Cyclodextrin (CD) is a ring-shaped molecule with three forms ( α-, β- and γ-CD) which differ in the number of glucose units. Of the three CDs examined, only β-CD suppressed food intake in the rat. Thus, we primarily investigated the mechanisms by which β-CD suppressed food intake in the rat before its application for dog foods. β-CD is known to form inclusion complexes easily with cholesteml and bile acids. resulting in decrease bile acid utilization. By co-suppiementing with cholesterol, food intake of β-CD diet was improved. To investigate the relationship of decreased bile acid utilization by β-CD to the suppressive effect of β-CD, the effect of β-CD was compared with cholestyramine (CSTY, a bile acid binding polymer). β-CD, but not CSTY, depressed food intake of rats. β-CD can also inhibit α-amylase activity. Therefere, the effect of the dietary carbohydrate source on the suppressive effect of β-CD was investigated. β-CD severely suppressed food intake when the carbohydrate source was corn starch, but not sucrose. Furthermore, supplementation with α-amylase improved the suppressive effect of β-CD. Thereafter. a preference for β-CD was investigated in rats and dog. There was no preference or avoidance for β-CD in dogs and rats. It is sugthat dietary β-CD may be a useful ingredient for obese and/or diabetic dogs.

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The effect of dietary β-cyclodextrln (CD), a ring-shaped molecule having seven glucose units, and cholestyramine (CSTY), a bile acid binding polymer on the prevention (Experiment 1) and amelioration (Experiment 2) of obesity was investigated in the beagle dogs given a diet high in fat for 4 weeks. The composition position of a control diet was: Hill's c/d dry 200g, lard 117g and corn starch 34g. β-CD (23.4g) and CSTY (10.6g) was induded in an experimental diet by replacing corn starch in the control diet. In Experiment 1, body weight rapidly increased in the control dog, but dogs given a diet containing both β-CD and CSTY slightly gained their body weight. In Experiment 2, body weights in obese dogs given the β-CD diet, CSTY diet or β-CD + CSTY diet were rapidly reduced compared with those given the control diet. However, no significant differences were observed among the three dietary treatments.
These results suggest that dietary β-CD and CSTY would benefit dogs with obesity in both before and after the incidence of the syndrome. J. Pet Anim. Nutr., vol.2 (no.2): 48-52.1999.

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肥満犬9頭を3群に分け,各群に共役リノール酸(CLA)を4,2,0%含むドッグフードを10週間給与し,飼料摂取量の変化,肥満改善効果を体重および血液生化学的検査成績から検討した。次いで,CLAを含まない飼料に切り換えて,その後の変化も調べた。その結果,飼料摂取量は3種類の飼料間に差は見られなかったが,肥満犬のrelative energy level (REL) を求めたところ,4 % C L A 群でのREL値は,ヘアレス犬>同体重の有毛犬>最も著しい肥満の有毛犬の順であった。体重の変化としては,4 % C L A群で1頭の体重が減少し,2%CLA群では3頭に1.5-3.0kg程の体重減少を認めた。ドッグフード切り換えによる体重の大きな増加は見られなかった。血液生化学的検査成績については,2%CLA群でトリグリセライド量および総コレステロール量の減少が確認された。4%CLA群では,アラニンアミノトランスフェラーゼおよびアルカリホスファターゼ活性の増加が認められた。以上から,2%CLA添加飼料は,肥満犬の過体重および脂質代謝系にある程度の改善効果があり,CLAを含まない飼料に切り換えても,体重のリバウンド現象や脂質代謝系の急激な変化は生じないことがわかった。また,4%高用量CLA添加は,肝臓・胆道系に何らかの障害をもたらす可能性があることもわかった。CLA添加ドッグフードは,イヌの肥満の予防および治療を進める上で役立つものと思われる。

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