巻号一覧
71 巻 (1959)
- 12-2 号 p. 8243-
- 12-1 号 p. 7861-
- 11supplement 号 p. 1-
- 11-2 号 p. 7531-
- 11-1 号 p. 7095-
- 10-2 号 p. 6691-
- 10-1 号 p. 6223-
- 9-2 号 p. 5773-
- 9-1 号 p. 5405-
- 8-2 号 p. 4993-
- 8-1 号 p. 4515-
- 7-2 号 p. 4069-
- 7-1 号 p. 3623-
- 6-2 号 p. 3149-
- 6-1 号 p. 2783-
- 5-2 号 p. 2423-
- 5-1 号 p. 1989-
- 4-2 号 p. 1655-
- 4-1 号 p. 1145-
- 3supplement-2 号 p. 1-
- 3supplement-1 号 p. 1-
- 3-2 号 p. 1145-
- 3-1 号 p. 691-
- 2-2 号 p. 691-
- 2-1 号 p. 323-
- 1 号 p. 1-
前身誌
99 巻, 3-4 号
選択された号の論文の21件中1～21を表示しています
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鳥越 昇一郎1987 年 99 巻 3-4 号 p. 179-189
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーHuman biliary mucin was isolated using Sepharose 6B gel chromatography and equilibrium density gradient centrifugation in caesium chloride. The carbohydrate and amino acid composition of mucin from patients with cholesterol gallstones was essentially the same as that from patients with pigmented gallstones. The molar ratio of galactosamine: glucosamine: galactose: fucose: sialic acid was 1:3:24:35:0.5. Serine, threonine, and glycine were major amino acids. Anti-mucin antibody was raised in a rabbit, and was found to be specific for human biliary mucin. Serum levels of antibody-reactive proteins were significantly elevated in patients with acute and chronic liver diseases, and patients with gallstones. They were significantly higher in chronic parenchymal liver disease patients than in acute hepatitis patients, and in liver cirrhosis and hepatocellular carcinoma patients than in chronic hepatitis patients. The levels in gallstone patients were comparable to those in chronic hepatitis patients. The present results suggest that 1) the carbohydrate composition of mucin dose not differ between cholesterol gallstones and pigmented gallstones, 2) serum mucin, which reacts with the antibody against biliary mucin, is increased in liver disease patients, and this mucin might originate from the biliary tract, and 3) among liver disease patients, those with liver cirrhosis and hepatocellular carcinoma have the highest serum mucin.抄録全体を表示PDF形式でダウンロード (1421K) -
中津 高明1987 年 99 巻 3-4 号 p. 191-201
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーThe flow mechanics of the right coronary system were studied in anesthetized open-chest dogs. The right coronary system fitted the intramyocardial pump (IMP) theory, and the IMP value was 19.3±3.7 mmHg. This value was lower than that of the left coronary system found by Spaan. Total resistance of the right coronary system was 1.0±0.4 mmHg/ml/100g RV. When the total resistance was assumed to be the sum of two components of resistance, one component (Rp) was proximal to the intramyocardial capacitor (Cim) and the other (Rd) was distal to Cim, the relationship between Rt and Rp was: Rt=0.36Rp+0.10 (r>0.88). The time constant of the right coronary system was 2.4±0.8 sec, and the capacitance of the right coronary system was calculated to be 0.074±0.024 ml/mmHg/100g RV. This capacitance was as large as that of the left coronary system reported by Spaan. In summary, the right coronary system had a large capacitance, so that the resistance of the right coronary system did not change throughout the cardiac cycle as in the left coronary system showed by Spaan. However, the flow mechanics of the right coronary system differed from the left quantitatively.抄録全体を表示PDF形式でダウンロード (1866K) -
谷 秀樹1987 年 99 巻 3-4 号 p. 203-212
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーOxygen metabolism of the right ventricle (RV) was studied in 7 dogs with RV hypertrophy in comparison with that of the left ventricle (LV). The main pulmonary artery of infant dogs was banded to raise the RV pressure by approximately 40mmHg above the control. Six months later, the oxygen content of arterial and venous blood from the right ventricular mid-anterior wall was preasured.
With RV hypertrophy, RV systolic pressure rose from 28±1 to 50±15 mmHg. Oxygen extraction (EO2) of the hypertrophic RV was higher (56.6±3.8%) than the that of the normal RV (51.0±3.0%), so that there was no significant difference in EO2 between the RV and LV.
Furthermoere, increases in right coronary artery (RCA) flow without changes in RV-EO2 met the increased RV O2 demand caused by isoproterenol infusion or pulmonary artery constriction in hypertrophic RV dogs. In the normal dogs, however RV-EO2 increased in addition to a rise in RCA flow. These results indicate that O2 metabolism in the hypertrophic RV is similar to LV O2 metabolism, and that there is a reduction in the O2 reserve in the hypertrophic right ventricle.抄録全体を表示PDF形式でダウンロード (498K) -
内藤 正之1987 年 99 巻 3-4 号 p. 213-220
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーPregnant ddN mice were injected intraperitoneally with 15, 000 IU of water-miscible vitamin A on the eighth day of pregnancy, and fetuses were removed from the mice on the eighteenth day. Pregnant Wistar rats were injected intraperitoneally with 200, 000 IU per kg body weight of water-miscible vitamin A on the tenth day of pregnancy, and fetuses were removed from the rats on the twenty-first day. The pathological changes of the malformed ears of the mouse and rat fetuses were observed by stereoscopic microscopy after combined staining of bone and cartilage. The incus, stapes and Reichert's cartilage all were malformed or absent in most of the mouse ears, much more than in the rat ears. The malleus and Meckel's cartilage were normally shaped in most of the ears of both animals. The author concluded that a considerable part of the incus is derived or originated from the second arch cartilage and that the malleus is derived entirely from the first arch cartilage.抄録全体を表示PDF形式でダウンロード (1216K) -
江原 收1987 年 99 巻 3-4 号 p. 221-238
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーThe relationship between the structural changes of the kidney and duration of lithium administration or lithium dosage was studied in rats. A diet containing LiCl was administered to mothers before birth and to the examined rats postnatally. Flattening and falling of the epithelium, exposure of the basal membrane and dilatation and cyst-building were observed in the proximal and distal tubules. Atrophy, necrosis, interstitial fibrosis and infiltration were observed in the glomeruli. These changes were seen at any age regardless of the dosage, and were not specific to lithium treatment. There were considerable individual variations in these changes. The number of cysts was higher in lithium treated rats, significantly so in the 20 mEq and 30 mEq dosage groups at 30 weeks. A significant elevation in the number of damaged glomeruli was found in the 20 mEq lithium groups at all ages. Long-term treatment with a large dosage of lithium could cause structural damages to the kidney.
Renal function was studied in 92 patients whose average age was 44.8±13.3 years (16-73 years), and who had been treated for 30.8±23.0 months (6-108 months) with lithium carbonate 611±190 mg/day (200-1200 mg/day). The serum lithium concentration was 0.41±0.14 mEq/l (0.2-1.0 mEq/l). Nine patients (10.5%) had low (below 1006) specific gravity of urine, and 3 patients (3.5%) had proteinuria, but their creatinine clearance, serum creatinine and urea nitrogen were within the normal range. The average creatinine clearance was 109.8±21.3 ml/min in men and 102.6±32.5 ml/min in women. Low creatinine clearance values were found in 9 patients (12.7%), but their other labobotory test results were normal. The levels of serum creatinine and urea nitrogen were not increased after lithium therapy. Lithium therapy at the level of 0.4 mEq/serum for 108 months should cause no serious renal dytfunction, though some patients may show slight changes such as low specific gravity of urine, proteinuria and low creatinine clearance.抄録全体を表示PDF形式でダウンロード (2225K) -
渡辺 淳一1987 年 99 巻 3-4 号 p. 239-250
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーEighty-three patients with cholesterol gallstones in a functioning gallbladder were treated with 400mg UDCA and 200mg CDCA (group A), 300mg UDCA and 300mg CDCA (group B), 200mg UDCA and 400mg CDCA (group C), 400mg CDCA alone (group D), 400mg CDCA and 240mg trihydroxy propiophenone (group E), or 600mg UDCA alone (group F). All patients were followed by cholecystography and ultrasonography. At the end of 6 months of treatment, the cumulative efficacy (complete plus partial dissolution) of all subjects were 41.0%. Twelve patients (14.5%) had complete dissolution. Group B had the highest dissolution rate (69.2%:38.5% complete and 30.7% partial dissolution), and this rate was significantly higher (p<0.01) than that of the CDCA-treated patients (group D). Diarrhea was frequently observed in patients treated with 400mg CDCA (27.8% in group D and 31.3% in group E). Combination with UDCA seemed to prevent this complication. No significant changes in the plasma lipids were observed. Changes in the bile acid composition, including lithocholic acid, did not seem to be determined solely by the doses of UDCA and CDCA. Patients whose lithogenic index dropped below 1.0 during the treatment did not always show dissolution of gallstones. Although the age of the patients, obesity and stone size did not affect the dissolution rate, the female sex and good gallbladder contractility were preferable factors for the dissolution of cholesterol gallstones.抄録全体を表示PDF形式でダウンロード (631K) -
杉山 明1987 年 99 巻 3-4 号 p. 251-260
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーThe kinetics of serum ferritin were studied in 42 male patients with alcoholic liver diseases (17 with alcoholic fibrosis, 10 with alcoholic hepatitis and 15 with alcoholic cirrhosis). In addition, the chromatic reaction of biopsied liver tissue to ferritin staining (PAP method) was examined and compared with serum ferritin levels and the iron-staining data. Serum ferritin levels in patients with alcoholic liver diseases, determined immediately after abstinence, were significantly higher than those in normal controls, although no significant difference was noted in serum ferritin among the different disease types. The serum ferritin levels decreased exponentialy after abstinence regardless of the disease type. There were positive correlations between serum ferritin and the intensity of hepatic hemosiderin and between the intensity of hepatic hemosiderin and hepatic ferritin. These correlations indicate that the ferritin level changes according to the amount of hepatic iron stores. These results indicate that hyperferritinemia of patients with alcoholic liver diseases reflects an increase in hepatic iron stores and that the escape of hepatic ferritin due to hepatocellular damage and the reduced clearance of serum ferritin are also related to hyperferritinemia.抄録全体を表示PDF形式でダウンロード (1283K) -
島村 淳之輔1987 年 99 巻 3-4 号 p. 261-272
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーPatterns of seven key carbohydrate-metabolizing enzyme activities were examined in liver tissue from 125 patients with various liver diseases. Along with the progression of chronic hepatitis to liver cirrhosis (LC), activities of high-Km hexokinase (high-Km HK), fructose-1, 6-bisphosphatase (FBPase) and glucose 6-phosphatase (G6Pase) decreased, and those of glucose 6-phosphate dehydrogenase (G6PD) and hexokinase (HK) increased. In hepatocellular carcinoma (HCC), similar alterations of these enzyme activities were observed. The extent of enzyme alteration was greatest in HCC and fetal liver, and slightly less in LC and the icteric stage of acute hepatitis. Phosphofructokinase (PFK) activity was increased in acute hepatitis, and pyruvate kinase (PK) activity was increased in HCC. Principal component analysis showed G6PD and HK to be located close to α-fetoprotein and the GOT/GPT ratio. G6Pase and FBPase were distributed symmetrically to G6PD and HK. Thus, the factor loadings effectively separated HCC from the benign liver diseases. The results indicate that the determinations of these enzyme activities are useful in the clinical assessment of the progression of liver disease, which is not revealed by routine blood chemistry.抄録全体を表示PDF形式でダウンロード (3131K) -
坂本 裕治1987 年 99 巻 3-4 号 p. 273-285
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーThe distribution of IgG, IgA and IgM was studied immunohistochemically in liver from 43 patients with type B chronic liver disease (chronic persistent hepatitis: 8 cases, chronic aggressive hepatitis 2A: 11 cases, chronic aggressive hepatitis 2B: 20 cases, liver cirrhosis: 4 cases) in relation to the hepatitis B virus-related antigen/antibody system. In 7 cases of chronic hepatitis, hepatocytes with IgG on the cell surface were scattered or clustered in the liver tissue. All 7 cases showed positive intrahepatic HBcAg and severe hepatitic activity. Immunoelectron microscopy revealed HBcAg to be localized in the membrane of the endoplasmic reticulum and on the cell surface of the hepatocytes. These findings suggest that the IgG on the hepatocytes may recognize HBcAg expressed on the surface of the hepatocytes. However, the cell surface IgG was also observed in liver tissue of chronic hepatitis patients which was obtained after acute exacerbation and in which HBcAg positive hepatocytes were scarcely seen. In such cases, the cell surface IgG may recognize HBV-related antigens other than HBcAg, neoantigens or liver specific membrane antigen.抄録全体を表示PDF形式でダウンロード (2894K) -
松原 一志1987 年 99 巻 3-4 号 p. 287-301
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーThe infuluence of 2 stout build on the body surface electrocardiogram was studied by comparing the body surface isopotential maps of 93 normal men and 107 obese men without cardiovascular abnormalities. There were no clear differences in the mean map patterns between these groups, although the position of the peak maximum positive potential shifted slightly leftward in the obese group. The maximum positive potentials of the QRS wave (Rmax V) and T wave (Tmax V) at 87 lead points on the left anterior chest and back surface were significantly greater in the obese group. However, on the lower anterior chest surface, the values of Rmax V were smaller in the obese group. The correlations between the Rmax V of the lead points where significant differences between the groups were found and the relative body weight, skinfold thickness, chest configuration, mean frontal QRS axis of ECG, age and respiratory function (% VC, FEV 1.0%) were studied statistically. There were good correlations between Rmax V and the QRS axis and relative body weight. However, there were no apparent correlations between Rmax V and the chest configuration and skinfold thickness. These results suggest that obesity might lead to an increase in abdominal grith and elevation of the diaphragma that produces a mechanical effect on the heart, causing a left-axis shift.抄録全体を表示PDF形式でダウンロード (4216K) -
第1編 -ラットにおける基礎的検討-杉原 徹1987 年 99 巻 3-4 号 p. 303-309
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーGastric mucosal lesions such as gastric ulcers and erosions are frequently observed in patients with liver cirrhosis. Although portal hypertension is suggested to play a role in the development of gastric mucosal lesions, the pathogenesis still remains undisclosed.
Gastric mucosal blood flow (BF), potential difference (PD) and prostaglandin E2 (PGE2) were analyzed using both rats with liver injury induced by carbon tetraoxide and rats with portal hypertension induced by incomplete portal occlusion. BF, PD and PGE2 were lower in the rats with injured liver and with portal hypertension than in control rats. BF and PD were lower in the rats with injured liver than in the rats with portal hypertension.
These results support the view that the impairment of the defensive factors of gastric mucosa represented by BF, PD and PGE2 play an important role in the pathogenesis of gastric mucosal lesions in rats with injured liver. Portal hypertension was considered to be a factor contributing to the impairment of the defensive factors of gastric mucosa.抄録全体を表示PDF形式でダウンロード (363K) -
第2編 -ヒト肝硬変症における臨床的検討-杉原 徹1987 年 99 巻 3-4 号 p. 311-320
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーIn order to clarify the pathogenesis of gastric mucosal lesions in patients with liver cirrhosis (LC), gastric mucosal blood flow (BF), potential difference (PD) and prostaglandin E2 (PGE2) of patients with LC were analyzed.
Of 277 patients with LC, gastric ulcer or gastric erosions were observed in 178 patients (64.2%). The incidence of gastric mucosal lesions in patients with LC correlated with the degree of liver damage estmated by Child's classification. BF, PD and PGE2 in patients with LC were lower than in control patients without liver disease. BF and PD decreased as the liver damage progressed.
These results support the view that the impairment of the defensive factors of gastric mucosa represented by BF and PD play an important role in the pathogenesis of gastric mucosal lesions in patients with LC. PGE2 was also implicated to be related to the pathogenesis of such lesions.抄録全体を表示PDF形式でダウンロード (420K) -
小瀧 規子1987 年 99 巻 3-4 号 p. 321-336
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーUrinary and serum cadmium levels as well as cadmium contents in kidneys of female rhesus monkeys given a cadmium (Cd)-containing diet and subjected to malnutrition were slightly elevated during the experimental period of 7 years. Particulary, greater excretion of cadmium in urine, elevation of serum cadmium and greater accumlation of cadmium in kidneys were observed early in the malnutritional groups (groups No.6, 7 and 8) as compared to the basal diet group (group No.5). One monkey in the low-nutritional and low-vitamin D group fed with Cd (group No.8) accumulated over 1000μg of Cd per g wet weight in the kidneys even at 36 months.
No remarkable changes in serum β2-microglobulin were observed in the Cd-treated groups (group No.5 to No.8) nor in the non-Cd treated groups (groups No.1 to No.4) during the experimental period. Although no significant leak of urinary β2-microglobulin was seen among the basal diet group fed with Cd (group No.5), the basal diet and low-vitamin D group fed with Cd (group No.7) and the non-Cd treated group (groups No.1 to No.4), much urinary β2-microglobulin began to leak at 36 months in the low-nutritional and low-vitamin D group fed with Cd (group No.8) and at 48 months in the low-nutritional group fed with Cd (group No.6).
The high levels of urinary β2-microglobulin seen in group No.8 reverted to normal with medical treatment, and the high levels observed in group No.6 sometimes decreased. These observations suggest mild renal dysfunction among the malnutritioned monkeys (groups No.6 and No.8) exposed to Cd.抄録全体を表示PDF形式でダウンロード (862K) -
岡崎 悟1987 年 99 巻 3-4 号 p. 337-345
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーTo investigate the precipitating effects of the westernized diet on diabetes mellitus, glucose tolerance and insulin response to oral glucose load (1.5g/kg body weight) and insulin sensitivity to exogenous insulin (0.2U/kg) were studied in rats fed an experimental diet for 8 weeks. Four experimental diets were used: low fat-no sugar diet (energy ratio of 10% fat, 70% starch, a model of the traditional Japanese diet), high fat-high sugar diet (40% fat, 20% starch, 20% sugar, a model of the westernized diet), low fat-high sugar diet (10% fat, 50% starch, 20% sugar) and high fat-no sugar diet (40% fat, 40% starch).
In high fat-high sugar diet rats, the body weight increased more, plasma glucose and insulin levels were higher while fasting and after oral glucose load, and insulin sensitivity was lower than in low fat-no sugar diet rats. Similar impaired glucose tolerance and hyperinsulinemia were present both in low fat-high sugar diet rats and in high fat-no sugar diet rats. However, insulin sensitivity was decreased in low fat-high sugar diet rats, but not in high fatno sugar diet rats.
These data indicate that the high fat-high sugar composition of the westernized diet has some precipitating effects on diabetes mellitus and that the diabetogenic mechanisms of the high fat diet and high sugar diet may be different.抄録全体を表示PDF形式でダウンロード (423K) -
渡辺 圀武1987 年 99 巻 3-4 号 p. 347-356
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーAn epidemiological study of the relationship between obesity and fatty liver of students in Japan was performed. Measurements of subcutaneous fatty tissue (Nagamine's method) and body weight (according to the Ministry of Health and Welfare 1971-standard body weight method and 1986-standard body weight method) were used to determine obesity. The data of 6, 485 18-year-old male and female students of Okayama University, obtained from records beginning 30 years ago, and the data of 1, 932 students, obtained in 1986, were examined.
The frequency of obesity of men increased since the nineteen-seventies (10.8% in 1986), but that of women did not change for the past 30 years. However, the frequency of emaciation of women has increased for the past 5-6 years (11.5-10.0%). Male students with negative HBsantigen, higher GPT levels than GOT levels with one or both levels being abnormal, and high choline-esterase level ( pH over 1.10) were suspected of having fatty liver, and many of them (85.7% by Nagamine's method, 66.7% by 1971-standard body weight method and 71.4% by 1986-method) were diagnosed as being obese. The students with fatty liver (judged by echography) had a greater frequency of obesity (86.7% by Nagamine's method, 80.0% by 1971-method and 76.7% by 1986-method) than those without fatty liver. The measurement of subcutaneous fatty tissue (Nagamine's method) was useful for screening fatty liver in students.抄録全体を表示PDF形式でダウンロード (510K) -
Polyclonal B cell activatorsによるリンパ球増殖反応に及ぼす鉄の影響並びにその作用機序について松枝 秀樹1987 年 99 巻 3-4 号 p. 357-374
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーIron deposition in synovial tissue from patients with rheumatoid arthritis (RA) was demonstrated coincidently with infiltration of immune cells. In order to investigate if ferric iron interacts directly with B-cells, the effect of ferric citrate on lymphocyte proliferation stimulated by mitogens was examined. Human peripheral blood mononuclear cells (PBM) were separated from venous blood by Conray-Ficoll gradients. PBM were cocultured with or without different polyclonal B-cell activators: Pokeweed mitogen (PWM), Staphylococcal phage lysate (SPL) and Staphylococcus aureus Cowan I (SAC). Ferric citrate significantly inhibited PWM, SPL and SAC responses as well as Con A responses. Furthermore, PBM were separated into PBM depleted of monocytes, E-RFC (T-cell enriched) and non E-RFC (B-cell enriched), and each cell fraction was cultured with mitogens and ferric citrate. Mitogen responses of fractionated cells were inhibited by co-addition of ferric citrate in the same way as PBM. These results indicated that iron may inhibit SAC responses of human B-cells by interacting directly with B-cells. Iron also inhibited specific antigen (PPD) stimulated lymphocyte proliferation in vitro. Iron was shown to act in the early phase of mitogen responses. Purified IL-1 or IL-2 was added to the PBM culture system with mitogen and ferric citrate. Neither IL-1 nor IL-2 reversed the inhibitory activity of iron on lymphocyte proliferation. Con A or ferric citrate itself was not toxic to PBM after 5 days of culture. However, low cell viability of PBM was noted when the cells were cultured together with Con A and ferric citrate for 5 days. The decrease in cell viability was blocked by co-addition of catalase or gold in PBM culture system, indicating that iron might release oxygen radicals from activated macrophages.抄録全体を表示PDF形式でダウンロード (1347K) -
今吉 英介1987 年 99 巻 3-4 号 p. 375-387
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーBlood level of nine hormones and one enzyme were measured in twelve patients with the aortitis syndrome and in seven normal women in order to analyze the endocrinological environment of the aortitis syndrome.
The hormones and enzyme measured were: pituitary system: TSH, ACTH; adrenal cortex: dehydroepiandrosterone-sulfate (DHEA-S); adrenal medulla: adoenaline (AD); sympathetic system: noradrenaline (NA); renin-angiotensin-aldosterone system (RAA): plasma renin activity (PRA), angiotensin-I (AT I), angiotensin-II (AT II), angiotensin converting enzyme (ACE), aldosterone (ald). The insulin-induced hypoglycemic stress test was introduced to further evaluate TSH, ACTH, DHEA-S, AD and NA. The hypoglycemic stress test revealed decreased reaction of the pituitary gland, adrenal cortex, adrenal medulla and sympathetic system in the patients with the aortitis syndrome. The RAA system showed unique results. The first half of the system was remarkably exaggerated, although the second half remained inappropriately in the normal range. These results suggest that the patients with the aortitis syndrome were in a state of hyperreninemic hypoaldosteronism with a shift of hormonal metabolism in the adrenal cortex. Discriminant analysis proved the most important hormones unique to the aortitis syndrome to be AD, DHEA-S and PRA. We concluded that the endocrinological changes seen in patients with the aortitis syndrome were a remarkable increase in PRA superimposed by hyperreninemic hypoaldosteronism, impaired function of the adrenal cortex associated with metabolic shift and markedly diminished function of the adrenal medulla.抄録全体を表示PDF形式でダウンロード (1017K) -
小林 弘治1987 年 99 巻 3-4 号 p. 389-401
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーCorrelations between catalase activity and the methemoglobin concentration in the blood of acatalasemic, homozygous hypocatalasemic and normal mice were investigated. The formation of methemoglobin by hydrogen peroxide in the red cells with or without the addition of glucose in vitro was also studied. Levels of methemoglobin concentrations in the blood were decreased in the order of female acatalasemic, male acatalasemic, female homozygous hypocatalasemic, male homozygous hypocatalasemic and normal mice. A good negative correlation were observed between the logarithm of catalase activity and methemoglobin concentration in the blood of acatalasemic, homozygous hypocatoalasemic and normal mice. No significant differences in glutathione peroxidase activity and NADH diaphorase activity among acatalasemic and normal mice were observed. The amount of methemoglobin formed by hydrogen peroxide from hemoglobin in acatalasemic mouse red cells with or without the addition of glucose was more than that in normal mouse red cells. The amount of methemoglobin in normal or acatalasemic mouse red cells without the addition of glucose was more than that in red cells with the addition of glucose. From the above results, the methemoglobin concentration appears to be mainly controlled by the blood catalase activity.抄録全体を表示PDF形式でダウンロード (579K) -
1987 年 99 巻 3-4 号 p. 403-405
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (159K) -
1987 年 99 巻 3-4 号 p. 406-413
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (391K) -
1987 年 99 巻 3-4 号 p. 414-422
発行日: 1987/04/30
公開日: 2009/03/30
ジャーナル フリーPDF形式でダウンロード (412K)
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