巻号一覧
76 巻 (1964)
- 11-12 号 p. 637-
- 10 号 p. 481-
- 7-9 号 p. 333-
- 4-6 号 p. 169-
- 1-3 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
76 巻, 7-9 号
選択された号の論文の13件中1～13を表示しています
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第1篇 重層法沈降反応による検討高木 健作1964 年 76 巻 7-9 号 p. 333-341
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーFluorocarbon extracted antigens from spleens and livers from normal and leukemia (lymphocytic and myelogenous) in C 58 mice were analysed by means of a precipitation ring test and the following results were obtained.
The viral antigen extracted from C 58 leukemic mice was different from the antigen extracted from C 58 normal mice.
The myelogenous leukemic antigen and lymphocytic leukemic antigen were not entirely different but shared a common antigenic component.抄録全体を表示PDF形式でダウンロード (1597K) -
第2篇Ouchterlony法並びに免疫電気泳動法による検討高木 健作1964 年 76 巻 7-9 号 p. 343-358
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーBy means of Ouchterlony's immunodiffusion method and immunoelectrophoresis the author analyzed fluorocarbon-extracted antigens from spleens and livers from 30 C 58 leukemic mice (16 myelogenous, 14 lymphocytic) and obtained the fellowing results.
1) Immunoelectrophoresis of normal antigens showed the presence of at least 25 precipitate components in the region of albumin, α-and β-globulin of normal serum.
2) The precipitate line specific to lymphocytic leukemic antigen was observed in the region of α-globulin of normal serum.
This line was found in 4 of 14 cases.
3) The precipitate line specific to myelogenous leukemic antigen was observed in the region of β-globulin of normal serum. It was found in 8 of 16 cases.
4) The precipitate line commou to both lymphocytic and myelogenous leukemic antigens but absent in normal antigen was found in the region of β-globulin of normal serum. It was detected in 8 of 14 lymphocytic leukemic cases and in 11 of myelogenous leukemic cases.
5) Staining of these lines specific to viral mouse antigens revealed that these precipitate lines contained proteins consisted of mucoprotein, glycoprotein and a trace of lipoprotein. The amount of DNA, however, was considered very small or entirely absent.抄録全体を表示PDF形式でダウンロード (15993K) -
第1編 ACTH,及び副腎皮質ホルモンによる実験的研究栗山 純一1964 年 76 巻 7-9 号 p. 359-370
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリー1) Pneumoconicosis was induced in rabbits by intratracheal injection of quarts powder and the prophylartic effects of predonisolone on the silicotic lung changes were studied.
2) The lymph nodes and lungs from predonisolone-treated and control groups were histologically examined. In the lymph nodes, there were no significant differences between these two groups, but the control lungs showed proliferation of septal macrophages, thickening of the alveolar wall, scattered quartz powder, and foreign body giant cells. These silicotic changes were seldom seen in the predonisolone-treated lungs.
3) It appeared that the steroid hormone was inhibitory to early silicotic changes and acted to prevent the development of silicosis.抄録全体を表示PDF形式でダウンロード (1984K) -
第2編 燐酸クロロキン,テトラハイドロオキシキノンによる実験的研究栗山 純一1964 年 76 巻 7-9 号 p. 371-379
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーQuarts powder was injected intratracheally into rabbits to induce experimental pneumoconiosis.
Simultaneous intravenous injections of chloroquine diphosphate or gastric intubation of tetrahydroxyquinone (THQ) were given. This was done with the expectation of preventing or delaying pulmonary fibrosis. As a result, though silicotic changes similar to those of the control group were found in the THQ-treated group, no such changes occured in chloroquine diphosphate-treated group.
Silicotic changes in the THQ-treated and control groups were as follows: The lungs showed proliferation of septal macrophages, thickening of the alveolar wall, scattered quartz powder, and foreign body giant cells. These silicotic changes were seldom seen in chloroquine diphosphate-treated lungs.
It appeared that chloroquine diphosphate was inhibitory to early silicotic changes and acted to prevent the dvelopment of silicosis.抄録全体を表示PDF形式でダウンロード (1219K) -
第3編 臨床的研究栗山 純一1964 年 76 巻 7-9 号 p. 381-391
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーSilicotic patients were administered predonisolon-chloroquine diphosphate, tetrahydroxyquinone (THQ) daily for eleven months and their subjective symptoms, heart lung-capacity, chest x-ray, and side effects were observed.
Patients given predonisolone-chloroquine diphosphate improved whereas the controls did not.
Of the group administered predonisolone-chloroquine diphosphate, twenty-five per cent of patients had improvement of subjective symptoms. All patients had increased maximum breathing capacity, and forty-three per cent had reduction of massive shadow on chest x-ray. In the control group or THQ-treated group, no improvement was found.
The side effects of these medicine were gastric troubles (nausea and anorexia) and slight pigmentation of the skin, but no changes were found in blood pictures, liver or adrenal functions. (Thorn's test).
From these facts we concluded that predonisolone-chloroquine diphosphate had beneficial effects on the patients but THQ did not.抄録全体を表示PDF形式でダウンロード (1105K) -
第1編 正常老壮年者の皮下脂肪厚について小坂 忠一郎1964 年 76 巻 7-9 号 p. 393-398
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーSkinfald thickness was measused in 102 subjects aged over 40 years using Keys's Caliper and its relationship by measuring points was considered.
Furthermore it was studied in 307 normel subjects with blood pressure less than 150 mmHg (systolic) and 90 mmHg (diastolic), in order to investigate a variation of the skinfold thickness by the body build and occupation.
Upper arm, abdomen and back ware chosen as a mesuring point.
Following results were obtained.
(1) The Skinfold thickness measured at three point were highly correlated among them.
(2) The skinfold thichness revealed largest in abdomen.
(3) The skinfold of the females, at each measusing point and each group, surpassed that of the males.
(4) The skinfold thickness was largest in the subjects aged between 40 and 50 years in both sex.
(5) Remarkable variation was seen in the skinfold thickness measured in abdomen and that mesured in back was considered to be best as a nutritional index.
(6) Skinfold thickness measured in abdomen was considerablly larger in the sedentary workers. No significant difference was seen in the thickness between abdomen and back in the manual workers.抄録全体を表示PDF形式でダウンロード (981K) -
第2編 高血圧者の皮下脂肪厚について小坂 忠一郎1964 年 76 巻 7-9 号 p. 399-408
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーTwo hundred and eighty five subjects aged more than 40 were chosen. Relationship of skinfold thickness with serum cholesterol and lipoprotein (β+γ/α ratio) was studied in the hyperensives.
The results were as follows.
1) In she hypertensive skinfold thickness increased especially of the abdomen,
2) Significant correlation was found between shinfold thickness and ophthalmoscopic findings and between skin-fold thickness and STT changes in the EKG.
3) Lipoprotein ratio and serum cholesterol were higher in the female than in malc aged more than 40. There were found low both male and female aged about 60.
4) Lipoprotein, cholesterol and skinfold thickness of abdomen showed well correlation and the skinfold thickness was considered to be a valid index of the lipid metabolism.抄録全体を表示PDF形式でダウンロード (361K) -
第一編 C58マウス白血病細胞の同系マウスへの移植による研究藤原 久義1964 年 76 巻 7-9 号 p. 409-417
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーIn 1961 two strains of transplantable leukemia in C58 mice were established in the Department of Internal Medicine, Okayama University Medical School. One is a lymphocytic leukemia (OHS-LL) of spontaneous origin and the other a myelogenous leukemia (OHS-ML) developing in a mouse inoculated with a cell-free extract from the lymphocytic leukemia. The present paper concerns transplantation experiments of both strains of leukemia into isologous mice.
Both strains of leukemia were transplantable in 100%, and the age or sex of the recipient mice did not considerably influence the survival days of the animals. The number of the inoculated leukemic cells and life span of the recipient mice showed an inverse relation, and even a single leukemic cell, when transplanted intraperitoneally, killed animals in 18 days. Transplantation of different organs indicated that the number of leukemic cells contained in the organs determined the survival pericds of the inoculated mice, and it was possible to assess the degree of leukemic infiltration in a given organ from the life span of the animals. The site of cell-graft influenced the survival days but very slightly the manifestation of the disease. However, the local changes following intracerebral, intratesticular and subcutaneous transplantation were more pronounced in OHS-LL in comparison with OHS-ML.抄録全体を表示PDF形式でダウンロード (1909K) -
第二編 C58マウス白血病細胞の抵抗に関する研究藤原 久義1964 年 76 巻 7-9 号 p. 419-427
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーTwo strains of transplantable leukemia in C58 mice described in the Part I, OHS-LL (lymphocytic) and OHS-ML (myelogenous), were compared as to the resistance and preservation of leukemic cells by means of bioassay experiments.
Both leukemic cell lines were not viable beyond 24 hours at room temperature, and rapidly lost transplantability at 65°C. For the preservation of leukemic cells it was more appropriate to keep them as frozen spleens or animals than to keep them as cell suspensions. OHS ML withstood for 60 days and OHS-LL for 47 days at -80°C., and it would be possible to preserve them for a longer period. OHS-ML was not transplantable below pH 5 and OHS LL below pH 3, indicating inferior resistance of the former to an acid solution. Both leukemic strains became negative for transplantation in NaCl solutions at 0% and over 10%, and showed no difference in osmotic fragility. Both cell stains proved to be cell-graftable after 5 times of freezing and thawing at -30°C. for 15 minutes, but not after 5 times of the same procedure at -30°C. for 60 minutes. Both cell lines were not transplantable after lyophilization. The lethal X-ray irradiation dose was 8, 000r against OHS-ML and 3, 000r against OHS-LL. OHS-ML became inactivated by formalin, trichloroacetic acid and marsonin at the concentration of over 10-1%, 10-2%, and 10-3%, and similarly OHS-LL at the concentration of over 10-2%, 10-1%, and 10-2%, respectively.抄録全体を表示PDF形式でダウンロード (557K) -
第三編 C58マウス白血病細胞の他系マウスへの移植による研究藤原 久義1964 年 76 巻 7-9 号 p. 429-437
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーIsologous transplantation experiments of two transp autable lines of C58 mouse leukemia, OHS-LL (lymphocytic) and OHS-ML (myelogenous) were reported in the Part I and II. The present communication deals with the results of homologous transplantation of these two strains of leukemia in C58 mice.
Mice used were strains C3H, Zb, AKR, ddN, C57Bl, Db, Strong A, Cb, Rf, D103, and RIII. When transplanted intraperitoneally, OHS-ML grew in 67% of C3H, 90% of Zb, and 30% of ddN, while OHS-LL grew in 30% of Zb, and 17% of AKR. All the other mice rejected the homotransplants. When injncted intravenously, OHS-ML grew in only a AKR mouse with negative takes in all the other cases. No positive takes resulted following subcu-taneous, intracerebral, and intratesticular transplantation. Temporary tumor formation was seen at the site of subcutaneous implantation of OHS-LL, which was not the case of OHS-ML. The pathological changes in mice showing positive takes of OHS-ML was similar to those of isologous transplantation, but mice bearing homografts of OHS-LL were atypical in that the latency was prologned with marked emaciation or without hepatosplenomegaly or lymphadenopathy. Some mice showed accumulation of ascites. OHS-ML could be serially passaged through Zb and C3H mice, and OHS-LL through Zb mice for 2 to 3 generations.抄録全体を表示PDF形式でダウンロード (570K) -
第2編 肝炎における肝表面像の観察について樋口 祥光1964 年 76 巻 7-9 号 p. 439-453
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーAlterations of the surface of the liver, in relation to histological findings, period of the course of hepatitis, splenomegaly, intraspleuic pressure and hepatic hemodynamics, were studied on 273 cases of viral hepatitis, which corresponded to “grosse rote Leber” and “grosse weisse Leber” introduced by Kalk.
1. Redness of the surface and enlargement of the liver were most frequently observed in the earliest stages of the disease and exhibited a relationship to the active histological changes of viral hepatitis.
2. Increased number and dilatation of small blood vessels as well as formation of small scars on the surface of the liver were observed in many cases showing a protracted course and were related to irreversible histological alterations. Abnormal hepatic blood flow was often demonstrated in these cases.
3. Splenomegaly was more frequently detectable in cases. with a longer period of the disease course. In relation to changes of the surface of the liver, increased, dilated small vessels on the surface were positively correlated with splenomegaly, whereas formation of small scars was negatively correlated.
4. There were some cases showing high intrasplenic pressure without an elevation of wedged hepatic venous pressure. These cases often corresponded to those of chronic hepatitis type III in peritoneoscopic classification (a type characterized by dilatation of small vessels on the liver surface) and type IIB in histological classification (a type characterized by scars in the Glisson's capsules).
5. Two sorts of small vessels were peritoneoscopically discernible on the surface of the liver: one was dendriform and the other retiform. Using intravascular injection of guttapercha, it was demonstrated that the majority of the former were originated from portal vein and the remainder from hepatic veins. On the other hand, the latter were branches of hepatic artery.抄録全体を表示PDF形式でダウンロード (1582K) -
第3編 肝炎時の門脈圧亢進症に関する腹腔鏡学的並びに肝生検材料の連続切片作成復構法による研究樋口 祥光1964 年 76 巻 7-9 号 p. 455-476
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーFactors causing portal hypertension were investigated on cases of chronic hepatitis (type III in peritoneoscopic classification), in which increased number and enlargement of small blood vessels on the liver surface were peritoneoscopically discernible and in which there were portal-hypertensive signs such as splenomegaly, enlarged vessels belonging to the range of portal vein. Three-dimensional observation on the hepatic blood circulation in hepatitis was performed by means of reconstruction of serial sections of liver tissues which were derived by hiopsy.
1. Narrowed vessels in the branches of portal vein below the 11th or 12th branch by Miyake were demonstrated in 14 out of 18 cases of chronic hepatitis with portal hypertension (43 out of 92 small branches of portal vein). On the other hand, such narrowing was observed only in 3 out of 13 cases without signs of portal hypertension.
2. In some cases, both narrowed branches and enlarged ones of portal vein were demonstrable on the same liver. Normal small branches were presumably enlarged in order to compensate the disturbad blood flow at the narrowed portions. In the Glisson's capsules with enlarged small branches of portal vein, there were few histological changes of fibrosis, cell infiltrations, etc.
3. Congestion of blood enlarges the vessels above the narrowed branches of portal vein. This may account for the enlargement of ‘Kollker’s Kapselvenc'' on the liver surface, which could be demonstraded by peritoneoscopic examination on the cases of chronic hepatitis type III.
4. In small branches of hepatic veins, few changes were observed even in cases with portal hypertension. Walls of vessels were thickened in some cases, but narrowing was not clearly discernible.
5. Cell infiltrations and fibrosis in the Glisson's capsules had a close relationship to narrowing of small branches of portal vein. Such histological alterations were assumed to be an important factor which produces narrowing of the vessels.
6. Portal hypertension in chronic hepatitis type III, therefore, may be caused chiefly by the disturbance of the pre-sinusoidal blood flow in portal vein, following the narrowed branches of the vessel.抄録全体を表示PDF形式でダウンロード (4483K) -
俵 寿太郎, 寺坂 隆, 坂野 才蔵, 西井 怜, 柴田 醇1964 年 76 巻 7-9 号 p. 477-479
発行日: 1964/09/30
公開日: 2009/08/24
ジャーナル フリーThe normal healthy human blood was heparinized with one-tenth volume of 0.1 per cent heparin solution. Ten thousand units of penicillin and 10 mg of streptomycin were added to each 100 ml of the blood. The whole blood was distributed into culture tubes in amounts of 0.5 ml or 1.0 ml.
The tubes were rubber-stoppered, inclined at 4045 degrees against the level, and iucubated in static state at 37°C. A few days after incubation, the plasma and free blood cells in tubes were discarded and washed with PBS twice. Then fresh culture medium was placed into the tubes to maintain a number of cells remained adhered on the wall.抄録全体を表示PDF形式でダウンロード (865K)
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