巻号一覧
107 巻 (1995 - 1996)
- 11-12 号 p. 235-
- 9-10 号 p. 179-
- 7-8 号 p. 61-
- 1-6 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
107 巻, 7-8 号
選択された号の論文の13件中1～13を表示しています
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高橋 健治1995 年 107 巻 7-8 号 p. 61-67
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーThe effect of UV-B radiation on immune responses was evaluated by radiation of rat spleen and skin epidermal cells in vitro. The radiation deteriorated the immune responses without influencing the viability of the irradiated cells. The mitogenic blastogenesis of the spleen cells was inhibited. The stimulatory effect of the spleen and skin cells was inhibited in mixed lymphocyte cultures. The cytotoxicity of spleen cells was decreased. The susceptibility of target skin cells to natural cytotoxicity was decreased. Therefore, UV-B radiation causes changes in the cell membrane resulting in the inhibition of immune responses.抄録全体を表示PDF形式でダウンロード (311K) -
遠藤 敦1995 年 107 巻 7-8 号 p. 69-78
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーUsing an experimental apparatus for estimating neurotransmitter release from brain slices, which involved an improved type of perfusion chamber and more well-controlled tube lines than the previous one were aspartic acid and γ-aminobutyric acid (GABA) release from hippocampal slices from epileptic El mice estimated more exactly and stably. Zonisamide had no effect on the aspartic acid release from hippocampal slices of El mice by zonisamide. However, zonisamide accelerated dose dependently GABA release from hippocampal slices of non-stimulated El mice, though no such acceleration was observed in stimulated El mice, i.e., repeatedly convulsed El mice.抄録全体を表示PDF形式でダウンロード (484K) -
加藤 勝也1995 年 107 巻 7-8 号 p. 79-90
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーTo evaluate the usefulness of dynamic MRI of kidneys in healthy volunteers and patients with different 24-hour creatinine clearance (Ccr) levels, a dynamic study that employed the T2* weighted gradient echo technique (FLASH: TR/TE=34/25msec, flip angle=20 degrees) with single images during breathhold was performed on 10 healthy volunteers and 35 patients, all examined for the Ccr and suspected of having renal parenchymal disease after a phantom study. T1-weighted and dynamic MR imagings were obtained with a 1.5T imager. I analyzed the time-intensity curve of renal cortex and medulla, and defined a cortex decreased ratio (CDR) and medulla decreased ratio (MDR) in comparison with the Ccr. The cortico-medullary difference ratio (CMDR) of T1WI was also compared with the Ccr. The parameters of the T2* dynamic MRI study (CDR, MDR) were better correlated with the Ccr than CMDR. Renal function can be quantitatively evaluated with the T2* dynamic MRI and there is a possibility that we can qualitatively evaluate the renal dysfunction and estimate its cause.抄録全体を表示PDF形式でダウンロード (2488K) -
岡村 容子1995 年 107 巻 7-8 号 p. 91-98
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーImmobilization stress for 6 hours induced hemorrhagic erosion in the rat stomach. Hydroxyl radicals significantly increased in the pons-medulla oblongata in stressed rats. Mitochondrial superoxide dismutase (SOD) activity was enhanced in the midbrain but was lowered in the cortex, hippocampus and cerebellum in stressed rats. Thiobarbituric acid reactive substances increased by stress in the cortex and midbrain. These findings suggested that immobilization stress generated hydroxyl radicals and accelerated lipid peroxidation, and affected mitochodrial SOD activity, which may lead to neuronal damage in stressed rats.抄録全体を表示PDF形式でダウンロード (902K) -
大守 伊織1995 年 107 巻 7-8 号 p. 99-109
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーTo clarify the characteristics of localization-related epilepsies occurring before 6 months of age, I carried out an electroclinical study on 28 cases which had been followed up for more than one year after the onset. The subjects were divided into two groups: the controlled group (8 cases) and the refractory group (20 cases). The controlled group was defined as the subjects whose seizures were suppressed within one year after the onset and the other subjects were classified into the refractory group. The characteristics of the refractory group were as follows: Most cases had serious underlying pathologies. The seizure type of most cases was simple partial seizure or complex partial seizure without secondary generalization. The interictal EEG showed focal abnormalities and severe dysrrythmia on the basic pattern associated with multifocal spikes in most cases. Some cases developed West syndrome after localizationrelated epilepsies, and generalized seizures or pseudoabsences appeared later in some other cases.
In conclusion, a comprehensive assessment and an intensive follow-up of clinical and EEG manifestations are of great value for determining the prognosis localization-related epilepsies occurring in early infancy.抄録全体を表示PDF形式でダウンロード (676K) -
遠藤 由美1995 年 107 巻 7-8 号 p. 111-119
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーThe effect of pellets of prosthesis materials on free radicals were examined using electron spin resonance spectrometry. Pellets used were titanium, alumina, ziruconia, an alloy of cobalt with chromium and polyethylene. These pellets were implanted in the abdominal skin and thigh muscle tissue of rats. Animals were sacrificed by decapitation at 1, 3, 20 hours and 2 and 4 weeks after implantation and subcutaneous and muscle tissues were dissected. Hydroxyl radicals and carbon centerd radicals were analyzed as spin adducts of spin trap, 5, 5-dimethyl-1-pyrroline-N-oxide. Hydroxyl and carbon centered radicals in the skin and muscle tissues were increased 1-3 hours after the implantation of these materials and these changes were almost recovered to the normal level 20 hours after the implantation except for alumina and ziruconia in the muscle. However, hydroxyl radicals and/or carbon centered radicals were increased in the skin 4 weeks after the implantation of zirconia, titanium, an alloy of cobalt with chromium and polyetylene. These results suggest that the subacute stage after the implantation of particles of prostheseis materials into the skin and muscle tissues induces the generation of free radicals and then these free radicals may produce tissue damage.抄録全体を表示PDF形式でダウンロード (412K) -
水口 栄太1995 年 107 巻 7-8 号 p. 121-129
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーTo elucidate the developmental changes in the visual evoked potentials of fronto-central derivations, 137 normal subjects between 0 month and 37 years of age were examined.
The latencies of early components (N60, P75) showed a gradual decrease up to 1 year of age. The N130 latency of late components showed a rapid decrease in 8 months, and afterwards, showed a gradual decrease until 10 years of age. The P190 latency showed a rapid decrease in 6 months, and afterwards, showed a gradual decrease until 15 years of age.
All four components (N60, P75, N130 and P190) showed a tendency of low amplitudes, up to 8 months of age.
During the sleep stages 1, 2 and REM, N130 and P190 latencies were prolonged, and amplitudes decreased, compared with those in the waking state. During sleep stages 3 and 4, these components disappeared.
Late components of visual evoked potentials at fronto-central derivations showed significant developmental changes, and the results of this study can be considered useful in the objective evaluation of brain development.抄録全体を表示PDF形式でダウンロード (480K) -
当真 純二1995 年 107 巻 7-8 号 p. 131-141
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーAs oxidation of neural membranes by reactive oxygen species (ROS), especially hydroxyl radicals (·OH), is involved in the biochemical pathogenesis of post-traumatic epilepsy, posttraumatic epilepsy is thought to be prevented by treatment with ROS scavengers. In the present study, I first examined the effects of adenosine (Ado), 2-chloroadenosine (Cl-Ado) and guanosine on ·OH and superoxide anion (O-2), generated by the Fenton reagent and the hypoxanthine-xanthine oxidase system, respectively, using electron spin resonance spectrometry. I also examined the effects of Ado and Cl-Ado on the occurrence of epileptic discharges on the electrocorticogram (ECoG) induced by FeCl3 injection (500nmol) into the sensorimotor cortex of rats, i.e., a model of an experimental post-traumatic epilepsy.
Although O-2 was not scavenged, ·OH were scavenged by Ado and Cl-Ado dose-dependently. The scavenging activity of Ado was 4 times stronger than that of Cl-Ado. On the ECoG of rats given FeCl3, sporadic spike discharges, polyspikes and/or ictal patterns started to be observed 15-90 min after the injection. Epileptic discharges did not appear or their occurrence was delayed by the intraperitoneal injection of Ado (5mg/kg) or Cl-Ado (1mg/kg) 30 min prior to the FeCl3 injection, although Cl-Ado showed a chronotropic action. Thus Ado and Cl-Ado may be useful in the prevention and the attenuation of progression of post-traumatic epilepsy by scavenging ·OH and by their anticonvulsant effect.抄録全体を表示PDF形式でダウンロード (632K) -
藤田 豊明1995 年 107 巻 7-8 号 p. 143-153
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーThe superoxide released from neutrophils works as a bacteriocidal agent in the biological protection system. On the other hand, superoxide also has been known to progress inflammation, tissue damage and fibrosis. Therefore, the superoxide production by neutrophils of patients with diffuse panbronchiolitis (DPB), idiopathic interstitial pneumonia (IIP) and collagen vascular disease with interstitial pneumonia (CVD+IP) were studied in relation to disease activity and progression. Superoxide production was measured by deduction of cytochrome C with a spectrophotometer.
The superoxide production was higher in DPB than in the normal controls. The superoxide in DPB showed a positive correlation with CRP and white blood cell count, but inverse correlation with arterial blood oxygen pressure. High levels of superoxide in DPB decreased following erythromycin therapy with clinical improvement. The average levels of superoxide in the patients with IIP and CVD+IP were lower than those in the normal controls. However, the superoxide level in the patients with IIP and CVD+IP in the active stage was higher than that in those in the nonactive stage. In the active stage, the increase of steroid dose was followed by a decrease of superoxide production in IIP and CVD+IP.
These findings indicate that measurement of superoxide production by neutrophils could be an useful means to evaluate activity in diffuse pulmonary diseases.抄録全体を表示PDF形式でダウンロード (567K) -
上川 康明, 猶本 良夫, 羽井 佐実, 上塚 大一, 井上 文之, 濱田 円, 森 淳, 金子 晃久, 八木 孝仁, 岡林 孝弘, 田中 ...1995 年 107 巻 7-8 号 p. 155-160
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーFrom December 1992 to October 1994, 15 patients who had esophageal superficial mucosal lesions (18 lesions) underwent endoscopic esophageal mucosal resection (EEMR). Among them, 12 cases and 12 lesions were squamous cell carcinomas. Although perforation complicated this procedure in one patient and hemorrhage in another, these were improved by conservative treatment. Marked subcutaneous emphysema occurred in the neck and face during EEMR without esophageal perforation in one patient. Therefore the procedure was stopped and the patient underwent radical operation 41 days later. Two of the 12 patients with carcinoma underwent radical operation 30 days after EEMR because pathological study revealed m3 and ly1 in one of them and sm1, ly2 and v1 in the other. Radiotherapy was indicated for another patient who had m3, ly0 and v0. In the other patients, the cancerous lesions developed within m2, ly0 and v0 except in one who had minimal m3 invasion, and the therapy was completed with only EEMR. The mean period of observation after EEMR was 15.1 months (7-24). Follow-up did not reveal any recurrence of carcinoma in these 9 patients. EEMR seems to be a highly useful method for treatment of esophageal mucosal carcinoma.抄録全体を表示PDF形式でダウンロード (314K) -
1995 年 107 巻 7-8 号 p. 161-168
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーPDF形式でダウンロード (359K) -
1995 年 107 巻 7-8 号 p. 169-173
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーPDF形式でダウンロード (231K) -
和漢薬によるIV型アレルギー反応の制御江田 昭英1995 年 107 巻 7-8 号 p. 175-178
発行日: 1995/08/31
公開日: 2009/08/24
ジャーナル フリーPDF形式でダウンロード (170K)
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