巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
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- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
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- 9-2 号 p. 5773-
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- 4-2 号 p. 1655-
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- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
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- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
98 巻, 3-4 号
選択された号の論文の15件中1～15を表示しています
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第1報 年齢階級別状況について大原 啓志, 堀川 俊一, 久繁 哲徳, 畑田 一憲, 鈴木 順一郎, 吉田 健男, 井谷 徹, 太田 武夫, 青山 英康, 大平 昌彦1986 年 98 巻 3-4 号 p. 219-231
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーWe investigated changes in life styles and health problems among the aged population in a rural area by means of a questionnaire differentiated as to age. Responses were obtained from 1, 545 (92.5%) out of 1, 671 people 65 years of age or over living in Ohgata Town, Kochi Prefecture, in March of 1982. Two hundred people in hospitals or nursing homes were excluded from the survey.
Among the aged of Ohgata, 1.6% and 9.0% were living in hospitals or nursing homes, respectively. Those in the hospitals increased with increasing age. Five percent of the males and 22.8% of the females lived alone, and no difference was observed according to age group. Sixty percent of the males and 80.2% of the females had jobs or roles at home, and significant decreases in those with roles were observed from 70 and 80 years of age or over in males, and between any successive 5-year age group in females. Seventy-seven percent of the respondents met with their friends, and 57.3% joined in the activities of old peoples' clubs. These rates decreased steeply from 80 or over in males and 85 or over in females. About the perceived health status, 54.9% of males and 51.3% of females had no complaints and those without preblems decreased slowly with increasing age.
Those who needed others' help in any of the activities of daily life such as eating, going to the toilet, bathing, dressing, washing the face or walking were 6.3% of males and 6.6% of females, and were over 20% among those 85 or over. Those with troubles in walking but without troubles in other activities were 7.2%, increasing steeply from 80 or over.
These findings demonstrated that age factors had important impacts on the health and welfare needs of aged.抄録全体を表示PDF形式でダウンロード (711K) -
第2報 家族構成別状況について大原 啓志, 堀川 俊一, 久繁 哲徳, 畑田 一憲, 鈴木 順一郎, 吉田 健男, 井谷 徹, 太田 武夫, 青山 英康, 大平 昌彦1986 年 98 巻 3-4 号 p. 233-241
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーProblems in life styles and health status according to family type and the presence or lack of a spouse among the aged in a rural area were investigated. The subjects were all residents of 65 or over who lived at home in Ohgata Town, Kochi Prefecture, in March of 1982. Responses to the questionnaire survey were obtained from 1, 545 (92.5%) out of 1, 671. The subjects were divided into three groups of family type, that is, “single”, “couple” and “other”, and into two groups by marital status, that is, “married” and “not married”.
The perceived health status of “single” subjects was not different from that of “other” subjects, but those requiring help in activities of daily living (ADL) were less among “single” than among “other” females. Also, the perceived health of “couples” was worse than that of “others” among males. No differences were observed in the rate of those with work among the three groups of family types. Those joining in group activities were fewer, but not significantly, so among “single” men than among men of the other two groups, but no differences were observed among females. The perceived health status of “married” males were worse than that of the “unmarried” males, but no differences were observed among females.
Those with work were greater among “married” than “unmarried” subjects of both sexes, and those having a role at home were greater among“married” than “unmarried” females. No differences were observed in the rate of joining in group activities or health practices between “married” and “unmarried” subjects.
These findings demonstrated that family patterns played the same important role in the health and welfare needs of aged people as age factors.抄録全体を表示PDF形式でダウンロード (443K) -
第1編 難治性成人急性非リンパ性白血病に対するaclarubicin, cytosine arabinoside併用療法効果原 雅道1986 年 98 巻 3-4 号 p. 243-254
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーSixteen patients with refractory acute non-lymphcytic leukemia (ANLL) were treated with 2 different therapeutic regimens including aclarubicin (ACR) and cytosine arabinoside (ara-C). ACR, 45mg/m2, was administered daily by intravenous rapid infusion from, day 1 to 3 in Regimen 1, and the same dose of ACR, divided into 2 doses, was administered every 12 hours by intravenous infusion from day 1 to 3 in Regimen 2. Ara-C, 80mg/m2, divided into 2 doses, was given every 12 hours by intravenous infusion from day 1 to 7 in Regimen 1 and 2. Seven of 10 patients, 70%, obtained a complete remission (CR) with Regimen 1, and 1 of 6 patients, 16.7%, with Regimen 2. The days required for CR ranged from 22 to 55 days (median: 40 days). The duration of CR ranged from 2 to 13 months (median: 9.3 months), and the survival from the initiation of therapy was from 9 to 41.3 months (median 19.6 months) in responders. Side effects on the digestive system such as nausea and vomiting were seen in 14 of 16 patients, 87.5%, but they were all controllable. The combination of ACR and ara-C, particularly Regimen 1, was also found to be more effective in the clinical management of refractory ANLL than a NCDVP (neocarzinostatin, area-C, daunorubicin, vincristine and prednisolone) regimen.抄録全体を表示PDF形式でダウンロード (624K) -
第2編 急性非リンパ性白血病寛解導入におけるdaunorubicin, cytosine arabinoside併用療法ならびにaclarubicin, cytosine arabinoside併用療法の比較検討原 雅道1986 年 98 巻 3-4 号 p. 255-264
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーA comparative trial of a combination of daunorubicin (DNR) and cytosine arabinoside (ara-C) (Regimen A) and a combination of aclarubicin (ACR) and ara-C (Regimen B) was performed. Sixteen patients with acute non-lymphocytic leukemia, previously untreated, included in this study. Five of 8 patients, 62.5%, obtained a complete remission (CR) with both Regimen A and B. The days until CR varied from 37 to 46 in Regimen A and from 22 to 56 in Regimen B. The total doses of DNR and ara-C in Regimen A were from 100 to 240mg and from 640 to 1, 120mg, respectively. Those of ACR and ara-C in Regimen B were from 180 to 300mg and from 660 to 1, 000mg, respectively. In a comparative study of hematological changes, toxic effects on peripheral white blood cells, platelets and nucleated cells in bone marrow tended to appear later in Regimen B than in Regimen A. Side effects on the digestive system such as nausea and vomiting and vascular pain were more frequently recognized in patients treated with Regimen B, although they were managed by symptomatic treatment. The present comparative study indicated that a new antileukemic anthracycline, ACR, has the same therapeutic activity against ANLL as DNR in combination with ara-C.抄録全体を表示PDF形式でダウンロード (467K) -
第一編 アルコール脱水素酵素(ADH)とアルデヒド脱水素酵素(ALDH)の組織化学白神 圭由1986 年 98 巻 3-4 号 p. 265-272
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーHistochemical staining methods for alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) were studied. Many reports on ADH staining have been documented, and in the current study the author attempted to stain cryostat-prepared tissue sections on the slide glass. The author studied the composition of the incubation medium, incorporating nitro-blue-tetrazolium (NBT) and the staining procedure. ALDH staining has been less documented, but the author obtained a satisfactory result by using a staining method basically the same as that for ADH, with disulfiram as the inhibitor.
In vivo distributions of ADH activity were studied in man, rabbit, quinea pig, rat and mouse. The activity varied sagnificantly from species to species. It was the highest in the liver, and found in the mucous membrane of the digestive tract, lung, pancreas and kidney to a lesser extent. In addition, ALDH activity in man was striking, not only in the liver, but also in the lung and kidney. It was also found in the mucous membrane of the digestive tract. When changes in ADH activity were studied in rabbits orally fed with ethanol every other day for one year, no such findings could be confirmed.抄録全体を表示PDF形式でダウンロード (2967K) -
第二編 飲酒後の血中ethanolおよび代謝産物濃度の推移と諸種要因の影響白神 圭由1986 年 98 巻 3-4 号 p. 273-283
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーIn legal medicine, it is an established procedure to determine blood levels of ethanol in the living body or the corpse and estimate the level of drinking after establishment of the fact of drinking. In this process, effects of external factors, such as differences in the individual bodies, physical condition, various diseases, impact of food or drugs, exercise and bathing, present a problem. This paper describes a study on changes in blood levels of ethanol and its metabolites under the influence of varied factors as viewed from the practice of legal medicine.
When rabbits were orally given Japanese “sake”, there was a positive relationship between the dose of ethanol and its levels in the blood, whereas there was no such relationship with acetaldehyde or acetate. In the forced walk experiment in rabbits, no changes could be found in the levels of ethanol or acetate, but high levels of acetaldehyde were found in some animals. When the animals were bathed in hot water, acetaldehyde disappeared in the blood rather quickly in some rabbits, but the blood levels of acetate remained unchanged. Concurrent administration of sugar and Japanese “sake” to the experimental animals tended to acelerate metabolism both of acetaldehyde and acetate as well as ethanol. Administration of cyanamide elevated the acetaldehyde levels, and similar effect occurred with ethanol and acetaldehyde levels, in rabbit with a CCl4-damaged liver. In rabbits given ethanol every other day for 10 months, normal function was maintained in the liver, and high blood levels of ethanol were found in some animals. On the other hand, no significant changes occurred in acetaldehyde or acetate levels.抄録全体を表示PDF形式でダウンロード (517K) -
今滝 知子1986 年 98 巻 3-4 号 p. 285-298
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーThe present study was undertaken to trace the thalamic projections to the second and fourth somesthetic areas in the anterior ectosylvian gyrus of the cat using the technique of retrograde axonal transport of horseradish peroxidase. The projections of the posterolateral and posteromedial ventral nuclei (VPL, VPM) to the second somesthetic area (S II) are organized somatotopically. The posterior portion of S II (hindlimb area) receives fibers largely from the dorsolateral part of VPL, the middle portion of S II (forelimb area) from the ventromedial part of VPL, and the anterior portion of S II (face area) from VPM. These topical projections are more loosely organized and less densely arranged than those to the first somesthetic area (S I). The S II receives a few fibers from the medial geniculate nucleus, particularly its magnocellular and dorsal principal parts, and from the suprageniculate nucleus. The posterior part of S II near the secondary auditory area receives many fibers from the medial geniculate and suprageniculate nuclei, and only a few fibers from the lateral central and paracentral nuclei.
The fourth somesthetic area (SIV), located in the dorsal bank of the anterior ectosylvian sulcus, receives fibers mainly from the dorsal principal and magnocellular parts of the medial geniculate nucleus, and from the suprageniculate nucleus. The SIV receives a few fibers from VPL and VPM in a somatotopical manner. The posterior portion of SIV receives fibers mainly from the dorsolateral part of VPL, the middle portion of SIV from the ventromedial part of VPL, and the anterior portion from VPM. In addition, SIV receives a few fibers from the lateral central, paracentral, ventral lateral and ventral medial nuclei. The SIV, together with the most posterior part of S II, forms an auditory area, receiving many fibers from the medial geniculate and suprageniculate nuclei.抄録全体を表示PDF形式でダウンロード (683K) -
長花 晴樹1986 年 98 巻 3-4 号 p. 299-312
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーThe effect of right ventricular overloading on body surface isopotential maps (maps) was investigated in 42 patients with the atrial septal defect of the secundum type (ASD) and isolated incomplete right bundle branch block without significant cardiovascular disorders. The patients were divided into two groups according to the presence or absence of right ventricular pressure overloading. Thirty-one patients had right ventricular volume overloading alone, ASD (V), with right ventricular systolic pressure of less than 59mmHg, and 11 patients had right ventricular volume overloading accompanied with pressure overloading, ASD (V+P), with right ventricular systolic pressure equal to or greater than 60mmHg.
In ASD (V), effects of RV volume overloading appeared in the positive potentials of the right anterior chest leads from the right midaxillar line to the anterior median line, and in the negative potentials of the left lateral chest leads from the left midclavicular line to the left posterior axillar line. The addition of pressure overloading, observed in ASD (V+P), affected the positive and the negative potentials over a slightly larger area than in ASD (V).
For estimating right ventricular pressure with maps semiquantitatively, the relationship between right ventricular systolic pressure and potentials of 87 lead-points utilized in maps were investigated in all 42 patients. Linear regression analysis revealed that the sum of the amplitude of the maximum positive potential in leads D3, D4 and D5 and the amplitude of the maximum negative potential in leads F3, F4 and G3 correlated well with right ventricular systolic pressure (r=0.79, p<0.005).
In 20 patients who received surgical correction, postoperation maps were compared with the maps obtained before operation. The patterns were not significantly different between the two maps, but the positive and negative potentials decreased in the late stage of ventricular depolarization. The Breakthrough minimun shifted to the right, with no significant changes in appearance time, after the operation.抄録全体を表示PDF形式でダウンロード (3864K) -
塚本 修司1986 年 98 巻 3-4 号 p. 313-321
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーStructure-binding relationships of γ-aminobutyric acid (GABA) and 40 of its relatives with GABA and benzodiazepine (BDZ) receptors was investigated. In the evaluation of the cross reactivity of 40 GABA relatives by the standard GABA radiolabeled receptor assay (GABA-RRA), it became clear that, for the molecule to react with GABA-receptors, the amino group needs to be free while the carboxy group is not always an essential factor. It was also demonstrated that the molecule loses its cross-reactivity if the distance between the carbon in the α-position and amino group exceeds a certain limit, and that the cross-reacting potency depends on the stereospecificity of the compound. When the cross-reactivdties of GABA relatives with the GABA receptor were compared with their BDZ receptor affinity-enhancing actions, a parallelism was found between the two actions. Between d-γ-amino-β-hydroxybutyric acid (d-GABOB) and l-GABOB, however, no difference was found in the BDZ receptor affinity-enhancing effect, although there was a large difference in the cross-reactivdty in the GABA-RRA. This result indicates that the sterospecificity of the carbon in the β-posotion is crucial for the binding of the molecule to the GABA receptor, but not essential for its binding to the BDZ receptor, suggesting that the GABA receptor and the BDZ receptor each recognize a different site in the molecule of GABA relatives.抄録全体を表示PDF形式でダウンロード (1063K) -
橋本 啓二, 木本 真, 白神 敏明, 上者 郁夫, 林 英博, 竹田 芳弘, 戸上 泉, 新屋 晴孝, 上田 裕之, 清水 光春, 杉田 ...1986 年 98 巻 3-4 号 p. 323-330
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーWe analyzed calcifications in 557 computed tomography films of the head. Adnormal findings of calcification of vertebral arteroes were obrained in 36 of the 577 cases. In the 36 cases, vertigo was observed in 24 cases (66.7%), and brain atrophy in 10 cases (27.2%). The calcification of vertebral arteries (arteriosclerosis) correlated significantly with vertigo. Patients with vertigo should be examined by computed tomography for calcification of vertebral arteries at the level of the foramen magnum.抄録全体を表示PDF形式でダウンロード (1331K) -
吉田 萬子1986 年 98 巻 3-4 号 p. 331-341
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーUsing 16mm color film, the radiating arterioles of the cochlea were examined in 23 guinea pigs to reveal statistical correlations between the blood flow velocity and the arterial plasma glucose level, plasma total protein and hematocrit. The guinea pigs, which had a normal Preyer's reflex, were fenestrated on the third turn on the cochlea. After filming the blood flow, the moving distance of the plasma space on the film was measured to calculate the velocity of the blood flow. The blood flow velocity of the hyperglycemic group (plasma glucose level≥200mg/dl, n=14) was significantly lower than that of the normoglycemic group (plasma glucose level<200mg/dl, n=9). Investigation of the regression lines of all the cases including 17 cases with plasma glucose levels less than 300mg/dl, indicated that higher plasma glucose levels correlate with lower blood flow velocity (r=-0.580 n=23, r=-0.814 n=17). The correlation matrix table showed a meaningful correlation (P<0.05) between the plasma glucose level and the blood flow velocity, but no significant correlation between the total protein in serum and the blood flow velocity or between the hematocrit level and the blood flow velocity. In the 17 guinea pigs having less than 300mg/dl of plasma glucose, we conducted multiple regression analysis to calculate the velocity of the blood flow from three defined variables: plasma glucose level, total protein in serum, and hematocrit. The coefficient of determination was 69%.抄録全体を表示PDF形式でダウンロード (1437K) -
庵谷 文夫1986 年 98 巻 3-4 号 p. 343-355
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーTo estimate quantitatively the infarct size of right ventricular infarctions (RVI), I studied the pre- and post-infarction body surface maps of 10 dogs with transmural RVI and 5 dogs with non-transmural RVI. The maximum decrease in the potential at all lead points was 0.8mV through the ventricular depolarization after a sham operation in 4 dog. Thus, a 1mV postoperative decrease was considered significant. In transmural RVI, the minimum and negative potential zone appeared early in the ventricular depolarization on the right anterior chest surface. The negative potential zone continued to the middle stage of depolarization the right chest surface, and afterward occupied a larger part of anterior surface. The maximum and positive potential zone shifted leftward in the early and middle stages of QRS. In transmural RVI, ΣQ16 (the sum total of the voltages which postoperatively decreased 16msec after the onset of QRS) was much greater than the ΣQ16 of non-transmural RVI and sham operation. Especially, reductions of ΣQ16 greater than 15mV were found in transmural RVI. Q waves were found on right precordial leads (V2R through V5R) in 5 cases of trans-mural RVI. The total number of leads with decreased potential over 1mV (Σn) and ΣQ16 from maps correlated well with the histologically determined infarct size of RVI. These data suggest that Σn and ΣQ16 would be good clinical indices for diagnosing quantitatively the infarct size of RVI. Maps obtained after intravenous administration of isoproterenol enabled the discrimination between nontransmural RVI and sham operation.抄録全体を表示PDF形式でダウンロード (4317K) -
黒川 秀夫1986 年 98 巻 3-4 号 p. 357-384
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーThe function of atrial specific granules has been obscure in spite of many morphological studies. However, the relationship between these granules and sodium and water metabolism has been suggested, and it has been confirmed that heart atrium extract has a diuretic action. An atrial natriuretic peptide (ANP) has been purified from the human atrium. The author investigated the kinetics of specific granules and discussed the relationship between these granules and ANP. A detailed study on the mechanism of secretion of these granules was also performed.
The number of atrial specific granules in rats fed at 5°C for 50 days tended to decrease, and number in rats fed at 33°C for 50 days increased. The number of granules in rats fed with 0.5-1% sodium chloride solution decreased after 45 days. An increase in the number of granules was observed after rats were fed without water 11 days. This increase in granules was observed in the sarcoplasm between myofibrils, and just beneath the plasma membrane as well as in the sarcoplasm at the periphery the nucleus. The continuous administration of diurtics (Lunetron) induced a decrease in granules at the periphery of the nucleus, while antidiuretics (Pitrssin) caused an increase in granules around the nucleus, between myofibrils and beneath the plasma membrane.
Type II granules were observed near Golgi apparatus, and their contents were similar to the materials seen in Golgi apparatus. From morpholgical studies, it was concluded that these type II granules matured to type I granules, and that they were transferred to the cell periphery and their contents were released by exocytosis.抄録全体を表示PDF形式でダウンロード (12865K) -
藤澤 達郎1986 年 98 巻 3-4 号 p. 385-401
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーThe innervation of the cardiac ganglia of rats was investigated by light and electron microscopies. The same specimens were studied by histochemical methods.
The cardiac ganglia were distributed densely around the pulmonary veins and consisted of nerve cells, satellite cells, nerve fibers, Schwann cells and connective tissue containing many fat cells. Most preganglionic nerve fibers ended in the dendrites of nerve cells, which were surrounded by Schwann cells. A few fibers invaginated and ended in the nerve cell body. Most nerve endings contained only non-cored vesicles (50nm), but a few endings contained large dense core vesicles (100nm) as well as non-cored vesicles.
Under light microscopy, the acetylcholinesterase (AChE) reaction was strongly positive in all nerve cells of all cardiac ganglia. By electoron microscopy, the reaction site was found to be the narrow space between axon and nerve ending membranes and Schwann cells.
These ganglia were investigated by the Falck-Hillarp method by fluorescence microscopy, and we confirmed that all ganglia did not contain sympathetic nerve endings. However there were small cells (10 microns in diameter) which showed intense fluorescence. These cells contained osmiophillic granules (150-300nm) and showed features similar to small intensely fluorescent cells (SIF cells). Around these cells, fenestrated capillaries were observed.
From these results, it was confirmed that the cardiac ganglia of rats were innervated by parasympathetic nerves and that SIF cells were present.抄録全体を表示PDF形式でダウンロード (6287K) -
鶴田 敬司1986 年 98 巻 3-4 号 p. 403-419
発行日: 1986/04/30
公開日: 2009/03/30
ジャーナル フリーThe action of δ-guanidinovaleric acid (DGVA) on the activity of the central nervous system was investigated in the rat using electroencephalography (EEG).
EEG using epidural electrodes revealed initiation of spike discharges within 5-10min on the side of DGVA (synthesized from O-methylisourea and δ-aminovaleric acid, according to Weiss and Krommer) application on pia matter of the sensorimotor cortex (0.3nmol). Thereafter, the frequency became 15-20 spike discharges/min. Spike discharges in the EEG of the opposite cerebral hemisphere were observed 5-10min after the onset of spike discharges. Spike discharges lasted until the end of recording after 2h.
Spike discharges induced by DGVA were completely suppressed within 10min by the supplimentation of (3R)-(-)-4-amino-3-hydroxybutanoic acid (L-GABOB) (1mM) or GABA (10mM) on the pia matter. In rats given L-GABOB topically together with DGVA, spike discharges were not induced. While L-GABOB showed a remarkable suppressive effect on spike discharges induced by DGVA, supplimenting α-amino-DGVA, i.e., arginine (Arg), (100mM) showed no effect on the discharges. DGVA induced spike discharges by topical application after pre-application of Arg.
Neither phenobarbital (PB) (20mg/kg, i. m.) nor diazepam (DZ) (10mg/kg, i. p.), applied 20min after the DGVA application, showed any suppressing effects on spike discharges. DGVA induced spike discharges by topical application 20min after the injection of PB or DZ. Two anticonvulsants known to correlate with the GABA-receptor had no effect on spike discharges induced by DGVA. Sodium valproate (200mg/kg, i. p.) and diphenylhydantoin (20mg/kg, i. p.) applied 20min after the DGVA application showed no suppressing effects on spike discharges induced by DGVA.
These findings suggest that DGVB might act directly on the GABA-receptor and might be a specific GABA antagonist.抄録全体を表示PDF形式でダウンロード (688K)
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