The Japanese Pharmacological Association has sponsored many researches on the effect of liver excision on the systemic metabolism [1-3] and, currently, new ones are in progress [4-6]. As is generally agreed, physiological function of the liver is quite extensive and as it plays a major function in the nutritive absorption, it is closely linked to the dental diseases. In the treatment of a liver complaint, what is known as a Liver preparation is usually administered but there is no definite indication by which the efficacy of this agent can be measured. A usual test method is to study a relation between this kind of liver preparation and toxic elements that disturb the liver function.
There has been recently published a report to the effect that though the remainder of it will enlarge itself to compensate for the liver subjected to an excision, the blood vessels connected with it will remain as they are. However, BENGMARK et al. [7] maintain that it is impossible to determine from outside whether the newly developed tissues will reach to the size of the original liver. Figs. 1 to 5 are based on their investigation.
As a part of our research endeavors dealing with the antidotal action of various drugs, we were concerned here with an experiment as to how much antidotal function of the liver becomes reduced following its excision and, for this purpose, a liver preparation was tested to find out how the reduced liver function would be restored by its administration.
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