巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
104 巻, 3-4 号
選択された号の論文の19件中1～19を表示しています
- |<
- <
- 1
- >
- >|
-
山本 仲吾1992 年 104 巻 3-4 号 p. 205-219
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーDissection of 227 Japanese adult cadavers showed that the scaleus anterior and medius muscles are interconnected with each other by some muscle bundles which run between the roots of the plexus brachialis. The subclavian artery originates in the intersegmental arteries. Taking this fact into consideration, we illustrated a typological diagram which can explain some positional anomalies of the subclavian artery and the roots of plexus brachiails. The inconsistent scalenus minimus muscle may be an aberrant slip separated from the scalenus medius muscle by the subclavian artery which may originate in the fifth or sixth intersegmental artery.抄録全体を表示PDF形式でダウンロード (687K) -
山本 正恒1992 年 104 巻 3-4 号 p. 221-234
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーThe CNS action of kainic acid (KA), quisqualic acid (QA) and 1-(4-chlorobenzoyl)-piperazine-2, 3-dicarboxylic acid (pCB-PzDA) was investigated in male Sprague Dawley rats, and their effects on monoamine metabolite levels in rat striatum were studied using brain dialysis.
Intracerebroventricularly injected KA and QA (100nmol) induced spike discharges, and pCB-PzDA (100nmol) suppressed electrocorticograms (ECoG) for 1 hour. pCB-PzDA aggravated KA induced spike discharges and inhibited QA-induced spike discharges.
Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels increased transitorily by injection of 10nmol and continuously by injection of 100nmol of KA. KA increased the 5-hydroxyindoleachtic acid (5-HIAA) level 2 hours after the administration dosedependently. Though 10nmol of QA increased the HVA level slightly, 100nmol of QA increased the DOPAC, HVA and 5-HIAA levels. Though 100nmol of pCB-PzDA increased the DOPAC and HVA levels, it inhibited the increases in DOPAC, HVA and 5-HIAA levels induced by KA. On the other hand, pCB-PzDA inhibited the increases in DOPAC, HVA and 5-HIAA levels induced by QA for 1 hour, after which the DOPAC and HVA levels increased additively.
These findings suggest that pCB-PzDA acts not only as a non-NMDA antagonist but also on dopaminergic neurons directly.抄録全体を表示PDF形式でダウンロード (807K) -
大河内 秀記1992 年 104 巻 3-4 号 p. 235-239
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーFerric chloride, when boiled with hydrazine hydrate and cacodylic acid, is converted into a fine cationic iron colloid. This colloid allowed good adhesion of biological micro-samples, including the fixed ones, to the glass slips and facilitated the scanning electron microscopy of these samples. The colloid was much more powerful in this mounting than the usually used and expensive poly-L-lysine. Living cells, such as human red blood cells, are esaily and sufficiently mounted with L-lysine or L-arginine on the glass slips.抄録全体を表示PDF形式でダウンロード (1273K) -
山本 浩史1992 年 104 巻 3-4 号 p. 241-246
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーWhen lymphokine activated killer cells (LAK cell) induced by IL-2 are infused into the same strain C3H mice following 70% partial hepatectomy, they display an action to suppress liver regeneration. Therefore, when Cyclosporin A (CsA) which inhibits IL-2 production was administered to mice following partial hepatectomy, we studied as our indicator the labeling index of hepatic parenchyma cells using Brdu. Our findings showed that proliferation of liver cells at 36 hours following partial hepatectomy was promoted by CsA, and the strongest promotion occuring at a dose of 5mg/kg. Before and after hepatectomy when CsA was administered at 10mg/kg for 3 days, a further strong proliferation increasing effect was observed, and under these conditions at 48 and 60 hours after hepatectomy a significant increase in liver weight was observed. Given the above results, CsA is thought to have a promoting effect in liver regeneration following hepatectomy.抄録全体を表示PDF形式でダウンロード (907K) -
第1編 インターフェロン並びにインターフェロン誘起剤の好中球Chemiluminescenceに及ぼす影響福本 光宏1992 年 104 巻 3-4 号 p. 247-258
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーTo evaluate one of the effects of interferon (IFN) and its inducers on neutrophil functions, neutrophil chemiluminescence (ChL) was assayed on 31 healthy individuals, nine patients treated with IFN-α (human lymphoblastoid interferon, 3×106units/day i. m. daily) and 11 patients treated with Ge-132 (2, 250mg/day p. o. daily). The base lines (BLs), peak levels (PLs) and times to PLs (PTs) of neutrophil ChL were examined before, one week and one month after the treatment. The direct effects of IFN-α, Ge-132 and OK-432 on neutrophil ChL were also evaluated by using an in vitro experimental system. PLs were significantly increased one week after the treatment with IFN-α or Ge-132. However, they were decreased to the pretreatment level one month after the treatment. In vitro experimental system IFN-α enhanced PLs of neutrophil ChL showing dose and time dependencies. On the other hand Ge-132 and OK-432 showed no direct effect on neutrophil ChL in vitro. These findings suggest that IFN-α and Ge-132 enhance the host defense mechanism by the activation of neutrophil functions, and also suggest that they have some benefits not only in the clinical management of cancer but also of chronic infection.抄録全体を表示PDF形式でダウンロード (1828K) -
第2編 急性非リンパ性白血病寛解期におけるβ-Carboxyethylgermanium sesquioxide (Ge-132)の臨床効果福本 光宏1992 年 104 巻 3-4 号 p. 259-266
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーThe clinical effects of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combination with Ge-132 (2, 250mg/day; p. o daily) and intermittent-alternating chemotherapy [daunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin, vincristine cytosine arabinoside and prednisolone (AVCP)] and patients in Group B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration; 5.7 month in Group A vs 8.1month in Group B/median survival time; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B. [2 of 7, (28.6%) in Group A vs 3 of 10, (30.0%) in B] Ge-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lower in patients treated with Ge-132. The liver damage which often develops during intensification chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevention of liver damage.抄録全体を表示PDF形式でダウンロード (475K) -
實井 俊典1992 年 104 巻 3-4 号 p. 267-286
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーThe afterdischarge threshold (ADT) in the limbic foci is reduced during limbic kindling. However, the changes of the ADT in the remote brain regions which receives no kindling stimuli remain unknown. To investigate the progressive neuronal changes during kindling, changes of the ADT were observed in the primary kindled sites and secondary unstimulated sites (pyriform cortex: PC and entorhinal cortex: EC) in amygdala (AM), hippocampal (HIPP) or neocortical (anterior portion of the suprasylvian gyrus: SS) kindled cats. The seizure threshold rapidly decreased, not only in the primary focus (AM or HIPP) but also in the remote brain regions (PC and EC), in the early process of acquisition of the limbic epileptogenesis and that the reduction of the ADT was closely related to the development of secondary epileptogenesis. In particular, the PC could acquire the neuronal hypere xcitability during limbic kindling. However, in contrast to limbic foci, no signgificant changes of the ADT in either primary focus (SS) or secondary focus (PC and EC) was observed. This suggested that the neocortical seizure develops due to another neuronal mechanism which differs from the mechanism of the limbic seizure.抄録全体を表示PDF形式でダウンロード (4774K) -
平野 由紀夫1992 年 104 巻 3-4 号 p. 287-295
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーLaparoscopic multiple punch resections were applied on the surface of the ovaries in 38 infertile patients who did not have spontaneous ovulation, and the effects on the clinical aspects of ovulation and gestation, and endocrinological state were examined. The patients were categorized into three groups to determine the indication of this treatment as follows. Group A (n=9): ovulated under administration of 100mg/day clomiphene. Group B (n=22): ovulated under administration of 200mg/day clomiphene, failed to ovulate under administration of 100mg/day. Group C (n=7): failed to ovulate even under administration of 200mg/day. The dose of clomiphene to induce ovulation was reduced in 8 (89%) in group A, 19 (86%) in Group B and 6 (86%) patients in group C. Although no patients became pregnant in group A, 17 (77%) in Group B and 5 (71%) in Group C became pregnant after this treatment. Irrespective of the good clinical outcome, no endocrinological improvements was found in the results of LH-RH test and serum testosterone levels. These findings suggest that this treatment is effective on the patients with severe anovulation, and that this effect is not based on the endocrinological improvement but on the local mechanical factors.抄録全体を表示PDF形式でダウンロード (498K) -
臼井 正明1992 年 104 巻 3-4 号 p. 297-310
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーClinical and radiological studies were performed on avascular necrosis of the femoral head (ANF) in 220 hips of 140 patients including 51 hips of 28 patients with systemic lupus erythematosus (SLE group). Sixty-nine hips of 41 patients were treated with corticosteroid administration (S group) and 100 hips of 71 patients without corticosteroid administration (Non-S group). All patients with SLE were treated with corticosteroid administration.
Thirty-one femoral heads (11 heads of SLE group, 9 heads of S group and 11 heads of Non-S group) were resected at operations and studied histologically.
Seventy-seven hips at an early stage showed that collapse of the femoral heads occurred in 80% within 3 years and no differences were found among these three group.
In the SLE group, bilateral involvement, multiple bone necrosis and predilection for young females were apparent. Collapse of the femoral head and subcapital fractures were more frequently seen in the SLE group.
Histologically, almost all heads even in the SLE group showed repair process such as enchondral ossification and appositional bone formation, while the heads with subcapital fracture showed no such changes.抄録全体を表示PDF形式でダウンロード (4045K) -
小林 直樹1992 年 104 巻 3-4 号 p. 311-321
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーThe role of type 1 fimbriae has well been discussed for analyzing the mechanisms of infectious diseases of the urinary tract. In this study, the ability and variety of mannose-receptor recognition in 92 strains of clinically isolated Escherichia coli were examined using various mannose-carriers such as guinea pig red blood cells, Saccharomyces cerevisiae cells and two carriers, latex and liposome. Type 1 fimbriated E. coli showed a variety of reactivity to the receptors on different mannose-carriers. Effects of mannose-carriers and inhibitors in agglutination assays were examined using 48 strongly haemagglutinable strains. In the recognition of Man (1-2) Man-carriers, a high affinity to pNPα-D-mannose was observed in the highly reactive strains to the receptor on liposomes. The MIC ratios of D-mannose to pNPα-D-mannose significantly correlated to the reactivities of these strains to the receptor on the liposome. By the values of MIC ratio, these strains could be classified into two groups; reactive and non-reactive strains. In the recognition of Man (1-3) Man-carriers, MIC ratios of D-mannose to pNPα-D-mannose differed among more highly reactive strains to Man (1-3) Man-latex, and AUP strains showed stronger reactivity and lower MIC ratio than AUC and ABP strains. The adhesins of type 1 fimbriae were divided into at least 4 types (α, β, γ and δ).抄録全体を表示PDF形式でダウンロード (1363K) -
守分 正1992 年 104 巻 3-4 号 p. 323-330
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーSeveral types of specific insulin-like growth factor binding proteins (IGFBPs) are produced by peripheral tissue-derived cells and they modulate the functions of insulin-like growth factors. In this study, both the secretion of IGFBP-3 from a human osteosarcoma cell line MG63 and effects of 1, 25-dihydroxyvitamin D3 (1, 25-(OH)2D3) on the production of IGFBP-3 were investigated. The β subunit of IGFBP-3 was detected immunocytochemically in the perinuclear cytoplasm of MG63 cells. Immunoblotting and SDS-PAGE analysis revealed that both 140-150KD MW entire molecules and 40-60KD MW β subunit molecules of IGFBP-3 were present in cell-conditioned media. 1, 25-(OH)2D3 stimulated the production of the IGFBP-3 molecule by MG63 cells. The concentration of IGFBP-3 in conditioned media began to rise at 24 hours after the addtiton of 10-9M of 1, 25-(OH)2D3 and reached the peak level at 48 hours. Dose-dependent effects of 1, 25-(OH)2D3 were demonstrated. These findings show that MG63 produces IGFBP-3 and that 1, 25-(OH)2D3 stimulates the production of this protein. These findings suggest that the synergistic effects of 1, 25-(OH)2D3 on the action of IGF-I on osteoblastic cells may be modulated by locally produced IGFBP-3.抄録全体を表示PDF形式でダウンロード (1736K) -
川上 登史1992 年 104 巻 3-4 号 p. 331-340
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーTo investigate the etiological role of human papillomavirus (HPV), 14 cases of papillomas in head and neck region were examined virologically and clinicopathologically. Both dot blot and Southern blot hybridization methods were applied for HPV DNA detection. In all 4 cases of multiple laryngeal papillomas, either HPV 6 (2 cases) or HPV 11 (2 cases) genomes were detected. The presence of the HPV genomes provides strong evidence for the HPV etiology of these laryngeal papillomas. Whereas, no HPV genome was detected in a case of single laryngeal papilloma. In one case of sinonasal papilloma (exophytic type), HPV 6 DNA was detected. No HPV genome was found in the DNA from the remaining 4 sinonasal papillomas. However, their clinicopathological findings suggested the viral etiology. No HPV genome was proved in 4 oral papillomas. Furthermore, neither their clinical course nor histopathological findings suggested viral etiology. The sensitivity of dot blot hybridization (Vira probe HPV) in detecting HPV DNA was the same as that of Southern blot hybridization.抄録全体を表示PDF形式でダウンロード (2255K) -
津島 義正1992 年 104 巻 3-4 号 p. 341-354
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーPlatelet aggregation was studied in 670 samples of 20 healthy controls and 279 patients in the late period after cardiovascular surgery.
Aggregating agents used were 0.5 and 2.0μM ADP as well as 2mM arachidonic acid (AA).
Among the healthy controls, a maximum aggregation rate over 18% (ADP 0.5μM) was considered hyperaggregability, those under 47% (ADP 2μM) or under 78% (AA 2mM) considered hypoaggregability.
Maximum aggregation rate in patients not given antiplatelet agents widely varied from hyperaggregability to hypoaggregability. There was a positive correlation botween the first sample and the second one gained from each patient. This suggested that individual variation existed on platelet aggregation.
Maximum aggregation rate significantly decreased by ticlopidine for ADP and by aspirin for AA. Both ADP and AA should be used for platelet aggregation.
Comparison among three groups of different ticlopidine doses revealed that the doses should be decided on the basis of platelet aggregation for each patient.
Thrombotic or hemorrhagic complications were observed in only 9 cases. Four of 7 cases of thrombotic complication showed hyperaggregability and only 1 case showed hypoaggregability. Both cases of hemorrhagic complication showed hypoaggregability.
These findings suggest that indication for antiplatelet therapy and doses of antiplatelet agent should be decided in consideration of individual variation on platelet aggregation.抄録全体を表示PDF形式でダウンロード (687K) -
尾上 仁一1992 年 104 巻 3-4 号 p. 355-364
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーIn chronic inflammations of rheumatoid arthritis (RA), polynuclear leukocytes, macrophages, synovial cells and other inflammatory cells release reactive oxygen species (ROS) and cause tissue impairment, and are regarded as the responsible agents in this pathological condition. In the present study, the electron spin resonance (ESR) method was used to measure superoxide dismutase (SOD) in 76 knee synovial fluid samples from rheumatoid knee joints and to compare the results with those of osteoarthritic knee joints and posttraumatic arthritis.
There was no significant difference in the SOD activity between RA and OA patients knee joint fluid, which was higher than that in patients with posttraumatic arthritis. The SOD activity in RA knee joint fluid showed no correlation with serum CRP (C-reactive protein) or erythrocyte sedimentation rate, indices of inflammation. According to Larsen's Grading of rheumatoid knee radiography, patients with moderate RA changes (grade III or IV) show higher SOD activity than patients with early (grade I or II) and terminal RA (grade V). Our findings suggest that the SOD activity in RA knee joint fluid is a valid index of articular destruction.抄録全体を表示PDF形式でダウンロード (1349K) -
池渕 佳史1992 年 104 巻 3-4 号 p. 365-374
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーHuman and monkey hands were dissected, together with the forepaws of the dog, rabbit and kangaroo. These dissections showed that the human lumbrical muscle inserting into the proximal phalanx or dividing into two tails belongs to an atavistic anomaly. In the kangaroo, the first lumbrical muscle commonly arose from the long flexor tendon of the first finger and the deep flexor tendon of the second finger. This strongly suggests that these tendons (or M. Flexor pollicis longus and M. flexor digitorum profundus) are homologous.抄録全体を表示PDF形式でダウンロード (943K) -
第1編 各種マクロファージにおけるトランスフェリンレセプターの局在に関する検討稲田 俊雄1992 年 104 巻 3-4 号 p. 375-386
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーThe delivery of iron into cells is mediated by transferrin via its receptors that reside on the cell surface.
To clarify the role of reticuloendothelial cells in iron metabolism, the distribution of transferrin receptors on macrophages in various organs and on peripheral blood monocytes was examined by scanning electron microscopy and radiobinding assay.
Radiobinding assay of human alveolar macrophages revealed the presence of 19.88±8.19×104 diferric transferrin receptors per cell (mean±SD) and a binding constant of 4.42±3.41×108M-1. Human peritoneal macrophages and macrophages in the thoracic cavity had fewer diferric transferrin receptors (2.68×104, 8.10×104, 4.3×103 and 2.1×104 receptors/cell). Peripheral blood monocytes had no diferric transferrin receptors. Diferric transferrin receptors were also found on guinea pig alveolar macrophages (2.25±0.78×104) and peritoneal macrophages (1.6±0.2×103), while they were absent on rat alveolar and peritoneal macrophages.
Scanning electron microscopic findings in guinea pig alveolar macrophages revealed a patch-formed distribution of apotransferrin receptors and diferric transferrin receptors on the characteristic ruffle-covered surface of macrophages. The number of transferrin receptors varied among individual cells even within the same species or same organs. These findings suggest that the macrophages with transferrin receptors in various organs of human and guinea pigs are heterogeneous among different species and cells, and have different functions in iron metabolism.抄録全体を表示PDF形式でダウンロード (2469K) -
第2編 鉄過剰及び鉄欠乏状態における肺胞マクロファージのトランスフェリンレセプターに関する検討稲田 俊雄1992 年 104 巻 3-4 号 p. 387-398
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーTransferrin receptors (TfR) are involved in the first step of iron uptake into cells. To clarify the changes in TfR under various conditions, radiobinding assay of 125I-labeled iron-saturated transferrin was performed in alveolar macrophages from 2 patients with idiopathic hemochromatosis and iron-overloaded or iron-deficient guinea pigs.
Patients with idiopathic hemochromatosis showed a reduction in the Fe-TfR count on alveolar macrophages (5.0×104/cell) as compared to that in healthy individuals (19.88±8.19×104/cell). Concerning the Fe-TfR binding constant, no difference was observed between patients with idiopathic hemochromatosis and healthy controls.
The Fe-TfR count on alveolar macrophages was significantly lower in iron-overloaded guined pigs than in normal controls. The count was significantly elevated in iron-deficient guinea pigs. Concerning the Fe-TfR binding constant, none of the iron-overloaded and iron-deficient groups showed any significant difference from the normal controls.
These findings suggest that experimentally-induced iron overload and iron deficiency may be autoregulated by intracellular iron levels.抄録全体を表示PDF形式でダウンロード (2718K) -
第1編 臨床集計による特発性間質性肺炎の検討藤田 道雄1992 年 104 巻 3-4 号 p. 399-412
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーClinical features, laboratory findings including hematological and biochemical examination, pulmonary function test and chest x-ray findings of patients with idiopathic interstital pneumonia (IIP) were analyzed to determine the response to steroid therapy. Sixty three patients with IIP were analyzed in comparison with 43 patients of interstitial pneumonia due to various diseases such as collagen disease, tuberculosis and chronic obstructive lung disease. Almost half of the patients with IIP were treated with steroids and improvement of interstitial pneumonia was shown only in the patients given steroid therapy. The improvement with steroid therapy was shown to be 50% in acute form of IIP, 32.1% in chronic form of IIP and 36.8% in total. Furthermore, the response of steroid therapy was better in patients with a relatively high oxygen level and high vital capacity and with no honeycombing on the chest X-ray film.
These findings indicate the therapeutic effectivesess of steroid therapy in some patients and it should be started in the early stage of the clinical course of IIP to obtain a good response rate.抄録全体を表示PDF形式でダウンロード (1446K) -
第2編 特発性間質性肺炎の気管支肺胞洗浄法による検討藤田 道雄1992 年 104 巻 3-4 号 p. 413-423
発行日: 1992年
公開日: 2009/03/30
ジャーナル フリーThe cellular components in lungs of idiopathic interstitial pneumonia (IIP) and interstitial pneumonia with collagen disease (IP with CD) were examined by bronchoalveolar lavage (BAL) to analyze the pathogenesis of IIP. The findings of BAL fluid of IIP and IP with CD were increase of total cell count and increased percent of lymphocytes, neutrophils, eosinophils and basophil/mast cells in comparison with the normal control. The BAL fluid of the patients with IIP and IP with CD in active stage contained a higher proportion of lymphocyte, neutrophil, eosinophil and basophil/mast cell than those in a nonactive stage. Furthermore, an increase of T-cells and Ia positive T-cells was detected in the examination of lymphocyte subpopulation in BAL fluid of patients with IIP, while the lymphocyte subpopulation of peripheral blood showed no significant difference. Cellular components in BAL fluid of IIP patients treated with or without steroids were compared. Under steroid therapy a decrease of total cell count and eosinophil was shown in BAL fluids of patients with IIP.
These findings indicate that various cells such as macrophage, lymphocyte, neutrophil, eosinophil and basophil/mast cell in lungs play important roles in the pathogenesis of IIP and IP with CD.抄録全体を表示PDF形式でダウンロード (1165K)
- |<
- <
- 1
- >
- >|