巻号一覧
85 巻 (1973)
- 11-12 号 p. 527-
- 9-10 号 p. 393-
- 7-8 号 p. 231-
- 5-6 号 p. 161-
- 3-4 号 p. 59-
- 1-2 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
85 巻, 5-6 号
選択された号の論文の7件中1～7を表示しています
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近藤 忠亮, 広畑 衛, 瀬尾 憲司1973 年 85 巻 5-6 号 p. 161-164
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリーDirect bilirubins in vivo was fractionated into bilirubin diglucuronide, bilirubin phosphate and bilirubin sulfate. Influence of pH concentration on the absorptions maximum of each azo-pigment was studied. The schift of absorptions maximum was the same in the former two direct bilirubins and the latter moved as nearly as the indirect bilirubin-azo pigment yielded after an addition of methanol. These results was supposed to the difference was based on the structual difference of bilirubin due to the conjugation type of bilirubin.抄録全体を表示PDF形式でダウンロード (179K) -
平 光雄1973 年 85 巻 5-6 号 p. 165-182
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリー1. Actinomycin Dをイヌの髄液内に投与すると, 3～5日の長い潜時で動物は全身痙攣を起こした.この痙攣量は0.025mgであり,それによって42例中33例に痙攣が見られ,その平均潜時は89.5±10時間であった.痙攣型は定型的な全身痙攣であり,動物は激しく痙攣を繰返したのち全例死に至った.
2. Actinomycinic acidを髄液内に投与しても痙攣は認められなかった.
3. ネコの髄液内にactinomycin Dを投与して数日後に,動物は脳波上定型的なgeneralized seizure dischargeを反復して示した.この場合まず高振幅spikeの群発が起こり,これにspike and waveまたはpolyspike and wave complexがつづいた.やがてspike and wave complexの出現頻度がしだいに減少し,発作波が終了した.またactinomycin D投与により, hippocampusに顕著なspike dischargeが見られることがあった.
また痙攣前駆期において, myoclonic jerkの発生と同時に, hippocampusを除く全誘導に8cpsの規則的な波が見られた.
他方, actinomycinic acidの投与によっては,脳波上にも顕著な変化はあらわれなかった.
4. Actinomycin Dと同時にDNAを髄液内に投与し,その拮抗作用の有無をしらべたが,このDNAの投与によっては, actinomycin D痙攣は防止できなかった.
5. Actinomycin Dとmethionine sulfoximineとの干渉作用を検討し,痙攣閾量以下のmethionine sulfoximineはactinomycin Dの痙攣作用を妨げないが,逆に痙攣量の半量付近のactinomycin Dはmethionine sulfoximineの痙攣作用を抑制することを観察した.
6. GABA, GABOB, S-GABAのactinomycin D痙攣に対する確実な抑制作用は,ほとんど認められなかった.抄録全体を表示PDF形式でダウンロード (978K) -
江草 国之, 関 周二, 小田 琢三1973 年 85 巻 5-6 号 p. 183-187
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリーIn our previous observation, the T-antigen in unclond mouse embryo cells transformed by SV 40 or SV 40 DNA declined gradually through long term cultivation. To analyze whether this phenomenon is due to selection or reversion and/or conversion, we observed the T-antigen of a series of clones derived from a single cell in the SV 40-transformed cells by the immunofluorescent method.
The T-antigen was either positive or negative in all cells in each clone, and none of the clones was consisted of the mixture of T-antigen positive and negative cells. The T-antigen negative cells were more predominant in the rate of growth than the T-antigen positive ones in this mouse embryo cells. One reasonable explanation on the data may be that the decline of T-antigen in the uncloned SV 40-transformed cells is due to the selection of the T-antigen negative cells. This fact may be one of the reason for difficulty in establishing the SV 40-transformed mouse embryo cell lines.抄録全体を表示PDF形式でダウンロード (735K) -
第1編 好塩基球および好酸球の同時直接算定法の考案とその臨床的評価谷崎 勝朗1973 年 85 巻 5-6 号 p. 189-197
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリーImproved methods were made to count the absolute numbers of basophils and eosinophils by adding phosphate buffer to Kovács staining fluid. The improved method has following advantages.
1) Both basophil and eosinophil leucocytes can be easily recognized and identified simultaneously.
2) The staining fluid is stable for more than one year at room temperature.
3) Within two hours after filling a pipette, precipittates or ghost cells still do not appear.
4) This method is simple and convenient for the routine examination like calculation of peripheral leucocytes.
Changes of basophil leucocytes in the peripheral blood in various diseases were investigated with above described method. Basophilia was shown in allergic rhinitis, bronchial asthma, parasite infection, idiopathic thrombocytopenic purpura, acquired hemolytic anemia, hypothyroidism, iron deficiency anemia, chronic myelogenous leukemia and Addisons disease.抄録全体を表示PDF形式でダウンロード (556K) -
第2編 気管支喘息における好塩基球の動態に関する研究谷崎 勝朗1973 年 85 巻 5-6 号 p. 199-210
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリーUsing mainly our improved method of Kovács, Changes of basophilic leucocytes in peripheral blood were observed in 181 patients with bronchial asthma and 20 patients with allergic
occupational asthma caused by inhaling the body fluid of sea spuirts attaching to the shell of cultured Oyster.
This study shows that basophils have a strict relationship to asthmatic attacks; the basophils show a normal level in non-attack stage as in healthy controls, an increase in pre-attack, and tend to decrease in attack. A close observation on changes in the numbers of peripheral basophils almost make an early detection of the forth-coming attack possible. The threshold of asthmatic attack indicated by basophil count, 65/cmm, is very significant for the observation of forth-coming asthmatic attack, and this threshold of asthmatic attack varied, in some extent, though constant, in each case. These changes of basophils were similar in the cases given corticosteroids. In eosinophils changes were not so clear-cut.
Concerning a prolonged therapeutic course, basophils in bronchial asthma were over the threshold in the stage of repeated asthmatic attacks, and lower in the non-attack stage.
Patients with allergic occupational asthma showed these similar changes.抄録全体を表示PDF形式でダウンロード (1536K) -
第3編 慢性骨髄性白血病における好塩基球の動態に関する研究谷崎 勝朗1973 年 85 巻 5-6 号 p. 211-221
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリーBasophils in peripheral blood and bone marrow in 25 cases with chronic myelogenous leukemia (CML) were counted and morphologically classified by our improved method; basophilis were classified into I to V types. The III and IV types were subclassified to S type with sharply defined granules and diffuse N type. This classification was adapted for basophilograms.
The basophilogram in healthy controls showed a left type and that in CML generally a right type. It shifted to the left approaching to the normal type in the cases with remission by chemotherapy. In relapsing patients with CML, the basophilogram clearly shifted to the right.
The basophilogram seen in 2 cases with the pre-stage of blastic crisis of CML indicated a definite right type. It was shown that an increase of S type occurred in the relapsing stage. Therefore, appearance of S type as well as a right type in basophilogram would be a useful clue to follow CML patients clinically. A basophils of S type was considered to be immature. The bone marrow basophilogram was shown to be more shifted to the right than that of peripheral blood, and this tendency became more remarkable in relapse.
Presence of a right type in basophilogram and appearance of S type are significant to observe the clinical course in CML patients, especially for judging acute exacerbation.抄録全体を表示PDF形式でダウンロード (602K) -
江草 国之, 佐藤 啓子, 小田 琢三1973 年 85 巻 5-6 号 p. 223-229
発行日: 1973/06/30
公開日: 2009/03/30
ジャーナル フリーSensitized lymphocytes have been demonstrated to inhibit tumor growth in vivo systems. In SV40-viral oncogenesis, some specified immunization with virns and with virus-induced tumors to the animals results in rejection of further transplantation of the tumor cells. To analyze these phenomena by our specially devised cytotoxicity test, the authors have studied cell mediated immunity for tumor specific transplantation antigen (TSTA) in SV40 viral oncogenesis. The results suggest that sensitized lymphocytes inhibit the growth of heterogenic SV40-transformed target cells as well as syngenic ones. And the lymphocytes from tumor-bearing animals have lower ability of the inhibition on the target cells, which may be explained that the lymphocytes in tumor bearing animals are under the condition of immunologically insufficient state.抄録全体を表示PDF形式でダウンロード (834K)
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