Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
52 巻 , 9 号
選択された号の論文の8件中1~8を表示しています
Detergents and Interface Science
  • Gohsuke SUGIHARA, Ayaki MIYAZONO, Shigemi NAGADOME, Tatsuo OIDA, Yoshi ...
    原稿種別: Regular Papers
    専門分野: Detergents and Interface Science
    2003 年 52 巻 9 号 p. 449-461
    発行日: 2003年
    公開日: 2003/08/15
    ジャーナル フリー
    Mixed micellization and mixed adsorbed film formation were investigated for the combination of a Gemini type cationic and a nonionic surfactants mixture: Bis-trimethyl ammonium Gemini derived from tartaric acid bromide (BAGTB) and n-Decanoyl-N-methylglucamide (MEGA-10). The surface tension of the aqueous mixed surfactant solution was measured at every 0.1 mole fraction of MEGA10 in the surfactant mixture applying a drop volume method at 30°C. From the curves of surface tension (γ) vs logarithmic concentration in molality (ln m ), critical micellization concentration (CMC), minimum surface tension at CMC (γCMC), surface excess (Γ), mean surface area occupied by a molecule (A m) and parameters related to synergism in surface activity such as pC20 and CMC / C20 were determined. Based on the regular solution theory, the relation of compositions of the singly dispersed phase (X MEGA10) and the micellar phase (Y MEGA10), and the relation of X MEGA10 with the composition in adsorbed film phase (Z 2) were estimated, and along with these, the interaction parameters in micelles (ωR) and in adsorbed film (ωA ) were calculated. Both the CMC-X MEGA-10 and CMC-Y MEGA-10 curves showed a negative deviation from ideal mixing and even the curve of Z MEGA10-m t (bulk phase concentration) produced a slightly negative ωA . However, the synergism in surface tension reduction was found to be rather weak from examination of partial molecular area (PMA) and the minimum free energy at surface G min(S) = (γCMC·A m·L ). As for the adsorbed film, the interaction mode between molecules, as well as two dimensional molecular packing, was observed to be separated into three regions; i. e. at X STDS = 0.45 and at X STDS = 0.75 different properties changed discontinuously.
Biochemistry and Biotechnology
  • Keita SOMEYA, Hiroyuki SHIMIZU, Chiyoko UCHIYAMA, Ichiro NAKAJIMA, Tat ...
    原稿種別: Regular Papers
    専門分野: Biochemistry and Biotechnology
    2003 年 52 巻 9 号 p. 463-470
    発行日: 2003年
    公開日: 2003/08/15
    ジャーナル フリー
    To confirm the antioxidant effects of the extract taken from Caesalpinia paraensis (ECP), we conducted various oxidation tests where the efficacy of this extract was compared to tocopherol (Toc) and ascorbic acid (AsA). We also evaluated the antioxidant effects of ECP on human-skin-lipid peroxidation using a chemiluminescence-HPLC (CL-HPLC) method. The ECP exhibited moderate antioxidant effectiveness in the conductometric determination method (CDM) test and oven test, which we carried out in homogeneous solution systems. In the β-carotene decoloring tests, which were heterogeneous systems, ECP had a strong antioxidant effect in both lipophilic and hydrophilic radical generation systems. In the singlet oxygen generating test, the ECP demonstrated very weak antioxidant properties. Furthermore, the topical application of ECP (at a concentration of 0.1 %) significantly suppressed the increase in the squalene monohydroperoxide (SqOOH)/squalene (Sq) ratios in human skin after UV irradiation. The ECP demonstrated various antioxidant effects, especially superior efficacy in the heterogeneous systems. Human skin consists of polyphasic systems. Therefore, we consider that the ECP could effectively prevent the skin lipid peroxidation caused by UV irradiation.
  • Mitsuo MIYAZAWA, Teruo OSHIMA, Misaki TOKURA, Masayoshi HISAMA
    原稿種別: Regular Papers
    専門分野: Biochemistry and Biotechnology
    2003 年 52 巻 9 号 p. 471-481
    発行日: 2003年
    公開日: 2003/08/15
    ジャーナル フリー
    A methanol extract from black rice bran showed a suppressive effect of the SOS-inducing activity on the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide) in the Salmonella typhimurium TA1535/pSK1002 umu test. The methanol extract was re-extracted with hexane, chloroform, ethylacetate, butanol and water. The ethylacetate fraction showed a suppressive effect. Suppressive compounds in an acidic fraction of the ethylacetate fraction were isolated by silica gel column chromatography and identified as vanillic acid (1) and protocatechuic acid (2) by GC, GC/MS, IR and 1H and 13C NMR spectroscopy. Compounds 1 and 2 suppressed the furylfuramide-induced SOS response in the umu test. Compounds 1 and 2 suppressed 37.7 and 44.5% of the SOS-inducing activity on furylfuramide at a concentration of 1.20 μ mol/mL. These compounds were assayed with other mutagens, 4-nitroquinolin 1-oxide (4NQO) and N -methyl-N ′-nitro-N -nitrosoguanidine (MNNG), which do not require liver metabolizing enzymes. In addition, compounds 1 and 2 were assayed with aflatoxin B1 (AfB1) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which require liver metabolizing enzymes. These compounds showed suppressive effects of the SOS-inducing activity against furylfuramide, 4NQO, MNNG, AfB1 and Trp-P-1. To research the structure-activity relationship, veratric acid (3) as a similar compound of 1 and methyl esters of 1,2 and 3 (1Me, 2Me and 3Me) were also assayed with all chemical mutagens. Compounds 1Me, 2Me and 3Me exhibited stronger suppressive effects of the SOS-inducing activity against all chemical mutagens than 1,2 and 3.
  • Kohsuke HAYAMIZU, Yuri ISHII, Norihiro SHIGEMATSU, Yasuhide OKUHARA, H ...
    原稿種別: Rapid Papers
    専門分野: Biochemistry and Biotechnology
    2003 年 52 巻 9 号 p. 499-504
    発行日: 2003年
    公開日: 2003/08/15
    ジャーナル フリー
    (-)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss. Recently, it was reported in a 52w toxicity study that Garcinia extract powder induced testicular atrophy in rats. In order to study the safety, Garcinia extract was administered to 10 healthy adult men at dose of 3,000 mg/day as HCA for 30 days. No toxicological changes were observed on anthropometric indices or clinical analysis. In addition, serum testosterone showed no change throughout the test period. In regard to subjective symptoms, very slight anorexia (two cases) and headache (one case) occurred. Therefore, we consider that Garcinia extract is safe as administered under the condition of this study.
Chemistry and Organic Synthesis
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