Extracts and polysaccharides from bone marrows were injected into rabbits, which were made toxic with benzol chronically and the changes in the peripherial blood pictures were studied.
After its recovery to normal, specimens of the medullary blood and tissues were made. Rabbits which made a natural recovery from benzol toxication were used as controls. Normal and toxic rabbits were also used for consideration during its observation.
When extracts and palysaccharides from bone marrows were injected just once, there was no temparary increase in the R. B. C.. The reticulo-endothelium in the medulla look edemic, which was thought to be caused by hypofunction of the reticulo-endothelium.
In the group which received continuous injection of marrow extract, the period of recovery for the R. B. C. was definitely shortened, the increase of reticulocytes appeared much earlier, and there was hardly any secondary leucopenia.
The marrow tissue was definitely rich in parenchymal cells and the cell deusity showed a medium increase. The blood picture in the marrow showed no shift to the left and there was an increase in cells showing nuclear divisions.
The group which received continuous injection of marrow polysaccharides showed no definite shortening in the recovery of the R. B. C., but the increase of reticulocytes appeared quite early. The shortening of the period for the recovery of the W. B. C. was abserved, and the recovery of parenchymal cells in the marrow was also seen. Cell density showed a slight increase and the nuclear division returned to its normal term.
From these facts I have learned that marrow extract works on the rabbits marrow toxic with benzol chronically and help it to recoverto its normal fauction. Polysaccharide from marrow, showed a similar action but not as strong as the previous one.
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