巻号一覧
96 巻 (1984)
- 11-12 号 p. 1037-
- 9-10 号 p. 865-
- 7-8 号 p. 665-
- 5-6 号 p. 449-
- 3-4 号 p. 263-
- 1-2 号 p. 1-
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
96 巻, 11-12 号
選択された号の論文の15件中1～15を表示しています
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宮田 輝雄1984 年 96 巻 11-12 号 p. 1037-1051
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーCalcification of articular tissue has been studied much since McCarty and others confirmed that pseudogout is caused by deposition of calcium pyrophosphate dihydrate (CPPD) crystals. However, there has been little attention paid to the hip joint in which detection of calcification is difficult because of the joint's deep location. In this study, arthritic hips were examined pathologically in relation to joint calcification.
In cases of total hip replacement (THR), the rate of pathological calcification was 11.7 percent in osteoarthritis, 13.7 percent in rheumatoid arthritis and 22.2 percent in avascular necrosis of the femoral head. However, blood chemical examinations showed no abnormalities in parathyroid or kidney function, so these cases were classified as sporadic articular calcification. Macroscopically calcified hips were found in 11 percent of the autopsy cases. Articular calcification causing crystal-induced arthritis in cases with severe secondary coxarthrosis treated with THR occurred often.
Calcified deposition was found in the articular cartilage as well as in the limbus, and even in synovial tissues. Light microscopy and scanning electron microscopy clearly demonstrated CPPD crystals. Infra-red spectrograms showed pyrophosphate crystals. In light microscopic observations, calcification in the articular cartilage appeared as granular accumulations of the crystals in the matrix of the surface and intermediate layers. Especially, the granular deposits were recognized in the marginal area of the chondrocyte lacunae in the intermediate layer. However, crystal deposits were seen along the fissures of collagen fibers in the surface and intermediate layer of the limbus. The crystals were square, rod or cube shaped, and 0.1-3.5 μm×0.2-4.0 μm in size, as were CPPD crystals detected previously.抄録全体を表示PDF形式でダウンロード (3981K) -
橋本 啓二, 木本 真, 白神 敏明, 新屋 晴孝, 加地 充昌, 戸上 泉, 小山 直樹, 日野 裕之, 山本 博道, 平木 祥夫, 杉田 ...1984 年 96 巻 11-12 号 p. 1053-1061
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーWe investigated the relationship between the frequency of basal ganglia calcification appearing in CT scans and clinical symptoms in 3, 599 patients. Basal ganglia were calcified in eleven patients (0.3%), of whom seven had calcification of the bilateral G. Pallidus, but no clinical symptoms. A relationship between calcification and clinical symptoms was shown in two patients under ten years old, a three-year-old with young brain atrophy and a six-year-old with a gonadotropin-producing brain tumor. Especially in patients over forty years old, a direct relationship between G.P. calcification and clinical symptoms was not shown, and calcification was considered to be pyhsilogical.抄録全体を表示PDF形式でダウンロード (1667K) -
松島 紀志夫, 小栗 宣博, 若狭 弘之, 中桐 義忠, 三上 泰隆, 平木 祥夫, 木本 真, 橋本 啓二, 青野 要, 藤本 亘, 小玉 ...1984 年 96 巻 11-12 号 p. 1063-1071
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーElectron beam therapy of lesions such as cutaneous metastatic carcinoma and reticulum cell sarcoma is performed via multiple portals for a wide irradiation field. However, the dose distribution in border areas is generally uneven, resulting in hot and cold dose areas depending on the intervals of the portals. We performed electron irradiation by the pendulum technique, especially on curved areas, and evaluated the technique in various respects.
Pendulum electron beam irradiation is indicated when the length of the cone must be reduced in order to deliver the target volume near the skin surface as well as to avoid the occurrence of hot spots deep in the body. We prepared a 15cm rotating cone by cutting a 30cm fixed irradiation cone. The modification posed no disadvantages in terms of extent and flatness of the beam, or stability during rotation. After determining the relationship between the rotation speed and the dose, the technique was successfully applied to a patient with adult T-cell lymphoma, at a total of 3000cGy.抄録全体を表示PDF形式でダウンロード (3480K) -
deafferentation hyperactivityとの関連性からの考察清水 洋治1984 年 96 巻 11-12 号 p. 1073-1089
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーDeafferentation hyperactivity, which was produced unilaterally in the neurons of the subnucleus caudalis of the spinal trigeminal nucleus (STNcd) in cats by a Gasserian ganglionectomy, was studied neurochemically and electrophysiologically.
The distribution of STNcd neurons responsive to various stimulations of the face was first determined with the extracellular microelectrode recording technique in 10 cats. Unilateral sensory deafferentation was made by a left Gasserian ganglionectomy in 6 cats. Spontaneous hyperactivity, which became progressively intensive, was provoked in the neurons of the denervated STNcd for about 10 days after the ganglionectomy.
In the principal experiment, another 18 adult cats were unilaterally devervated. The analysis of neuronal activities on both sides of the STNcd was done 11 to 63 days after the denervation. On the non-denervated side, as many as 44 of the 51 STNcd neurons identified were wide dynamic range neurons. On the denervated side, 37 neurons (57%) of the 65 neurons identified showed deafferentation hyperactivity. Continuous and spontaneous firings of these hyperactive neurons were inhibited neither by the intraventricular administration of morphine or enkephalinamide nor by the electrical stimulation of periaqueductal gray. In contrast, the facilitation of the pain perceptive neuronal activities in the STNcd of the non-denervated side, was remarkably inhibited both by the administration of the same drugs and by periaqueductal gray stimulation. After Gasserian ganglionectomy, the cats showed abnormal behavior never seen in those without the ganglionectomy: incessant rubbing of the face of the denervated side against the cage caused the vibrissae to break and the skin to ulcerate.
These results are compatible with the clinical experiences that the facilitation of the opioid-mediated pain inhibiting system is effective in relieving pain in patients with excess pain, but not in patients with deafferented pain. Therefore, the deafferentation hyperactivity produced in this experiment in the STNcd of the denervated side may have a close physiological relationship to the deafferented pain of clinical patients.抄録全体を表示PDF形式でダウンロード (4336K) -
第1編 走査型電子顕微鏡による観察佐藤 俊雄1984 年 96 巻 11-12 号 p. 1091-1104
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーIn order to observe peripheral monocytes by scanning electron microscopy (SEM), a simple method was developed as described below. Mononuclear cell suspensions prepared by Ficoll-Hypaque gradient centrifugation were fixed in 1% paraformaldehyde and then stained with alpha-naphthyl butyrate which served to specifically identify monocytes. Monocytes were recognized by their red-brown color under a light microscope, and processed for SEM. The monocytes were characterized further in healthy controls and patients with bronchogenic carcinoma using this method. The surface of monocytes from controls was uneven and covered with ruffles and ridges. The monocytes from patients with bronchogenic carcinoma were smaller and had more large ruffles than controls.
The changes in the surface of monocytes when treated with some chemoattractants were less obvious in patients with bronchogenic carcinoma than in healthy controls.
This method is useful in studying the surface structure of peripheral monocytes and may help in further examining monocyte function.抄録全体を表示PDF形式でダウンロード (2423K) -
第2編 膜表面受容体と貪食能佐藤 俊雄1984 年 96 巻 11-12 号 p. 1105-1117
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーThe phagocytic function of monocytes was measured by complement-binding zymosan particles (ZC). The phagocytic indices of monocytes prepared by glass-adherence and by gradient centrifugation were closely correlated (r=0.95, p<0.01). The former method was easier than the latter in the identification of monocytes. The phagocytic index was significantly reduced in patients with bronchogenic carcinoma (mean=53.2±20.2, p<0.01), malignant lymphoma (mean=52.9±20.6, p<0.01), and sarcoidosis (mean=51.1±20.2, p<0.01) compared with controls (mean=76.0±14.5). In contrast, there was no significant difference between controls and patients with pulmonary tuberculosis (mean=77.0±14.2). In bronchogenic carcinoma patients, a low phagocytic index was observed in all clinical stages. However, there was no significant correlation among phagocytic index, histological type and stage of disease. The C3 and Fc receptors of monocytes were also determined by rosette formation with ZC and IgG-treated ox erythrocytes (EA), respectively. In bronchogenic carcinoma, the percent of C3 receptor bearing monocytes was lower than that of controls, but the percent of Fc receptor bearing monocytes was in the normal range. However, the phagocytosis of EA was enhanced in comparison with controls. These data showed that monocyte phagocytic function was suppressed in patients with bronchogenic carcinoma. It was suggested that malignant tumors might affect monocyte function.抄録全体を表示PDF形式でダウンロード (872K) -
第1編 Dystonic型およびathetotic型脳性麻痺患者の節電図学的研究村上 昌穂1984 年 96 巻 11-12 号 p. 1119-1134
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーSeven dystonic and eight athetotic patients with cerebral palsy were clinically diagnosed following the classification of motor symptoms of the American Academy for Cerebral Palsy, and examined with surface electromyography while at rest in the supine position, under mental stress, making voluntary contractions and responding to passive stretch.
Involuntary movements of both dystonic and tension athetotic cerebral palsy were characterized by nonreciprocal involuntary muscle activity in agonists and antagonists. There was more tonic involuntary muscle activity in dystonic than in tension athetotic cerebral palsy patients. During involuntary movements in three dystonic patients, muscle action potentials recorded simultaneously in different muscles had a uniform pattern of duration and amplitude. Electromyographical findings under mental stress were almost the same as those at rest in both dystonic and tension athetotic forms, except that the amplitude and duration of muscle activity was larger under mental stress than at rest. When both dystonic and tension athetotic patients were asked to make voluntary contractions, they were unable to do so smoothly, because involuntary movements were induced in agonists and antagonists. Especially in dystonic patients, voluntary efforts induced involuntary movements not only in agonists and antagonists but also in other muscles not concerned with voluntary contraction. In all dystonic patients, the responses to passive stretch were characterized by rigidity or rigidospasticity. In five tension athetotic patients, the stretch reflex was characterized by spasticity, but in three patients the stretch reflex was not seen at all. Therefore, it is assumed that dystonic movements arise from rigidity or rigidospastic hypertonus. In three dystonic patients, the stretch reflex brought about action potentials not only in antagonists of the stretched muscle, but also in other muscles not concerned with passive stretch. These synchronized action potentials were neither of involuntary muscle activity induced by passive stretch nor of paradoxical contraction of Westphal. It is presumed that such action potentials are induced by suprasegmental central mechanisms closely related to the stretch reflex.抄録全体を表示PDF形式でダウンロード (4669K) -
第2編 脳性麻痺における定位脳手術と遠隔成績村上 昌穂1984 年 96 巻 11-12 号 p. 1135-1150
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーStereotaxic operations were carried out in 96 cases of athetotic cerebral palsy to relieve involuntary movements and muscle hypertonus between 1955 and 1970, of which 43 cases (22 dystonic, 21 tension athetotic) were followed up postoperatively from 6 months to 12 years at the clinic or by questionnare. Many severely disabled patiensts were included in this study and 30 of the 43 cases belonged to Class IV of the classification of functional capacity of the American Academy for Cerebral Palsy. Ages at operation ranged from 5 to 40 years, and about a half of the patients were 5 to 10 years. Targets of operation included the ventrolateral nucleus of the thalamus (VL), VL plus centromedian nucleus of the thalamus (CM), globus pallidus (GP) and field of Forel H. A total of 79 operations were performed in these 43 cases. Sixteen (11 dystonic, 5 tension athetotic) out of the 43 cases were operated on unilaterally and 27 (11 dystonic, 16 tension athetotic) were operated bilaterally.
Concerning the relationshp between targets and postoperative results, both VL and GP lesions were effective on muscle hypertonus. However, VL or VL plus CM lesions produced better effects on both involuntary movements and muscle hypertonus than GP or field of Forel H lesions. Patients who had improvement in voluntary control were limited to those who had good results in both involuntary movements and muscle hypertonus. Dystonic patients generally obtained much better postoperative results than tension athetotic patients. Postoperative courses of bilateral operations were variable and complex. When bilateral operations are attempted, it is desirable that the contralateral operation be performed more than six months after the initial one. Dystonic patients operated on unilaterally maintained excellent postoperative results for a long period. Dystonic patients who were operated on bilaterally also had good surgical results for long periods. However, the long-term results in tension athetotic patients operated on either unilaterally or bilaterally were not as good as those in dystonic patients. Therefore, the dystonic form of cerebral palsy is a good candidate for stereotaxic operation. Complications of the operations were of almost the same frequency in unilateral and bilateral operations. In bilateral operations, the bilateral VL lesion and VL plus CM lesion were the most effective long-term. When motor symptoms recurred, they did so within six months of the operation.抄録全体を表示PDF形式でダウンロード (2498K) -
第1編 サルコイドーシス患者における気管支肺胞洗浄液の検討小林 洋三1984 年 96 巻 11-12 号 p. 1151-1161
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーThe present study was designed to investigate the local immunity and pathological state of sarcoidosis. Cell populations and angiotensin converting enzyme (ACE) activity were examined in the fluid obtained by bronchoalveolar lavage (BAL) of 28 patients with sarcoidosis and 31 healthy volunteers.
The proportion and number of lymphocytes in BAL fluid were significantly higher in patients with sarcoidosis than in healthy volunteers. Furthermore, the number of T lymphocytes and B lymphocytes were increased. The cell number in BAL fluid was also higher in non-smokers with sarcoidosis than in healthy non-smokers. The ACE activity in bronchoalveolar lavage fluid (BALF-ACE activity) was highly elevated in patients with sarcoidosis as compared with healthy volunteers and correlated with the number of macrophages in BAL fluid of non-smokers with sarcoidosis (r=0.474, p<0.05). The elevation of BALF-ACE activity was suggested to be due to alveolar macrophages. In smokers with sarcoidosis and healthy volunteres who smoked, the number of cells and macrophages in BAL fluid was markedly increased, while the number of lymphocytes was not affected by smoking.
It was concluded that lymphocytes, mainly T lymphocytes which play a major role in forming granuloma, were incerased in patients with sarcoidosis and that high BALF-ACE activity was probably due to activated macrophages and epithelioid cells in sarcoid granulomas of the lung.抄録全体を表示PDF形式でダウンロード (1697K) -
第2編 Corynebacterium parvumとMuramyl dipeptideによる実験的肺肉芽腫症作製の試み小林 洋三1984 年 96 巻 11-12 号 p. 1163-1174
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーPropionibacterium acnes (P. acnes) is isolated in high incidence from biopsied specimens obtained from patients with sarcoidosis. In some reports, P. acnes successfully produced localized granulomatous changes in experimental animals, but not systemic granulomatous changes. The present study was undertaken to analyze the formation of granulomatous lesions, especially the immunological mechanism of epithelioid granuloma formation, induced by sensitization with Corynebacterium parvum (C. parvum) and muramyl dipeptide (MDP).
Intratracheal administration of MDP to guinea pigs presensitized with C. parvum produced epithelioid granulomas in the lungs and regional lymph nodes, but not in the liver and spleen. These granulomas in the lungs gradually invated regional lymph nodes and were observed a relatively long time, as the patients with sarcoidosis. An increase in lymphocytes was found in bronchoalveolar lavage fluid of sensitized animals in accordance with granuloma formation in the lungs. This result suggests that lymphocytes play a major role in producing epithelioid granulomas.
Serum angiotensin converting enzyme activity was elevated in guinea pigs, in which granuloma formation was recognized. These data suggest that activation of macrophages and lymphocytes is necessary to produce epithelioid granulomas and persists for a long time in experimental animals.抄録全体を表示PDF形式でダウンロード (3489K) -
松島 紀志夫, 若狹 弘之, 小栗 宣博, 北山 卓一, 中桐 義忠, 三上 泰隆, 橋本 啓二, 平木 祥夫, 青野 要1984 年 96 巻 11-12 号 p. 1175-1182
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーThe fieldsize in electron beam therapy is determined by the cone size. In cases of skin metastasis of a malignant tumor and so on, which need a large field size and whose area is much larger than the size of the cone, a large field size is usually produced by dividing the portals. However, the dose distribution at the border of the field becomes unequal, and hot and cold dose areas are produced according to the distance between portals. We tried the strip field technique in a large field along the long axis of the body in order to flatten the dose of the border employing the moving strip used for whole abdominal irradiation in ovarian cancer.
We set the film in Mix-DP and used the strip field technique with 2.5cm steps. We discussed the relationship between the interval (distance between portals) and the flattening of the dose within the field. Skin movement due to breathing and influences on the flattening of the dose were considered.
The proper flatness was obtained at depths of 0, 1, 2, and 3cm by setting the interval at 0.5cm. When skin movement was produced by breathing in ±1.5mm, the proper flaness was obtained also at a 0.5-cm interval. It seems that smoothing is increased by breathing.
An “electron beam moving strip” with a 2.5-cm step and 0.5-cm interval was clinically effective in the treatment of patients with skin metastasis of colon cancer.抄録全体を表示PDF形式でダウンロード (3216K) -
第1編 抗HLAモノクロナール抗体結合制癌抗生剤(ブレオマイシン,マイトマイシンC, マクロモマイシン)の作製とその生物活性眞鍋 雄一1984 年 96 巻 11-12 号 p. 1183-1193
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーBleomycin (BLM) and mitomycin C (MMC), potent anticancer agents, were linked covalently to murine monoclonal anti-HLA IgG1 antibody (H-1) with the use of dextran T-40. Macromomycin (MCR) was coupled to H-1 in the presence of carbodiimide. H-1 alone did not inhihit cell growth. BLM-(H-1) and MMC-(H-1) conjugates showed stronger cytotoxicity to an HLA-bearing cell line than BLM and MMC, respectively. MCR-(H-1) and free MCR showed the same cytotoxicity to HLA-bearing cells, while the conjugate was less toxic than free MCR against cells lacking HLA. These results indicate that BLM-(H-1), MMC-(H-1) and MCR-(H-1) exert antibody-targeting cytotoxicity in vitro.抄録全体を表示PDF形式でダウンロード (575K) -
第2編 抗HLAモノクロナール抗体結合代謝拮抗制癌剤(サイトシンアラビノシド,メソトレキセート)の作製とその生物活性眞鍋 雄一1984 年 96 巻 11-12 号 p. 1195-1203
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーThe anticancer agents 1-β-D-arabinofuranosylcytosine (ara-C) and methotrexate (MTX) were linked covalently to murine monoclonal IgG1 antibody (H-1) with the use of dextran T-40. H-1 alone did not inhibit cell growth. The ara-C-(H-1) conjugate showed weaker cytotoxicity to an HLA-lacking cell line than ara-C, while ara-C-(H-1) and ara-C showed the same cytotoxicity to HLA-bearing cells. The MTX-(H-1) canjugste showed stronger cytotoxicity to HLA-bearing cells than MTX, while MTX-(H-1) and MTX showed the same cytotoxicity to cells lacking HLA. These results indicate that ara-C-(H-1) and MTX-(H-1) exert antibody-targeting cytotoxicity in vitro.抄録全体を表示PDF形式でダウンロード (433K) -
松島 紀志夫, 永谷 伊佐雄, 稲村 圭司, 門久 繁文, 中桐 義忠, 三上 泰隆, 杉田 勝彦, 青野 要1984 年 96 巻 11-12 号 p. 1205-1215
発行日: 1984/12/30
公開日: 2009/03/30
ジャーナル フリーIn 1979, we published an article about an alternate irradiation system in the Japanese Journal of Radiological Technology. This system was very useful for wide local radiation.
In the present study, we examined the usefulness of this system in T-shape fields for patients bearing esophageal cancer, lung cancer, etc; in a 90° angle, two-portal teratment for a patient with maxillary cancer, and in a tangencial treatment for a patient bearing a rib metastatic tumor.
The system was very useful, and side effects were minimal.抄録全体を表示PDF形式でダウンロード (4319K) -
1984 年 96 巻 11-12 号 p. 1217-1231
発行日: 1984/12/30
公開日: 2012/10/29
ジャーナル フリーPDF形式でダウンロード (6637K)
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