巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
101 巻, 3-4 号
選択された号の論文の13件中1～13を表示しています
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住居 広士, 井上 一, 伊藤 士郎, 田辺 剛造, 武智 秀夫, 池田 正五, 小田 琢三1989 年 101 巻 3-4 号 p. 285-293
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThe amplification and rearrangement of five cellular oncogenes (c-myc, c-K-ras, c-fos, c-raf-1, and N-myc) were studied by Southern hybridization in fourteen human bone and soft tissue tumors obtained at surgery. Amplification of c-myc was detected in the two of four osteosarcomas and one of two malignant fibrous histiocytomas. The c-myc genes in these tissues were amplified 4- to 8-fold in comparision with the placenta DNA. One of these osteosarcomas had 16- to 32-fold amplification of c-raf-1 gene without rearrangement. The clinical course of osteosarcoma and malignant fibrous histiocytoma with the amplified c-myc or c-raf-1 gene showed a rapid malignant progress with lung or bone metastasis. There appears to be a correlation between clinical prognosis and oncogene amplification.抄録全体を表示PDF形式でダウンロード (8416K) -
神崎 典子1989 年 101 巻 3-4 号 p. 295-302
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThe purpose of this study is to present a method of boundary enhancement algorithms for magnetic resonance images using a V-filter and clinical applications.
By iterated V-filtering, the signal-to-noise ratio can be increased with preservation of edge sharpness. This is due to the relationship of the signal-to-noise ratio to the mean-to-variance ratio.
These techniques were applied to clinical cases using MRI in the evaluation of the brain tumor. The boundaries of the brain tumor and the edematous region were precisely extracted.抄録全体を表示PDF形式でダウンロード (2917K) -
水田 昭文1989 年 101 巻 3-4 号 p. 303-314
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThe cytotoxic effect of anticancer agents depends markedly on the intracellular uptake of the anticancer drug; its maintenance is increased by accelerating the intracellular uptake of anticancer agent and inchbiting. Using with flow-cytometry, we demonstrated that the intracellular uptake of adriamycin (ADM) is increased by hyperthermia, and that cepharanthine (CEP) and Verapamil inhibit its retention.
We investigated the cytotoxic effect of the combination of ADR, CEP and hyperthermia, using a NIH3T3 cell line. The cytotoxic effect of ADR is increased by hyperthermia; its effect is acquired at a lower temperature which has no cytotoxic effect alone. With the conbination of CEP, ADR and hyperthermia, the cytotoxic effect is further increased. The synergism is increased by the elevation of temperature and a long of exposure time of CEP. The increase of the intracellular accumulation anticanceragent is important to overcome multidrugresistance, a phenomenon which has that attracted agreat deal of attention.抄録全体を表示PDF形式でダウンロード (775K) -
柏谷 尚子1989 年 101 巻 3-4 号 p. 315-325
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーAdriamycin (ADR) is a well known anticancer agent which is frequently used alone or combination with other anticancer agents. An ADR-resistant cell line derived from Ehrlich ascites tumor cells (EATC) was established in our laboratory. In this report, differences between wild EATC and ADR resistant EATC were studied.
The intracellular ADR uptake increased at a temperature (41.0°C) that had a little effect on the viability of wild EATC. The intracellular ADR uptake of ADR-resistant EATC also increased at elevated temperature (41.0°C). However, ADR resistant EATC had an enhanced acquired capacity that increased the efflux of intracellular ADR. Cepharanthine (CP), 1mcg/ml, inhibited the efflux of intracellular ADR and maintained the retention of ADR at high levels in cells from both cell lines, so the killing effects were enhanced with a combination ADR and CP.
From these results, the mechanisms of resistance to ADR may be discussed. The killing effects of ADR depend on intracellular ADR uptake, retention and maintenance. Hyperthermic treatment accelerates the influx of ADR. In addition, CP suppresses the efflux of intracellular ADR, and increased markedly the cytotoxic effect of ADR on ADR resistant EATC.
The combination of ADR, CP and hyperthermia may be effective and useful therapy to overcome ADR-resistant cancer cells.抄録全体を表示PDF形式でダウンロード (749K) -
谷川 雅洋1989 年 101 巻 3-4 号 p. 327-345
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーScalp and depth EEG were obtained during thalamotomy in 19 Parkinsonian patients, and a correlation analysis was performed to demonstrate additional information.
1) The decrease in mean frequency of alpha and increase in theta activity constituted a characteristic feature in Parkinsonism. The degree of these findings was closely related to the progression of the disease.
2) Simultaneous recordings in the thalamus and the scalp tended to show approximate spectral values in mild cases, but demonstrated some differences as the disease progressed.
3) Comparison of scalp and thalamic recordings revealed the existence of coincident and independent alpha activities in each area.
4) Cross-correlation analysis of the scalp EEG revealed that there were some progessive changes in phase relationships, including advance of activities from the front and delay of from the occiput with phase shifts over 90°.
5) Travelling waves were also found in the depth EEG, and the direction was from the thalamus to the cortex in some cases, but reversed in others.
The phase shifts of alpha activities between the scalp and the thalamus were from 10° to 90°. From these values, the conduction velocity of the spreading alpha were from 2.4m/s to 21.6m/s.抄録全体を表示PDF形式でダウンロード (1471K) -
河西 敏晴1989 年 101 巻 3-4 号 p. 347-361
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーClinical and radiological investigations of the changes in the spinal column were performed on 50 patients admitted with classical rheumatoid arthritis (RA) during a period from 1986 to 1988. In these patients, eight of them were classified as arthritis mutilans.
Clinically, 96% of the patients had subjective symptoms due to the cervical changes; 54% in the thoracic level and 68% in the lumbar region. Objectively, restricted motion in the cervical spine was detected in 84% of the patients, although only two examples of radiculopathy and one of myelopathy were found. No neurological disorders were seen in the thoracic and lumbar levels. Radiological rheumatoid changes in the spines were noted in 72% of the upper cervical spines, 66% of the subaxial cervical spines and 72% of the thoracic and lumbar spines, showing erosion and destruction of the facet joints, erosion of the end plates, disc narrowing and subluxation and destruction of the vertebral bodies. Compression fractures of the vertebral bodies due to osteoporosis combined with rheumatoid changes were recognized in 28% of the thoracic and 28% of the lumbar spines.抄録全体を表示PDF形式でダウンロード (5607K) -
クアニジノ酢酸および腎グリシンアミヂノトランスフェラーゼ活性の変動株丹 浩二1989 年 101 巻 3-4 号 p. 363-369
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーIt was reported that serum guanidinoacetic acid (GAA) levels are elevated in acute hapatic failure. To explore the mechanism of this GAA level change, the activities of kidney glycine amidinotransferase (GAT) and liver GAA-methyltransferase (GAA-MT) were measured in experimental rat models of acute hepatic failure. GAA is synthesized by the former enzyme and catabolized by the latter enzyme. In the early stage, kidney GAT activity was increased (P<0.1) but the serum GAA level remained normal. In the late stage, liver GAA-MT activity was decreased (P<0.01) and serum GAA level was increased. From this result, it is concluded that GAA synthesis is increased in acute hepatic failure and that serum GAA level is increased when liver is severely damaged.抄録全体を表示PDF形式でダウンロード (430K) -
北浦 道夫1989 年 101 巻 3-4 号 p. 371-377
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーA metabolic relationship between the liver and kidney exists in combination with the urea cycle. In patients with acute renal or hepatic insufficiency, certain variations among several guanidino compounds are relevant to the condition of the liver or kidney. An experimental model of rats exposed to inhaled halothane was evaluated for metabolic changes in the liver and kidney by measuring guanidino compound levels using high performance liquid chromatography. As a result, no significant difference in serum ornithine carbamoyltransferase (OCT) activities were observed among all groups. In the liver, concentrations of creatine (CR) and guanidinobutyric acid (GBA) were significantly elevated immediately after inhalation of halothane without any accompanying changes in guanidinoacetic acid (GAA) and argnine (ARG). In the kidney, ARG and GAA were significantly decreased without any accompanying changes in CR and GBA. No significant difference in serum GC levels was observed among the groups.
The inhalation of halothane appers to change the concentrations of GAA, ARG and CR in the liver and kidney. It also appers that inhalation of halothane caused GBA to appear in the blood, indicating a possible association of halothane with hepatotoxicity.抄録全体を表示PDF形式でダウンロード (496K) -
香曽我部 義則1989 年 101 巻 3-4 号 p. 379-385
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーRenal failure causes various metabolic disorders, especially increases of uremic toxins. Of the uremic toxins, guanidino compounds have a main role in uremia. Although lung injury is often complicated by renal failure, the role of guanidino compounds in lung injury is obscure. I have studied the changes in guanidino compounds in the lung of rat with ischemic acute renal failure. Guanidino compounds increased the first day after ischemia, but methylguanidine, which is the most toxic guanidino compound, showed a delayed increase in the lung. These results suggest the de novo synthesis of methylguanidine in the lung. A guanidinogram may by useful to judge changes in guanidino compounds.抄録全体を表示PDF形式でダウンロード (466K) -
長野 修1989 年 101 巻 3-4 号 p. 387-394
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーThe influences of HCO3-induced and CO2-induced pH changes on the action of nondepolarizing muscle relaxants (MRs) were investigated using a rat phrenic nervehemidiaphragm preparation. Changes in pH were induced by varying HCO3 concentration of the modified Krebs' solution (mK') or by varying the CO2 concentration in the gas aerating the mK'. Changes in [Ca++] and [Mg++], associated with changes in HCO3 concentration, were measured and corrected. A change in HCO3 from 50mM to 13.5mM or a change in CO2 from 2.5% to 9%, augmented the partial neromuscular blockade produced by d-Tc or vecuronium (p<0.01), while inhibiting that produced by metocurine or pancuronium (p<0.01). A change in HCO3 from 13.5mM to 50mM or a change in CO2 from 9% to 2.5%, inhibited the partial neuromuscular blockade produced by d-Tc or vecuronium (p<0.01), while augmenting that produced by metocurine or pancuronium (p<0.01). These findings suggest that the HCO3-induced and CO2-induced pH changes have a similar influence on the action of MRs. A difference exists between mono- and bisquaternary MRs with regard to their response to pH changes.抄録全体を表示PDF形式でダウンロード (2172K) -
1989 年 101 巻 3-4 号 p. 395-402
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (542K) -
1989 年 101 巻 3-4 号 p. 403-413
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (753K) -
1989 年 101 巻 3-4 号 p. 414-422
発行日: 1989年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (583K)
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