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71 巻 (1959)
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前身誌
99 巻, 1-2 号
選択された号の論文の16件中1～16を表示しています
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兵頭 多津男1987 年 99 巻 1-2 号 p. 1-13
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーHemodynamic and electrocardiographic changes caused by acute ischemia of the interventricular septum (IVS) were studied in 33 anesthetized dogs. IVS ischemia was produced by occluding the first septal branch of the anterior descending coronary artery. Acute IVS ischemia resulted in a significant elevation of LVEDP in open-pericardium dogs in the absence of right ventricular pressure changes. With the pericardium closed, however, RVEDP rose substantially in addition to a further increase in LVEDP. Hemodynamic effects of the ischemia of the left ventricular free wall were larger than the changes caused by IVS dysfunction similar in size to the free wall ischemia. Twelove-lead electrocardiograms showed ST depression in the inferior leads, but neither ST elevation nor appearance of an abnormal Q wave was observed after the occlusion of the first septal coronary branch. A-V or intraventricular conduction disturbance was seen in one-third of the dogs. These data suggest that acute myocardial ischemia of the IVS affected only left ventricular function in the absence of the pericardium, while it affected the hemodynamics of both ventricules when the pericardium was intact. There were no ECG changes indicating interventricular ischemia except A-V or intraventricular conduction disturbances.抄録全体を表示PDF形式でダウンロード (2618K) -
林 英博, 平木 祥夫, 上者 郁夫, 柏谷 尚子, 三宅 正淑, 山本 淑雄, 神崎 典子, 井上 信浩, 則安 俊昭, 橋本 啓二, 竹 ...1987 年 99 巻 1-2 号 p. 15-23
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーWe studied the results of radiotherapy in 65 patients with brain metastases of lung cancer. In the 34 patients whose treatment consisted of radiotherapy alone, the median survival time was 164 days and the mean survival time was 210 days. Remission was achieved in 29 (85%) of these patients, indicating that radiotherapy was effective. A minimum radiation dose of 30 Gy was necessary to decrease neurological symptoms, and 40 Gy or more was considered to be desirable.
Survival after radiotherapy appeared to be dependent largely on factors other than brain metastases such as the effectiveness of management of the primary lesion, the presence or the extent of metastases to other organs, and the patient's general condition.
Our study suggests that greater efforts must be made for early detection and early treatment to achieve prolongation of as well as qualitative improvements in the survival time.抄録全体を表示PDF形式でダウンロード (394K) -
西岡 慶子, 田村 耕三, 頼実 哲, 陶山 貴世子, 西川 邦男, 東川 俊彦, 増田 游, 小倉 義郎1987 年 99 巻 1-2 号 p. 25-31
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーEight hundred twenty-six patients with allergic rhinitis were clinically analyzed in our clinic from 1980 to 1984. The incidence of this disease did not increase in relation to the number of outpatients. More than half of the allergic patients visited our clinic before reaching the age of 20. Intracutaneous tests to housedust and Japan ceder were positive in 74.5% and 26.0% patients, respectively. In more than half of the patients positive to house dust allergen, the onset of allergic symptoms occurred by the time the patients were 14 (male) and 19 (female) years old.抄録全体を表示PDF形式でダウンロード (287K) -
山本 昌司1987 年 99 巻 1-2 号 p. 33-47
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーThe release of indoleamine and catecholamine within the caudate nucleus of freely moving and immobilized rats during convulsions induced by pentylenetetrazol (PTZ) was investigated by in vivo differential pulse voltammetry. In voltammograms obtained from the caudate nucleus, there were two distinct oxidation peaks: one at 130 mV (peak P2) and the other at 300 mV (peak P3). Thier potentials are characteristic of the oxidation of 3, 4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. During tonic convulsions induced by 60 mg/kg of PTZ i.p., the amplitude of peak P2 obtained from the caudate nucleus of freely moving rats significantly decreased to 75% of the peak height recorded prior to the injection of PTZ, and recovered to normal within 60 min of the end of tonic convulsions. The amplitude of peak P3 showed almost no change during and after tonic convulsions. These results suggest that the release of dopamine (DA) in this region of freely moving rats during tonic convulsions is induced by PTZ. The heights of peaks P2 and P3 were not influenced by phenobarbital (10-80 mg/kg, i.p.) or diazepam (10 mg/kg, i.p.) administration. In voltammograms from the caudate nucleus of immobilized rats, the amplitude of peak P2 significantly increased during seizures. The increase lasted for 3 to 6 min after the seizures induced by PTZ (60-90 mg/kg, i.p.). This data suggests that DA release was increased in this region of immobilized rats during EEG-verified convulsions induced by PTZ. As the height of peak P3 increased somewhat during seizures, so the release of serotonin increased during convulsions induced by PTZ. Although the changes in the DA release during convulsions were opposite in freely moving and immobilized rats, changes in DA and serotonin release in the caudate nucleus might participate in the development of convulsions induced by PTZ.抄録全体を表示PDF形式でダウンロード (763K) -
松原 堅, 渡辺 明治, 東 俊宏, 戸部 和夫, 長島 秀夫1987 年 99 巻 1-2 号 p. 49-56
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーThe first case of macromolecular GOT was reported by lida et al. in 1973, and since then only 11 cases have been reported. In the present paper, we report two cases of abnormally elevated serum GOT, which was difficult to explain by organic disorders. Using various biochemical and immunological methods, the GOT was concluded to be macromolecular GOT. Sephadex G-100 column chromatography was carried out to estimate the molecular size. After dividing the GOT into isoenzymes by Cellogel membrane electrophoresis, the GOTs were dyed using the GLDH method developed by Lippe. The immunofixation method was used to examine what kind of immunogloblin combined with GOT. Case 1 was a 69-year-old woman with angina pectoris and hypertension. Her serum GOT level was 279IU/l. Her serum GOT was found to be combined with IgG-χ. Case 2 was an 8-year-old boy who suffered from bronchial asthma. His serum GOT levels were highly elevated (192IU/L). The GOT was combined with IgG-λ. In both cases, we estimated the GOT molecular weight to be 14, 0000 Daltons.抄録全体を表示PDF形式でダウンロード (769K) -
第2編 消化性潰瘍および急性ビラン性胃炎における検討網岡 逸男1987 年 99 巻 1-2 号 p. 57-67
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーProstaglandin E (PGE) in the gastric juice of patients with peptic ulcer and acute erosive gastritis was determined by a radioimmunoassay. In gastric and duodenal ulcer patients, the concentration and output of PGE in the gastric juice were not significantly different from those of normal subjects both basally and after pentagastrin stimulation, but in acute erosive gastritis patients they showed significantly lower levels. The concentration of PGE in the gastric juice was lower in all cases after pentagastrin stimulation compared to the basal level because of dilution due to an increased gastric juice volume. After pentagastrin stimulation, PGE output tended to increase in all groups, but this increase was not statistically significant and probably was caused by an increased gastric juice volume. No correlation could be found among acid output, pepsin output and gastric PGE output.
These results do not support the concept that endogenous PGE deficiency may be an etiological factor in peptic ulcer disease, and seem to argue against a possible inhibitory role of PGE in gastric acid secretion by a negative feedback mechanism in man. However, a low level of endogenous PGE may be intimately related to the pathogenesis of acute erosive gastritis.抄録全体を表示PDF形式でダウンロード (588K) -
脇谷 勇夫1987 年 99 巻 1-2 号 p. 69-84
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーThe distribution of carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), carbohydrate antigen 19-9 (CA19-9), pancreatic oncofetal antigen (POA), Ferritin, Amylase and Elastase 1 was studied immunohistochemically using an immunoperoxidase method in 26 conventional histopathologic sections of pancreatic tumor. CEA and CA19-9 were regarded as markers secreted into the glandular lumina from cancer cells, but TPA and POA were not. The expression of these markers was different from one case to another and had no fixed pattern in cases of pancreatic cancer. The degree of CEA staining correlated positively with that of TPA. CEA, TPA and CA19-9 were demonstrated on the luminal border, cytoplasma and marginal region of cancer cells in various degrees, but POA was only found in the cytoplasma of cancer cells. CEA, TPA and CA19-9 tended to be stained more strongly as the pancreatic cancer was more highly differentiated. The specimens were more frequently stained with CEA and TPA than with CA19-9. In two cases, CA19-9 was not expressed in tumor specimens, although serum levels of this marker were abnormally elevated. In these cases CA19-9 in normal epithelium of the pancreatic duct and choledochus may have leaked into the blood stream. The same process was considered in one case each of TPA and POA expression. TPA, Ferritin and Elastase 1 were expressed in two cases of islet cell tumor, while none of them was expressed in one case of apudoma. Elastase 1 was stained intensively on tumor cells in one case of pancreatic cancer and one case of islet cell tumor.抄録全体を表示PDF形式でダウンロード (3039K) -
藤川 信昌1987 年 99 巻 1-2 号 p. 85-96
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーA method for repeated sampling of cerebrospinal fluid (CSF) from freely moving rabbits was developed. Levels of guanidino compounds were estimated in the CSF of rabbits with pentylenetetetrazol (PTZ)-induced convulsions by high performance liquid chromatography. A catheter was implanted via the skull into the cisterna magna and was fixed by screws. One week after the operation, 100 μl of CSF was collected with a microsyringe. PTZ solution (3.3%) was injected intraveneously, and CSF was collected simultaneously until clonic-tonic convulsions appeared. Clonic-tonic convulsions continued for about 20 seconds. After that, no convulsion was induced for one hour after the injection. CSF was also collected 20 min and 60 min after the injection. For the control, CSF was collected 5 min before PTZ injection. Guanidinoacetic acid, creatinine and arginine were found in 100μl of rabbit CSF. Levels of guanidinoacetic acid and creatinine increased and then recovered to the control level 2 hours after convulsions. Arginine started to decrease 2 hours after convulsions and continued to decrease gradually untill 2 days after convulsions. The levels recovered to the control level 4 days after convulsions.抄録全体を表示PDF形式でダウンロード (1806K) -
諏訪 文明1987 年 99 巻 1-2 号 p. 97-104
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーGlycoproteins (PNABGP: PNA binding glycoproteins) possessing inhibitory activity against hemagglutination of PNA, a lectin specific for Galβ (1→3) Gal NAc linkage in the non-reducing end of carbohydrate chains, were detected in the serum of patients with malignant tumors. These glycoproteins were purified from ascites collected from patients bearing carcinoma of the liver, pancreas and stomach by affinity chromatography using PNA, anti-whole human serum and anti-cirrhotic ascitic fluid. SDS-polyacrylamide gel electrophoresis of these glycoproteins yielded are main band (120 K daltons). Using this preparation, PNABGP in the serum was quantitated by an enzyme-linked immunosorbent assay (ELISA). The levels of these glycoproteins were high in hepatocellular carcinoma and other malignancies.抄録全体を表示PDF形式でダウンロード (362K) -
土屋 正夫1987 年 99 巻 1-2 号 p. 105-113
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーFor the purpose of analyzing immune responses to endotoxin in liver diseases, an enzyme-linked immunosorbent assay (ELISA) employing microplates and hematocrit tubes for spectrophotometry was developed. The new ELISA allowed the analysis of extremely small serum samples (e.g. 10 μl-100 μl), and the assay had specificities for antibodies to various endotoxin antigens. The details of the method were presented. It was concluded that the new ELISA was useful clinically.抄録全体を表示PDF形式でダウンロード (366K) -
土屋 正夫1987 年 99 巻 1-2 号 p. 115-124
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーThe antibody, and its immunoglobulin class, against endotoxin (LPS; E. coli 026:B6) in sera from patients with various liver diseases was examined by the use of an enzymelinked immunosorbent assay (ELISA). The IgG-antibody titer to endotoxin was high in sera from patients with liver cirrhosis (LC), fulminant hepatitis (FH), severe chronic active hepatitis (CAH2B), alcoholic hepatitis and acute hepatitis (AH), and its titer was associated with the severity of liver injury. The IgA-antibody titer was high in sera of patients with alcoholic hepatitis, FH, LC, CAH2B and AH. The patient with the highest titer had alcoholic hepatitis. The IgM-antibody titer was not associated with the severity of liver injury, but it was associated with the acute stage of acute hepatitis and acute exacerbation of chronic hepatitis. The antibody titer was higher in sera of LC patients with ascites and/or esophageal varices than in LC patients without them (especially IgA-antibody: p>0.01). The ELISA for detection of antibody to endotoxin was useful for clinical observation of patients with liver diseases.抄録全体を表示PDF形式でダウンロード (421K) -
高橋 健二1987 年 99 巻 1-2 号 p. 125-134
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーIn the present study, the antigen proteins of Sprague-Dawley rat pancreas islets recognized by islet cell cytoplasmic antibodies (ICA) cross-reactive with rat islets were characterized. A detergent lysate of rat islets (islet lysate) and Maclura pomifera agglutinin-binding glycoprotein (MPA-GP) of rat pancreas were used as antigen sources. Reactivities of these two crude antigen proteins against 4 ICA-positive sera from patients with Type 1 (insulin-dependent) diabetes mellitus (IDDM) were examined by SDS-polyacrylamide gel electrophoresis followed by immunoblotting, and by fluoroimmunoassay (FIA).
Two of the 4 ICA-positive sera specifically bound a peptide of 59kdalton (Kd) from islet lysates. This peptide was detected even after absorption of sera with rat acetone liver powder or viable rat islet cells. One serum sample was examined for rectivities to MPA-GP, and the serum bound a peptide of 59Kd from MPA-GP. In an absorption test of the serum with MPA-GP, decreased specific fluorescence of rat pancreas islets was shown by an indirect immunofluorescent technique. The binding activity of MPA-GP to ICA-positive sera measured by the FIA method was higher in the ICA-positive sera than in the ICA-negative sera.
It was concluded that a peptide of 59Kd is one of the target antigen proteins of ICA, and that the peptide has binding activity with MPA. It was suggested that ICA can be measured by the FIA method using MPA-GP. It was also suggested that ICA in sera from Type 1 diabetic patients is heterogenous and that the target antigen is polyvalent.抄録全体を表示PDF形式でダウンロード (2793K) -
澤原 正彦1987 年 99 巻 1-2 号 p. 135-145
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーTo examine the characteristics of hepatitis B virus (HBV) in sera from hepatitis B patients in various stages of disease, the protein volume percent of each constituent peptide of HBV was investigated, and both the HBV-pAR activity and HBsAg activity of each peptide were examined. The relationship between HBV, immunoglobulins and complements was also investigated. The constituent peptides were divided into a few bands of more than 94Kdal., 3 bands of 9467Kdal. and 12 bands of 67, 52, 49, 43, 39, 35, 31, 27, 22, 19, 15 and 8Kdal.. The samples of HBeAg positive sera showed increased 22, 27, 31, 35 and 67Kdal. bands, and the samples of anti-HBe positive sera showed decreased 22 and 27Kdal. bands and increased 15 and 43Kdal. bands.
The samples of sera from asymptomatic carriers showed an increased 43Kdal. band, and that from patients with chronic active hepatitis showed an increased 15Kdal. band. HBV-pAR consisted of 67, 52, 43, 35, 31 and 8Kdal. peptides, and the determinants of HBsAg consisted of 67, 52, 49, 43, 39, 35, 31, 27 and 22Kdal. peptides. HBV-peptides of 67, 52 and 22Kdal. bound with immunoglobulins and complements in Western-blotting.抄録全体を表示PDF形式でダウンロード (2170K) -
白數 明義1987 年 99 巻 1-2 号 p. 147-156
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーLevels of peroxide intermediate radicals, Cu2+ and superoxide dismutase (SOD) activity were estimated by electron spin resonance (ESR) spectrometry, and levels of copper and zinc were measured by atomic absorption spectrometry in the CSF of rabbits with pentylenetetrazol (PTZ)-induced convulsions. One hundred microliters of CSF was collected until clonic-tonic convulsions occurred following the injection of PTZ solution (3.3%). CSF was collected again 20 min and 60 min after the convulsions. Peroxide intermediate radicals, SOD activity, copper and zinc were found in the rabbit CSF. Peroxide intermediate radicals decreased and SOD activity increased at the onset of convulsions. A large Cu2+ signal, which was not found in the CSF of normal rabbits, appeared at the same time. These levels recovered to the normal level 20 min after the convulsions, but the copper level decreased. Sixty min after the convulsions, the copper level recovered to the normal level. The ESR spectrum of Cu2+ at the onset of convulsions was identified as the reduced glutathione-Cu2+ complex by computer simulation. However, there was no change in the zinc level duirng PTZ-induced convulsions.抄録全体を表示PDF形式でダウンロード (565K) -
松浦 一陽1987 年 99 巻 1-2 号 p. 157-168
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーThe binding activity of polymerized human serum albumin to the receptor on hepatitis B virus (HBV-pAR activity) was examined in relation to the evolution of the HBeAg/anti-HBe system in sera from symptom-free carriers and patients by the use of an enzyme-linked immunosorbent assay (ELISA). The sera of 80 HBsAg-positive symptom-free students (1820 years old) and of 2 patients with severe chronic active hepatitis (CAH 2B) followed up for 3 years were used. The students were divided into 2 groups: 3 cases of horizontal infection (group 1) and 77 cases of maternal infection (group 2). The students of group 1 initially showed positive HBeAg and high HBV-pAR activity, but showed positive anti-HBe and low HBV-pAR activity after a typical course of acute hepatitis. In group 2, 35 (45.5%) of the 77 students showed initially positive HBeAg, and all except one student had hgih HBV-pAR activity. Ten of the 34 students with both positive HBeAg and high HBV-pAR activity had abnormal S-GPT levels in the 3-year follow-up period. Six of the 10 students became symptom-free with negative HBeAg and low HBV-pAR activity, and two students showed positive anti-HBe. Four students developed middle HBV-pAR activity and had persistent abnormal S-GPT levels. Twenty-four (68.6%) of the 35 students with positive HBeAg did not undergo seroconversion. One student with positive HBeAg and low HBV-pAR activity became symptom-free with negative HBeAg and negative anti-HBe without abnormal S-GPT levels. The two HBsAg, HBeAg-positive patients with CAH 2B had an acute exacerbation, and showed high HBV-pAR activity 12 months before the exacerbation. One of them became symptom-free with negative HBeAg and low HBV-pAR activity, but the other became symptom-free with positive HBeAg and low HBV-pAR activity after the exacerbation.
The results indicate that HBV-pAR activity might be a more useful marker for determining the prognosis of HBsAg-positive students than HBeAg/anti-HBe.抄録全体を表示PDF形式でダウンロード (587K) -
渡辺 正博1987 年 99 巻 1-2 号 p. 169-178
発行日: 1987/02/28
公開日: 2009/03/30
ジャーナル フリーIt was studied whether IgG-immune complexes were taken up by liver parenchymal cells and whether liver injury was induced by the immune complexes. When asialo-orosomucoid, orosomucoid and human serum albumin immune complexes at various antigen-antibody ratios were infused into the portal vein of rats, the antibody-excess immune complexes were partly taken up by liver parenchymal cells via the asialogly-coprotein receptor. However, liver injury was not caused by the immune complexes. These observations suggest that 1) immune complexes at certain antigen-antibody ratios bind to the asialogycoprotein receptor, 2) immune complexes bound to the asialoglycoprotein receptor do not activate the complement system and 3) a transient increase in plasma immune complexes does not induce liver injury.抄録全体を表示PDF形式でダウンロード (1111K)
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