Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
Online ISSN : 1882-4528
Print ISSN : 0030-1558
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Volume 119, Issue 3
Displaying 1-18 of 18 articles from this issue
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The 2006 Okayama Medical Association Awards
  • Increased expression of receptor for advanced glycation end products by synovial tissue macrophages in rheumatoid arthritis
    Katsue Sunahori, Masahiro Yamamura, Jiro Yamana, Koji Takasugi, Hirofu ...
    2008 Volume 119 Issue 3 Pages 223-227
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.223
    JOURNAL FREE ACCESS
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  • Adenoviral p53 gene therapy for lung cancer
    Toshiyoshi Fujiwara, Noriaki Tanaka
    2008 Volume 119 Issue 3 Pages 229-234
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.229
    JOURNAL FREE ACCESS
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    To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit.
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  • Quinone formation as a common neurotoxic factor in dopaminergic neurotoxicity induced by an excess amount of cytosolic dopamine
    Ikuko Miyazaki, Masato Asanuma, Francisco J. Diaz-Corrales, Ko Miyoshi ...
    2008 Volume 119 Issue 3 Pages 235-239
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.235
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Review
Original Papers
  • Impaired coronary capillary hemodynamics with decreased glycocalyx thickness and irregular inner wall remodeling in right ventricle of pulmonary hypertensive rats
    Masahito Kajiya
    2008 Volume 119 Issue 3 Pages 247-251
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.247
    JOURNAL FREE ACCESS
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    We hypothesized that coronary capillary function is impaired with a decreased glycocalyx layer and uneven inner wall remodeling in right ventricles that are hypertrophied due to pulmonary hypertension (PH). Five-week-old male Sprague-Dawley rats were divided into 2 groups (PH: n=25, control: n=27). In the PH group, Monocrotaline (60 mg/kg SC) was administrated at 5 weeks. Coronary capillary hemodynamics was visualized in vivo at 8 weeks of age using our high-resolution intravital videomicrosopy, and RBC velocities in RV capillaries were evaluated, along with capillary diameters. Configuration of the capillary cast was assessed by a confocal laser scanning microscope. The thickness of the glycocalyx on the capillary endothelial surface was evaluated with Alcian blue 8GX by electron microscopy. RV systolic pressure increased in PH (by 142%, p<0.01). The diameters of capillaries were uneven in PH (coefficient of variation of diameters along capillary trees; 24±8% vs. 11±3%, p<0.05). The thickness of the glycocalyx in PH was less than half that of control (0.20±0.05 vs. 0.45±0.14 μm, p<0.05). RBC velocity was decreased in PH (820±110 vs. 1,100±230 μm/sec, p<0.05). The capillary flow reduction in PH may be closely related to the changes in the glycocalyx and vessel irregularity, resulting in insufficient oxygen supply to the heart.
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  • Apoe+/-ldlr+/- mice as a useful model to evaluate accelerated atherogenesis by Helicobacter pylori infection
    Jinhua Cui
    2008 Volume 119 Issue 3 Pages 253-260
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.253
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    Atherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis.
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Case Reports
  • Eosinophilic gastroenteritis with ascites and diffuse intestinal wall thickening
    Hiromi Tachibana, Daisuke Ogawa, Kenji Kahara, Souichiro Fujii, Nobuhi ...
    2008 Volume 119 Issue 3 Pages 261-265
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.261
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    A 60-year-old woman was admitted to our hospital with abdominal pain and diarrhea. Examination revealed eosinophilia (white blood count, 24,900/ml; eosinophils, 79.9%) and an elevated immunoglobulin E level. Abdominal computed tomography showed fluid collection and diffuse intestinal wall thickening, and biopsy specimens from the stomach, duodenum and colon showed eosinophil infiltration. We diagnosed the patient with eosinophilic gastroenteritis, and started treatment with steroid hormones (predonisolone, 40 mg/day perorally). The patient's symptoms and eosinophilia improved dramatically and she was discharged.
    Eosinophilic gastroenteritis is an inflammatory disease characterized by eosinophil infiltration into the gastrointestinal tract. It usually involves the stomach and small intestine, but may also involve the entire whole gastrointestinal tract. Although ascites sometimes complicates this disease, massive ascites, as in our patient, is rare. Here we report a case of eosinophilic gastroenteritis with massive ascites and diffuse intestinal wall thickening. Steroid hormones are an effective treatment for this disease, and early diagnosis and the administration of steroid hormones are essential.
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  • A collaborative approach to head and neck carcinoma for oral surgeons, head and neck surgeons, and plastic surgeons: The role of oral surgeons in two cases
    Nobuyoshi Mizukawa, Susumu Tominaga, Yoshihiro Kimata, Tomoo Onoda, Sh ...
    2008 Volume 119 Issue 3 Pages 267-272
    Published: January 04, 2008
    Released on J-STAGE: July 04, 2008
    DOIhttps://doi.org/10.4044/joma.119.267
    JOURNAL FREE ACCESS
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    There is a medical team approach used in many hospitals for oral cancer patients. The members are head & neck surgeons and plastic surgeons, or oral surgeons and plastic surgeons. However, in Japan, it is very difficult for oral surgeons to cooperate with head & neck surgeons, except in the case of extractions and oral health care, because both surgeons treat oral carcinomas and there is therefore a conflict in their scope of practice. We believe it desirable for head & neck surgeons to treat oral cancer patients with tumors extending to other regions, and oral surgeons should be in charge of occlusion in head and neck carcinomas. We treated two patients with oral carcinomas in collaboration with head and neck surgeons and plastic surgeons, with head & neck surgeons resecting the tumors, plastic surgeons reconstructing, and oral surgeons (dentists) taking charge of the occlusion for patients in the operating room. This collaboration resulted in patients having good position of the temporomandibular joint and occlusions after the operation. We therefore conclude that this collaborative team approach may be of benefit to the patients.
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