巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
86 巻, 5-6 号
選択された号の論文の11件中1～11を表示しています
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石野 博志, 福井 秀明, 花岡 正憲1974 年 86 巻 5-6 号 p. 189-199
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリー1) One case of Inose-type of hepatocerebral disease was reported clinicopathologically.
2) The literature on spongy state of the gray matter of the nervous system is reviewed.
Fischer's opinion that the spongy state is the end result of neuron loss is no longer accepted.
The functional disturbances of Hortega's angio-glione are especially put forward nowadays.
A historical review of neuropile spongy state stresses the enormous contribution of the German neuropathological school. Different authors have studied some particular features which a posteriori take a new signification: Spielmeyer has discovered the notion of glial insufficiency; Konowalow has put forward the glio-capillary intoxication; Scholz has considered the problems of dysoria and serous exsudation; von Braunmühl has discussed the hydratation and deshydratation phenomena. Finally, Stochdorph has emphasized the importance of the main vascular territories.
The ideas of Spielmeyer, Scholz, von Braunmühl and Stochdorph remain highly and fundamentally valuable but must be associated together in order to obtain a dynamical conception of the way spongy state is produced.
Every spongy state results from different factors: some of them are susceptible to predominate but very often they act together.
According to the historical features we mentioned, it becomes evident that the facts revealed by the more recent developments of molecular biology represent only further progress and materialization of Hortega's angio-glione disturbances theory.抄録全体を表示PDF形式でダウンロード (3530K) -
友利 哲二1974 年 86 巻 5-6 号 p. 201-213
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーThe author studied on the protein synthesis of rat liver influenced by adrenal surgery. The rat liver conditions were normal, acute medical toxicosis, treated with anticancer agents, and liver cirrhosis. On these conditions, adrenalectomy, or adreno-portal operation was performed and the nessesity of glucocorticoid and importance of albumin were clarified.抄録全体を表示PDF形式でダウンロード (567K) -
小倉 義郎, 木村 雄介, 植村 恒義, 山本 芳孝, 宇田川 哲夫1974 年 86 巻 5-6 号 p. 215-219
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーHolographic interferometry is a specific technique for the analysis of vibration. Images of vibrating body reconstructed with this method are superimposed by interference fringes.
As the fringes represent iso-amplitude contours like those on geodesic maps, the mode of vibration is clearly discernible at a glance. As the amplitudes relating to each fringe are calibrated according to the wavelength of the laserlight the value is most precise and submicroscopic, viz., 10-5cm order.
In this study eardrum vibrations are investigated by means of time-averaged holography on frogs and guinea-pigs. The first fringe appeared at about 80 dB sound pressure level in both animals. The vibratory pattern appeared to be constant depending upon the number of frequencies of the test tones. At low frequency the eardrum showed rather a simple pattern; with increasing frequencies the pattern became more complicated containing two or more mounds.抄録全体を表示PDF形式でダウンロード (4388K) -
田辺 正忠, 玉井 豊理, 平木 祥夫, 江原 一彦, 高木 寿生, 羽井佐 芳雄, 久万田 泰昌, 若林 弘, 橋本 郷之助1974 年 86 巻 5-6 号 p. 221-229
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーWith 63 cases on whom we performed the scintigraphy of pancreatic diseases, we studied the possiblity of differential diagnosis and oter points relevant to the diagnosis in this disease group by comparing retrospectively clinical findings with postoperative findings of these cases, and arrived at the conclusions as follows:
1) For the scintigraphy of pancreas, scinticamera is excellent, and it is especially useful to take consecutive pictures at intervals of 10 minutes each for one hour with this camera after injecting 75Se-methionine.
2) The major cases of the pancreas that gives normal visualization can be considered as normal, but as normal pictures can be obtained even in the cases of chronic pancreatitis. There are some cases where differential diagnosis between the two disease groups is difficult by scintigraphic finding.
3) In the case of a focal decrease of uptake first of all cancer can be suspected. However, there are cases where differentiation from chronic pancreatitis is difficult. In such instances, about half of the cases demonstrating roentgenologically calcification proves to be of chronic, calcified pancreatitis, but excluding these cases the percentage of cancer cases is high.
4) Among those cases showing pancreas in scintigram faint or nonvisible, there were two cases out of 3 where chronic pancreatitis was complicated with calcification. Excluding the two cases, cancer occupies a decidedly high percentage, and the cancer is mostly located around the head of pancreas, indicating that pathologic changes have invaded main pancreatic ducts.
5) There were 7 cases of chronic, calcified pancreatitis, one case giving normal pancreatitis, one case giving normal scitigraphic findings, 4 cases a focal decrease of uptake, and two cases showing the pancreas faint or nonvisible.抄録全体を表示PDF形式でダウンロード (1623K) -
赤塚 和也, 高津 智子, 金政 泰弘, 俵 寿太郎1974 年 86 巻 5-6 号 p. 231-238
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーThe effects of growth on the lipid composition of liver from the white leghorn were studied. The studies were designed to determine liver dry weight, per cent total lipid, per cent neutral lipid, per cent phospholipid, neutral lipid class composition, phospholipid class composition and fatty acid composition at 0, 1, 2, 4, 7 and 18 days after hatch.
1. Neutral lipid content abruptly decreased but phospholipid slightly increased with ages after hatch.
2. Neutral lipid was fractionated further into cholesterol esters, cholesterol and mono-, di and triglycerides. The chicken just after hatch showed considerably high levels of cholesterol esters and cholesterol which decreased dramatically with growth, while it showed low level of glycerides which increased slightly.
3. Phospholipid was composed of phosphatidylcholine, phosphatidylethanolamine, cardiolipin, phosphatidylserine and phosphatidylinositol. Cardiolipin and phosphatidylethanolamine increased along with growth while hardly and difference could be seen in the composition of phosphatidylcholine, phosphatidylserine and phosphatidylinositol.
4. The principal fatty acids of neutral lipid as well as of phospholipid were myristic, palmitic, palmitoleic, stearic, oleic, linoleic and arachidonic acids. The unsaturation degree of fatty acids constituting both lipids were found to be decreased with growth. The greater part of the decrease in unsaturation degree of neutral lipid could be accounted for by the decrease in oleic and the increase in palmitic acid.
The decrease in unsaturation of phospholipid was mainly due to the decrease in arachidonic acid.抄録全体を表示PDF形式でダウンロード (397K) -
第1編 Bleomycinによる小型肺癌の治療高野 純行1974 年 86 巻 5-6 号 p. 239-250
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーSeven cases of lung cancer, five of them being so-called small sized, were treated with Bleomycin preoperatively and following results were obtained.
1) In X-ray studies the reduction of tumor size was obtained in three cases, the thinning of tumor shadow in two cases, and the change of shadow configuration in two cases.
2) In histological sections, the degeneration of cancer cells and bizarre cells were seen in all cases. Moreover coagulation necrosis and fibrosis of cancer tissue were also seen in all cases.
3) As to the influence of Bleomycin to the normal lung tissue, the swelling of alveolar cells, the widening of alveolar septa and interstitial edema of alveoli as well as the dilation and edema of the alveolar capillaries and sparseness, swelling and thickening of vascular wall were seen. These capillary and vascular changes showed a parallel relation to the total dose of Bleomycin.
4) Six patients, who were operated, have survived from two years and a half to four years, and have no relapse.
From these findings, the author believes that in the opeartion of lung cancer, the preoperative administration of Bleomycin of 150mg, combined with fibroblast-inhibiting agents, would be beneficial for the prevention of the postoperative recurrence and of the lung fibrosis due to Bleomycin.抄録全体を表示PDF形式でダウンロード (13714K) -
第2編 Bleomycinによる原発性肺癌(進行癌)及び転移性肺腫瘍の治療高野 純行1974 年 86 巻 5-6 号 p. 251-259
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーTwenty-four cases of lung cancer, mainly of advanced cases and seven cases of metastatic lung tumors were treated with Bleomycin in combination with fibroblast-inhibiting agents such as chloroquine, phytonadione and prednisolone, and following results were obtained.
1) Of 24 lung cancers, 14 cases were evaluated by the chemotherapy evaluation standard adopted by the Japan Society For Cancer Therapy and “improvement” in 4 cases, “no change” in 8 cases and “aggravation” in 2 cases. The effects evaluated with histlogical types included “improvement” in 2 cases of 4 epidermoid carcinomas, but “no improvement” in adenocarcinomas and in undifferentiated carcinomas.
2) Of 7 metastatic lung tumors, 4 cases were evaluated, and “improvement” was obtained in a case of uterus carcinoma origin.
3) The side effects of Bleomycin were changes of skin such as pigmentation or sklerosis in 7 cases, phlebitis, fever and pulmonary disorder in 3 cases each, epilation and anorexia in 2 cases and stomatitis in 1 case. Of these side effects, pulmonary disorder must be paid careful attention and early detection of its occurrence is required and combination of fibroblast-inhibiting agents is believed necessary for the prevention of its occurrence.抄録全体を表示PDF形式でダウンロード (4888K) -
第3編 肺癌の予後に関する臨床的検討高野 純行1974 年 86 巻 5-6 号 p. 261-268
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーWe have studied 93 lung cancer patients, who were treated in this hospital for the past eleven years, with regard to the factors which influence the prognosis, by figuring out the survival curve, and obtained the following results.
1) Of various treatments, operation is the most favourable for the median survival and combination-therapy of irradiation and chemotherapy is the second, and chemotherapy only is the least favourable. In chemotherapy cases, the median survival shows little difference between different drugs used.
2) Of each clinical stage, Stage I is the most favourable, Stage II is the second, and Stage III and Stage IV is not favourable for the median survival. In chemotherapy cases, patients with Stage I+Stage II are the longest in the median survival, but their survival is shorter comparing with the total cases of Stage I+Stage II.
3) In 58 cases, whose cell types were defined, the median survival of adenocarcinoma cases is the longest, and that of undifferentiated carcinoma cases the second and that of epidermoid carcinoma cases the shortest.
4) In two groups of patients which are divided before and after 1968, the median survival of latter groups is apparently long, but in the cases treated with chemotherapy, the median survival of the two groups show little difference, although the latter group contains many effective cases.
5) In three groups according to the therapeutical effects (‘improvement’, ‘no change’, ‘aggravation’), the median survival of the group of ‘improvement is the longest, but the group of ‘no change’ shows almost the same survival, indicating there is no strict correlation between the prolongation of life and effect of chemotherapy. The results stated above lead to the following conclusions.
I) For the improvement of the prognosis of lung cancer, early detection and operation should be done.
II) The advanced cases had better be treated with the combination therapy of radiation and chemotherapy.
III) At present, the effect of chemotherapy is not as great as it should be, but could be improved by minimizing its side effects.抄録全体を表示PDF形式でダウンロード (487K) -
第1編 Ehrlich腫瘍の増殖に及ぼす間質成分の影響西崎 良知1974 年 86 巻 5-6 号 p. 269-275
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーIn 1925 Fisher found that the growth of Rous sarcoma was acceralated by adding fibrobalsts into the culture medium of the sarcoma. Takeuchi found that the rapidly growing tissue of Brown-Pearce cancer contained much mucopolysaccaride and he suggested that mucopolysaccaride had acceralated the tumor growth.
On the basis of these findings, the author has attempted a few experiments as follows:
Experiment 1.
Chondroitin sulfate was injected into Strong A mice either subcutaneously or intraperitoneally. After this pretreatment, Ehrlich ascites tumor cells were transplanted to the back of mice. The tumor growth was observed until they were killed on the 12 th day after the transplantation.
No signigicant difference in the tumor weight was found between the control group and the group which had been pretreated by the intraperitoneal injection. A significant difference in the tumor weight, however, was found between the control group and the group given the subcutaneous pretreatment (P<0.01).
Experiment 2.
By using the same method, some other substances (extracts of L-strain cells and of mouse fetus, and P. V. P.) were studied. No intraperitoneal injection was tried this time.
A significant difference in the tumor growth was found between the control group and the group which had been pretreated with the extracts of L-strain cells and mouse fetus, but not between the controls and the group pretreated with P. V. P..抄録全体を表示PDF形式でダウンロード (421K) -
第2編 Ehrlich腫瘍及びSarcoma 180の増殖に及ぼす無菌性炎症及び間質成分の影響西崎 良知1974 年 86 巻 5-6 号 p. 277-286
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーThe author's previous paper reported that chondroitin sulfate and some other substances accelerated the growth of Ehrlich ascites tumor. In this paper. the author studied the relationship between inflammation and tumor growth.
The tumor cells were transplanted to the back of mice where inflammation had been proboked by injecting croton oil two days prior to the transplantation.
Experiment 1.
The daily growth of the transplanted Ehrlich ascites tumor was observed in the controls and the groups with either chondroitin sulfate or the inflammation until the 14th day after the transplantation when they were killed.
The tumor growth in both the chondroitin sulfate group and the inflammation groups was significantly faster than in the control group (P<0.01).
Experiment 2.
Using sarcoma 180, the same experiment was performed and the same results were obtained as in the Ehrlich ascites tumor.
Experiment 3.
The influence of chondroitin sulfate and the inflammation on the growth of Ehrlich ascites tumor was histologically studied.
1. Although no morphological differences of the tumor cells themselves were found in the group pretreated with chondroitin sulfate as compared with the control, the space between each tumor cell was wide, and tumor tissue seemed to have grown multifocally. The number of ma-The number of mast cells around the tumor tissue was definitely increased in the chondroitin sulfate group, but there was not so much difference in the amount of connective tissue and metachromatically stained fibers.
2. Compared with the control group, the inflammation group showed large amount of connective tissue around the tumor, and the tumor cells seemed to have been scattered into the network of fibrous tissue.
The number of mast cells was decreased in the inflammation group.
These findings were not observed in the chondroitin sulfate group.抄録全体を表示PDF形式でダウンロード (6365K) -
1974 年 86 巻 5-6 号 p. 287-292
発行日: 1974/06/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (283K)
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