巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
71 巻, 4-2 号
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第I編 離乳食の実態とそれが乳幼児身体発育に及ぼす影響について瀬之口 スミ1959 年 71 巻 4-2 号 p. 1655-1665
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーFrom 1952 to 1953, in the agricultural and mountaineous villages of Okayama Pref. and Hiroshima Pref., an investigation was made about the actual state of “Weaning food” for infants and its effect exerted upon their bodily development both at the period fo weaning and at the later period of infancy; 520 infants (0-2 years old) and 626 infants (3-7 years old) were used as the subjects of investigation, giving the following results:
(1) Of the 520 infants chosen (0-2 years old), the percentage of undernourished infants changed monthly as follows: (0-6 months old) 21%; (7-12 months old) 25%; (1-2 years old) 33.9%.
Thus the percentage rose highest at the weaning period.
(2) In the monthly change in infants' body-weight, the percentage of growth was rather low at the weaning period, the boy babies showing 80% of the standard value and the girl babies 89%.
(3) The research on the actual state of weaning in those regions of Japan revealed that the starting time and the weaning food used then were almost proper, but that the delay in the development of staple chief food taken and the lack in protein taken were quite remarkable.
(4) It was fonfirmed those infants who were not properly weaned were suffering from malnutrition far more than those who were properly weaned.
(5) Among those who were delayed in weaning, move underdeveloped infants were found than in other cases, but it seems not to be reliable from the viewpoint of sampling statistics. Such a correlative relation as seen between the body-weight at birth and the growth of infants in the later period could not be found.抄録全体を表示PDF形式でダウンロード (597K) -
第II編 主としてInstant foodを用いた簡易離乳食とその摂取状況瀬之口 スミ1959 年 71 巻 4-2 号 p. 1667-1682
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーSix kinds of weaning food were made chiefly of “Instant Food” and with them 50 healthy infants were fed. As a result of this experiment the following data were gained.
(1) The change in the amount of porridge daily taken dy the infants were as follows:
6 months old (30-50gr.)
7 months old (50-100gr.)
8 months old - (150-200gr.)
9 months old (250-300gr.)
10 months old (400-450gr.)
11 months old (450-500gr.)
(2) “Flake food”, which was used in order to save time in cooking porridge, was very suitable as a weaning food in the early period, and later it could be favorably replaced by soft boiled-rice, supplying enough calorie and ample protein.
As the flake food Was best ingested in the 5th experiment, it was revealed that its density should be 15% at the beginning and less than 30% in the later period and its quantity should be as follows:
6 months old (50-90gr.)
7 months old (100-150gr.)
8 months old (200gr.)
9 months old (200gr.)
10 months old (150gr.)
(3) Though “Milk Food” is better than home-made “Instant Food” in the respect of ingestion by infants; but the former is regrettbly more expensive, and the latter should be improved on the point of taste.
In addition “Oatmeal” is also considered to be quite excellent as a kind of weaning food.
(4) By using “Flake Food” as a short-period weaning food, those infants who were delayed in weaning could be easily made to complete weaning in 3-4 months and at the completion period the amount of calorie and protein ingested by the infants was nearly ideal.抄録全体を表示PDF形式でダウンロード (3555K) -
第III編 充分な医学的監理下に於ける離乳食摂取状態が乳児の身体発育に及ぼす影響瀬之口 スミ1959 年 71 巻 4-2 号 p. 1683-1688
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーAfter making experiments concerning 50 infants under a perfect medical guidance, the following results were revealed by an investigation of the relation between their ingestion of “weaning food” and their bodily growth in the weaning period.
(1) When the period before the beginning of weaning (about six months after birth) was compared with its completion time (about one year after birth), it was found that Kaup's index number rather rose at the completion time.
(2) As to those infants whose Kaup's index number at the completion period of weaning became less than the index seen before the starting time, the amount and the percentage of calorie of milk taken daily are less than in the case of those infants whose index number became greater at the completion period than at the beginning.
(3) The body-weight at the completion time of weaning seemed to have a close relation with the whole amount of calorie and protein daily taken by infants.
(4) The body-weight at the completion time of weaning was still influenced by the weight at birth, but it was much slighter than before the start of weaning.抄録全体を表示PDF形式でダウンロード (365K) -
前編 尾側腸間膜動脈及びその分枝の血流阻止が大腸下部の血流に及ぼす影響に就いての実験的研究浜本 泰夫1959 年 71 巻 4-2 号 p. 1689-1704
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリー1. The blood supply to the lower colon has been investigated in the rabbits. and compared with the arterial arrangements in man.
2. Ligation experiments of 6 types have been undertaken in 45 animals, and the morphology of the collateral circulation and its evolution have been studied in the rabbits sacrificed at various intervals from 1 to 4 weeks after operation.
3. The vascular reserve of the lower colon is very great. The only effect in usually a temporary ischemia in the area of the interrupted circulation due to the ligation. Necrotic changes of the lower colon were only occurred when the inferior mesenteric artery is occulded and in addition many sigmoid arteries are occulded.
4. The intrinsic anastomosis of vessels in the wall of the colon are inadequate to compensate fully for interruption of sigmoid artery.抄録全体を表示PDF形式でダウンロード (3583K) -
後編 尾側腸間膜動脈結紮による大腸下部切除乃至切断術後の血流に就いての実験的研究浜本 泰夫1959 年 71 巻 4-2 号 p. 1705-1723
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe arterial arrangements and the collateral circulation have been studied after the high ligation of the inferior mesenterie artery and the anterior resection of the sigmoid colon and amputatio-recti in 15 dogs.
The dogs were killed at various intervals and injected with a radiopaque medium through the thoratic aorta. Arteriographs were taken of the specimen.
The collateral circulation after the anterior resection of sigmoid colon and amputatiorecti, has not been interrupted, and and necrotic change and insuficiency were not morphologically & histologically recognized.
The anal function in the amputatio-recti with preservation of the sphincter has been recovered in 2 weeks after the Operation.抄録全体を表示PDF形式でダウンロード (5768K) -
檜垣 修生1959 年 71 巻 4-2 号 p. 1725-1739
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーAbout 203 cases of simple diffuse goiter in the recent two years was measured with I131 for their iodine metabolism.
They were classified by their tissue pictures and the relation between the tissue pictures and iodine metabolism was studied.
Simple diffuse gioter is classified by its uptake curve into two types:
1. One which continues to ascend 24 hours.
2. One which reaches to its maximum uptake at 1-6 hours.
The first type was found in 78 cases. Generally speaking, in these cases, the biological half life of I131 in the thyroid is shorter than in normal man but longer than in the second type. No discharge of I131 after the administration of thiocyanate is found. Also failure to convert into an organic form is not found either by I131conversion ratio in the thyroid nor by analysis of labeled iodine in the thyroid with paper chromatograph. In T. S. H.-test, the uptake ratio shows no change but many of them shows the ascending of P. B. I.
The second type was found in 125 cases. The biological half-life of I131 is shorter than the first type. Examination using thiocyanate and analysis of labeled iodine in the thyriod shows a distinct organic failure. In T. S. H.-test many of them shows no ascending in uptake curve and P. B. I.
Desiccate thyroid mostly does not effect therapeutically on the first type but is markedly effective on the second type.
This disease was classfied histologically into 3 types and the iodine metabolism was studied.
I. Type (colloidal type) no organic failure
II. Type (type with diffuse epithelial hyperplasia) marked organic failure
III. Type (type with degeneration)
a. Colliod stays considerably; no organic failure
b. Colloid reduced and the destructive follicles intensive; organic failure found抄録全体を表示PDF形式でダウンロード (3253K) -
田中 芳夫1959 年 71 巻 4-2 号 p. 1741-1761
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe addition of cortisone to stored blood brings the following results:
1) Cortisone represses the decrease of flagility of red cells and the increase of permeability of red cell membranes for sodium and potassium ions. Consequently it retards the swelling of red cells in stored blood and its hemolysis.
2) This reaction of cortisone in stored blood is markedly accelerated when co-existing with serum and glucose.
3) Cortisone represses the utilization of glucose in stored blood somewhat and keeps the glycolysing ability of red cells longer, but it does not effect on the decreasing of organic phosphate of red cells. Therefore the prolongation of the glycolysing ability of red cells is regarded as a secondary result of its reaction to red cell membranes.
4) The addition ef cortisone to the stored blood improves the post- transfusive survival of the red cells and reduces ill reactions in blood transfusion.
From the facts above mentioned the addition of cortisone to stored blood is one of the adequate methodes of the preservation of blood.抄録全体を表示PDF形式でダウンロード (1900K) -
第1編 解糖作用西原 庸一1959 年 71 巻 4-2 号 p. 1763-1770
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーChanges of glucose and lactic acid in stored blood was investigated and glycolysis of red cellswas experimentally studied.
1) As the storage becomes longer, glucose lessens but lactic acid increases. This change is marked until the third week and from the forth week they show no definite change. The dereasing of glucose and the increasing of lactic acid are nearly in proportion.
2) The glycolysis of red cells of stored blood in physiological saline solution after 24-hour and 6-hour heating was measured.
3) The glycolysing power after 24-hour heating is much stronger than that after 6-hour heating.
4) The glycolysis of red cells in stored blood shows a same tendency to that in physiological saline solution.
5) The change from glucose to lactic acid is performed in blood almost completly while in physiological saline solution it works weaker.抄録全体を表示PDF形式でダウンロード (403K) -
第2編 保存溶血々液輸血の副作用に関する実験的研究西原 庸一1959 年 71 巻 4-2 号 p. 1771-1780
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリー1. After the transfusion by fresh hemolyzed blood the animal become feverish, but after that with stored hemolyzed blood almost no fever is seen.
2. In case of transfusion with fresh hemolyzed blood, a descending of blood pressure is found but in that with stored hemolyzed blood it is not found.
3. After transfusion with fresh or stored blood a temporary decrease of nonprotein nitrogen is seen. It is especially marked after that with stored hemolyzed blood.
4. After transfusion with fresh hemolyzed blood the serum A/G decreases but γ-globulin increases. After that with stored hemolyzed blood the latter decreases rather weakly.
5. In the histological findings aftes transfusion with fresh or stored hemolyzed blood, in the kidney nephrosis, in the lever degeneration and in the spleen and lung a blood stagination are seen. The changes after transfusion with stored blood are much stronger.
6. From the results mentioned above, after transfusion with fresh hemolyzed blood the symptomatic effects as fever, drop of blood pressure are strong but ill effects upon nonprotein nitrogen and histological findings are weak. On this point the stored hemolyzed blood has ill effects stronger than that of the fresh hemolyzed blood.抄録全体を表示PDF形式でダウンロード (2264K) -
小野田 収, 朝比奈 勝, 西原 庸一, 田中 美登, 森 昭胤1959 年 71 巻 4-2 号 p. 1781-1784
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe oxidations of G-6-P, 6-P-G and R-5-P in the human epileptic cerebral cortex were measured by Warburg's manometer and compared with those of non-epileptic cerebral cortex. The results were as follows:
1) The oxidation of G-6-P, 6-P-G and R-5-P in epileptic cerebral cortex, showed stronger tendency to be controlled than that of the non-epileptic.
2) The oxidation of G-6-P and 6-P-G were more accerelated by the addition of TPN in both cases, and then the difference of oxidation in the each cases of epileptic and non-epileptic cerebral cortex became less.
3) From the facts mentioned above, it is considered that the shunt pathway of glucose metabolism, i. e. Warburg-Dickens scheme, exists in the brain also as in the liver.抄録全体を表示PDF形式でダウンロード (208K) -
望月 義夫, 那須 昭三, 黒田 健, 岡平 和磨, 村上 貞夫, 東原 良頴1959 年 71 巻 4-2 号 p. 1785-1792
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーFluorescent lamp was compared with incadescent lamp concerning the influence upon the shift of the near point after the task seeing the rotating objects with colored stripes. The apparatus is shown in Fig. 1. The drum is covered by paper with stripes of white and one of the standard colors is used by Japanese Color Institution (black, red, yellow and green). Each stripe has the width of 3 cm and an angle of 45° to its moving direction. It rotates at the speed of 60 times per minute. Each examinee has to see this object through a window of 4×5 cm opened in the midst of black carton paper, from the distance of 30cm for 20minutes. During the examination he is requested to number the stripes in order to fix his attention to this visual activity.
Examinees were men and women of 19-33 years old, with normal vision and without any ophthalmological defect. Mazda Daylight Fluorescent Lamp (FI-200, 20 watt) and Mazda Gas-filled Lamp (100 volt, 100 watt) were used for the examination. The near point optometer by Dr. Ishihara was used for the measurement of near point.
The results were as follows:
1) In the illumination of 200 lux, the near point shifts much further in fluorescent lighting than in incadescent lighting. This is true in every color.
2) In fluorescent lighting black and red are more effective than yellow and green. In incadescent lighting no distinguishable difference can be seen among the colors.
3) The examinee feels more comfortable by the case of incadescent lighting than fluorescent lighting. Yellow is the best and green follows in his subjective feeling.
From the above results, the authors conclude that incadescent lighting is better than fluorescent lighting when we are engaged in works to see moving objects.抄録全体を表示PDF形式でダウンロード (401K) -
第1編 潜在性脳局所アナフィラキシー猫(実験的癲癇症)における過敏症抗体と血清蛋白分屑の変動に関する研究宮武 昭三郎1959 年 71 巻 4-2 号 p. 1793-1807
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe cats with latent local cerebral anaphylaxis were produced by injecting inactive bovine serum antigen. During 300 days after the last effective injection, anaphylactic antibody in the blood and electrophoretic fraction of serum protein were investigated by precipitin reaction and the use of Tiselius apparatus.
1) The title of antibody stays at maximum meanly during 60 days after the last effective injection and then gradually decreases.
After 120 days it descends markedly. But even after a considerable period of time as 300 bays it still can be proved.
2) The ups and downs of total protein and globulin shows a parallel relation with that of γ-globulin. Their increase is regarded to owe to that of γ-globulin. No difinite relation is seen between the ups and downs of protein, α-globulin and β-globulin.
3) The ups and downs of the title of antibody and that of γ-globulin were compared. The latter shows a tendency of an earlier descending than the former but generally they have a parallel relation.
In the latent local cerebral anaphylactic cats the abnormal irritability of brain nerve cells especially the descending threshold of cardiazol seizure has been proved by many works done in our institute.
In such cats the title of antibody is high, can be kept during a long time and also the increase of γ-globulin is seen.
This fact can be proof that cats with LLCA is disposed to convulsion by any stimulation.抄録全体を表示PDF形式でダウンロード (843K) -
第2編 潜在性脳局所アナフィラキシー猫(実験的癲癇症)の脳含水量と脳波宮武 昭三郎1959 年 71 巻 4-2 号 p. 1809-1818
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーLLAC were produced experimentally by injecting inactive bovine serum as antigen in cats. During 300 days after the last effective injection, brain water content of cats with LLCA was measured and their EEG was recorded.
1) The water content in the motor cortex of cat with LLCA tends to increase during a considerable period as 60 days after the last effective injection. This increasing is the edema type which mainly dues to that of free water. About half of this edema type shows an electroencephalographically dominant slow wave more markedly than the normal.
2) In cats with LLCA the stadium in which the title of antibody shows maximum and in which γ-globulin increases accordes with the existing time of brain edema. The antibody remains much longer.
The increase of water content in the brain tissue is regarded to provocate or accerlate the convulsion. Therefore we can prove from the stand point of water metabolism in the berain tissue that the cats with LLCA is xperimentally disposed to convulsion.抄録全体を表示PDF形式でダウンロード (1303K) -
第1編 ビタミンB2の各種単糖類の腸管内吸収におよぼす影響松本 増夫1959 年 71 巻 4-2 号 p. 1819-1826
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe author had the experiment infusing the several kinds of monosaccharide (glucose, xylose and galactose) to the intestinal canals of rats and investigating the influence of Vitamin B2 upon the absorption of monosaccharide and obtained the following results:
1) The young animals have increased their weight by the injection of the proper quantity of Vitamin B2. In this case, the rate of increase was proportionated to the quantity of injected Vitamin B2.
2) Owing to the injection of the proper quantity of Vitamin B2, the absorption index of glucose to the rat's intestinal canal became to rise. In this case, the rising rate was proportionated to the quantity of the injected Vitamin B2.
3) Owing to the injection of the proper quantity of Vitamin B2, the absorption index of galactose to the rat's intestinal canal became to rise. In this case, the rising rate was proportionated to the quantity of the injected Vitamin B2.
4) The absorption index of xylose to the intestinal canal has no relation with the injection of Vitamin B2. This can be said because the absorption of xylose (pentose) is difference with that of hexose as glucose, galactose and etc.抄録全体を表示PDF形式でダウンロード (420K) -
第2編 ビタミンCの各種単糖類の腸管内吸収におよぼす影響松本 増夫1959 年 71 巻 4-2 号 p. 1827-1834
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe author had the experiment infusing the several kinds of monosaccharide (glucose, xylose and galactose) to the intestinal canals of rats, and investigating the influence of Vitamin C upon the absorption of monosaccharide, and obtained the following results.
1) The injection of the proper quantity of Vitamin C was effective for the absorption of glucose to the intestinal canal, but the much injection did reduce the index of absorption.
2) The same action was seen at the absorption of galactose.
3) The injection of the proper quantity of Vitamin C had no influence upon the absorption of xylose. This can be said because the absorption of xylose (pentose) is difference with that of hexose as glucose, galactose and etc.抄録全体を表示PDF形式でダウンロード (389K) -
松本 増夫1959 年 71 巻 4-2 号 p. 1835-1838
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーUsing rats, the author experimented the influence of the refined Vitamin B2 upon the fixation of liver glycogen and obtained the following results.
1) On the lack of Vitamin, all quantity of glycogen in liver decreased.
2) The quantity of glycogen in liver increased by the injection of Vitamin B2.
3) From the results mentioned above, Vitamin B2 is one of causes to make a good influence upon the fixation of liver glycogen.抄録全体を表示PDF形式でダウンロード (273K) -
第1編 牛血清感作家兎の腹腔単球の抗原との接触反応について林 弘1959 年 71 巻 4-2 号 p. 1839-1847
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe fact that the degradiation products evolving out of cell destruction in the local tissue are the factors playing an important role in a series of exsudative phenomena called as the inflammatory reaction is well-known as already reported by Menkin and others. It is difficult to distinguish the primary disturbance caused by inflammation-inducing substances from the secondary disturbance due to the products of tissue disintegration, but it may be possible to learn the manner of the inflammation-inducing cell destruction if the action of the inflammation-inducing substances is so swift that the cells can be observed prior to the onset of the secondary reaction. From these viewpoints the author selected allergic inflammation as the subject for study, and first of all with the use of a phasecontrast microscope pursued the changes caused by the action of antigen on those free cells not being in inflammatory situation.
When antigen is made to act on the peritoneal monocytes of the rabbits sensitized with bovine serum the cells quickly retract their pseudopodia; cells become swollen; the nuclear membrane becomes distinct and the nuclear and cytoplasmic structures become indistinct.
In addition, when supra vitally-stained cells are observed, they change the shapes rapidly, and the dye, losing its granular form, spread very quickly and extensively in the cytoplasma. These phenomena seem to suggest the acceleration of permeability due to the destruction of the cell membrane with resultant flow of external fluid into the cell, a rapid change in molecular arrangement within the cell, and the demolition of the cell itself due to the activation of various catabolic enzymes, and the emigration of disintegrated substances to the outside of the cell.抄録全体を表示PDF形式でダウンロード (1874K) -
第2編 腹腔単球の細胞膜透過性について殊に抗原作用後の変化林 弘1959 年 71 巻 4-2 号 p. 1849-1855
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーAs reported in the previous paper in the belief that tha acceleration of the cell-membrane permeability and the resultant inflow of external-fluid into the cell are responsible for the dispersion of vital-staining dye particles within the cell when the antigen is made to act on peritoneal monocytes from the rabbits sensitized with bovine serum, the author estimated the fluctuation in the permeability of Janus green and Nile blue both before and after the action of antigen. In this series of experiments the author employed the conventional supra-vital staining combined with the method for the fixation of the dye by potassium mercuric iodide solution devised by Seno, Haba, Maki et al. and estimated the changes in the permeability under a microspectrophotometer.
As the result, it has been verified that cells coming in contact with antigen increase in the cell-diameter by about 2.5μ and the permeability for dyes is accelerated 1.71 to 2.22 times in one minute.抄録全体を表示PDF形式でダウンロード (1609K) -
第3編 感作家兎腹腔単球に対する抗原の作用に関する電子顕微鏡的観察林 弘1959 年 71 巻 4-2 号 p. 1857-1864
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe change occurring at the time when antigen it acting on the peritoneal monocytes in the rabbits sensitized with bovine serum was observed under an electronmicroscope. By the action of antigen monocytes become swollen and devoid of pseudopodia, at the same time mitochondria also swell up and cristae ase destroyed. Likewise endoplasmic reticulum swelling up, grow indistinct. Moreover, when antigen is made to act on the supra-vitally stained cells, in the case of Neutral Red there is no significant difference in the cell picture from that of cells receiving no supra-vital staining. As has previously been clarified, since Neutral Red is the substance existing in the cell as the dye droplets showing no affinity to the any one of cell organellae, the dispersion of dye particles seem to be due to the destruction of endoplasmic reticulum, which is supposed to keep the dye as droplets. Janus Green has been proved to have a special affinity to mitochondria, and in the cells previously stained supra-vitally when they come in contact with antigen, their mitochondria do not expand as much as in the case of unstained cells, but the cells show a marked agglomeration of cytoplasm. This seems to be due to the concomitant acceleration in the affinity of Janus Green to organellae other than mitochondria, and also due to the changes in molecular arrangement in the cell at the time of the swelling of endoplasmic reticulum.抄録全体を表示PDF形式でダウンロード (1894K) -
第1編 癌組織抽出液の血清並びに臓器Phosphataseに及ぼす影響小西 等1959 年 71 巻 4-2 号 p. 1865-1878
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーPhosphatases in serum and organs (the liver, adrenal gland, spleen, jejunum and the bone marrow) were estimated biochemically after injection of the cancer tissue extract into rabbits, and following results were obtained.
1) Following injection of cancer extract serum phosphatases were decreased, though, alkali phosphatase was slightly increased only when the toxic effect was severe.
2) In the organs of normal rabbits alkali phosphatase was larger in amount than acid phosphatase, excepting only the adrenal gland in reverse. Acid phosphatse was largest in amount in the jejunum, subsequently the spleen, adrenal gland, kidney, liver and the bone marrow. Alkali phosphatse was also largest in the jejunum, subsequently the kidney, spleen, liver, bone marrow and the adrenal gland.
3) Influences of injection of the cancer extract on the phosphatases in organs were as follows:
The liver; alkali phosphatse was increased but no changes in acid phosphatse.
The adrenal gland; alkali phosphatse was increased but no changes in acid phosphatse.
The spleen, no changes in the phosphatses were observed.
The kidney; decreases in both phosphatases were seen.
The je junum; decreases in both, especially marked in alkali phosphatase.
The bone marrow; no changes were observed, though, alkali phosphatase was slightly increased when the toxic effect was severe.
4) It was surmised that an intimate relation between the liver and the phosphatase was present.抄録全体を表示PDF形式でダウンロード (872K) -
第2編 四塩化炭素,胆管結紮,網内系填塞の血清並びに臓器Phosphataseに及ぼす影響小西 等1959 年 71 巻 4-2 号 p. 1879-1896
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーPhosphatases in serum and organs (the liver, adrenal gland, spleen, kidney, jejunum and the bone marrow) were estimated biochemically after subcutaneous injection of CCl4, ligation of the choledochus and R. E. S. blocking by India ink, obtaing following results.
1) Following injection of CCl4 the phosphatases in serum were increased temporarily and later decreased markedly, but alkali phosphatase became below the level of which before injection. Also in the rabbits ligated the choledochus those, especially alkali phosphatase, were remarkably increased, and decreased in R. E. S. blocking.
2) After injection of CCl4 alkali phosphatse was decreased in the liver with no changes in the acid phosphatase, and no changes were observed in the liver after ligation of the choledohhus.
3) From the facts obtained in 1) and 2), it is concluded that phosphatases (at least alkali phosphatase) were produced in the liver.
4) In the R. E. S. blocking alkali phosphatase was remarkably decreased in the liver, spleen and the bone marrow.
This indicates that the R. E. S. plays an important role on the phosphatase, in cooporation with decrease of acid- and alkali-phosphatase in the serum.
5) Phosphatases in the adrenal gland have shown no changes by those procedures.
6) Phosphatases in the kidney were not changed by those procedures, with only exception of decrease in alkali phosphatase after ligation of the choledochus.
7) Alkali phosphatase in the jejunum was decreasd after injection of CCl4 or ligation of the choledochus, and increased after R. E. S. blocking.
8) The spleen is related to the storage of phosphatase and has a regulation effect.
9) Acid phospnatase in the bone marrow was tended to increase after injection of CCl4 or ligation of the choledochus, and alkali phosphatase was decreased after blocking of R. E. S.抄録全体を表示PDF形式でダウンロード (1141K) -
第1編 血球のコハク酸脱水素酵素系に関する細胞化学的研究酒井 晃1959 年 71 巻 4-2 号 p. 1897-1907
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーIn the field of hematology the supravital staining by Janus green has been used extensively for counting of the number of mitochondria of leucocytes. But it has been clarified that all the mitochondria can not be stained by this method. With the purpose to establish a method to stain all mitochondria the author has scrutinized the histochemical method for the respiratory system, especially the succinic dehydrogenase system, localizing solely in mitochondria and devised the color reaction to appear coinciding fairly exactly at the site of mitochondria improving the past method. For the enzyme reaction sodium succinate was used as the substrate and neotetrazolium chloride, nitro-neotetrazolium chloride or nitro-blue tetrazolium chloride as the hyrogen acceptor. In this paper by the application of this method the author stuied the correlation between the site and intensity of the reaction in each cell species with reference to the differentiation and maturation. The results are as follows:
1. The cytochemical reaction of this enzyme appears positive in all blood cells with exception of mature erythrocytes. This enzyme reaction decreases its intensity along with the maturation and differentiation of cells.
2. The enzyme reaction appears specifically coinciding with the site of mitochondria in cells including reticulocytes.
3. This enzyme reaction is extremely useful for counting the number of mitochondria in blood cells as well as for ascertaining their enzymatic activity.抄録全体を表示PDF形式でダウンロード (2189K) -
第2編 血球のチトクローム酸化酵素系に関する細胞化学的研究酒井 晃1959 年 71 巻 4-2 号 p. 1909-1913
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーIt is difficult to make an accurate cytochemical demonstration of the cytochrome oxidase system in the mitochondria of blood cells by the conventional Nadi reaction. By applying the Oda's method for the cytochemical detection of cytochrome c-cytochrome oxidase system and cytochrome c oxdase the author succeeded in demonstrating cytochemically the cytochrome c oxidase or the cytochrome c-cytochrome oxidase system in the mitochondria of blood cells by using p-phenylenediamine as substrate and neotetrazolium salt as hydrogen acceptor with or without the addition of cytochrome c. This reaction appears in the cytoplasm of all blood cells with an exception of mature erythrocytes in the form of distinct violet-colored round or rod-like granules coinciding with mitochondria. The number, distribution and the grades of the enzyme activity of mitochondria can be seen. whose pictures are specific to each call species. Maturation and differentiation of cells generally proceed with the decrease both in number and enzyme activity.抄録全体を表示PDF形式でダウンロード (752K) -
第3編 血球のDPNH-脱水素酵素系に関する細胞化学的研究酒井 晃1959 年 71 巻 4-2 号 p. 1915-1919
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーWith a view to demonstrate cytochemically the terminal respiratory enzyme system that plays the leading role in the energy production of the cells, especially the DPNH-dehydrogenase system of blood cells, the author executed cytochemical reactions with the use of sodium malate and sodium L-glutamate as the first substrate and DPN as the second substrate and having neotetrazolium salt or nitro-neotetrazolium salt as hydrogen acceptor. The results are as follows:
1. This dehydrogenase reaction appears as clear-cut spherical or rod-like particles at the sites coincidiug with mitochondria of all blood cells with an exeption of mature erythrocytes.
2. This reaction seems to appear positive on whole mitochondria but enzyme activity are greater in the immature blood cells.
3. The mitochondria of reticulocytes are also positive in this oxidase reaction suggesting that these mitochondria take a part in the hemoglobin synthesis.抄録全体を表示PDF形式でダウンロード (723K) -
第4編 血球ミトコンドリアの細胞化学的電子顕微鏡的研究酒井 晃1959 年 71 巻 4-2 号 p. 1921-1927
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーIn order to elucidate the microstructures of the mitochondria in blood cells in the relation with the sites of enzyme activities the author carried out electron microscopic observations on the ultra-thin sectioned specimens prepared from the normal blood cells on which the cytochemical reaction of the respiratory enzyme system has been made with the use of potassium tellurite, a heavy metal salt.
As the result, it has been verified that the terminal respiratory enzyme system is localized mainly in mitochondria, and that these are significant differences in the enzyme activity, of mitochondria not only between those belonging to the different kind of blood cells but also even in those found in a cell. It has also been demonstrated that these enzymes are found as a farily dense contiguous mass mainly locating in the cristae of mitochondrion, and some in the mitochondrial membrane.
These observations show that there are some differences in the enzyme activity between the membrane and the cristae of mitochondria.抄録全体を表示PDF形式でダウンロード (1926K) -
第III編 冬季における溺死体臓器における植物性Plankton珪藻の死後における消長について白神 清敏1959 年 71 巻 4-2 号 p. 1929-1936
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーThe author has had an experiment on the changes by death, of the vegetative Plankton (diatoms) in the organs of drowned bodies at winter, and has acquired the following results:
1) There were the 11 Diatoms were found in the water of the river used for this exepriment.
2) Most Diatoms were found in the lung and femur even two months after death but in the heart, liver and kidney in which each organs became softon, found the Diatoms only one month after death. Even after treating those organs, just a few Diatoms could be found.
3) Among 11 Diatoms, Cymbells parva, Melosira islandica and Cyclotella comta were considered in the strength for resisting to decomposition; and it was Tabellaria fenestrata which was not found at the earliest time.抄録全体を表示PDF形式でダウンロード (379K) -
第1編 鉤虫犬の鉄代謝について上塚 香1959 年 71 巻 4-2 号 p. 1937-1948
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーUsing dogs such as ones spontaneously infected with hookworms, ones dewormed of these hookworms, those experimentally infected with hookworms showing marked intestinal hemorrhage as well as normal dogs (the control), and orally administering them radioactive iron, Fe59, the author determined the radioactive iron in erythrocytes and plasm periodically. Then 48 hours later perfusion is given and fractionating the visceral iron by Yoneyama-Konno's method, the iron contents and Fe59 are estimated.
As the results, it has been found that the iron-absorption rate is lowest in the dogs spontaneously infected with hookworms, followed in an ascending order of normal dogs and dewormed dogs, and highest in the dogs with experimental hookworm disease. As for the distribution of Fe59 absorbed, in the spontaneously infected dogs it is distributed mostly in the liver, spleen and bone marrow, demonstrating an extremely low portion of it taken into erythrocytes. In the dewormed dogs, on the contrary, the major portion of the absorbed Fe59 is taken up by erythrocytes and it is sparsely distributed in the liver, spleen and bone marrow, and this tendency is still more marked in the dogs with experimental hookworm disease, Furthermore, the iron contents of various organs in the dogs spontaneously infected with hookworms, though slightly less than in the normal, are greater than those found in the dewormed dogs, proving a marked decrease in the dogs with experimental hookworm disease. From these data it is assumed that there is a definite impediment to the absorption and mobilization of iron in hookworm disease and that such an impediment together with hemorrhage induce anemia.抄録全体を表示PDF形式でダウンロード (1810K) -
第2編 鉤虫乳剤注射の鉄代謝に及ぼす影響について上塚 香1959 年 71 巻 4-2 号 p. 1949-1958
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーAfter the oral administration of radioactive iron, Fe59, to the rabbits injected with emulsion of hookworms from human or dogs and to normal rabbits (control), the author investigated the effects of toxin of the hookworm body on the iron metabolism.
As the results the rabbits injected with hookworm emulsion show the lower rate of absorption by the digestive tract and up-take of the absorbed Fe59 to erythrocytes when compared with the control, and Fe59 tends to be distributed more in the liver, spleen and bone marrow. At the same time the iron contents in organs show a tendency of an increase as compared with the control.
From these findings it appears that toxin in the body of hookworm plays an important role in the disturbances of the absorption and mobilization of iron. In addition, the author conducted similar experiments on the rabbits with chronic anemia by blood depletion and on the rabbits with benzol anemia and compared their results.抄録全体を表示PDF形式でダウンロード (653K) -
第3編 鉤虫症血清注射の鉄代謝に及ぼす影響について上塚 香1959 年 71 巻 4-2 号 p. 1959-1968
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーBy oral administration of radioactive iron, Fe59, to the rabbits injected with the serum of patient with hookworm disease or with the serum of dogs with hookworms as well as to the rebbits (the control) injected with sera of normal person or of normal dogs, the author studied the effects of toxin in the sera of hookworm disease upon the iron metabolism.
As the results it has been found that the rate of iron absorption in the rabbits injected with the sera of hookworm disease is lower than that in the control, and in these test animals the rate of iron being taken into erythrocytes is also low. Fe59 tends to be distributed more in the liver and spleen, at the same time the iron contents in organs show a tendency of increasing. This tendency is exactly identical with the results observed in the rabbits injected with hookworm emulsion (Part 2), proving that the toxin in the serum of hookworm disease is also involved in the interferance with the absorption and mobilization of iron as the case of toxin of the body of hookworm.抄録全体を表示PDF形式でダウンロード (2531K) -
藤井 愼一郎1959 年 71 巻 4-2 号 p. 1969-1988
発行日: 1959/04/05
公開日: 2009/05/26
ジャーナル フリーIn this study, the auther has attempt to study electrophysiologically the aspect of pallidofugal fibers which are intermediated by the pallidum to the fibers arising from the motor area as the conduction system of epileptic discharge. Action potentials of motor cortex, basal ganglia, nuclei of the midbrain and spinal cord were recorded during major convulsive or subclinical seizures which are elicited by local administration of metrazol to the motor cortex or the thalamus of dogs. For subcortical recordings, a pair of bipor needle electrodes made of steel wire, mapproximately 200 μ in diameter on tungsten microelectrodes approximately 20 μ in diameter at the tip were used. Both steel and tungsten electrodes insulated by baking enamel except the tip. Spike discharges (duration of each spike is 20-60 msec. amplitude 50-100 μV recorded by abovementioned electrodes) are accounted for the epileptic discharges in this study.
The results were as follows:
1) There are two different pathways transmitting the discharges from the motor area to the pallidum, one is direct connection between the motor cortex to the pallidum and the other has some relays the nuclei, thalamus and caudate nucleus, between them. These different pathways are connected separately to two different pallidofugal fiber group at the pallidum.
2) The pallidofugal fiber group, which is connected to the former pathways at the pallidum, are relayed at the contralateral substantia nigra and then terminated to anterior horn cells of the spinal cord. There is a fiber crossing to the other side at the midbrain between the pallidum and substantia nigra.
3) The pallidofugal fiber group connected to the latter at the pallidum does not show crossing to the other side on its course to the homolateral substantia nigra.
But the downward fibers from the substantia nigra show a crossing to the other side at the pons and terminate in the contralateral anterior horn cells.抄録全体を表示PDF形式でダウンロード (3599K)
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