoes extended to the adjacent bronchoarterial sheath and alveolar spaces, and in the latter, it extended to the ectatic bronchial lumen. In the intimal sarcoma, the lesions resembled multiple nodular shadows; however, the pulmonary artery markedly increased in diameter and elongated. We emphasized the relation of the lesions to inherent structures of the lung instead of pattern recognition in order to interpret chest radiogramas.
  • 田邉 正忠, 佐藤 功, 余田 みどり, 津内 保彦, 川瀬 良郎, 水川 帰一郎, 大川 元臣, 南城 悟, 前田 昌純
    1988 年 100 巻 11-12 号 p. 1123-1128
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    We reported two cases of peripheral adenocarcinoma about 10mm in diameter. High resolution. thin-slice CT images were reviewed in comparison with pathologic findings. The margins of both lesions were ill-defined, and corresponded to superficial tumor replacement of alveolar cells without collapse. In one case, the pulmonary vein was viewed as going toward the central portion of the mass on CT, which suggested the possibility of malignacy because such a finding is different from the pattern of centrilobular inflammation. In the other case, airbronchograms of bronchioles and alveolar ducts on CT suggested the possidility of malignancy instead of ordinary inflammatory changes. These radiological findings corresponded to radiograms of specimens and pathologic findings. Inflated and fixed lung were useful for diagnosis by radiological imaging, including CT.
  • 高島 均, 大川 元臣, 児島 完治, 佐藤 功, 水川 帰一郎, 日野 一郎, 瀬尾 裕之, 松野 慎介, 玉井 豊理, 田邉 正忠, 三 ...
    1988 年 100 巻 11-12 号 p. 1129-1136
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    After super-selective embolization of the external carotid arterial branch, some improvement in the symptoms of two patients (63-year-old female, 68-year-old female) were observed, but some symptoms continued after the embolization. One month after the embolization, external irradiation (10 MeV X ray, 2Gy/day, 5fr/W, total 30Gy) was administered to the region of the fistula. An angiogram after completion of the irradiation showed complete disappearance of CCF, and almost complete improvement of symptoms was observed. For three years following the completion of irradiation, neither recurrence of sympoms nor side effects were noted.
  • 日野 一郎, 大川 元臣, 児島 完治, 瀬尾 裕之, 佐藤 功, 玉井 豊理, 田邉 正忠
    1988 年 100 巻 11-12 号 p. 1137-1140
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Angiography with a new method using a transbranchial selective catheterization technique was performed on 20 patients. A slim and soft catheter was used for safety reasons and decrease the stress of the patients. Selective angiography was attempted an arteries including the celiac axia and its branches, SMA, and renal artery. Successful results were obtained in 87% of the patients by using a guidewire with the catheter. We also performed TAE and/or infused drugs into target arteries in 5 patients. Our method was of diagnostic value and made angiography possible for outpatients without complication.
  • 児島 完治, 余田 みどり, 外山 芳弘, 影山 淳一, 坂本 和裕, 宮本 勉, 細川 敦之, 瀬尾 裕之, 佐藤 功, 大川 元臣, 玉 ...
    1988 年 100 巻 11-12 号 p. 1141-1148
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    A 64-year-old woman without any respiratory symptoms was diagnosed as having pulmonary alveolar microlithiasis from the characteristic finding of her chest radiograms. Diffuse fine nodular shadows of microliths were seen throughout both lungs. Linear shadows, which were considered to be typical Kerley's lines (A, B, and C), were also noted. Conventional tomography and high resolution, thin-slice CT disclosed the anatomical structures and the distribution of interlobular septa in vivo, which were responsible for Kerley's lines. Lateral chest radiograms revealed oblique short linear shadows just behind the sternum, which were caused by interlobular septa at the mediastinal side of the upper lung. These shadows seemed to represent new septal lines.
  • 宮本 勉, 川崎 幸子, 佐藤 功, 玉井 豊理, 高島 均, 大川 元臣, 余田 みどり, 田邉 正忠, 川瀬 良郎, 水川 帰一郎
    1988 年 100 巻 11-12 号 p. 1149-1154
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    Two patients who were suspected of having arteriovenous malformation (AVM) by plain and contrast enhancement cranial CT were examined by brain SPECT with I-123-IMP. One case, which showed defects on early and delayed images, was diagnosed as AVM. The other was diagnosed as cerebral infarction with luxury perfusion, based on the finding of hyperperfusion on two images. The final diagnoses of these two patients were confirmed by angiography and/or operation. We considered brain SPECT with 1-123-IMP to be very useful for the differentiation between AVM and cerebral infarction with luxury perfusion, which was suspected of being AVM by cranial contrast enhancement CT.
  • 宮本 勉, 児島 完治, 大川 元臣, 瀬尾 裕之, 外山 芳弘, 影山 淳一, 津内 保彦, 森 泰胤, 田邉 正忠, 日野 一郎
    1988 年 100 巻 11-12 号 p. 1155-1160
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    A clinical survey on the adverse reaction to a new low osmolality contrast medium (ioxaglate) was performed in 83 patients during June-October 1987. These patients were followed up for 24 hours following angiographic examination. The incidence of adverse reactions due to ioxaglate was 8.4% (7/83). There were no severe reactions, but we encountered nausea, rash and others. The incidence of vascular pain was 6.0% (5/83), we excluded vascular pain from this data because of the difficulty of objectively evaluating vascular pain. The incidence of adverse reactions excluding vascular pain, in our survey, was lower than that (38.8%) reported by Katayama et al.6), because of the low osmolality of ioxaglate. Adverse reations were encountered in 4 of 7 patients after leaving the examination room. Panto et al.8) reported that there were some delayed adverse reactions to contrast media. We propose that clinical surveys of adverse reactions should be discussed in consideration of data obtained after the patient leaves the examination room.
  • 壽満 文彦
    1988 年 100 巻 11-12 号 p. 1161-1175
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    The locations of human T-cell leukemia (HTLV-I) antigens in HTLV-I and HTLV-I-producing T-cells were studied with special reference to the inner structure proteins (MA, p19 and CA, p24) by electron microscopy using the peroxidase-labeled antibody method with monoclonal antibodies. ATL-associated antigens (ATLA) were detected by electron microscopy of cells incubated in cell suspension with sera from adult T-cell leukemia (ATL) patients on the surface of virus particles and the plasma membrane, but not inside the virus and cells. Intraviral and intracellular antigens were detected by the immunoelectron microscopy of frozen-sectioned specimens of paraformaldehyde-fixed cells. The viral matrix protein (MA, p19) was detected with the anti-p19 monoclonal antibody in the viral envelope, the viral matrix and some parts of the plasma membrane. The viral capsid protein (CA, p24) was detected with the anti-p24 monoclonal antibody in the viral core. The positive reactions detected on the viral envelope, plasma membrane, endoplastic reticulum, and nuclear envelope with sera of ATL patients were deduced to be mainly due to the viral envelope proteins and their precursors or to proteins fused to the viral envelope proteins.
  • 愛甲 博美
    1988 年 100 巻 11-12 号 p. 1177-1183
    発行日: 1988/12/28
    公開日: 2009/03/30
    ジャーナル フリー
    The amount of mercury exhaled from normal and acatalasemic mice exposed to metallic mercury vapor after administration of aminotriazole or ethanol was investigated. The cumulative amount of mercury exhaled from acatalasemic mice was significantly higher than that of normal mice. Moreover, the cumulative amount of mercury exhaled from acatalasemic mice pretreated with aminotriazole or ethanol was significantly higher than that of normal mice, although the difference in mercury exhaled from normal and acatalasemic mice was not significant. The cumulative amount of mercury exhaled from normal and acatalasemic mice pretreated with aminotriazole or ethanol was significantly higher than that of control mice. The results suggest that catalase activity in the lungs was inhibited by aminotriazole or ethanol, resulting in an increase in the level of mercury exhaled from the mice.
    The mercury concentration in organs of normal and acatalasemic mice, and mice exposed to metallic mercury vapor after administration of aminotriazole or ethanol was investigated. The mercury concentration in the liver of acatalasemic mice, and acatalasemic mice pretreated with aminotriazole or ethanol was higher than that of normal mice. In contrast, the concentration in the lungs and blood were lower than those of normal mice.
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