The guanidino compounds in various mouse organs after i. p. administration of ferric citrate (Fe) and after inhalation of pure oxygen(O
2) were studied.
Guanidinoacetic acid and N-acetylarginine levels were markedly higher in the kidney, and they decreased after administration of Fe or inhalation of O
2. Creatinine decreased in the liver after administration of Fe, and it decreased in the liver and muscle after inhalation of O
2. γ-Guanidinobutyric acid level was significantly higher in the normal liver, but decreased after administration of Fe or inhalation of O
2. Arginine (Arg) increased in the kidney and muscle after administration of Fe, while it decreased in the liver. Arg decreased in the kidney and the muscle after inhalation of O
2.
Methylguanidine (MG) increased in the brain after administration of Fe or inhalation of O
2. However, MG decreased in the liver after administration of Fe, and also decreased in the liver, kidney and muscle after inhalation of O
2.
MG increased only in the brain. This finding suggested that the reactive oxygen species (O
-2, H
2O
2, ·OH) were most effective there, because oxygen consumpution in the brain was much more than in the other organs.
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