巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
100 巻, 5-6 号
選択された号の論文の24件中1～24を表示しています
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能勢 総一郎1988 年 100 巻 5-6 号 p. 441-453
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーIn the human lymphoreticular system, the α subunits of S-100 protein is found in the ordinary monocyte-macrophage lineage, and the β subunit is found in so-called T-zone histiocytes, including interdigitating reticulum cells. The β subunit is also present in some of CD8+ T lymphocytes. In the present study, the ontogeny of these histiocytes and lymphocytes was investigated. Human yolk sacs, embryos and fetuses from the 4th to 21st weeks of gestation were examined for the presence of S-100 protein subunits by an immunohistochemical method, using antisera monospecific to each subunit. S-100α+ histiocytes were present in yolk sacs and hepatic sinusoids by the 4th week of gestation, before bone marrow hematopoiesin had developed. As gestation proceeded, their distribution and frequency became similar to those of S-100α+ histiocytes of the adults. No S-100β+ cells were found in yolk sacs. S-100β+ histiocytes were first detected in the hepatic sinusoids of 5th week embryos and later, they distributed in other lymphoid organs. S-100β+ lymphocytes were not found in the liver and they were first detected in the thymus at the 12th week of gestation, subsequently distributing in other lymphoid organs.
These results suggest that S-100β+ lymphocytes and histiocytes may belong to different cell lineages, and that S-100β+ lymphocytes may not be the precursors of histiocytes.抄録全体を表示PDF形式でダウンロード (9034K) -
松下 治1988 年 100 巻 5-6 号 p. 455-464
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーThe effect of lincomycin on the production of TEM β-lactamase by E. coli was studied to elucidate the mechanism of the stimulation by this antibiotic of the production of enterotoxins by certain bacteria. TEM β-lactamase was consistently measurable by a microiodometric assay. Lincomycin enhanced the activity of the enzyme encoded on the plasmid pBR322 2.4 times, while chromosomal β-galactosidase activity was inhibited. Lincomycin also stimulated the production of β-lactamase coded for by the bla gene integrated into the chromosome, but the antibiotic did not stimulate that of chloramphenicol acetyltransferase encoded on a ColEl-derived plasmid. The effect was independent of the copy number of the gene, suggesting that the effect takes place after transcription.
The amount of bla mRNA was measured by [3H]-uridine pulse-labeling of mRNA followed by DNA-RNA hybridization. Lincomycin caused a 1.8 to 2.4-fold increase in the amount of bla mRNA. The possible presence of the repressor of the bla gene was examined by transducing the excess bla promoter region into E. coli 112-2, which carries Tn3 on its chromosome, but the repressor was not detected. The effect of bla promoters was examined by the construction of promoter deletion mutants of pBR322, each of which lacked one of two bla promoters. Lincomycin stimulated the production of β-lactamase coded by these plasmids at the same level as that coded by original pBR322, indicating that the effect was not due to increased transcription initiation. Preliminary examination of the degradation rate of bla transcripts showed that lincomycin increased half-life of bla mRNA.抄録全体を表示PDF形式でダウンロード (670K) -
橋本 訓招, 斉藤 大治, 上枝 正幸, 辻 孝夫, 国司 研介, 岩野 郁造1988 年 100 巻 5-6 号 p. 465-471
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーA case of periarteritis nodosa with advanced A-V block and ventricular tachycardia is reported. The patient was a 62-year-old man who was admitted to Ibara City Hospital because of leg pain and fever. Laboratory examinations and microscopic examination of biopsy sections of the soleus muscle revealed that he had periarteritis nodosa. His electrocardiogram (ECG) and chest X-ray films on admission were normal. Treatment with prednisolone resulted in relief of his complaints, and improved laboratory data. One year later the parient complained of fainting attacks, and an ECG indicated non-sustained ventricular tachycardia. Two months later, a A-V block with LBBB appeared, which progressed to complete A-V block within a month. Good results were achieved with ventricular pacing (VVI) in this patient.抄録全体を表示PDF形式でダウンロード (6069K) -
川端 昌弘1988 年 100 巻 5-6 号 p. 473-482
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーA method coupling gas chromatography/negative ion chemical ionization mass spectrometry (GC/NCI/MS) with a rapid one-step purification on a Sephadex G-10 column was developed to measure free phenylacetic acid (PAA), the major metabolite of β-phenylethylamine (PEA), in small amounts of the rat brain. Recovery of PAA for the Sephadex G-10 column was 96.2±2.0%. Pentafluorobenzyl derivatives of PAA (PAA-PFB) and heptadeuterated PAA (PAA-d7-PFB) were determined by GC/NCI/MS. No interfering peaks were present on the mass fragmentogram. A calibration curve constructed from the observed peak area ratio of PAA-PFB to PAA-d7-PFB and known weight ratio was linear within the range of 1.25 to 40 pg PAA, with a correlation coefficient of more than 0.999. In the rat striatum, PAA was determined with ‘within batch’ and ‘between batches’ coefficients of variation of 0.81% and 1.24%, respectively. While PAA was significantly decreased by 40% of controls following treatment with pargyline, the monoamine oxidase inhibitor, a remarkable increase in the metabolite level was found following treatment with PEA. Acute and chronic treatment with antidepressants had no significant effects on PAA levels in the rat striatum. The present method should be useful in future investigations of the functional role of PEA in the brain.抄録全体を表示PDF形式でダウンロード (671K) -
吉永 泰彦1988 年 100 巻 5-6 号 p. 483-494
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーThe mechanism of immune deficiency in patients with chronic renal failure (CRF) was investigated by testing both the ability of monocytes to produce IL-1 and the ability of To cells to produce IL-2.
IL-1 production by lipopolysaccharide (LPS)-stimulated monocytes from CRF patients was not less than that of healthy controls. In fact, some patients showed higher values than the normal range (mean±2SD of normal value).
IL-2 production by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) from patients on hemodialysis was significantly greater than that of healthy controls and non-hemodialysis patients. To exclude the influence of monocytes, the ability of T cells to produce IL-2 was also examined. IL-2 production by PHA-stimulated T cells was also increased in patients on hemodialysis. There was no correlation between IL-2 production by PHA-stimulated T cells and IL-1 production by LPS-stimulated monocytes. These results indicated that the enhanced IL-2 production by T cells was independent of monocytes.
The mean IL-1 activity produced by non-stimulated monocytes was less than 1U/ml in all groups. IL-2 production by unstimulated T cells was not observed in any subject. Both the expression of the IL-2 receptor (IL-2R) and that of the transferrin receptor on PBMC were less than 2% at the time cultures were started, or after incubations without stimulation. Thus, the possibility that monocytes and T cells were preactivated could be excluded.
There was a significant correlation between IL-2 responsiveness and IL-2R expression on PHA-stimulated PBMC. Both were significantly lower in non-hemodialysis patients than in healthy controls, and gradually improved with the continuation of hemodialysis. One of the causes of immune deficiency, particularly in patients with non-hemodialysis renal failure, might be decreased IL-2 responsiveness based on defective expression of IL-2R.抄録全体を表示PDF形式でダウンロード (5648K) -
上田 裕之1988 年 100 巻 5-6 号 p. 495-505
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーIt is extremely important to prevent opportunistic and hospital infection. Therefore, bacterial contamination of instruments, equipment and floors is frequently checked. MacConkey agar (Mac agar) is routinely to dtect Gram negatiue rods (GNR), caustive organisms of opportvnistic or hospital infection. However, only a few colonies of GNR were detected from hospital floors on Mac agar, while many colonies of GMR were detected on brain heart infusion agar (BHIA). It is thought that the 0.1% of bile salts in Mac agar is too inhibitory for the growth of GNR existing on floors. Therefore a new medium for the detection of GNR form floors was developed.
Firitly. bacteria obtained by swabbing a floor were inocunlted on Drigalski agar containing desoxycolate (DOC) at various concetrations. Drigalski agar containing 0.03% DOC (D-D agar) was found to be suitable for the growth of GNR, while at the same time suppressing the growth of GPC. Secondly, D-D agar, Mac agar and BHIA were used to detect GNR adhering on gless plates. 50-80% CFU of the total GNR grown on BHIA were detected on D-D agar, but only 10-20% CFU were detected on Mac agar. Thirdly, these agars were uned to detect GNR on floors and the hands of nurses. D-D agar was apparently better than Mac agar. Consequently, D-D agar is very ureful for the selective detection of GNR on floors and hands.抄録全体を表示PDF形式でダウンロード (676K) -
光延 文裕1988 年 100 巻 5-6 号 p. 507-517
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーThe transcriptional promoter activity of the proviral long terminal repeat (LTR) of a retrovirus produced in a human lymphoblastoid cell line was studied in a variety of cell types, in comparison with that of the simian virus 40 (SV40) early promoter and Rous sarcoma virus (RSV) LTR. Recombinant plasmids containing these promoter sequences linked to the chloramphenicol acetyltransferase (CAT) gene were constructed and tested in a transient assay system to measure relative rates of transcriptional activites in different cell types, including human lymphoblastoid cell lines. The transcriptional activity of this proviral LTR was much higher than that of the SV40 early promoter and RSV LTR in various cell types, especially in human lymphoblastoid cell lines. This result is consistent with the fact that this retrovirus is a lymphotropic virus. This proviral LTR could be useful for the analyses of the expression and biological activity of various genes in human lymphoblastoid cell lines.抄録全体を表示PDF形式でダウンロード (4096K) -
秋山 公祐1988 年 100 巻 5-6 号 p. 519-531
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーTo clarify the biological activity of the cloned provirus genome of a retrovirus produced in a human lymphoblastoid cell line, the cloned genome was introduced into cultured cell lines by DNA transfection techniques, and the viral gene products were analyzed. The transient expression of virus-related antigens was detected immunocytochemically in a canine thymus cell line two days after the introduction of the cloned provirus genome. Stable transfectants of a human lymphoblastoid cell line (Jurkat) were established by introducing recombinant molecules constructed with the provirus genome and neomycin resistance gene and by selecting with G-418. Southern blotting analysis showed that the full-length provirus genome was integrated into these cellular DNA. The provirus genome-containing transfectants were shown to express 35S RNA, which was thought to be viral genome RNA, by Northern blotting analysis. Western blotting analysis showed that the viral major structural protein p34 and p34-related proteins were expressed in these transfectants. These data indicate that this cloned provirus genome encodes viral RNA and proteins and suggest that this provirus genome could be useful for the introduction of various genes and the analysis of their expression in human lymphoblastoid cell lines.抄録全体を表示PDF形式でダウンロード (7225K) -
岡田 尚志郎1988 年 100 巻 5-6 号 p. 533-545
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーRecently, dantrolene has been applied to the treatment of neuroleptic malignant syndrome. In some treated patients, dramatic changes in the electroencephalogram and in the levels of monoamine metabolites in cerebrospinal fluid were observed. Nonetheless, little is known about the effect of dantrolene on the central nervous system. In this study, I investigated the effects of dantrolene on rat brain tryptophan hydroxylase (TrpOHase) activity. Intraperitoneal administration of dantrolene (20mg/kg) increased the TrpOHase activity to approximately 130% of the control level. An increase in TrpOHase activity was found in a synaptosomal fraction. Activation of TrpOHase by dantrolene was observed in a dose dependent manner in vitro, and the highest activity was obtained with 6.0μM dantrolene (approximately 125% of the control level). Preincubation with dantrolene had no remarkable effect on TrpOHase activity. The effect of dantrolene on TrpOHase was manifested kinetically as a decrease in the apparent Km of the enzyme for cofactors (BH4 and 6MPH4). Dantrolene had no effect on TrpOHase partially purified by affinity chromatography. These findings suggest that dantrolene influences the central nervous system and alters TrpOHase activity.抄録全体を表示PDF形式でダウンロード (2781K) -
赤尾 正樹1988 年 100 巻 5-6 号 p. 547-554
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーI studied host resistance to infection in critically ill patients with nosocomial pneumonia due to gram-negative bacilli. The bactericidal activity of polymorphonuclear leukocytes (PMNs) against pathogenic bacteria was estimated by zymosan-induced and bacteria-induced chemiluminescence (CL). The function of B lymphocytes was examined by measurement of lymphocyte numbers, subpopulations, subsets, and plasma immunoglobulins. The zymosaninduced CL did not correlate significantly with the bacteria-induced CL. This finding indicates that zymosan cannot be used for the estimation of bactericidal activity of PMN against pathogenic bacteria in critically ill patients. Lymphocyte numbers were very low, and the parcentage of suppressor T lymhocytes was low, and consequently the ratio of helper to suppressor T lymphocytes was somewhat high. There was a significant negative correlation between the plasma level of IgG and the percentage of B lymphocytes (p<0.05). The bactericidal activity of PMNs and the function of B lymphocytes tended to be suppressed as the plasma level of IgG increased. From these results, I conclude that: 1. There is negative feedback between IgG and B lymphocytes. 2. Host resistance to infection is suppressed in critically ill patients, if IgG is elevated.抄録全体を表示PDF形式でダウンロード (512K) -
頓宮 廉正, 板野 一男, 石井 明1988 年 100 巻 5-6 号 p. 555-563
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーAdult chironomid midges were collected using light traps at 9 stations in Okayama Prefecture. The light traps were set for an entire night once a month from May to September in 1985 and 1986. A total of 34, 313 (1985) and 73, 667 (1986) chironomid midges were collected. Among them, the dominant species were Chironomus yoshimatsui (7.3%), C. kiiensis (18.3%) and Tanytarsus oyamai (14.1%). They emerged mostly in July and August. Sixty par cent of the weight of all air-dried midges was recorded in July.抄録全体を表示PDF形式でダウンロード (467K) -
第1編 カンジダ抗原による末梢血中及びBALF中リンパ球のinterleukin 2 (IL-2)産生能の検討宮川 秀文1988 年 100 巻 5-6 号 p. 565-575
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーCandida antigen is known to be the major causative agent of adult bronchial asthma, especially intractable asthma. High responsiveness of lymphocytes in bronchoalveolar lavage fluid (BALF) to Candida antigen has been reported in patients with intractable asthma. Therefore, IL-2 production of peripheral blood (PB) lymphocytes and BALF lymphocytes in patients with various types of bronchial asthma was evaluated to clarify the role of cellular immunity against Candida antigen in the pathogenesis of intractable asthma. IL-2 production of PB lymphocytes in intractable asthma patients was higher than in non-intractable asthma patients and normal controls (p<0.01). Patients with intractable asthma receiving prednisolone at a dose of over 10mg/day showed lower IL-2 production by PB lymphocytes than patients receiving prednisolone at a dose of under 10mg/day. The direct suppressive effect of prednisolone was also evaluated in a vitro study, which revealed that the suppression of IL-2 production was dose dependent in the range of therapeutic concentrations. IL-2 production by BALF lymphocytes against Candida antigen was also studied, and it was shown that IL-2 production was higher in intractable asthma patients than in non-intractable asthma patients (p<0.01). IL-2 production correlated significantly (p<0.05) with lymphocyte blastogenic responses against Candida antigen in patients with intractable asthma.抄録全体を表示PDF形式でダウンロード (4241K) -
第2編 カンジダ抗原による末梢血単核球由来の好中球遊走活性の検討宮川 秀文1988 年 100 巻 5-6 号 p. 577-587
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーThe role of cellular immunity in the pathogenesis of intractable asthma was studied. Increased IL-2 production in intractable asthma patients as the result of lymphocyte response to Candida antigen was shown in the previous paper. Although the exact role of cellular immunity in the pathogenesis of intractable asthma is still obscure, various activities of lymphokines are suspected of contributing to intractable asthma. While neutrophils are well known to release various chemical mediators, neutrophils in bronchoalveolar lavage fluid (BALF) has been reported to increase in patients with intractable asthma. The accumulation of neutrophils could be important in the pathogenesis of intractable asthma. Therefore, neutrophil chemotactic activity (NCA) derived from mononuclear cell culture with Candida antigen was studied. High NCA was observed in patients with intractable asthma in comparison with patients with non-intractable asthma and normal controls. Intractable asthma patients raceiving prednisolone at a done of over 10mg/day showed less NCA than patients receiving prednisolone at a dose of under 10mg/day. NCA levels in the culture supernatant correlated with IL-2 levels in the same culture supernatant. It seemed likely that NCA is derived at least in part from the lymphocyte blastogenic response to Candida antigen.抄録全体を表示PDF形式でダウンロード (2347K) -
健康保険組合の保健施設事業の評価中瀬 克己1988 年 100 巻 5-6 号 p. 589-598
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーWith the rapid increase in medical costs, insured employees and employers have had to pay higher premiums in Japan. As a result, many health insurance schemes are providing health services not only to improve the health condition of the employees but also to reduce medical costs. A questionnaire study on health services provided by employees' health insurance schemes was carried out, and the relationship between the activities of health services and medical costs was analyzed.
The schemes provided different kinds of health services such as physical fitness programs, information services, and gymnastic facilities. The highest correlation was found between the mean age of the insured employees, and the second highest correlation was found between the total costs for health services and the medical expenditure. The items of health services relating to medical expenditure differed according to the mean age of insured employees. The health services among the schemes for younger employees were effective in reducing medical costs, while no significant correlation between health services and medical expenditure was observed among the schemes for elder employees.抄録全体を表示PDF形式でダウンロード (678K) -
松田 力哉1988 年 100 巻 5-6 号 p. 599-608
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーIn order to understand the metabolic abnormalities occurring with renal failure, the biosynthetic pathway of guanidinosuccinic acid (GSA) was investigated in normal rat liver, because GSA is known as a uremic toxin and its synthetic pathway is unclear.
After fresh liver was homogenized and centrifuged for 60 min at 100, 000×g, the supernatant was fractionated by precipitation with ammonium sulfate. It was found that the activity of GSA biosynthetic enzymes was highest in the fraction between 30% and 40% saturation of ammonium sulfate. The reaction mixture contained potassium phosphate buffer (pH7.4), aspartate, urea, ATP and an ATP-generating system, MnCl2, and enzyme solution. The optimum pH was 7.4. The activity was strongly accelerated by Mn++ and Cu++, while it was completely inhibited by Fe++. Hydroxyurea, L-canaline, L-canavanine, and L-arginine could not substitute for urea.
These results suggest that GSA is not formed by the transamidination of arginine to aspartate as proposed by Cohen, or by way of the guanidine cycles proposed by Natelson. It is possible that GSA is mainly synthesized from urea and aspartate directly in rat liver.抄録全体を表示PDF形式でダウンロード (590K) -
第1編 悪性リンパ腫の診断における腹部超音波検査法に関する検討吉田 光雄1988 年 100 巻 5-6 号 p. 609-619
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーIn order to determine the usefulness of ultrasonography (US) as a diagnostic tool for intraabdominal disease of malignant lymphoma, US was compared with computed tomography (CT) as to the ability to detect an abnormality. The diagnostic accuracy of US and CT was evaluated on the basis of the overall outcome of the intra-abdominal disease, which was determined by serial studies of US, CT and other non-invasive diagnostic procedures, coupled with the serial measurement of superficial lymph nodes as an indication of changes in the intra -abdominal disease. Between September 1984 and February 1987, 158 echographic scan series were obtained in 58 lymphoma patients, among those, 56 instances of US imaging were examined concurrently with CT. In detecting the enlargement of the hepatic hilar nodes, CT showed a sensitivity of 73% and a specificity of 98%. For the splenic hilar nodes, CT showed a sensitivity of 50% and a specificity of 100%. Whereas, the sensitivity and specificity of US for the hepatic and splenic hilar nodes were all 100% for both sites, showing a trend favoring for US over CT. On the other hand, CT was somewhat superior to US in detecting the enlargement of para-aortic massses: CT showed a sensitivity of 97% and specificity of 100%, while US showed sensitivity of 71% and specificity of 100%. However, in detecting a mass to be composed of pathologic lymph nodes, US was more reliable than CT. US was almost comparable to CT in indicating the size of the liver and spleen. Finally, US and CT appeared to be supplementary in the imaging diagnosis of intra-abdominal disease of malignant lymphoma. US was also thought to be useful for the evaluation of tumor response to therapy.抄録全体を表示PDF形式でダウンロード (4715K) -
第2編 びまん性大細胞型非ホジキンリンパ腫におけるAdriamycinを含む多剤併用療法の有用性に関する検討吉田 光雄1988 年 100 巻 5-6 号 p. 621-631
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーA comparison was made between the therapeutic outcome of patients with diffuse large-cell non-Hodgkin's lymphoma treated with combination chemotherapy containing adriamycin (adriamycin regimen) and those treated with combination chemotherapy not containing adriamycin (non-adriamycin regimen). All the patients had no prior therapy, and there were no differences in any other background factors between the two treatment groups. Of 32 patients on the non-adriamycin regimen, 19 (59%) achieved complete response (CR) and 12 (38%) achieved partial response (PR). Of 20 patients on the adriamycin regimen, 14 (70%) achieved CR and 6 (30%) achieved PR. For those on the non-adriamycin regimen, the median duration of CR was 10 months, the projected 5-year relapse-free rate was 27%; the median survival time for all patients was 1 year 7 months; and the projected 5-year survival rate was 24%. For those on the adriamycin regimen, a median duration of CR was not reached, the projected 5-year relapse-free rate was 85%; the median survival time for all patients was 1 year 11 months; and the projected 5-year survival rate for all patients was 58%. These results show the superiority of combination chemotherapy containing adriamycin, indicating that adriamycin is a essential agent for the initial induction chemotherapy for the large-cell type of non-Hodgkin's lymphoma.抄録全体を表示PDF形式でダウンロード (679K) -
第1編 進展期肺非小細胞癌におけるIfosfamide・Cisplatin・Vindesine併用療法の検討小塚 彰1988 年 100 巻 5-6 号 p. 633-642
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーBetween February 1986 and September 1987, we conducted a phase II clinical trial of a three-drug combination in advanced non-small cell lung cancer patients. The combination consisted of ifosfamide, 1, 300mg/m2, on days 1 through 5; cisplatin, 20mg/m2, on days 1 through 5; and vindesine, 3mg/m2, on days 1 and 8. Courses were repeated at 3- to 4-week intervals until disease progression or unacceptable toxicity occurred. Of 26 patients evaluated, two had a complete response and 16 had a partial response, with an overall response rate 69%. The projected median response duration was 30 weeks. The median survival for all patients has not been reached: 16 of 26 patients are still alive with a median follow-up period of 46 weeks (range, 16 to 95 weeks). Responders survived significantly longer than non-responders. The major toxicity was myelosuppression. One patient died of septicemia while neutropenic, but the toxicity was generally well-tolerated by the rest of the patients. Neurotoxicity and nephrotoxicity occurred less frequently. However, these toxicities were cumulative and persistent, and were the major cause of discontinuation of the regimens in a few patients. These results indicate that the three-drug combination is active against non-small cell lung cancer and warrants further clinical trials.抄録全体を表示PDF形式でダウンロード (679K) -
第2編 肺非小細胞癌化学療法例の予後因子についての検討小塚 彰1988 年 100 巻 5-6 号 p. 643-654
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーPrognostic factors were analyzed in 91 patients with advanced non-small cell lung cancer entered in protocol studies of combination chemotherapy between 1975 and 1986. Patients were divided into two or three groups according to pretreatment clinical and laboratory parameters. The stage of the disease, pretreatment erythrocyte sedimentation rate, serum albumin level and serum alkaline phosphatase level were revealed by univariate analysis to significantly affect patient survival. The pretreatment serum lactic dehydrogenase level slightly affected patient survival. Patients responding to chemotherapy and those with stabilized disease had a better prognosis than those with progressive disease. When these factors were evaluated by multivariate analysis, the most influential prognostic factors for survival were in the order of stage of the disease, serum albumin level, serum alkaline phosphatase level and lymphocyte number in the peripheral blood. After inclusion of tumor response to chemotherapy, the factors were in the order of stage of the disease, tumor response, lymphocyte number in the peripheral blood and serum albumin level. These results indicate that improved survival can be achieved even in patients with advanced disease when a potent chemotherapy is applied while the patient is in good condition.抄録全体を表示PDF形式でダウンロード (696K) -
佐藤 透1988 年 100 巻 5-6 号 p. 655-667
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーThe effect of the tissue temperature on regional cerebral blood flow (rCBF) was studied using anesthetized and respiratory-controlled normal monkeys. rCBF was sequentially measured by the inhalation hydrogen clearance method, during localized brain heating under generalized hypothermia or differential hypothermia (DH), and was compared to that obtained by whole-body heating and cooling (WB). For WB in 6 animals, the body temperature was controlled by immersion of the body in a hot or cold water bath. rCBF changed with a change in the tissue temperature in the range of 27.8 to 39.7°C, showing a constant 12.2% per degree Celsius change. For DH in 7 animals, the brain was locally heated by external 2450 MHz microwave irradiation, while the body was kept hypothermic (30.0-30.8°C) by immersion in a cold water bath. rCBF rate of 15.2% per degree Celsius change was obtained in response to change in the tissue temperature ranging from 29.4 to 40.7°C. The results indicated that rCBF changed proportionately with the change in the tissue temperature within a specific temperature range between shallow hypothermia and modest hyperthermia. rCBF changed at a higher rate after DH treatment than was possible by WB treatment. The response of the rCBF to changes in the tissue temperature of the normal brain may play a significant role in thermotherapy for brain tumors.抄録全体を表示PDF形式でダウンロード (2848K) -
藤本 俊治, 吉岡 孝, 苅田 成人, 大塚 長康1988 年 100 巻 5-6 号 p. 669-671
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーThe human heart was stained by the modified PAS method (Otsuka and Hara method) and the distribution of Purkinje's fibers the subendocardium of the cardiac ventricle was reported. The Purkinje's fibers in subendocardium of the ventricular septum and the free region in humans are arranged as a network. On detailed investigation it was found that there were two areas that were mingled: One area that was macroscopically indistinguishable was found to have a fine and dense distribution. The other area was devoid of a distribution of the network. This distribution pattern resembles that of pigs but is unlike the morphology of other animals (monkeys, cows, goats, dogs, rabbits, rats and mice.)抄録全体を表示PDF形式でダウンロード (1853K) -
1988 年 100 巻 5-6 号 p. 673-680
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (474K) -
1988 年 100 巻 5-6 号 p. 681-689
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (491K) -
1988 年 100 巻 5-6 号 p. 690-700
発行日: 1988年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (678K)
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