巻号一覧
71 巻 (1959)
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- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
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前身誌
106 巻, 7-8 号
選択された号の論文の22件中1～22を表示しています
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村瀬 敏夫1994 年 106 巻 7-8 号 p. 701-716
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーAn endogenous colony formation assay was performed on 24 patients with chronic myelogenous leukemia in the chronic phase (CML-CP), 11 patients with CML-accerelated phase (CML-AP), nine patients with CML-blastic crisis (CML-BC), nine patients with polycythemia vera, two patients with essential thrombocythemia, two patients with primary myelofibrosis, two patients with juvenile CML (JCML), one patient with chronic neutrophilic leukemia, two patients with unclassified myeloproliferative disorder (UMPD), five patients with refractory anemia with excess of blasts (RAEB), 10 patients with RAEB in transformation (RAEBt) or overt leukemia, and 10 patients with chronic myelomonocytic leukemia (CMML). Endogenous colony formation was observed in two patients with CML-AP, one patient with CML-BC, two patients with JCML, one patient with UMPD, one patient with RAEBt, and seven patients with CMML.
All of these endogenous colonies were identified as CFU-C by chemical staining. In some patients with CML or RAEBt, endogenous colonies were observed when progression of disease occurred. Endogenous colony formation was partially inhibited by the depletion of phagocytes in five patients with CMML or RAEBt. Four of these patients revealed increased releases of granulocyte-macrophage colony stimulating factor (GM-CSF) to the culture medium, and the addition of anti-GM-CSF antibody totally inhibited the formation of endogenous colony in one case. Patients who formed endogenous colonies often had chromosomal abnormalities and short survival.
These findings suggest that paracrine or autocrine GM-CSF plays an important role in endogenous colony formation and that such endogenous colony formation is one of the risk factors in hematological malignancies.抄録全体を表示PDF形式でダウンロード (1898K) -
長尾 一孝1994 年 106 巻 7-8 号 p. 717-730
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーThe APEX nuclease is a mammalian multifunctional repair enzyme having 5' apurinic/apyrimidinic (AP) endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3' phosphatase activities. The mouse Apex gene for the enzyme, was isolated from a mouse leukocyte genomic library by plaque hybridization with the mouse Apex cDNA as a probe. The nucleotide sequence of the Apex gene and its 5'-and 3'-flanking regions were determined. With reference to the published Apex cDNA sequence, the mouse Apex gene can be divided into five exons and four introns with a total length of about 2.6 kb. The boundaries between exon and intron follow the GT/AG rule. The translation initiation and termination sites are located in exons II and V, respectively. A part of the 5' flanking region belongs to a CpG island, which extends to intron II. The CpG island is thought to be a putative transcription regulatory region of the Apex gene, a housekeeping gene.抄録全体を表示PDF形式でダウンロード (1875K) -
第1編 喘息患者におけるHLAによる遺伝的要因の検討岡本 誠1994 年 106 巻 7-8 号 p. 731-742
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーHeredity has long been suspected to play an important role in the occurrence of bronchial asthma. Recently familial and twin sibling studies demonstrated the role of genetic factors in asthma. Therefore, we measured HLA antigens of 53 asthmatics and analyzed the relationship to clinical parameters to elucidate the role of HLA in the occurrence of bronchial asthma.
Four major findings were obtained. 1) Study of the HLA system in asthmatics showed a significantly higher frequency of DR53 and DQ3 and lower frequency of DQ1, DQ6 (1) and DQ7 (3). This suggests that DR molecules demonstrate positive associations and DQ molecules negative associations with bronchial asthma. 2) DQ1 was associated with IgE production in asthmatics. 3) B39 (16) positively associated with RAST score of Candida. 4) The study of late onset asthmatics, intractable asthmatics and the high responder group of in vitro lymphocyte reaction to Candida allergen showed a cooperatively and significantly higher frequency of DR53 (P<0.05).
These findings suggest that DR53 has a positive association with onset of late onset intractable asthma.抄録全体を表示PDF形式でダウンロード (579K) -
第2編 喘息患者におけるサイトメガロウイルス抗原によるリンパ球幼若化反応の検討岡本 誠1994 年 106 巻 7-8 号 p. 743-750
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーThe possible role of virus infection in the occurrence and attack of asthma was examined by measuring the lymphocyte transformation test to CMV in 44 asthmatic and 14 healthy subjects and analyzed their relation to the clinical parameters.
CMV-induced lymphocyte reactivity (CMV-LR) in adult asthmatics was significantly higher than that in the healthy controls. A positive correlation was observed between CMV-LR titer and CMV-complement fixation (CMV-CF) antibody titers (r=0.35). In adult asthmatics, the CMV-LR in the high IgE titer (100U/ml) group was significantly higher than that in the low IgE titer (<100U/ml) group.
These findings suggest that CMV is an important factor in the pathogenesis of adult asthma mediated by lymphocytes and probably IgE, although the precise mechanism in still unknown.抄録全体を表示PDF形式でダウンロード (370K) -
石井 泰則, 井上 文之, 伴 秀利, 上川 康明, 折田 薫三1994 年 106 巻 7-8 号 p. 751-756
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーEsophageal cyst is a relatively rare disease and about 91 cases have been reported in Japan. We report a new case of esophageal cyst. The patient was a 36-year-old male who complained of nausea and vomiting. We performed esophagography, endoscopy, endoscopic echography, CT and MRI and found a cystic lesion in the lower esophagus. We made the diagnosis of an esophageal cyst and performed operation. The tumor was in the esophageal muscle but did not have a commissure to the esophageal lumen. We extirpated it with esophageal muscle and repaired the muscle defect with diaphragma. This tumor, 7.5×5.0cm in size, was a monolocular cyst and contained brown muddy material. Microscopic findings revealed a ciliated columnar epithelium and squamous epithelium in the cyst wall but cartilage was not found. The cyst was covered with double smooth muscle layers. It was difficult to differentiate an esophageal cyst from a paraesophageal bronchogenic cyst but these histological findings suggested that this cyst was an esophageal cyst.抄録全体を表示PDF形式でダウンロード (1679K) -
鬼嶋 みゆき, 矢尾 和久, 安原 加奈子, 末丸 克矢, 古野 勝志, 大石 了三, 五味田 裕, 大田原 俊輔1994 年 106 巻 7-8 号 p. 757-762
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーTo clarify the pharmacokinetic interaction in poly-therapy for epilepsy, the serum concentration of carbamazepine (CBZ) was measured in epileptic patients to whom CBZ had been prescribed chronically with or without phenytoin (PHT) and sodium valproate (VPA). The serum CBZ concentrations increased with increasing doses of CBZ, but increased less at higher doses. Children (<12 yrs) showed lower serum CBZ concentrations than patients 12 years old and older. The L/D ratios (L: CBZ level, D: dose/body weight) were significantly decreased by the combined treatment with PHT and VPA in a dose-dependent manner, probably due to an induction of metabolizing enzyme.
These findings suggest that especially in the case of change of the drug therapy from mono-therapy to poly-therapy, careful monitoring of serum concentration is necessary.抄録全体を表示PDF形式でダウンロード (267K) -
富岡 憲明1994 年 106 巻 7-8 号 p. 763-769
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーThe natural cytotoxicity against isolated epithelial cells of rat small intestine was studied. The isolation of intestinal epithelial cells was easily performed using EDTA and DTT digestion with good viability. The cells were labelled by 51Cr sufficiently to be usable for the in vitro 51Cr release assay. The cytotoxic activity of spleen cells to syngeneic and allogeneic epithelial cells was 13.5% and 13.7%, respectively. Cold inhibition assays revealed that the susceptibility of isolated epithelial cells to killing is non-specific for lineage and no restriction with major histocompatibility complexes was noticed. These findings correspond to the cytotoxicity against skin epidermal cells, in which skin cells are killed by normal spleen cells by natural killer systems. Therefore, the isolated epithelial cells of rat small intestine can become the target of natural killer cells, suggesting that rapidly differentiating cells may be controlled by natural killer systems.抄録全体を表示PDF形式でダウンロード (1380K) -
近藤 秀則, 興津 輝, 近藤 正美, 津下 宏, 折田 薫三1994 年 106 巻 7-8 号 p. 771-778
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーWe performed 75 consecutive laparoscopic cholecystectomy from July 1991 to October 1993 on the patients with gallstones and/or gallbladder polyps. The patients consisted of 30 males and 45 females between 32 and 88 years old with a mean age of 59.4 years. In 72 of these 75 patients (96.0%) laparoscopic cholecystectomy was successfully completed. In the remaining 3 cases (4.0%) the operation was converted to the open cholecystectomy. All patients were free of major complications. Three patients required conversion to a conventional open cholecystectomy due to fallen gallstones in the peritoneal cavity, dense adhesions surrounding the gallbladder and severe acute cholecystitis. This procedure is advantageous in comparison with the conventional open cholecystectomy, because of less postoperative pain, rapid postoperative recovery and high cosmetic value as well.
Laparoscopic cholecystectomy seems to be a safe and effective treatment for selected patients with benign gallbladder diseases.抄録全体を表示PDF形式でダウンロード (479K) -
山中 良孝1994 年 106 巻 7-8 号 p. 779-787
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーIGFBP-4 is a 24kD protein, originally isolated from the conditioned medium of human bone cells, and has been implicated as a potent inhibitor of IGF action in vitro. To clarify its biological functions in human bone, I measured the serum concentration of IGFBP-4 from patients with endocrinologic disorders, using Western immunoblot.
In normal children, IGFBP-4 increased with age. The serum IGFBP-4 levels of patients with GH deficiency and panhypopituitarism were lower than those of normal children. In addition, the serum levels of IGFBP-4 were also significantly lower in children with Turner's syndrome than in the age-matched normal children who were post pubertal. These findings suggest that GH and the sex steroid increase the production of serum IGFBP-4.
Then, I examined the influence of GH on the serum level of of IGFBP-4. In the good responders to GH therapy, IGFBP-4 decreased rapidly during the first month, continued to decrease until the third month, and then increased slowly. On the contrary, in the poor responders to GH therapy, the IGFBP-4 level increased until the third month and then remained at a high level. The increased serum IGFBP-4 level may, at least in part, contribute to the low response to GH therapy in the poor responders.抄録全体を表示PDF形式でダウンロード (2737K) -
難波 靖治1994 年 106 巻 7-8 号 p. 789-798
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーThirty-one patients with lung cancer in Okinawa known as HTLV-I endemic area, and 140 patients in Okayama were evaluated in regard to HTLV-I infection and interstitial pulmonary shadows. The presence of HTLV-I infection was examined by the polymerase chain reaction (PCR) method in peripheral blood mononuclear cells, and indirect immunofluorescent (IF) assay in sera. Interstitial pulmonary shadows on the chest roentgenograph, were classified according to the grade of fibrosis. The rate of HTLV-I infection in patients with lung cancer was higher than that in healthy controls by IF assay in both districts. The rate of anti-HTLV-I antibody was higher in lung cancer patients with severe fibrosis than in those with milder fibrosis, but the grade of fibrosis and existence of pX gene had no relation in Okinawa or in Okayama. The incidence of patients with anti-HTLV-I antibody was higher in patients with adenocarcinoma and squamous cell carcinoma than in those with small cell carcinoma. These findings suggested that HTLV-I infection was closely involved in some patients with non-small cell lung cancer having interstitial pulmonary shadows.抄録全体を表示PDF形式でダウンロード (1304K) -
大野 繁1994 年 106 巻 7-8 号 p. 799-809
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーClinical and electroencephalographic studies were carried out to clarify the characteristics of latent epilepsy (LE) in children and to obtain criteria for treatment. LE was defined as a condition manifesting epileptic EEG abnormalities without any clinical epilepsy, febrile convulsion or other seizures. Three hundred and thirty-nine children with LE seen at the Department of Child Neurology, Okayama University Hospital were divided into four groups by their etiological backgrounds (e. g., organic brain damage and convulsive predisposition) and were compared with 149 controls with clinical epilepsy.
Clinical epileptic seizures appeared in 14 (4.1%) of the 339 children during follow-up of two months to 19 years. Thirteen of the 14 cases belonged to the organic brain damage group.
The EEG findings in children susceptible to clinical seizures consisted of slow spike-wave, generalized cortico-subcortical discharges, multiple focal cortical discharges, focal discharges with focal slow wave, and discharges activated by hyperventilation.
The EEG findings in children not disposed to develop clinical epilepsy consisted of sharp wave, small sharp wave, Rolandic spike, parietal focal spike, and photo-sensitivity discharges in adolescence.
Convulsive and epileptic predisposition was not regarded as a risk factor in clinical epilepsy.
On the basis of these findings, criteria for antiepileptic drug therapy for LE were proposed.抄録全体を表示PDF形式でダウンロード (1252K) -
原田 圭子1994 年 106 巻 7-8 号 p. 811-823
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーTo clarify the functions of the renal metallothioneins (MTs) in rats following ischemic acute renal failure, the expression of MT mRNA and the localization of MT in rats undergoing 60 min of bilateral renal artery clamp ischemia followed by reperfusion was examined by Northern blot analysis, in situ hybridization and immunohistochemical analysis. Induction of MTmRNA was observed in the kidney as early as 3 hours after release of the clamp, with a maximum at 1 to 3 days followed by a gradual decrease. Histologically, both MT mRNA and MT were detected in renal tubular cells intensely and specifically on the outer medulla at 1 day after release of the clamp. These findings suggest that MTs protect the tubular cells by scavenging the free radicals, which probably cause renal tubular cell damage by ischemiareperfusion, and that MTs provide the zinc ions to zinc-requiring apo-enzymes necessary for healing and regenerating renal tubular cells.抄録全体を表示PDF形式でダウンロード (2852K) -
辻 晃仁1994 年 106 巻 7-8 号 p. 825-835
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーTo elucidate the cause of severe asthma in adults, an animal model of chronic asthma was established in guinea pig sensitized by intraperitoneal injection of Ascaris suum and inhalation of the antigen repeated ten times. Then airway hyperresponsiveness, inflammatory cells and eicosanoids in the bronchoalveolar lavage fluid (BALF) and peripheral blood were examined. Airway responsiveness was acquired after inhalation of the antigen. Two types of airway responsiveness were observed; accerelating-group and recovering-group. Total cell count and numbers of eosinophils and neutrophils in the BALF were significantly increased in the accerelating-group compared with the recovering-group and the control-group. The TXB2 level in the BALF was increased in the accerelating-group, and the LTB4 level in the BALF and peripheral blood were also increased in the accerelating-group. These findings suggest that the airway hyperresponsiveness is caused by eicosanoids, such as thromboxanes and leukotrienes produced by some inflammatory cells which are organized by activated lymphocytes as well as mast cell-basophils.抄録全体を表示PDF形式でダウンロード (1427K) -
植木 康文1994 年 106 巻 7-8 号 p. 837-846
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーA bone marrow coculturing system developed by M. Y. Gordon was modified for easier evaluation of the function of bone marrow stromal cells. In the method agar was not used, and cells were dried and stained directly on a 35-mm petri dish after culture. The sustaining capacity of hemopoiesis by human stromal cells in bone marrow obtained by this method was compared between eight young and five elderly healthy volunteers. Hemopoietic progenitor cells were obtained from young volunteers and cultures were prepared for seven days.
There appeared 86±28 colonies from 105 non-adherent bone marrow cells on the sheet of stromal cells from the young volunteers and 89±27 colonies from the elderly. The colonies were classified into two types according to cytochemical appearance through peroxidase staining, but all of them proved to be composed of myeloid cells by enzyme-labeled antibody staining.
Colonies were identified easily and accurately by the newly modified coculturing method. No difference in sustaining capacity of hemopoiesis by human stromal cells in bone marrow was found between the young and the elderly using this system.抄録全体を表示PDF形式でダウンロード (1783K) -
フローサイトメーターによるカルシウム動態の解析洲脇 俊充1994 年 106 巻 7-8 号 p. 847-860
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーA new method for flow cytometric analysis of calcium mobilization in human peripheral blood basophils without prior purification was developed. The method is based on dual color analysis of centrifugation-enriched mononuclear cell populations using fluo-3 and phycoerythrin (PE)-conjugated CD2, CD14, CD16, CD19 monoclonal antibodies (mAb) to stain contaminated cells. This technique allows the detection of fluo-3 fluorescence as a measure of an increase in the cytoplasmic free calcium concentration ( [Ca2+] 1) while simultaneously discriminating PE-mAb-unlabelled basophils.
To clarify whether the human peripheral blood basophil is activated through the low affinity IgG receptor, Fc γ RII, as well as the high affinity IgE receptor, Fc ε R I, calcium mobilization after Fc γ RII stimulation was analyzed by this method. After cross-linking of Fc γ RII, transient [Ca2+] 1 elevation was observed but there was no apparent difference with interleukin-3 (IL-3)-treated cells, and no significant histamine release was observed with or without short pre-incubation of IL-3. These findings suggest that the cross-linking of Fc γ RII, not only Fc ε R I, can activate human basophils which may result in mediator release other than histamine.抄録全体を表示PDF形式でダウンロード (2475K) -
谷水 将邦1994 年 106 巻 7-8 号 p. 861-874
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーBone marrow cell cycle analysis was performed on 23 patients with myelodysplastic syndrome (MDS) [12 with refractory anemia (RA), two with RA with ringed sideroblasts (RARS), three with RA with excess blasts (RAEB), six with RAEB in transformation (RAEBt)], and 14 normal volunteers. Cells were stained with propidium iodide and analyzed by flowcytometry.
Patients with RA and RARS (low-risk MDS) showed higher rates of S-phase (21.2±4.9%) and patients with RAEB and RAEBt (high-risk MDS) showed lower rates of S-phase (9.9±5.9%) compared with normal controls (15.2±3.1%). Although the rate of S-phase decreased with disease progression, it was normalized with complete remission. An intermediate correlation (r=0.64, p<0.01) existed between the rate of S-phase and the percentage of erythroblasts in MDS.
The rate of S-phase clearly reflects the severity of MDS. The high rate of S-phase in low-risk MDS was considered to be due to erythroid hyperplasia with ineffective hematopoiesis.抄録全体を表示PDF形式でダウンロード (694K) -
江口 純治1994 年 106 巻 7-8 号 p. 875-882
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーTo evaluate the roles of transforming growth factor-β (TGF-β) on the glomerular cell proliferation and sclerosis, a new colorimetric bioassay system for urinary excretion of TGF-β has been developed by using NRK49-F cell culture. The urinary TGF-β activity was detected by this method in focal glomerular sclerosis (FGS) and purpura nephritis but not in minimal change nephrotic syndrome and IgA nephropathy. The bioassayed TGF-β activity was confirmed by a blocking experiment using a neutralizing antibody and by Western immunoblotting. These findings suggest that TGF-β plays an important role in the progression of the glomerular lesions, in FGS and purpura nephritis.抄録全体を表示PDF形式でダウンロード (1824K) -
河内 和久1994 年 106 巻 7-8 号 p. 883-892
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーAlveolar macrophages attack various foreign bodies inspired through the airway and destroy cell debris. Furthermore, a part of the surfactant produced by alveolar epithelium would be phagocytized by alveolar macrophages forming foamy cells in lung tissue. These formy cells could be detected by oil red O staining as xanthoma cells in sputa of patients with airway diseases. Therefore, xanthoma cells in sputa of patients with DPB, chronic bronchitis and bronchial asthma were evaluated to clarify the role in the pathogenesis of these respiratory diseases. All patients with DPB expectorated enormous amounts of xanthoma cells in sputa while 88% of the patients with chronic bronchitis and 41% of those with bronchial asthma had sputa containing xanthoma cells in a smaller number than DPB. Increased xanthoma cells were shown in DPB with longer disease duration, lower vital capacity, lower arterial blood oxygen pressure, and pseudomonas infection. However, extreme obstruction of small airway diminished xanthoma cells in sputa. Xanthoma cells were shown in bronchial asthma especially in late onset and intractable asthmatics.
These findings indicate that xanthoma cells in sputa reflect the existence of organic changes in the small airway which disturb the drainage of surfactant from alveolar area to bronchial trees.抄録全体を表示PDF形式でダウンロード (1505K) -
小島 研介1994 年 106 巻 7-8 号 p. 893-906
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーClinical utility of sideroblastogram was evaluated by analyzing the sideroblastogram and other clinical data in 66 patients with myelodysplastic syndrome (MDS) [nine with refractory anemia (RA), 27 with RA with excess blasts (RAEB), 24 with RAEB in transformation (RAEBt), and six with chronic myelomonocytic leukemia (CMMoL)]. The sideroblastogram was constituted based on the classification of erythroblasts according to the numbers of stainable iron granules in their cytoplasm: briefly, type 0 as no granules, type I as 12 granules, type II as 35 granules, type III as more than 6 granules.
The type III dominant sideroblastogram (type III predominace) was observed in 73% of the patients with MDS in contrast with type 0I predominance in 100% of the healthy volunteers. Although type III predominance appeared distinctly in patients who presented erythroid morphological abnormalities, 50% of the patients without abnormalities also had type III predominance. Patients with type III predominance had more severe macrocytic anemia compared with other dominant types, but type III predominance did not influence the disease prognosis. In two cases the sideroblastogram was normalized at complete remission, and returned to type III dominance at recurrence of the disease.
The type III dominant sideroblastogram reflects the disorders of iron metabolism in erythroblasts, and the normalization of the sideroblastogram indicates the appearance of normal erythropoiesis from the normal clone in marrow. We conclude that the sideroblastogram is useful not only in diagnosing MDS but also in clinical evaluation of the therapeutic effect.抄録全体を表示PDF形式でダウンロード (2324K) -
宮原 信明1994 年 106 巻 7-8 号 p. 907-915
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーTo clarify the pathogenesis of bronchial asthma, we established T cell clones specific for Candida antigen and for mite antigen from the peripheral blood of three asthmatic patients. Flow cytometric analysis was performed on these clones. The surface phenotype of all clones was helper/inducer type. These clones were analyzed for the ability to produce interferon gamma (IFN-γ) and interleukin 4 (IL-4).
The T cell clone established from the patient who showed late asthmatic response (LAR) after bronchial inhalation of Candida, as well as the clones from the patient who showed IAR and LAR after inhalation of housedust mite, produced a higher amount of IFN-γ and lower amount of IL-4. The T cell clone established from the patient who were under corticosteroid therapy and showed IAR after inhalation of Candida produced lower amounts of IFN-γ and IL-4, which seemed to be inhibition of cytokine production from antigen specific T cell clone by corticosteroids.
These findngs indicate that T cell clones established from the patients who showed LAR produced a large amount of IFN-γ, suggesting that IFN-γ plays an important role in allergic reactions of LAR.抄録全体を表示PDF形式でダウンロード (693K) -
1994 年 106 巻 7-8 号 p. 917-924
発行日: 1994年
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (347K) -
1994 年 106 巻 7-8 号 p. 925-929
発行日: 1994年
公開日: 2012/10/29
ジャーナル フリーPDF形式でダウンロード (241K)
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