The relaxing effects of protease inhibitors, EACA, PAB and aprotinin on the Ach-contracture of ABRM ofMytilus edulis were observed by measuring the half-relaxation time of Ach-contracture in comparison with the effects of serotonin and dopamine on it. 1. Serotonin and dopamine rapidly relaxed Ach-contracture of ABRM. These effects were dependent on the concentration of those two agents and consistent with those of other investigators. 2. EACA, PAB and aprotinin relaxed Ach-contracture of ABRM, and showed the lower potency as compared with serotonin and dopamine in relaxing action. These effects were dependent on the concentration of those agents by 10-4 M, respectively. The significance of the results obtained was also discussed in relation to protease, contractile elements and elements maintaining prolonged contraction induced by Ach in ABRM.
A verrucous carcinoma of the right lower gingiva treated with active chemotherapy and cryosurgery has been described. Chemotherapy with bleomycin and 5-fluorouracil, and cryosurgery using surface contact freezing were not found effectively. We wish to thank Professor G. Hirai for useful advice.