巻号一覧
71 巻 (1959)
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- 11supplement 号 p. 1-
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前身誌
89 巻, 5-6 号
選択された号の論文の20件中1～20を表示しています
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田村 仁1977 年 89 巻 5-6 号 p. 551-564
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーThe hippocampal formation of mouse, rat, guinea pig, rabbit, cat, dog, goat and monkey were seen by sulfide silver technique. Intense positive reaction to the this method was found in the stratum radiatum of h3, h4 and h5 of the hippocampus, as well as the stratum multiforme of the fastia dentata. All these areas corespond to the endings of mossy fibers at the apical dendrit of pyramidal cells in the hippocampal formation. No histochemical reaction of zinc was observed in the brains of rat of newborns up to 10 day after birth. The hippocampal formation showed a slight reaction on and after the 11 day of life and the zinc contents of these areas reacted almost normal level about 2 weeks after birth.
Histochemical evidence has been observed by the sulfide silver method that the zinc distributed in the region becomes temporarily undemonstrable for a certain brief period (1-3 hours) following administration of dithizone (200 mg/kg).
Sections taken at 1.5 hours after administration of dithizone (5 mg/kg) showed positive reaction by the sulfide silver method. During the first three hours following the administration of dithizon (10 mg/kg-300 mg/kg) the hippocampal formation remains unstained.
The distribution of zinc in the hippocampal formation of the rat was changed by circadian rhythm.抄録全体を表示PDF形式でダウンロード (8249K) -
近藤 忠亮, 中村 教夫, 米井 二郎1977 年 89 巻 5-6 号 p. 565-569
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーBiliary bilirubin conjugates were investigated in heterozygote Gunn rat after loading of phenobarbital or bucolome for 4 days. 50mg of phenobarbital or 200mg of bucolome per Kg of body weight was given intramusculary once a day. The bile collection by bile duct canulation was started 24 hours after the final drug loading and continued for 22 hours. The following results were obtained:
1) Bile volume increased significantly in both groups compared with the control group (no treatment group). The amount of excreted bilirubin increased significantly in the phenobarbital loading group than the control group, but not in the bucolome loading group.
2) A significantly increased amount of biliary bilirubin sulfate was observed in the Phenobarbital loading group compared with the control group, but not in the bucolome loading group.
3) The amount of excreted biliary bilirubin glucuronide increased significantly in the phenobarbital loading group compared with the control group, but not in the bucolome loading group.抄録全体を表示PDF形式でダウンロード (219K) -
第1編 乳癌ラットのGonadal Hormoneについて庄 達夫1977 年 89 巻 5-6 号 p. 571-578
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーGonadotropin was assessed using radioimmunoassay on the rat sera of DMBA-induced breast cancer and tissue obtained from DMBA-induced rat breast cancer.
In the above materials, there were no significant differences in the amount observed between control group and nontreated groups, ovariectomized and adrenalectomized animals. After removal of the both ovaries and adrenal glands, the rats were given estradiol followed by lutenizing hormone-releasing hormone. In these treated animals' sera, the level of lutenizing hormone was elevated markedly. Concerning the organ uptake of 125I-lutenizing and follicle stimulating hormones after their intraperitoneal injections, one found the highest distribution of these hormones in the kidney and liver and in lesser degree, in the DMBA-induced rat breast cancer tissue and ovary.抄録全体を表示PDF形式でダウンロード (387K) -
第2編 人乳癌のGonadal Hormoneについて庄 達夫1977 年 89 巻 5-6 号 p. 579-587
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーGonadotropin was assessed using radioimmunoassay on sera from the patients with breast cancer.
Lutinizing and follicle stimulating hormones in the sera showed higher level in the breast cancer patients, who are in pre- and post-menopause, ovariectomized and adrenalectomized, than among control. Sequential changes of lutenizing and follicle stimulating hormones in the patients, who had bilateral adrenalectomies due to advanced and recurrent disease, were observed. The hormonal level rose rapidly until the 7th post-operative day, and then was kept rising gradually for one month after the operation. In patients with breast cancer, who are administered lutenizing hormone-releasing hormone, the level of follicle stimulating hormone in the sera elevated rather slowly and no marked peak as compared to healthy subjects.抄録全体を表示PDF形式でダウンロード (370K) -
石川 純1977 年 89 巻 5-6 号 p. 589-607
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーRats were given MNNG perorally and were killed periodically. In the effective 69 rats, after 26 weeks, 67 lesions of glandular epithelial proliferation developed in glandular stomach of rats. These lesions were classified in three types, as follow: 1) Type A (43 lesions) with scanty cellular and structural atypism. 2) Type B (20 lesions) with moderate grade of atypism. 3) Type C (4 lesions) with severe atypism which can be easily diagnosed as carcinomatous.
In histological and electron microscopical aspect of their stroma, type A lesions are surrounded by prominent formation of both fibroblast sheath and basement membrane.
However, type B lesions exihibit the reminiscent or absence of basement membrane, as well as fibroblast sheath, especially in the following situation: 1) cytoplasmic protrusion into the extra-epithelial space. 2) occurrence of polymorphonuclear leucocytes adjacent of the epithelium 3) fibroblast directly contact with the epithelium 4) basement membrane appeared corrugated and multiple layered, which is similar to the human gastric cancer, mainly as poorly differentiated adenocarcinoma.
In the present time, histological criteria of the experimental stomach cancer is not clear. But, in this study the author suggest that the type B lesions can be concluded to stomach carcinoma, because various changed of the basement membranes in the type B lesions are similar to poorly differentiated adenocarcinoma of human gastric cancer.
The changing mode of the basement membrane is contributed not only by epithelical cells but also by mesenchymal cells, especially fibroblasts. Moreover MNNG could affect both these two types of cells, because various mesenchymal tumors are produced.抄録全体を表示PDF形式でダウンロード (5332K) -
沖田 美佐子1977 年 89 巻 5-6 号 p. 609-613
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーTyramine and octopamine were identified by means of mass fragmentography in human serum. The peaks identical to the retention time of tyramine and octopamine were found on gaschromatogram obtained from serum sample. Two fragments, M/e 316 and M/e 303 in mass spectrum of tyramine were used in tyramine identification, and M/e 528 and M/e 515 were used in octopamine identification. As the experimental results, the ratio M/e 303: M/e 316 of the sample was identical to that of authentic tyramine, and ratio M/e 515: M/e 528 was identical to that of authentic octopamine. These results suggest that tyramine and octopamine could exist in human serum.抄録全体を表示PDF形式でダウンロード (619K) -
第I編 特にEstrogen binding proteinの分析について鶴野 正基1977 年 89 巻 5-6 号 p. 615-625
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーEstrogen binding protein (EBP) in mammary tumor was studied in DMBA induced rat mammary carcinoma, Shionogi carcinoma 115, Shionogi carcinoma 42 and human mammary tumor by use of 3H-estradiol.
Free and bound estradiol was separated by Sephadex G-25.
Specific EBP was calculated 4.5S by sucrose gradient centrifugation. Non-specific EBP was observed in the 3.2S-3.6S region of the ultracentrifugal analysis.
Specific EBP was migrated to anodic region of α- or β-position in disc electrophoresis.抄録全体を表示PDF形式でダウンロード (1842K) -
第II編 特にホルモン依存性との関連について鶴野 正基1977 年 89 巻 5-6 号 p. 627-635
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーHormone dependency of mammary tumor was studied from the concentration of estrogen binding protein (EBP) by use of 3H-estradiol. Estrogen dependent rat mammary tumor induced by DMBA was high concentration of EBP, and androgen dependent tumor of Shionogi carcinoma 115 and non-dependent tumor of Shionogi carcinoma 42 were low concentration of EBP. In human mammary tumor the dependent tumor was high and the independent tumor was low concentration of EBP.
In case of hormonal dependent breast cancer, EBP was bound above 3μg/mg. protein of estradiol. In case of independent ones, it was below 2μg/mg. protein.
Specific EBP was migrated to anodic region of α - or β -position in disc electrophoresis.抄録全体を表示PDF形式でダウンロード (800K) -
第1編 DMBA誘発乳癌ラットにおけるProlactin valueについて郷原 真清1977 年 89 巻 5-6 号 p. 637-643
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーSerum prolactin values in S-D strain female rats with DMBA induced mammary tumors were measured by double antibody radioimmunoassay. Serum prolactin values before and after resected DMBA induced tumors were similar, but serum prolactin values of ovariectomized rats were remarkably fallen with reduced tumors. Serum prolactin values after both ovariectomy and adrenalectomy followd by administration of cortisol were remarkably rised, but were reduced.抄録全体を表示PDF形式でダウンロード (316K) -
第2編 人乳癌のProlactin valueについて郷原 真清1977 年 89 巻 5-6 号 p. 645-652
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーSerum prolactin values on patients with breast cancer were measured by double antibody radioimmunoassay. In postmenopausal normal and women with mastopathy disease serum prolactin values were higher than premenopausals, and in premenopausal breast cancer patients they were higher than postmenopausals. But these results were within normal limits. Serum prolactin values of breast cancer patients after ablative hormone therapy also were within normal limits.抄録全体を表示PDF形式でダウンロード (339K) -
第1編 組織培養法とdiffusion chamberとによる可溶性因子の検索竹内 義郎1977 年 89 巻 5-6 号 p. 653-658
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーFor the in vitro studying transplantation immunity of mice the soluble factors of sensitized lymphoid cells were investigated by the tissue culture and diffusion chamber methods. As the result it was found that sensitized lymphoid cells obtained from A(H-2a) mouse sensitized 9 days previously by a skin graft from C3H (H-2k) mouse, and enclosed within the diffusion chamber did not inhibit the proliferation of the primary culture kidney cells from C3H mouse. However, sensitized lymphoid cells obtained from C3H mouse sensitized 9 days previously by a skin graft from A mouse, and enclosed within the diffusion chamber did inhibit the proliferation of the primary culture kidney cells from A mouse.
In other words, the soluble factors elaborated by the sensitized lymphoid cells exert cytotoxic action on target cells, and such action seems to grow more marked as the difference in H-2 histocompatibility antigens becomes greater.抄録全体を表示PDF形式でダウンロード (1006K) -
第2編 マクロファージ遊走阻止試験間接法による可溶性因子の検索竹内 義郎1977 年 89 巻 5-6 号 p. 659-665
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーFor the in vitro studying allograft immunity of mice the soluble factors of sensitized lymphoid cells were investigated by indirect macrophage migration inhibition test. As a result it has been shown that the sensitized lymphoid cells obtained from A (H-2a) mouse previously sensitized by a skin graft from C3H (H-2k) mouse elaborate macrophage migration inhibition factor (MIF) over a long period of time though migration inhibitory activity is not so strong. The sensitized lymphoid cells obtained from C3H mouse previously sensitized by a skin graft from A mouse show a strong migration inhibitory activity but the period of MIF production is short. In either instance MIF becomes measurable 5 days after skin grafting, and it can no longer be measured after the time when all the skin graft has become necrotic.
In other words, the extent of the migration inhibition activity seems to reflect the degree of difference in the H-2 histocompatibility antigens, and the time-lapse changes in MIF would serve as a useful parameter of allograft rejection.抄録全体を表示PDF形式でダウンロード (1074K) -
第1編 14C標識可溶性コラーゲンを基質としたコラゲナーゼの迅速測定法の検討寺戸 国昭1977 年 89 巻 5-6 号 p. 667-677
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーA rapid assay method of collagenase activity has been developed using 14C-labeled soluble collagen as substrate. This method is based on following three parts; first, carrying out the enzyme reaction with 14C-labeled collagen in solution containing 0.25M glucose to prevent collagen fiblil formation at 35°C under neutral condition, second, denaturation of the enzyme digestion products at 35°C for 1hr after stopping the reaction by adding o-phenanthroline and third, selective extraction of the denatured 14C-products into dioxane at a final concentration of 50% and counting 14C-activity in the surpernatant. The rate of the reaction was about 10 times higher than that obtained by the conventional method using reconstituted collagen fiblils as substrate and relationship between enzyme activity and enzyme concentration was linear over a wider range regardless of the purity of collagenase.抄録全体を表示PDF形式でダウンロード (1199K) -
第2編 ヒト好中球および関節液コラゲナーゼ活性測定への溶液法の応用寺戸 国昭1977 年 89 巻 5-6 号 p. 679-691
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーA newly developed collagenase assay method using 14C-labeled soluble collagen as substrate has been applied to the determination of collagenase activity in human leucocytes and synovial fluids. The results indicated that collagenase activity in the both samples could be measured by this method as observed with tadpole collagenase, except that 35% dioxane was preferable for the extraction of the enzyme digestion products in the case of synovial fluids. Collagenase activity determined by the present method was well correlated with that obtained by the conventional assay method using reconstituted collagen fiblils as substrate (r=0.963 and 0.829 (p<0.01) respectively).
In preliminary experiments with leucocytes from patients with diabetes mellitus (DM), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), it was observed that collagenase activity in leucocytes increased significantly in SLE and from some patients with RA, while no appreciable differences were observed in diabetics, compared to that in normals.
In synovial fluids from patients with RA and osteoarthritis (OA), the accumulation of large amount of inactive (latent) form of collagenase was demonstrated by the treatment of synovial fluids with 3M KI. And it was varied significantly in one patient at different time while no appreciable amount of the active form was observed during the period.抄録全体を表示PDF形式でダウンロード (1218K) -
第1編 Neocarzinostatin単独による寛解導入療法上村 致信1977 年 89 巻 5-6 号 p. 693-699
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーNeocarzinostatin (NCS) is an antitumor antibiotic isolated from streptomyces carzinostaticus by Ishida et al. in Japan in 1957. The chemical structure of NCS is a single chain made of acidic polypeptide consisting of 112 amino acids. Its antitumor activities have been demonstrated in various experimental tumors.
Its mode of action is considered to inhibit DNA synthesis at early stage of S phase and to block it at G2 phase. The agent has been used clinically for solid tumors without remardable effects, although never been used in treating human leukemia. For the first time the author has given NCS alone to patients with acute leukemia in the dose ranging from 0.04-0.06mg/kg/day for 4-5 days as one course of treatment. In case no sufficient remission was induced further courses of treatment were repeated after an internal of 4-10 days, and obtained the following results.
1) Of 18 cases 7 (38.9%) attained complete remission and 4 (22.2%) partial remission.
2) Complete remission was obtained even in the patients with refractory varieties of acute leukemia, i.e., acute promyelocytic leukemia, monocytic leukemia and leukemia in aged group.
3) No noteworthy side effects other than occasional nausea or anorexia were observed and suppression on normal hematopoiesis was very slight.
From these results it can be concluded that NCS is one of the most potent antileukemic agents for inducing remission in acute leukemia.抄録全体を表示PDF形式でダウンロード (353K) -
第2編 Neocarzinostatinを中心にした多剤併用による寛解導入療法上村 致信1977 年 89 巻 5-6 号 p. 701-711
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーIn an attempt to improve the chemotherapy of acute leukemia in adults, the author has studied the induction therapy on 63 cases with acute leukemia with Neocarzinostatin (NCS; N) in combination with conventional antileukemic agents; Vincristine (V), Daunorubicin (D), Cytosine Arabinoside (A), 6-Mercaptopurine-Riboside (M) and Prednisolone (P).
Eighteen cases with acute lymphocytic leukemia (ALL) was treated with protocol A (NVMP, NDMP, NAMP). Out of 45 cases with acute non-lymphocytic leukemia (ANLL), 25 was treated with protocol A and 20 treated with protocol B (NADP, NAVP), and obtained the following results.
1) Of all 63 cases 51 (81.6%) attained complete remission and 9 (14.3%) partial remission.
2) Complete remission was obtained in 15 cases (83.3%) out of 18 with ALL and 36 cases (80.0%) of 45 with ANLL; the latter cases with ANLL consisted of 18 of 25 cases (72.0%) treated with protocol A and 18 of 20 cases (90.0%) with protocol B.
3) Refractory varieties included cases with acute myelogenous leukemia who had passed through atypical hematological findings, cases with monocytic leukemia, cases with WBC count over 50, 000 per μl or with nucleated cell count in bone marrow over 500, 000 per μl before treatment and cases over 50 years old.
4) In this induction therapy with NCS in combination, antileukemic effects was remarkable, while suppression on normal hematopoiesis, especially on thrombocytes, was very slight.
5) As to the other side effects no noteworthy disturbances other than occasional nausea, anorexia and liver damage in protocol B were observed.
From these results it can be concluded that NCS in combination is one of the most potent remission induction therapies in acute leukemia in adults.抄録全体を表示PDF形式でダウンロード (1137K) -
石井 義久, 平野 和博, 河合 辰哉, 斉藤 大治, 原岡 昭一1977 年 89 巻 5-6 号 p. 713-720
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーApexcardiogram by mean of non-invasive method may be more usefull provided that the technique for the transducer attachment was easier and reprodusable. In this report, some attempts on the transducer of apexcardiogram were described.
A precordial electrode was placed about 1.5 mm above the chest wall of a patient. The electrostatic capacitance between the electrode and chest wall was transmitted to the CR oscillator and it modulated the frequency of pulse train generated with the oscillator. The signals were led to a conventional D. C. recorder or a cathode ray oscilloscope.
There was no remarkable differences of the wave pattern between the apexcardiogram obtained by our method and by conventional piezoelectric transducer in normal cases. In some patients, however, some differences were observed especially in the depth of O-wave. The depth of O-wave increased in accordance with a rise in pressure of the transducer to the chest wall using the conventional method.
The observations suggest that the A/E-O ratio might be varied depending on attaching pressure of the transducer to the chest wall.抄録全体を表示PDF形式でダウンロード (2014K) -
石津 日出雄1977 年 89 巻 5-6 号 p. 721-724
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーThe distribution of haptoglobin (Hp) types of 600 healthy adults in Okayama district was examined by the method of Smithies', and the following results were obtained.
1) The phenotype distribution of Hp types in Okayama district was found to be: Hp 1-1, 39 (6.5%); Hp 2-1, 234 (39.0%); and Hp 2-2, 327 (54.5%), and the calculated genotype frequencies are Hp1=0.260 and Hp2=0.760.
2) No relationship between the distribution of Hp types and sex, ABO blood groups or Rh (D) blood groups was observed.抄録全体を表示PDF形式でダウンロード (169K) -
第1編 健常若年者と加令に於ける血清と膵液遊離アミノ酸の比較検討佐々木 雅英1977 年 89 巻 5-6 号 p. 725-735
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーThe effect of aging on the free amino acid in serum and pancreatic juice was studied, particularly in relation to the concentraion and the secretion dynamics of them, followed by some interesting results.
1. Concentration fo almost all kinds of serum amino acids were decreased in the fasting state of the aged, especially in essential amino acid. Moreover, the concentration of free amino acid in the female aged was less than in the male aged.
2. The concentration of serum amino acid fluctuated more strongly in the aged after the injection of Pancreozymin and Secretin (P-S) and substantially, non-essential and glycogenic amino acid were augumented.
3. In the course of P-S stimulated amino acid secretion in pancreatic juice, the aged showed a delayed response time, at which the concentration of amino acid would reach the maximal level and also displayed the less fluctuated curb.
4. In totally recovered amino acids from pancreatic juice stimulated by P-S, the concentration of phenylalanine and arginine were significantly decreased in the aged, and also alanine, valine, isoleucine, leucine, glutamic acid and lysine were decreased.抄録全体を表示PDF形式でダウンロード (1069K) -
第2編 糖尿病・慢性膵炎・膵癌に於ける血清並びに膵液遊離アミノ酸の比較検討佐々木 雅英1977 年 89 巻 5-6 号 p. 737-747
発行日: 1977/06/30
公開日: 2009/03/30
ジャーナル フリーThe concentration and its dynamics of the amin acid in serum and pancreatic juice were observed comparatively among the diabetics the chronic pancreatitis and the pancreas cancer, together with the endocrine and exocrine function of pancreas. Patients with the chronic pancreatitis and/or the pancreas cancer were pointed out their abnormal exocrine function of the pancreas. On the contrary, the diabetics was proved to have an abnormal endocrine function and a disorder of the free amino acid metabolism in serum and pancreas juice, as followed.
1. Glutamic acid, valine and lysine were highly increased in the fasting serum amino acid of the diabetics. The dynamic change of amino acid concentration fluctuated more strongly in the course after P-S stimulation of the diabetics than of the normal control.
2. The time at which the concentration of amino acid would reach the maximal level, delayed significantly in the pancreas cancer as well as in the diabetics. Alternatively, in the chronic pancreatitis all the amino acids diminished their concentraion in pancreas juice.
3. In regard with the concentration of the free amino acid recovered from pancreas juice after P-S stimulation, the diabetics reduced all of them other than alanine, gutamic acid and lysine which were inversely increased.抄録全体を表示PDF形式でダウンロード (3840K)
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