Novel superoxide dismutase (SOD) mimics, the macromolecule-ironporphyrin possessing poly(L-lysine) (PLL
N) and iron tetraphenylporphyrin derivative are synthesized and their SOD activities are evaluated. The synthesis of PLL
N-bound iron nicotinoylamido-fenced tetraphenylporphyrin (PLL
N/FeNFP), iron pivaloylamido-fenced tetraphenylporphyrin (PLL
N/FePFP) and iron tetraphenylporphyrin (PLL
N/FeP) is conducted: The molar ratio of the iron tetraphenylporphyrin derivative to the structural unit of PLL
N is found to be about 1/10 under the condition of this study. The rate constant, k
cat, as indicator of SOD activity is about 10
6 M
-1 s
-1. PLL
N/FePFP is shown far more capable of functioning as a SOD mimic compared to macromolecule-ironporphyrins, owing to creation of space for an active site due to the cationic polymer domain and fenced-groups.
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