The Japanese Journal of Nephrology
Online ISSN : 1884-0728
Print ISSN : 0385-2385
ISSN-L : 0385-2385
Volume 16, Issue 4
Displaying 1-5 of 5 articles from this issue
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    Neal S. Bricker
    1974 Volume 16 Issue 4 Pages 327-339
    Published: April 30, 1974
    Released on J-STAGE: July 05, 2010
    JOURNAL FREE ACCESS
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  • Hidekazu Shigematsu, Koichi Nagao, Toshitada Yazima
    1974 Volume 16 Issue 4 Pages 341-349
    Published: April 30, 1974
    Released on J-STAGE: July 04, 2011
    JOURNAL FREE ACCESS
    A case (44 yrs. female) of rapidly progressive glomerulonephritis with vasculitis in various organs was reported with special reference to the histopathogenesis of the development of the extracapillary disorganizing glomerulonephritis. Severe exudation with massive fibrinoid material into the Bowmann's space was observed in local and segmental glomerular loops. This was followed by the granulomatous proliferative reaction in the Bowman's space as well as from the pericapsular interstitium, resulting in the destruction of the glomerular structure. Etiopathogenesis of vasculitis and glomerulitis was discussed with reference to the findings in some experimental glomerulonephritides.
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  • Naohiko Ueda, Shigeharu Urakabe, Yoshimasa Orita, Motoo Kohama, Dairok ...
    1974 Volume 16 Issue 4 Pages 351-363
    Published: April 30, 1974
    Released on J-STAGE: March 01, 2011
    JOURNAL FREE ACCESS
    Forty-four patients with glomerulonephritis were treated with an antiinflammatory drug, indomethacin, especially in order to assess whether the effect on proteinuria continues ever after its withdrowal. Thus the amount of urinary protein was examined both during and after the treatment at appropriate intervals. One of the patients had a post-acute glomerulonephritis and the other a chronic glomerulonephritis, among the latter 14 patients showed a nephrotic syndrome. In 84% of the patients proteinuria markedly decreased within several days after the start of this drug, but in most cases returned to respective control levels in a few days after the withdrowal. In the follow up study up to 2 years after the stop of this therapy, 20% of the patients showed some extent of remission. It should be noted, however, that the drug assessment is extremely difficult, because spontaneous remission could not be neglected. There exists no relation between the effect on proteinuria and the histopathological findings in biopsy specimens either during or after the treatment. Membranous type of nephrotic syndrome was found to be completely resistant to indomethacin. Subjective complaints such as dull headache and nausea were found in 66% only during the administration. An elevation of blood urea nitrogen and of bloodpressure, anemia and peptic ulcer frequently occured in the cases with moderately damaged renal function. In brief indomethacin was proved to induce an imcomplete remission in some cases with chronic, glomerulonephritis even after the withdrowal.
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  • Koichi Hasegawa, Teruo Okamoto, Yoshiki Matushita, Noboru Hamada, Ryoh ...
    1974 Volume 16 Issue 4 Pages 365-377
    Published: April 30, 1974
    Released on J-STAGE: July 05, 2010
    JOURNAL FREE ACCESS
    The serum TSH was measured by radioimmunoassay after i. v. injection of 500 .Eg of TRH in 9 undialysed patients and 12 dialysed patients with chronic renal failure and in 6 healthy subjects. The basal level of the serum TSH in dialysed patients with chronic renal failure was significantly higher than in healthy subjects. The serum TSH rose to maximum level 30 minutes in healthy subjects and 60 minutes in patients with chronic renal failure after TRH injection. The mean maximum increment of the serum TSH in healthy subjects was significantly higher than that in patients with chronic renal failure. Although the serum TSH in healthy subjects returned to basal level 120 minutes after TRH injection, the recovery to basal level was very much retarded in patients with chronic renal failure. These findings may indicate a reduced response of the pituitary to TRH and decreased turnover of TSH in patients with chronic renal failure.
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  • A study on the specific method for the measurement of guanidino derivatives, especialy methylguanidine, and its clinical application
    Fumitake Gejyo
    1974 Volume 16 Issue 4 Pages 379-389
    Published: April 30, 1974
    Released on J-STAGE: March 01, 2011
    JOURNAL FREE ACCESS
    Guanidine base was determined using activated charcoal according to Yatzidis, and methylguanidine was separated by ion exchange columnchromatography(Dowe×50), and then measured colorimetrically by the Sakaguchi reaction. By using these technigues, serum levels and urinary excretions of guanidino derivatives in uremic and control subjects were compared. 1) Serum level of guanidine base in 11 normal subjects was 0.3±0.1 mg/dl, and 1.5±0.4 mg/dl in 28 uremic subjects. 2) Serum level of methylguanidine in 6 normal subjects was 0.0046±0.002 mg/dl, and 0.093±0.043 mg/dl in 19 uremic subjects. 3) Urinary excretion of methylguanidine was 0.5±0.35mg/day in normal subjects, and 10.0±0.43 mg/day in uremic subjects. 4) A correlation between guandine base and serum creatinine (r=0.88) was more closer than the blood nitrogen (r=0.63). 5) The guanidino derivatives were dialyzable easily by cuprophane membrane, and the value of guanidine and creatinine dialyzance was the same in the standard kiil dialyzer.
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