岡山医学会雑誌
Online ISSN : 1882-4528
Print ISSN : 0030-1558
84 巻 , 7-8 号
選択された号の論文の7件中1~7を表示しています
  • 牧山 政雄
    1972 年 84 巻 7-8 号 p. 143-155
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
    The antimitotic effect of cornin extracted from dog intestine, are summarized as follows.
    1. Canine intestine cornin (CIC) inhibit the proliferation of HeLa cell in tissue culture. It's antimitotic effect, however, increases depend on the cornin dose per cell.
    2. CIC is stable substance. Antimitotic effect of CIC does not decrease after stocking in desiccater over 3 years, and also 2 days preincubation in 37°C. DTT treated CIC show no differences with untreated CIC in growing HeLa cell.
    3. Both dialysable and nondialysable fractions show antimitotic effect to HeLa cell. And nondialysable fraction is more effective.
    4. Ultrafiltration is done by Diafilter membrane. The most effective fraction of molecular weight is over than 55, 000. The next is molecular weight 20, 00055, 000, the third is molecular weight below 10, 000. The component molecular weight 10, 00020, 000 is slightly effective.
    5. The antimitotic effect of molecular weight over than 55, 000 fraction decreases by 2 days treatment in 0.025% trypsin at 37°C.
    6. CIC is separated in 3 fractions by Sephadex G200 column. The most effective fraction is FIII. It suggests that the antimitotic action of CIC is more effective in relatively small molecular weight of molecular weight over than 55, 000 fraction.
  • 西下 明
    1972 年 84 巻 7-8 号 p. 157-166
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
  • 西下 明
    1972 年 84 巻 7-8 号 p. 167-176
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
  • 西下 明
    1972 年 84 巻 7-8 号 p. 177-188
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
    With the purpose of elucidating the role of the stroma for the growth of tumors, the vascular structures in the parenchymal stroma and the surroundings of animal tumors were studied.
    In the first chapter, the vascular structures of Bashford tumors and Ehrlich subcutaneous tumors were examined employing the India ink method. The Blood vessels of tumors are derived from their surrounding host connective tissue. The structure of blood vessels of every tumor has features of its own. Further, it was observed that metastatic tumors in the lungs of Ehrlich ascites carcinoma and Brown-Pearce tumors had an individuality in their vascular structures.
    In the second chapter, the vascular structures of Ehrlich subcutaneous tumors and first generation transplants of C3H spontaneous mammary cancers were observed employing ultrasoft X-ray, and the relationship between the blood vessels and the stromaltissue of these tumors was investigated using several special staining methods. Characteristic features were also observed on the vascularization and the stromal tissues of Ehrlich subcutaneous tumors treated with chondroitin sulphate.
    In the third chapter, the influences of administration of Bleomycin on C3H spontaneous mammary cancers were abserved with respect to the vascular struture and stromal tissue. It was found that small tumor vessels were narrowed, obstructed and destroyed by administration of this drug. Further, it was observed that the vasculature and stromal tissue of lungs of mice and humans administered with this agent were likewise damaged, and that prednisolone and chloroquine considerably inhibited these pulmonary damages caused by this drug.
  • 清水 頼子
    1972 年 84 巻 7-8 号 p. 189-200
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
    1. 食細胞の異物認識機構を究明する目的で固定赤血球に対するマウス単球の付着・貪食過程を試験管内で観察し,次の様な結果を得た。
    2. ハンクス液中で単球は固定赤血球を付着,貪食するが,等張糖液中では付着も貪食もしない。
    3. 単球の固定赤血球付着率は媒液のイオン強度と一定の関係を示す.低イオン強度間ではイオン強度の指数函数に比例して直線的に付着率は減少する。
    4. 媒液のカルシウムイオン及びPH値は単球表面への固定赤血球付着現象に特別な関係はない。
    5. ナトリウムイオンを除いたハンクス液中で単球の固定赤血球付着能の抑制が起る。これはハンクス液の89%のイオンをナトリウムイオンがしめるためで媒液中のイオン強度減少による抑制反応である。
    6. メチル化固定赤血球は蔗糖液中でもハンクス液中と同様単球に付着する。
    7. 以上の実験結果より単球の異物認識機構は細胞表面及び貪食物表面の荷電と共に媒液のイオン強度が密接に関係していると結論される。即ち単球の固定赤血球付着は,表面の疎水基がかなり大きく働いて,先づ付着し,ついで表面の荷電基が働いて静電結合が起り両者の結合が強固になるものと考えられる。
  • 井上 堅太郎
    1972 年 84 巻 7-8 号 p. 201-207
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
    The author calculated, using Pasquill's chart, the logical concentration of sulfur dioxide concerning principal 15 chimneys in many places of Mizushima industrial area which had emitted 74 percent sulfur dioxide over Mizushima, and compared concentrations measured practically at the respective station of Fukuda-cho, Mizushima Harbor Office and Amagi with the logical concentration calculated by Pasquill's chart. The results obtained were as follows.
    1. The high concentrations of sulfur dioxide measured practically at Fukuda-cho station could be logically explained by the diffusion called C-stability following Pasquill, and those at Amagi station could be also explained by the diffusion called D-stability.
    2. Under the condition of each of A and B stabilities following Pasquill, sulfur dioxide diffused itself significantly on C-stability in Pasquill's chart, and in the case of each B and C stabilities, it diffused itself on D-stability in Pasquill's chart.
  • 1972 年 84 巻 7-8 号 p. 209-213
    発行日: 1972/08/30
    公開日: 2009/03/30
    ジャーナル フリー
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