1. After having Prepared extracts each from normal prostate gland, slightly glandular hypetrophied prostate gland in mixed form, as well as from highly hypertrophied prstate gland, all taken out of human being, injected them subcutaneously in a dog, in doses of 5-2cc per day, for 14-16 weeks continually; and examined in each case such as general view, changes that happened to Rest-N, Cl, Ur as well as Ur in the Blood, at the same time making efforts to find out changes in function, by way of urinal symptoms, and alike by way of fluid test.
2. In cases where the extract from human normal prostate gland has been administered, no conspicuous change could be seen.
3. All cases in which extracts from human hypertrophied prostate gland were injected, as to the genral view, first came thirst, followed by loss of appetite, anxietly, depression; moreover, gave rise to a general exhaution. Then, abatement of body weight, as well as oedema appeared in limbs (esp. in back limb); which seemed to be accompanied by icterus.
4. As for Rest-N, Cl, Ur and Ur, all have indicated rapid or certain gradual increase.
5. As for urinal symptoms, red blood cells were recognized in almost all cases, which verified albumin, at the last stage of administration. In most outstanding cases, urinal cylinder could be detected.
6. In fluid test, an important hindrance of concentration ability was recognized; and though the dog was kept in normal state, there occurred something like hyposthenuria. However, no great change happened to the abilities both of excretion as well as dilution. Besides, no clear sign of initial polyuria could be seen.
7. These changes have all differed in degree, dne to histological diversion of admi-nistered prostate gland; and in general, the glandular hypertrophy type affected greater than mixture hypertrophy type; where moreover, the greater the hypertrophy, stronger in hindrance.
8. In our experiment, in only one case (3rd case) it was found that 6 mouths after the suspension of administration, every symptoms became normal.
9. Hindrance of kidney function seen among those in which extracts from hypertrophied prostate gland were administered, seems to have resulted from Nephrose incurred histolo-gically, which, even if a extract of very slightly hypertrophied prostate gland has power to incur.

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1. After having prepared some extracts, made respectively from a dog's normal prostate, moderately hypertrophied prostate in mixed form, as well as from highly glandular hypertrophied prostate, both of dog, injected them subcutaneously in a dog, in doses of 5-2cc per day, for about 14-16 weeks successively, and examined such as general view, changes occurred to Rest-N, Cl, Ur as well as Ur within blood; moreover, employing some fluid test, and in view to urinal symptoms, has endeavoured to find out those changes that have occurred in kidney functions.
2. Among the cases in which extracts out of dog's normal prostate gland were administered, no important perpetual changes could be recognized.
3. In the case where extracts from the moderate hypertrophied prostate in mixed form were administered, (2nd case), fluid test proved to be utter failure, submitted no results, but probably this may be due to some individual quality of test animals, in the urin of which one could always detect certain spermo. However, during ten-weeks course allotted to this case, loss of body weight, (about minus 7.8%), together with a regular gradual increase on the part of Rest-N, Cl, Ur and Ur in blood, could be detected, whose final values all have exceeded normal area.
4. Among cases in which highly glandular hypertrophied gland were administered, first such symptoms as thirst, then came loss of spirit, followed by anxiety as well as depression, which ended in the appearance of edems in the back limb at the middle of, 11th week; growing higher and higher.
5. The increase of Rest-N, Cl, Ur and Ur within blood has also been clearly seen; above all, the last-mentioned one showed a special increase.
6. Moreover, in fluid test, a clear obstruction of concentration ability could be seen.
7. As for urin, here also appeared changes that have accompanied to general view and fluid test.
8. The dog which supplied the moderately hypertrophied prostate in mixed form employed in 2nd case (7 years), has been verified diagnosed owing to histological search of its kidney, that has given rise to a distinct Nephrose.
9. From the above results obtained by experiments, it is thought most proper for us to consider that the kidney trouble discovered in hypertrophy of prostate is apt to be accompanied with certain poisonous changes of kidney parenchyma, which may be ascribed to the poisoned substance due to hypertrophy of prostate.

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Verff. berichteten einen Fall von Prostatasyphilis, welcher Pollakisurie, Schmerzen bei der Miktion und erschwerte Harnentleerung klagte. WaR, Murata- sowie Kahn-Reaktion fielen alle stark positiv aus. Bei der digitalen Untersuchung war die Prostata Kleinhühnereigroß, stark derb und leicht empfindlich auf Druck. Spirochaetanachweiß im Preßsekret war negativ, Murata-Reaktion desselben Sekrets fiel aber schwach positiv aus. Krebsreaktionen von Kürten u. Hichijo waren negativ. Die klinische Symptome waren nach d. regelmäßigen Arsen- u. Penicillinkur gänzlich verschwunden.

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After the investigation of 303 patients of impetigo contagiosa who have been visited the clinic for 6 years from 1949 to 1954, the author got the following results.
1) This disease increases many in the summer time and in the other month, there are very few.
2) As for the increase of the patient, this epidemy has the tendency of being popular every five years during latest II years.
3) After the result of the sexual statistical observation, there is a difference between male and female.
4) As for the age, there are overwhelmingly between the baby and the 5 years-old child.
5) As for the predilection, the face is mostly affected.
6) Its main symptoms are pustulous, crusted, vesicular and erosive.
7) The course of disease was calculated by the days of which the patient visited the clinic.
8) Judging from the seasonal observation, the patient inceerses in the hot temperature, and also, many in the comparatively dump wet time.

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The following bacteriological studies of Impetigo Contagiosa were made by the author.
The conclusion reached was as follows,
The staphylococci derived from every case of Impetigo Contagiosa show agreement in thei characters, that is, the coagulation of milk, lique faction of gelatine, formation of haemolysin, coagulation of blood plasma, toxic action in mice, formation of acid from sugar and resistance for heat.
Most of them belong to the saprophitic staphylococci.
After his investigation of the decomposition of sugar the author recognizes that the factors concerned in the decomposition were nothing but the pathogene staphylococci which are classified as staphylococci by YOSHIOKA beeause they decompose sugar. They composed mannose, trehalose, mannite, galactose and lactose, but on the ther hand arabinose, raffinose and salicin were not influenced by them.
Every staphylococcus derived from air had quite different characters from the coccimentioned above and there are no qualities common to each stammes.

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On the staphylococci which was divided from the impetigo contagiosa, the author examined the sensitibity and resistance of penicillin.
1) The penicillin sensitibity of the staphylococci is comparatively high, that is, 0.01-0.08 u/cc is 25.0%, 0.16-0.64 u/cc is 41.7%, and L. 28-20.48 u/cc is 33.3%.
2) The penicillin resistance of staphylococci in vivo was recognized 2 among 16 cases.
3) The resistance and recovery of staphylococci to penicillin was recognized in vitro.
4) The permeability of penicillin in vesicles and pustules are good, but their level are not enough for staphylococci of higher sensitivity.

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Having taken up as my thema the question we are still unable to solve ever since Hippocrates, namely, the question of human skin-color, in order to improve those shortcomings found in the skin-colour table until present, but instead, to obtain one which is easily available to everybody, and moreover. Possesses an excellent statistical merit, i. e, the standard color index classified according to lightness, edited by Japanese Institute for Color Study: employing this latter one, studied the skin-color by classifying it into three phases, namely, mien, tone as well as tint, due to the equality method in color mhich proves three layers of color, that is to say. by considering any skin color as a point in a vast space, using figures, at 13 places stimated the skin color, attributed to inhabitants who were by profession either farmers, fishermen, highlanders, or town dwellers, who, though different in their modes of living, qualified about the same: thus, I have arrived at. results as follows.-
(1) Normal skin color of those who live around the Seto Inland Sea coincides with Mr. Tsubaki's “The Skin-color of Tokyoits” or that reported by Mr. Okamoto; but in general, shows lower in mien as well as tone, while higher in tint. That the color of both the breast, upper inner arm, and thigh, due to Mr. Tsubaki prove slight change may be ascribed to imperfections of Luschan Table. In this respect, the standard color index according to the tone that I have employed has indicated two supreme merits, i. e, pretty scientific, at the same time, available to use any figure: has enabled me to estimate very minutely at each positions, even to very slight differencer.
(2) Among normal human skin colors, comparatively slight change has been detected, in modes of living, for their skin color: but effects from the outer world seemed to be quite great. Among the four groups whihe were able to be cosidered approximately equal in qualifications, in male, those who live in town proved 4.7 in mien, which is the highest. With females, farming people has proved highest, while fisherwomen, town-dweller as well as highlanders proved to be lower. As to tone, it was higher in male town dwellers or female farmers: as to the difference between men and women, it has proved least in towns people; great deal in farmers, followed by fishermen and highlanders. As to tint, in male it has proved steadfast in general, but in female who lived in hills it has proved lowest. As to differences of mien, there was slight variation, the mere difference being that females show higher in tone, but lower in tint than with male. That is to say, women prove whiter (fairer) than men, with a slight deddishness.
(3) It indicates an aspeet onyl slightly closer to ‘yellowish orange’ than to ‘orange’ in the skin-color of any normal human being its comparative ratio of reflection has a range from 287 to 37.6%; in tone, ranges 46%-63% in a comparative ratio of reflection. On the whole, redness shows a decrease in the order of fisher-people, highlanders, showing no such thinness of skin-color seen among highlanders as having been told by Pluscharl, but also giving certain support to the theories of Antanne, Dabagie or Wiener, which described the color density in proportion to the hight of land: they both possesses some truth: with females, mien enhances according to its height, while in males, the same circumstances improves tint. Generally speaking. I must conclude that no speeially remar-kable changes could he detected. However, my opinion would not be appropriate, because I have not investigated highlanders in particular.
(4) Forehead is best-fitted for examination of skin-color, it being comparatively secure place: then comes upper inner arm, inner thigh, abdomen, places also comparatively safe, subject to little change throughout seasons or sex. Where the mien appears highest proved to be abdomen in a male, but the waist in a female;

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1) I have conducted a V. C. determination in blood and skin of a rabbit, due to revised method adopted by Fujita & Ebihara.
2) The total V. C. content in the blood of a rabbit fed with vitamine-C-less food proved 6.51mg% at maximum, 1.39mg% at minimum, in average, 3.08mg%; 93% of total instances indicated between 2 and 5mg%
3) The Total V. C. content in the skin of a rabbit fed with vitamine-C-less food proved 12.79mg% at maximum, 1.52mg% at minimum, while, In average, proved to be 5.35mg% The 86.6% of total cases proved between 4 and 7mg%
4) The curve of changes due to lapse of time attributed to Total V. C. within blood and skin of a rabbit fed with vitamine-C-less food, when it has been pealed skin and picked blood, proved a glass-picture in a parallel state, as it indicated a slight increase for the estimated within blood, while, a slight decrease when estimated within skin; the ratio both of increase and decrease shown by this increase-decrease curve, is very small; and proved almost no influence on the V. C. amount due to pealing skin and picking blood.
5) The effect of such-like operations on Total V. C. metabolism within blood and skin, though slight in degree, continues for a considerable duration of time; besides, effects due to temperature, though slight too, is thought to occur to a certain extent.

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1) In half an hour after the injection of Penicillin, Total V. C. in blood proved an increase, which after 5 hours, reached 102.6% at the highest, and showed still an increase after 24 hours. The Total V. C. amount in skin has risen to 21.9% in an hour after the injection. 81.0% at highest after an hour, and still indicated an increase even after 24 hours.
2) The increasing tendency occurred for total amount after the injection of Penicillin has proved to lower in the course of time, yet showed an increase even after 7 days' durati on.
3) By the injection of Penicillin, the rabbit fed with vitamine-C-less food had been stimulated its formating faculty of Vitamine C.

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1) In case 20 mg/kg Streptomycin has been injected, Total V. C. content in blood indicated a decrease of 24.3% Within 2 hours, 44.0% increase after 5 hours on the contrary, but again a decrease happened after 10 hours. The changes that occurred to Total V. C. in skin proved a decrease of 6.2% in 2 hours, 22.8% in 5 hours, but in 10 hours, indicated an increase on the contrary.
2) In case 60 mg/kg Streptomycin has been injected, Total V. C. content within blood proved a decrease in 2 hours, but on the contrary, an increase of 22.5% in 10 hours; after 24 hours, itagain showed a decrease. Total V. C. content within skin kept on decreasing since 2 hours.

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1) When 40mg/kg of Chloromycetin is injected, Total V.C. within blood indicated a decrease, still showing the same tendency even after 24 hours. In skin, after 2 hours, there happened an increase of 30.3%, but after 5 hours, decreased on the contrary.
2) When Chloromycetin 120 mg/kg has been injected, Total V.C. amount in blood decreased to an extent of 18.7% after two hours, but showed an increase of 21.7% after 5 hours, and again proved a decrease of 27.1% after 10 hours. In skin, it has decreased ever since 2 hours. After 24 hours' lapse, Total V.C. amount within blood and skin has been recovered to its normal state.

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1) By injecting Terramycin 20mg/kg intravenously, Total V. C. content within blood decreased 16.5% in an hour; after 2 hours' duration, experienced an increase of 8.9% on the contrary. Within skin, it has increased 8.2% in an hour, 28.4% in 2 hours; on the contrary, it has proved a decrease after 5 hours.
2) In case 60 mg/kg Terramycin has been intravenously injected, Total V. C. amount in blood kept on decreasing from 2 hours after, but returned to its normal state after 24 hours. In skin, it has also undergone a similar slight decrease, but has recovered to its normal state after 24 hours, without any noticeable influences.

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