岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
81 巻, 1-2supplement 号
選択された号の論文の8件中1~8を表示しています
  • 日本脳炎の疫学的研究 第21報
    緒方 正名, 長尾 寛, 友国 勝麿, 寺谷 巌, 人見 硬, 高塚 佳子, 西岡 慶子, 安井 茂夫, 木南 富吉, 熊代 一男, 本郷 ...
    1969 年 81 巻 1-2supplement 号 p. 1-8
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The Japanese encephalitis patients of Okayama Prefecture in 1968 were less, and the median date of epidemic time curve was later in coming than in 1965-1967. In order to clarify this fact, variation of the level of HI and 2-ME sensitive antibodies in the serum of swine, canine, bovine and inhabitants were measured every week in summer of 1968, and the relationship between these seasonal variation of antibody level and the seasonal outbreak of patients were examined. By comparing these findings with those in 1965-1967, the following results were obtained.
    1) In both northern and southern parts of Okayama Prefecture in 1968 year, the respective date showing 50 per cent positive HI reaction and 2-ME sensitive reaction (D. 50% pos. HI and D. 50% 2-ME in short) in swine were 3 weeks later respectively than in 1965-1967.
    2) In canine of southern part of Okayama Prefecture and bovine of northern part, D. 50% pos. 2-ME was later in coming, and the positive rate of 2-ME sensitive reaction also was lower than that of the previous year.
    3) In inhabitants also, of both parts of the prefecture, D. 50% pos. 2-ME was more later in coming, and the positive rate of 2-ME sensitive reaction was also lower than in 1965-1967, that is, inhabitants received inapparent infection later and the rate of receiving inapparent infection was lower than in 1965-1967.
    4) The median date of the epidemic time curve of the prefecture in 1968 was later in coming than usual and also the morbility incidence rate showed its lower value than usual.
    From the results above mentioned, we could prove immunologically the following; transmission of Japanese encephalitis virus by mosquitoes, from swine as amplifire or other animals as the source of infection to various kinds of animals was later seasonally and smaller in quantity than usual, and also inapparent infection to inhabitants was later in date and the infection rate was lower, and correspondingly the prevalence of the epidemic was more later in coming and the morbidity incidence rate was lower than usual.
  • (日本脳炎の疫学的研究,第22報)
    緒方 正名, 長尾 寛, 実成 文彦, 北村 直次
    1969 年 81 巻 1-2supplement 号 p. 9-17
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    We devised the vaccination with formalin inactivated virus of Japanese encephalitis mixed with complete adjuvant to the swine, rabbits and chicks for inducing high titer of hemoagglutinin inhibiting (HI in short) and neutralizing antibody which could prevent viremia, when these animals were bitten by hazardous mosquitoes.
    The results obtained were as follows.
    1) The higher titer (1:240) of HI antibody was induced to swine, rabbits and chicks by two times injections of 1 ml of inactivated Japanese encephalitis vaccine with complete adjuvant, than that without adjuvant, and titer of HI antibody (1:53) showed itself 46 days after 1st injection. The neutralizing antibodies in the serum of swine, and rabbit obtained by the vaccination were proportional to HI antibodies.
    2) In rabbits, the group vaccinated with inactivated vaccine mixed with incomplete adjuvant yielded lower HI antibody than the group of complete adjuvant, but yielded higher HI antibody than the non-vaccinated group. Therefore this method, almost free from side effects, can be used as the vaccination.
    3) It was found on 27th of August that HI antibodies of swinewere increased by natural infection. And it was recognized that 2-mercaptoethanol resistant antibodies were prcduced by vaccination with complete adjuvant as well as vaccination without complete adjuvant. However 2-mercaptoethanol sensitive antibodies were produced in the swine of the non-vaccinated group by natural infection.
  • 日本脳炎の疫学的研究,第23報
    緒方 正名, 大崎 紘一
    1969 年 81 巻 1-2supplement 号 p. 19-23
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    For the purpose of forecasting the prevalence of Japanese encephalitis in Japan, we tried to get the correlation of factors among average atmospheric temperatures in prefectures of June and July in 1965-1967 (T 6, 7 in short), the date when HI reaction of swine became positive in degree of 50 per cent (D. pos. swine in short), the latitude and longitude in respective prefecture. And we estimated the median date of this epidemic time curve of the prevalence from the regression equation of one variable and multiple regression equation from the above factors using an electronic computer. And the following results were obtained.
    1) To estimate median date (y1, y2, y3, y4) of the epidemic time curve of the prevalence, we can use the next equation:
    The regression equation to estimate y from T6, 7 (x1) is as follows.
    y1=-8.0x1+236 σ0=10.1……(1)
    The regression equation from D. pos. swine (x2) is as follows.
    y2=0.67x2+31.8 σ0=10.0……(2)
    The multiple regression equation from T6, 7 and D. pos. swine is as follows.
    y3=-1.11x1+0.62x2+60.29 σ0=9.61……(3)
    The multiple regression equation from T6, 7 D. pos. swine, latitude and longitude is as follows.
    y4=-0.96x1+0.58x2+0.75x3-0.03x4+36.94
    σ0=9.57……(4)
    (2) We got the estimated value of median date in 15 prefectures in Kyushu, Chugoku, Shikoku, Kinki and Kanto provinces from (1) or (2) or (3) or (4) equation. Four prefectures out of 15 prefectures by equation (1), 10 out of 15 by (2), 10 out of 15 by (3), and 10 out of 15 by (4) could be estimated with 10 days error or less. Equation (2) is superior to (1), and (3) is very useful to correct the value in case of delaying of coming the D. pos. swine. The value from (4) is most correct, that is, the estimation by the multiple regression equation using many factors is most useful for the calculation.
  • (日本脳炎の疫学的研究,第24報)
    緒方 正名, 大崎 紘一
    1969 年 81 巻 1-2supplement 号 p. 25-28
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    For the purpose of forecasting the prevalence of Japanese encephalitis in Japan, we tried to get the correlation of factors among average atmospheric temperatures of prefectures of June and July in 1965-1967 (T6, 7 in short), the date when HI reaction of swine became positive in degree of 50 per cent (D. pos. swine in short), the latitude and longitude in respective prefecture. And we estimated the mode date of this epidemic time curve of the prevalence from the regression equation of one variable and multiple regression equation from the above factors using an electronic computer. And the following results were obtained.
    1) To estimate mode date (y1, y2, y3, y4) of the epidemic time curve of the prevalence, we can use the next equation:
    The regression equation to estimate y from T6, 7 (x1) is as follows,
    y1=-3.36x1+145.2 σ0=11.1……………(1)
    The regression equation from D. pos. swine (x2) is as follows.
    y2=0.63x2+43.7 σ0=9.0……………(2)
    The multiple regression equation from T6, 7 and D. pos. swine is as follows.
    y3=-1.15x1+0.56x2+73.29 σ0=8.84……………(3)
    The multiple regression equation from T6, 7 D. pos. swine, latitude and longitude is as follows.
    y4=-0.73x1+0.43x2+2.15x3-0.03x4-2.30 σ0=8.8……………(4)
  • 実成 文彦
    1969 年 81 巻 1-2supplement 号 p. 29-34
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    Effect of bursectomy of chicken's bursa of Fabricius to produce HI antibody of Japanese Encephalitis (JE) was determined by the injection of JE vaccine, and HI test of chicken's serum after the injection.
    On the non-bursectomized chicken, higher HI antibody was produced by twice injections of JE vaccine with complete adjuvant or once injection of JE vaccine with complete adjuvant followed by once injection of JE vaccine.
    In contrast to this, bursectomized chicken produced very low titer of HI antibody or did not produce at the first stage of injection.
  • 稲臣 成一, 板野 一男, 村主 節雄, 作本 台五郎, 頓宮 廉正, 木村 道也, 旦 基, 山本 友子
    1969 年 81 巻 1-2supplement 号 p. 35-53
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
    The light-traps were set up at 12 different places in Okayama Prefecture during the year 1968 as usual to observe the distribution of mosquitoes. We collected the data on the seasonal changes in the mosquito growth during the period of 7 months from April to October, when Japanese B encephalitis occurs in Okayama Prefecture, and studied the correlation between the propagation of mosquitoes and the incidence of the disease. Looking at the weather conditions as reported by the Okayama Weather Bureau the temperature during the period from the end of April to June, 1968 was 2-3°C lower than in 1967, and the day when the temperature exceeded 25°C was on July 17, being 5 days later than that in the preceding year, which persisted for 41 days, namely up to August 26, and the temperature fell below 25°C 16 days earlier than in 1967.
    As for the amounts of rainfall, we had as much rainfall as over 100 ml. on July 15, which proved to be favorable for mosquito growth. Mosquito growth in 1968 had its peak in the middle of July (in northern distiricts) and in the latter part of July (in southern regions), showing a shortening of the maximum growth period. When we observe the propagation of Culex tritaeniorhynchus (C. t.) the activity of C. t. started about 20 days later than in 1967, and the period of their activity is also prolonged about 20 days. On the other hand, in the number of C. t. caught there is not difference from that in the preceding year and also peaks have become smaller and sharper in the northern districts. In the southern regions the growth of C. t. is somewhat increased having the growth peaks during the period from the latter part of July to the beginning of August. The onset fo Japanese B encephalitis is seen about 3 weeks later, i. e. during the period between the end of August and the beginning of September. There were 12 patients of Japanese B encephalitis in 1968 according to the report by Okayama Prefectural Health Center and all of them proved positive to HI tests. This is a decrease of about 3/4 down to about one-fourth of 54 cases in 1967, and there was no fatal case among them.
  • 中山 沃
    1969 年 81 巻 1-2supplement 号 p. A1-A11
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
  • 1969 年 81 巻 1-2supplement 号 p. A13-A18
    発行日: 1969/02/28
    公開日: 2009/03/30
    ジャーナル フリー
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