岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
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119 巻, 3 号
選択された号の論文の18件中1～18を表示しています
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平成18年度岡山医学会賞受賞論文
総説
原著
  • 肺高血圧ラット右室冠毛細管における内皮グリコカリックスの減少を伴う内壁リモデリングとヘモダイナミクスの変化
    梶谷 昌史
    2008 年 119 巻 3 号 p. 247-251
    発行日: 2008/01/04
    公開日: 2008/07/04
    DOIhttps://doi.org/10.4044/joma.119.247
    ジャーナル フリー
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    We hypothesized that coronary capillary function is impaired with a decreased glycocalyx layer and uneven inner wall remodeling in right ventricles that are hypertrophied due to pulmonary hypertension (PH). Five-week-old male Sprague-Dawley rats were divided into 2 groups (PH: n=25, control: n=27). In the PH group, Monocrotaline (60 mg/kg SC) was administrated at 5 weeks. Coronary capillary hemodynamics was visualized in vivo at 8 weeks of age using our high-resolution intravital videomicrosopy, and RBC velocities in RV capillaries were evaluated, along with capillary diameters. Configuration of the capillary cast was assessed by a confocal laser scanning microscope. The thickness of the glycocalyx on the capillary endothelial surface was evaluated with Alcian blue 8GX by electron microscopy. RV systolic pressure increased in PH (by 142%, p<0.01). The diameters of capillaries were uneven in PH (coefficient of variation of diameters along capillary trees; 24±8% vs. 11±3%, p<0.05). The thickness of the glycocalyx in PH was less than half that of control (0.20±0.05 vs. 0.45±0.14 μm, p<0.05). RBC velocity was decreased in PH (820±110 vs. 1,100±230 μm/sec, p<0.05). The capillary flow reduction in PH may be closely related to the changes in the glycocalyx and vessel irregularity, resulting in insufficient oxygen supply to the heart.
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  • ヘリコバクター・ピロリ感染による動脈硬化促進検討モデルとしてのapoe+/-ldlr+/-マウスの有用性
    崔 錦花
    2008 年 119 巻 3 号 p. 253-260
    発行日: 2008/01/04
    公開日: 2008/07/04
    DOIhttps://doi.org/10.4044/joma.119.253
    ジャーナル フリー
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    Atherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis.
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症例報告
  • 腹水貯留と広範囲な腸管壁の肥厚を伴う好酸球性胃腸炎の1例
    橘 洋美, 小川 大輔, 加原 健治, 藤井 総一郎, 早川 信彦, 鶴見 哲也, 三宅 孝佳, 國友 忠義, 岡崎 守宏
    2008 年 119 巻 3 号 p. 261-265
    発行日: 2008/01/04
    公開日: 2008/07/04
    DOIhttps://doi.org/10.4044/joma.119.261
    ジャーナル フリー
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    A 60-year-old woman was admitted to our hospital with abdominal pain and diarrhea. Examination revealed eosinophilia (white blood count, 24,900/ml; eosinophils, 79.9%) and an elevated immunoglobulin E level. Abdominal computed tomography showed fluid collection and diffuse intestinal wall thickening, and biopsy specimens from the stomach, duodenum and colon showed eosinophil infiltration. We diagnosed the patient with eosinophilic gastroenteritis, and started treatment with steroid hormones (predonisolone, 40 mg/day perorally). The patient's symptoms and eosinophilia improved dramatically and she was discharged.
    Eosinophilic gastroenteritis is an inflammatory disease characterized by eosinophil infiltration into the gastrointestinal tract. It usually involves the stomach and small intestine, but may also involve the entire whole gastrointestinal tract. Although ascites sometimes complicates this disease, massive ascites, as in our patient, is rare. Here we report a case of eosinophilic gastroenteritis with massive ascites and diffuse intestinal wall thickening. Steroid hormones are an effective treatment for this disease, and early diagnosis and the administration of steroid hormones are essential.
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  • 頭頸部癌における耳鼻咽喉科, 形成外科, 口腔外科3科合同手術の意義 : 2症例における口腔外科の役割を中心に
    水川 展吉, 冨永 進, 木股 敬裕, 小野田 友男, 野宮 重信, 杉山 成史, 川本 知明, 山近 英樹, 植野 高章, 高木 慎
    2008 年 119 巻 3 号 p. 267-272
    発行日: 2008/01/04
    公開日: 2008/07/04
    DOIhttps://doi.org/10.4044/joma.119.267
    ジャーナル フリー
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    There is a medical team approach used in many hospitals for oral cancer patients. The members are head & neck surgeons and plastic surgeons, or oral surgeons and plastic surgeons. However, in Japan, it is very difficult for oral surgeons to cooperate with head & neck surgeons, except in the case of extractions and oral health care, because both surgeons treat oral carcinomas and there is therefore a conflict in their scope of practice. We believe it desirable for head & neck surgeons to treat oral cancer patients with tumors extending to other regions, and oral surgeons should be in charge of occlusion in head and neck carcinomas. We treated two patients with oral carcinomas in collaboration with head and neck surgeons and plastic surgeons, with head & neck surgeons resecting the tumors, plastic surgeons reconstructing, and oral surgeons (dentists) taking charge of the occlusion for patients in the operating room. This collaboration resulted in patients having good position of the temporomandibular joint and occlusions after the operation. We therefore conclude that this collaborative team approach may be of benefit to the patients.
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